Comprehensive Physiology Wiley Online Library

Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

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Abstract

The sections in this article are:

1 Initiation
1.1 Initiating Agents
1.2 Metabolic Response to Chemical Carcinogens
1.3 Aryl Hydrocarbon Hydroxylases
1.4 Role of Cutaneous Aryl Hydrocarbon Hydroxylase in Tumorigenesis
1.5 Conjugases
2 Role of the Pilosebaceous Apparatus in Initiation
2.1 Interaction of Chemical Carcinogens with Cells
3 Promotion
3.1 Modification of the Initial Carcinogen‐Cell Interaction
3.2 Later Stages of Promotion
4 Photochemical Carcinogenesis
5 Conclusion
Figure 1. Figure 1.

Kinetics of aryl hydrocarbon hydroxylase induction in mouse skin . Various amounts of benz[a]anthracene in 0.2 ml of acetone were applied to the shaven skin of Swiss mice and enzyme activity (pmole of phenolic product/mg protein/30 min) was determined in homogenates at various times after application as described by Gelboin and co‐workers .



Figure 1.

Kinetics of aryl hydrocarbon hydroxylase induction in mouse skin . Various amounts of benz[a]anthracene in 0.2 ml of acetone were applied to the shaven skin of Swiss mice and enzyme activity (pmole of phenolic product/mg protein/30 min) was determined in homogenates at various times after application as described by Gelboin and co‐workers .

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F. J. Wiebel, H. V. Gelboin. Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 337-348. First published in print 1977. doi: 10.1002/cphy.cp090121