Comprehensive Physiology Wiley Online Library

Renal Circulation

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Dynamics of the Renal Microcirculation
1.1 Glomerular Capillary Pressure
1.2 Glomerular Dynamics
1.3 Single‐Nephron Filtration Rate
1.4 Segmental Vascular Resistance
1.5 Peritubule Capillary Dynamics
2 Intrarenal Distribution of Blood Flow
2.1 Cortical Blood Flow
2.2 Medullary Blood Flow
3 Autoregulation of Blood Flow
3.1 Autoregulation in Various Renal Zones
3.2 Localization of Resistance Changes
3.3 Mechanisms of Autoregulation
4 Additional Reading
Figure 1. Figure 1.

Pressure profile of renal circulation. Ra, renal artery; Aa, afferent arteriole; Glom, glomerular capillaries; Ea, efferent arteriole; Pc, peritubular capillaries; V, venule; Rv, renal vein. Experimental data from rat.

From Frohnert
Figure 2. Figure 2.

Starling forces regulating glomerular filtration. Net filtration pressure (ΔP) is result of opposing hydrostatic pressure (HP) in glomerular capillary and sum of hydrostatic pressure in Bowman's space and plasma oncotic pressure (OP). Net filtration pressure is maximal at afferent arteriolar site of capillary and approaches 0 toward efferent arteriolar site because of increasing plasma oncotic pressure, a direct consequence of ultrafiltration.

From Frohnert
Figure 3. Figure 3.

Autoregulation of renal plasma flow (RPF) and glomerular filtration rate (GFR) over a similar range of mean arterial pressures.

Adapted from Shipley and Study
Figure 4. Figure 4.

Effects of graded reductions in renal perfusion pressure on several measures of surface nephron and microvascular function in plasma‐loaded rats.

From Robertson et al.


Figure 1.

Pressure profile of renal circulation. Ra, renal artery; Aa, afferent arteriole; Glom, glomerular capillaries; Ea, efferent arteriole; Pc, peritubular capillaries; V, venule; Rv, renal vein. Experimental data from rat.

From Frohnert


Figure 2.

Starling forces regulating glomerular filtration. Net filtration pressure (ΔP) is result of opposing hydrostatic pressure (HP) in glomerular capillary and sum of hydrostatic pressure in Bowman's space and plasma oncotic pressure (OP). Net filtration pressure is maximal at afferent arteriolar site of capillary and approaches 0 toward efferent arteriolar site because of increasing plasma oncotic pressure, a direct consequence of ultrafiltration.

From Frohnert


Figure 3.

Autoregulation of renal plasma flow (RPF) and glomerular filtration rate (GFR) over a similar range of mean arterial pressures.

Adapted from Shipley and Study


Figure 4.

Effects of graded reductions in renal perfusion pressure on several measures of surface nephron and microvascular function in plasma‐loaded rats.

From Robertson et al.
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Franklyn G. Knox, William S. Spielman. Renal Circulation. Compr Physiol 2011, Supplement 8: Handbook of Physiology, The Cardiovascular System, Peripheral Circulation and Organ Blood Flow: 183-217. First published in print 1983. doi: 10.1002/cphy.cp020306