Comprehensive Physiology Wiley Online Library

Putative Interventions

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Criteria for Claiming Retardation of Aging Processes
1.1 Life Span Extension
1.2 Modulation of Functional, Structural, and Morphological Changes as Evidence for Aging Retardation
1.3 Modulation of Pathology
2 Dietary Restriction, A Robust Antiaging Intervention
2.1 Historical Notes
2.2 Dietary Restriction, an Aging Intervention
2.3 Population Mortality Characteristics
2.4 Age‐Related Disease Processes
2.5 Physiological Characteristics
2.6 Cellular Actions
3 Modulation of the Aging Process by Other Interventions
3.1 Antioxidant Feeding
3.2 Deprenyl
3.3 Melatonin
3.4 Hypophysectomy
3.5 Dehydroepiandrosterone
4 Concluding Remarks
Figure 1. Figure 1.

Survival curves from two separate studies of male F344 rats. The lined curves (solid, ad libitum–fed; broken, diet‐restricted) indicate the study of Yu et al. with 115 rats in each group. The circled curves (closed, ad libitum–fed; open, diet‐restricted) indicate the study of Yu et al. with 40 rats in each group.

Reproduced with permission
Figure 2. Figure 2.

Effects of age and dietary restriction on protein synthesis (left) and protein degradation (right). Solid line, dotted line refer to ad libitum–fed and diet‐restricted rats, respectively.

Reproduced from Ward with permission
Figure 3. Figure 3.

Structure of deprenyl.



Figure 1.

Survival curves from two separate studies of male F344 rats. The lined curves (solid, ad libitum–fed; broken, diet‐restricted) indicate the study of Yu et al. with 115 rats in each group. The circled curves (closed, ad libitum–fed; open, diet‐restricted) indicate the study of Yu et al. with 40 rats in each group.

Reproduced with permission


Figure 2.

Effects of age and dietary restriction on protein synthesis (left) and protein degradation (right). Solid line, dotted line refer to ad libitum–fed and diet‐restricted rats, respectively.

Reproduced from Ward with permission


Figure 3.

Structure of deprenyl.

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Byung P. Yu. Putative Interventions. Compr Physiol 2011, Supplement 28: Handbook of Physiology, Aging: 613-631. First published in print 1995. doi: 10.1002/cphy.cp110123