Comprehensive Physiology Wiley Online Library

Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

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Abstract

The sections in this article are:

1 Initiation
1.1 Initiating Agents
1.2 Metabolic Response to Chemical Carcinogens
1.3 Aryl Hydrocarbon Hydroxylases
1.4 Role of Cutaneous Aryl Hydrocarbon Hydroxylase in Tumorigenesis
1.5 Conjugases
2 Role of the Pilosebaceous Apparatus in Initiation
2.1 Interaction of Chemical Carcinogens with Cells
3 Promotion
3.1 Modification of the Initial Carcinogen‐Cell Interaction
3.2 Later Stages of Promotion
4 Photochemical Carcinogenesis
5 Conclusion
Figure 1. Figure 1.

Kinetics of aryl hydrocarbon hydroxylase induction in mouse skin 202. Various amounts of benz[a]anthracene in 0.2 ml of acetone were applied to the shaven skin of Swiss mice and enzyme activity (pmole of phenolic product/mg protein/30 min) was determined in homogenates at various times after application as described by Gelboin and co‐workers 61.



Figure 1.

Kinetics of aryl hydrocarbon hydroxylase induction in mouse skin 202. Various amounts of benz[a]anthracene in 0.2 ml of acetone were applied to the shaven skin of Swiss mice and enzyme activity (pmole of phenolic product/mg protein/30 min) was determined in homogenates at various times after application as described by Gelboin and co‐workers 61.

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F. J. Wiebel, H. V. Gelboin. Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 337-348. First published in print 1977. doi: 10.1002/cphy.cp090121