Comprehensive Physiology Wiley Online Library

Circulation to Skin and Adipose Tissue

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Skin
1.1 Introduction
1.2 Arrangement of Vessels
1.3 Arteriovenous Anastomoses
1.4 Skin Vessels as Heat Exchangers
1.5 Measurement of Flow
1.6 Vasomotor Innervation
1.7 Reflex Control of Flow
1.8 Responses to Physical Stimuli
1.9 Responses to Humoral Agents
2 Adipose Tissue
2.1 Introduction
2.2 Arrangement of Vessels
2.3 Vascular Exchange
2.4 Measurement of Flow
2.5 Vasomotor Innervation
2.6 Reflex Control of Flow
2.7 Responses to Physical Stimuli
2.8 Responses to Humoral Agents
Figure 1. Figure 1.

Diagram of vascular anatomy in plantar skin.

From Conrad 97. Reproduced with permission from Conrad, M. C.: Functional Anatomy of the Circulation to the Lower Extremities. Copyright © 1971 by Year Book Medical Publishers, Inc., Chicago
Figure 2. Figure 2.

Effects of body cooling and heating on blood flow in normal and cutaneous nerve‐blocked forearm. CNB, cutaneous nerves on left side blocked with local anesthetic.

From Blair, Glover, and Roddie 63
Figure 3. Figure 3.

Forearm and hand blood flow before and during body heating. Rectangle represents period of body heating. •, Forearm flow; ○, hand flow in ml · 100 m−1 · min−1; ○, current (μA) flowing through forearm skin is an index of sweat gland activity.

From Roddie et al. 308
Figure 4. Figure 4.

Blood flow through bodies of hands before and during indirect heating. Circulation to digits was arrested by rubber bands applied around the base of each digit. ○, Control hand; •, experimental hand. Atropine sulfate (0.3 mg) was infused into the brachial artery on the experimental side immediately before observations commenced.

From Roddie et al. 308
Figure 5. Figure 5.

Schematic representation of changes in blood flow in normal and nerve‐blocked hand and forearm during body cooling and heating. At CNB, vasomotor nerves to the hand and forearm skin were blocked with local anesthetic solution.

Figure 6. Figure 6.

Effects of body cooling and heating on blood flow in normal and cutaneous‐nerve‐blocked forearm, upper arm, calf, and thigh: ▪, right side; □, left side. CNB, cutaneous nerves on left side blocked with local anesthetic.

From Blair, Glover, and Roddie 63
Figure 7. Figure 7.

Effect of cutaneous nerve block, body cooling, and body heating on skin temperature of ear. CNB, great auricular nerve to left ear blocked; ○, left ear; •, right ear.

From Blair, Glover, and Roddie 64
Figure 8. Figure 8.

Effect of heat flow from regions of upper chest by blocking cutaneous nerve supply. Failure to dilate during body heating and absence of vasoconstrictor reflexes in nerve‐blocked areas are clearly shown.

From Fox et al. 143
Figure 9. Figure 9.

Top: record from above downward shows signal, central venous pressure, and brachial arterial pressure. Depression of signal indicates period during which both common carotid arteries were compressed. Bottom: plethysmography tracings of calf and hand blood flow before, during, and after compression of both common carotid arteries; arrows mark beginning and end of compression. Static calibrations on plethysmographic record represent 10‐ml volume increases.

From Roddie and Shepherd 305
Figure 10. Figure 10.

Effect of Valsalva's maneuver on sympathetic activity recorded in a median nerve fascicle innervating glabrous skin. Upper tracing: respiratory movements, inspiration upward. Middle tracing: integrated sympathetic nerve activity. Lower tracing: arterial blood pressure.

From Delius et al. 109
Figure 11. Figure 11.

Effects of 2 consecutive periods of neck suction on total, muscle, and skin vascular resistance and blood flow and on mean arterial pressure and heart rate in a single subject. Each point represents mean value for all determinations made during each control and intervention period.

From Beiser et al. 41
Figure 12. Figure 12.

Effect of leg exercise on blood flow in the hand (▿) and forearm (•). Left panel: average result of 19 runs on 3 subjects when increase in oxygen consumption above resting level was <500 ml/min (avg 326 ml/min). Right panel: average result of 17 runs on the same subject when increase in oxygen consumption was >500 ml/min (avg 780 ml/min). Rectangle indicates 5‐min period of leg exercise.

From Blair, Glover, and Roddie 65, by permission of the American Heart Association Inc
Figure 13. Figure 13.

Effect of severe emotional stress on arterial pressure: Δ, heart rate; •, forearm blood flow; ○, hand blood flow. During the time indicated by rectangle, the subject was led to believe that he was suffering from severe blood loss.

From Blair, Roddie, et al. 57
Figure 14. Figure 14.

Effect of 2 min of ischemia on blood flow and oxygen saturation in deep superficial veins in forearm. Hatched lines: time of ischemia.

From Dornhorst 115
Figure 15. Figure 15.

Critical closure of digital blood vessels during reduction of transmural pressure in 4 subjects. Heat flow is expressed as percentage of flow from corresponding finger of opposite hand kept under control conditions at heart level. ○, Transmural pressure reduced by hand elevation; •, transmural pressure reduced by positive tissue pressure.

From Roddie and Shepherd 304
Figure 16. Figure 16.

Effect of increased transmural pressure on oxygen saturation of blood samples obtained from deep forearm vein. Forearm was exposed to a pressure 50 mmHg below atmospheric for period shown.

From Roddie and Shepherd 304
Figure 17. Figure 17.

Approximate levels of blood flow in the hand when immersed in water at temperatures between 0°–45°C and when vasoconstrictor fiber activity is inhibited (heat load), moderate (comfortable), and intense (cold stress).

From Folkow and Neil 141
Figure 18. Figure 18.

Heat loss (in cal · 100 ml−1 · min−1) from right index finger of single subject to water at 0°–6°C. Clear area represents heat derived from circulating blood. Pain is indicated by a roughly quantitative scale at top of the figure and relationship between pain and heat loss is striking.

From Greenfield et al. 181
Figure 19. Figure 19.

Effect of histamine (10 μg/min for 3 min) on forearm blood flow. Each point is mean of 3 blood flow rates recorded in each minute during 1–2 infusions in each of 5 subjects. Vertical bars, SEM. A: •, control response (2 infusions in each subject); ○, in presence of mepyramine (avg response to 2 infusions, the 1st after 25 mg, the 2nd after an additional 3–5 mg of mepyramine); ▪, in presence of both drugs together (30–35 mg mepyramine and 10–15 mg metiamide). B: •, control response (2 infusions in each subject); ▵, in presence of metiamide (avg of response to 2 infusions, the 1st after 10 mg, the 2nd after an additional 15 mg of metiamide; ▪, in presence of both drugs together (30–40 mg metiamide and 25 mg mepyramine).

From Chipman and Glover 91
Figure 20. Figure 20.

Effect of infiltrating local anesthetic solution around radial, ulnar, and median nerves to forearm on blood flow changes with CO2 inhalation. Black rectangle indicates period when the subject breathed 12.5% CO2 in O2. ○, Nerve‐blocked forearm; •, normal forearm.

From Blair, Roddie, et al. 61
Figure 21. Figure 21.

Effect of voluntary hyperventilation with air and 5% CO2 in 95% oxygen on blood flow through hand and forearm. •, Intact hand or forearm; ○, nerve‐blocked hand or forearm. Periods between dotted lines represent periods of hyperventilation.

From Roddie et al. 309


Figure 1.

Diagram of vascular anatomy in plantar skin.

From Conrad 97. Reproduced with permission from Conrad, M. C.: Functional Anatomy of the Circulation to the Lower Extremities. Copyright © 1971 by Year Book Medical Publishers, Inc., Chicago


Figure 2.

Effects of body cooling and heating on blood flow in normal and cutaneous nerve‐blocked forearm. CNB, cutaneous nerves on left side blocked with local anesthetic.

From Blair, Glover, and Roddie 63


Figure 3.

Forearm and hand blood flow before and during body heating. Rectangle represents period of body heating. •, Forearm flow; ○, hand flow in ml · 100 m−1 · min−1; ○, current (μA) flowing through forearm skin is an index of sweat gland activity.

From Roddie et al. 308


Figure 4.

Blood flow through bodies of hands before and during indirect heating. Circulation to digits was arrested by rubber bands applied around the base of each digit. ○, Control hand; •, experimental hand. Atropine sulfate (0.3 mg) was infused into the brachial artery on the experimental side immediately before observations commenced.

From Roddie et al. 308


Figure 5.

Schematic representation of changes in blood flow in normal and nerve‐blocked hand and forearm during body cooling and heating. At CNB, vasomotor nerves to the hand and forearm skin were blocked with local anesthetic solution.



Figure 6.

Effects of body cooling and heating on blood flow in normal and cutaneous‐nerve‐blocked forearm, upper arm, calf, and thigh: ▪, right side; □, left side. CNB, cutaneous nerves on left side blocked with local anesthetic.

From Blair, Glover, and Roddie 63


Figure 7.

Effect of cutaneous nerve block, body cooling, and body heating on skin temperature of ear. CNB, great auricular nerve to left ear blocked; ○, left ear; •, right ear.

From Blair, Glover, and Roddie 64


Figure 8.

Effect of heat flow from regions of upper chest by blocking cutaneous nerve supply. Failure to dilate during body heating and absence of vasoconstrictor reflexes in nerve‐blocked areas are clearly shown.

From Fox et al. 143


Figure 9.

Top: record from above downward shows signal, central venous pressure, and brachial arterial pressure. Depression of signal indicates period during which both common carotid arteries were compressed. Bottom: plethysmography tracings of calf and hand blood flow before, during, and after compression of both common carotid arteries; arrows mark beginning and end of compression. Static calibrations on plethysmographic record represent 10‐ml volume increases.

From Roddie and Shepherd 305


Figure 10.

Effect of Valsalva's maneuver on sympathetic activity recorded in a median nerve fascicle innervating glabrous skin. Upper tracing: respiratory movements, inspiration upward. Middle tracing: integrated sympathetic nerve activity. Lower tracing: arterial blood pressure.

From Delius et al. 109


Figure 11.

Effects of 2 consecutive periods of neck suction on total, muscle, and skin vascular resistance and blood flow and on mean arterial pressure and heart rate in a single subject. Each point represents mean value for all determinations made during each control and intervention period.

From Beiser et al. 41


Figure 12.

Effect of leg exercise on blood flow in the hand (▿) and forearm (•). Left panel: average result of 19 runs on 3 subjects when increase in oxygen consumption above resting level was <500 ml/min (avg 326 ml/min). Right panel: average result of 17 runs on the same subject when increase in oxygen consumption was >500 ml/min (avg 780 ml/min). Rectangle indicates 5‐min period of leg exercise.

From Blair, Glover, and Roddie 65, by permission of the American Heart Association Inc


Figure 13.

Effect of severe emotional stress on arterial pressure: Δ, heart rate; •, forearm blood flow; ○, hand blood flow. During the time indicated by rectangle, the subject was led to believe that he was suffering from severe blood loss.

From Blair, Roddie, et al. 57


Figure 14.

Effect of 2 min of ischemia on blood flow and oxygen saturation in deep superficial veins in forearm. Hatched lines: time of ischemia.

From Dornhorst 115


Figure 15.

Critical closure of digital blood vessels during reduction of transmural pressure in 4 subjects. Heat flow is expressed as percentage of flow from corresponding finger of opposite hand kept under control conditions at heart level. ○, Transmural pressure reduced by hand elevation; •, transmural pressure reduced by positive tissue pressure.

From Roddie and Shepherd 304


Figure 16.

Effect of increased transmural pressure on oxygen saturation of blood samples obtained from deep forearm vein. Forearm was exposed to a pressure 50 mmHg below atmospheric for period shown.

From Roddie and Shepherd 304


Figure 17.

Approximate levels of blood flow in the hand when immersed in water at temperatures between 0°–45°C and when vasoconstrictor fiber activity is inhibited (heat load), moderate (comfortable), and intense (cold stress).

From Folkow and Neil 141


Figure 18.

Heat loss (in cal · 100 ml−1 · min−1) from right index finger of single subject to water at 0°–6°C. Clear area represents heat derived from circulating blood. Pain is indicated by a roughly quantitative scale at top of the figure and relationship between pain and heat loss is striking.

From Greenfield et al. 181


Figure 19.

Effect of histamine (10 μg/min for 3 min) on forearm blood flow. Each point is mean of 3 blood flow rates recorded in each minute during 1–2 infusions in each of 5 subjects. Vertical bars, SEM. A: •, control response (2 infusions in each subject); ○, in presence of mepyramine (avg response to 2 infusions, the 1st after 25 mg, the 2nd after an additional 3–5 mg of mepyramine); ▪, in presence of both drugs together (30–35 mg mepyramine and 10–15 mg metiamide). B: •, control response (2 infusions in each subject); ▵, in presence of metiamide (avg of response to 2 infusions, the 1st after 10 mg, the 2nd after an additional 15 mg of metiamide; ▪, in presence of both drugs together (30–40 mg metiamide and 25 mg mepyramine).

From Chipman and Glover 91


Figure 20.

Effect of infiltrating local anesthetic solution around radial, ulnar, and median nerves to forearm on blood flow changes with CO2 inhalation. Black rectangle indicates period when the subject breathed 12.5% CO2 in O2. ○, Nerve‐blocked forearm; •, normal forearm.

From Blair, Roddie, et al. 61


Figure 21.

Effect of voluntary hyperventilation with air and 5% CO2 in 95% oxygen on blood flow through hand and forearm. •, Intact hand or forearm; ○, nerve‐blocked hand or forearm. Periods between dotted lines represent periods of hyperventilation.

From Roddie et al. 309
References
 1. Abramson, D. I. Vascular Responses in the Extremities of Man in Health and Disease. Chicago, IL: Univ. of Chicago Press, 1944.
 2. Abramson, D. I., and E. B. Ferris, Jr. Responses of blood vessels in the resting hand and forearm to various stimuli. Am. Heart J. 19: 541–553, 1940.
 3. Abramson, D. I., and E. B. Ferris, Jr. Cited by D. I. Abramson, 1944. In: Vascular Responses in the Extremities of Man in Health and Disease. Chicago, IL: Univ. of Chicago Press, 1944.
 4. Abramson, D. I., K. H. Katzenstein, and E. B. Ferris, Jr. Observations on reactive hyperemia in various portions of the extremities. Am. Heart J. 22: 329–341, 1941.
 5. Abramson, D. I., H. Landt, and J. E. Benjamin. Peripheral vascular responses to acute anoxia. Arch. Intern. Med. 71: 583–593, 1943.
 6. Adson, A. W., and G. E. Brown. Calorimetric studies of the extremities following sympathetic ramisectomy and ganglionectomy. Am. J. Med. Sci. 170: 232–240, 1925.
 7. Adson, A. W., and G. E. Brown. The treatment of Raynaud's disease by resection of the upper thoracic and lumbar sympathetic ganglia and trunks. Surg. Gynecol. Obstet. 48: 577–603, 1929.
 8. Allen, J. A., J. E. Armstrong, and I. C. Roddie. The regional distribution of emotional sweating in man. J. Physiol. London 235: 749–759, 1973.
 9. Allen, J. A., J. E. Armstrong, and I. C. Roddie. Sweat responses in a hyperhidrotic subject. Br. J. Dermatol. 90: 277–281, 1974.
 10. Allwood, M. J., H. Barcroft, J. P. L. A. Hayes, and E. A. Hirsjarvi. The effect of mental arithmetic on the blood flow through normal, sympathectomised and hyperhidrotic hands. J. Physiol. London 148: 108–116, 1959.
 11. Allwood, M. J., and G. P. Lewis. Bradykinin and forearm blood flow. J. Physiol. London 170: 571–581, 1964.
 12. Alpert, J. S., and J. D. Coffman. Effect of intravenous epinephrine on skeletal muscle, skin and subcutaneous blood flow. Am. J. Physiol. 216: 156–160, 1969.
 13. Amberson, W. R. Physiologic adjustments to the standing posture. Bull. Sch. Med. Univ. Md. 27: 127–145, 1943.
 14. Anderson, D. P., W. J. Allen, H. Barcroft, O. G. Edholm, and G. W. Manning. Circulatory changes during fainting and coma caused by oxygen lack. J. Physiol. London 104: 426–434, 1946.
 15. Ardill, B. L., R. G. Bannister, P. H. Fentem, and A. D. M. Greenfield. Circulatory responses of supine subjects to the exposure of parts of the body below the xipisternum to subatmospheric pressure. J. Physiol. London 193: 57–72, 1967.
 16. Ardill, B. L., V. M. Bhatnagar, and P. H. Fentem. Reduction in the vasoconstriction produced by sympathetic adrenergic nerves during reactive hyperaemia. Cardiovasc. Res. 1: 327–334, 1967.
 17. Armin, J., R. T. Grant, R. H. S. Thompson, and A. Tickner. An explanation for the heightened vascular reactivity of the denervated rabbit's ear. J. Physiol. London 121: 603–622, 1953.
 18. Arnott, W. M., and J. M. Macfie. Effect of ulnar nerve block on blood flow in the reflexly vasodilated digit. J. Physiol. London 107: 233–238, 1948.
 19. Aronovsky, E., R. Levari, W. Kornblueth, and E. Wertheimer. Comparison of metabolic activities of orbital fat with those of other adipose tissues. Invest. Ophthalmol. 2: 259–264, 1963.
 20. Auckland, K., and H. M. Johnsen. Protein concentration and colloid osmotic pressure of rat skeletal muscle interstitial fluid. Acta Physiol. Scand. 91: 354–364, 1974.
 21. Ballantyne, B. Histochemical and biochemical aspects of cholinesterase activity of adipose tissue. Arch. Int. Pharmacodyn. Ther. 173: 343–350, 1968.
 22. Ballard, K. Blood flow in canine adipose tissue during intravenous infusion of norepinephrine. Am. J. Physiol. 225: 1026–1031, 1973.
 23. Ballard, K., C. A. Cobb, and S. Rosell. Vascular and lipolytic responses in canine subcutaneous adipose tissue following infusion of catecholamines. Acta Physiol. Scand. 81: 246–253, 1971.
 24. Ballard, K., T. Malmfors, and S. Rosell. Adrenergic innervation and vascular patterns in canine adipose tissue. Microvasc. Res. 8: 164–171, 1974.
 25. Ballard, K., and S. Rosell. The unresponsiveness of lipid metabolism in canine mesenteric adipose tissue to biogenic amines and to sympathetic nerve stimulation. Acta Physiol. Scand. 77: 442–448, 1969.
 26. Ballard, K., and S. Rosell. Adrenergic neurohumoral influences on circulation and lipolysis in canine omental adipose tissue. Circ. Res. 28: 389–396, 1971.
 27. Barbolini, G., F. Tischendorf, and S. B. Curri. Histology, histochemistry and function of the human digital arteriovenous anastomoses (Hoyer Grosser's organs, Messon's glomera). I. The possible relationship with Pacinian corpuscles. Microvasc. Res. 2: 142–153, 1971.
 28. Barclay, J. A., W. T. Cooke, and R. A. Kenney. Observations on the effects of adrenaline on renal function and circulation in man. Am. J. Physiol. 151: 621–625, 1947.
 29. Barcroft, H. Problems of sympathetic innervation and denervation. Br. Med. Bull. 8: 363–370, 1952.
 30. Barcroft, H., K. D. Bock, H. Hensel, and A. H. Kitchin. Die Muskeldurchblutung des Menschen bei Indirekter Erwärmung und Abkühlung. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 261: 199–210, 1955.
 31. Barcroft, H., W. McK. Bonnar, O. G. Edholm, and A. S. Effron. On sympathetic vasoconstrictor tone in human skeletal muscle. J. Physiol. London 102: 21–31, 1943.
 32. Barcroft, H., and H. Konzett. On the actions of noradrenaline, adrenaline and isopropylnoradrenaline on the arterial blood pressure, heart rate and muscle blood flow in man. J. Physiol. London 110: 194–204, 1949.
 33. Barnett, A. J., R. B. Blacket, A. E. Depoorter, P. H. Sanderson, and G. M. Wilson. The action of noradrenaline in man and its relation to phaeochromocytoma and hypertension. Clin. Sci. 9: 151–179, 1950.
 34. Barron, J. N., and N. Veall. Application of radioactive sodium to problems in plastic surgery. Br. Med. Bull. 8: 197–202, 1952.
 35. Barsoum, G. S., and J. H. Gaddum. The pharmacological estimation of adenosine and histamine in blood. J. Physiol. London 85: 1–14, 1935.
 36. Bayliss, W. M. The action of carbon dioxide on blood vessels (Abstract). J. Physiol. London 26: 32P–33P, 1901.
 37. Bayliss, W. M. On the local reactions of the arterial wall to changes of internal pressure. J. Physiol. London 28: 220–231, 1902.
 38. Beaconsfield, P., and J. Ginsburg. The effect of body posture on hand blood flow. J. Physiol. London 130: 467–473, 1955.
 39. Beckett, E. B., G. H. Bourne, and W. Montagna. Histology and cytochemistry of human skin. The distribution of cholinesterase in the finger of the embryo and the adult. J. Physiol. London 134: 202–206, 1956.
 40. Behnke, A. R., and T. L. Willmon. Cutaneous diffusion of helium in relation to peripheral blood flow and absorption of atmospheric nitrogen through the skin. Am. J. Physiol. 131: 627–632, 1940.
 41. Beiser, G. D., R. Zelis, S. E. Epstein, D. T. Mason, and E. Braunwald. The role of skin and muscle resistance vessels in reflexes mediated by the baroreceptor system. J. Clin. Invest. 49: 225–231, 1970.
 42. Belfrage, E. Vasodilatation and modulation of vasoconstriction in canine subcutaneous adipose tissue caused by activation of β‐adrenoceptors. Acta Physiol. Scand. 102: 459–468, 1978.
 43. Bernard, C. Influence du grand sympathique sur la sensibilité et sur la calorification. C. R. Soc. Biol. 3: 163–164, 1851.
 44. Bernard, C. Sur les effets de la section de la portion céphalique du grand sympathique. C. R. Soc. Biol. 4: 168–170, 1852.
 45. Bernard, C. Sur les variations de couleur dans le sang veineux des organes glandularies suivant leur état de fonction ou de repos. J. Physiol. Paris 1: 233–244, 1858.
 46. Berne, R. M. Regulation of coronary blood flow. Physiol. Rev. 44: 1–29, 1964.
 47. Berne, R. M. Adenosine and coronary blood flow. Circ. Res. 47: 807–813, 1980.
 48. Best, C. H., and E. W. McHenry. Histamine. Physiol. Rev. 11: 371–477, 1931.
 49. Bevegård, B. S., and L. Orö. Effect of prostaglandin E1 on forearm blood flow. Scand. J. Clin. Lab. Invest. 23: 347–353, 1969.
 50. Bevegård, B. S., and J. T. Shepherd. Circulatory effects of stimulating the carotid arterial stretch receptors in man at rest and during exercise. J. Clin. Invest. 45: 132–142, 1966.
 51. Bevegård, B. S., and J. T. Shepherd. Regulation of the circulation during exercise in man. Physiol. Rev. 47: 178–213, 1967.
 52. Bier, A. Die Enstehung des Collateralkreislauf. I. Die arterielle Collateralkreislauf. Arch. Pathol. Anat. Physiol. 147: 257–293, 1897.
 53. Bini, A. Vascoiarizzione del tessuto dispose e rapporti tra capillari e cellule adipose. Boll. Soc. Ital. Biol. Sper. 14: 368–369, 1939.
 54. Bishop, J. M., K. W. Donald, S. H. Taylor, and P. N. Wormald. Blood flow in human arm during leg exercise. J. Physiol. London 137: 294–308, 1957.
 55. Black, J. E., and I. C. Roddie. The mechanism of the changes in forearm vascular resistance during hypoxia. J. Physiol. London 143: 226–235, 1958.
 56. Black, T. W., A. M. Duncan, C. T. Durant, C. R. Ganellin, and E. M. Parsons. Definition and antagonism of histamine H2 receptors. Nature London 236: 385–390, 1972.
 57. Blair, D. A., W. E. Glover, A. D. M. Greenfield, and I. C. Roddie. Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J. Physiol. London 148: 633–647, 1959.
 58. Blair, D. A., W. E. Glover, A. D. M. Greenfield, and I. C. Roddie. The increase in tone in forearm resistance blood vessels exposed to increased transmural pressure. J. Physiol. London 149: 614–625, 1959.
 59. Blair, D. A., W. E. Glover, and B. S. L. Kidd. The effect of continuous positive and negative pressure breathing upon the resistance and capacity blood vessels of the human forearm and hand. Clin. Sci. 18: 9–16, 1959.
 60. Blair, D. A., W. E. Glover, B. S. L. Kidd, and I. C. Roddie. Peripheral vascular effects of bretylium tosylate in man. Br. J. Pharmacol. 15: 466–475, 1960.
 61. Blair, D. A., W. E. Glover, L. McArdle, and I. C. Roddie. The mechanism of the peripheral vasodilatation following carbon dioxide inhalation in man. Clin. Sci. 19: 407–423, 1960.
 62. Blair, D. A., W. E. Glover, and I. C. Roddie. The abolition of reactive and post‐exercise hyperaemia in the forearm by temporary restriction of arterial inflow. J. Physiol. London 148: 648–658, 1959.
 63. Blair, D. A., W. E. Glover, and I. C. Roddie. Vasomotor fibres to skin in the upper arm, calf and thigh. J. Physiol. London 153: 232–238, 1960.
 64. Blair, D. A., W. E. Glover, and I. C. Roddie. Cutaneous vasomotor nerves to the head and trunk. J. Appl. Physiol. 16: 119–122, 1961.
 65. Blair, D. A., W. E. Glover, and I. C. Roddie. Vasomotor responses in the human arm during leg exercise. Circ. Res. 9: 264–274, 1961.
 66. Bolton, B., E. A. Carmichael, and G. Sturup. Vasoconstriction following deep inspiration. J. Physiol. London 86: 83–94, 1936.
 67. Braithwaite, F., F. T. Farmer, and F. I. Herbert. Observations on the vascular channels of tubed pedicles using radioactive sodium: III. Br. J. Plast. Surg. 4: 38–47, 1951.
 68. Braverman, I. M., and A. Yen. Demonstration of immune complexes in spontaneous and histamine‐induced lesions and in normal skin of patients with leukocytoclastic angitis. J. Invest. Dermatol. 64: 105–112, 1975.
 69. Brigden, W., S. Howarth, and E. P. Sharpey‐Schafer. Postural changes in the peripheral blood flow of normal subjects with observations on vasovagal fainting reactions as a result of tilting, the lordotic posture, pregnancy and spinal anaesthesia. Clin. Sci. 9: 79–90, 1950.
 70. Brod, J., V. Fencl, Z. Hejl, and J. Jirka. Circulatory changes underlying blood pressure elevation during acute emotional stress (mental arithmetic) in normotensive and hypertensive subjects. Clin. Sci. 18: 269–279, 1959.
 71. Brodie, T. G., and A. E. Russel. On the determination of the rate of blood flow through an organ. J. Physiol. London 32: XLVII–XIIX, 1905.
 72. Brown, E., J. S. Goei, A. D. M. Greenfield, and G. C. Plassaris. Circulatory responses to simulated gravitational shifts of blood in man induced by exposure of the body below the iliac crests to sub‐atmospheric pressure. J. Physiol. London 183: 607–627, 1966.
 73. Bruck, L., and H. Hensel. Wärmedurchgang und Innentemperatu der menschlichen Extremitäten. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 257: 70–86, 1950.
 74. Buchanan, T. J., E. W. Walls, and E. S. Williams. Studies in radiosodium clearance from the skin in man. Clin. Sci. 13: 133–343, 1954.
 75. Bulow, J., and J. Madsen. Adipose tissue blood flow during prolonged heavy exercise. Pfluegers Arch. 363: 231–234, 1976.
 76. Burch, G. E., and N. P. de Pasquale. Bradykinin, digital blood flow, and the arteriovenous anastomoses. Circ. Res. 10: 105–115, 1962.
 77. Burnstock, G. Cholinergic and purinergic regulation of blood vessels. In: Handbook of Physiology. The Cardiovascular System, edited by D. F. Bohr, A. P. Somlyo, and H. V. Sparks, Jr. Bethesda, MD: Am. Physiol. Soc., 1980, sect. 2, vol. II, chapt. 19, p. 567–612.
 78. Burton, A. C. The range and variability of the blood flow in the human fingers and the vasomotor regulation of body temperature. Am. J. Physiol. 127: 437–453, 1939.
 79. Burton, A. C. On the physical equilibrium of small blood vessels. Am. J. Physiol. 164: 319–329, 1951.
 80. Carlson, L. A., L. G. Ekelund, and L. Orö. Circulatory and respiratory effects of different doses of prostaglandin E1 in man. Acta Physiol. Scand. 75: 161–169, 1969.
 81. Carlson, L. A., and J. Eriksson. Femoral‐artery infusion of prostaglandin E1 in severe peripheral vascular disease. Lancet 1: 155–156, 1973.
 82. Carlsten, A., B. Folkow, G. Grimby, C.‐A. Hamberger, and O. Thulesium. Cardiovascular effects of direct stimulation of the carotid sinus nerve in man. Acta Physiol. Scand. 44: 138–145, 1958.
 83. Carmichael, E. A., and F. R. Fraser. The effects of acetylcholine in man. Heart 16: 263–274, 1933.
 84. Casey, B. H., and G. D. Thornburn. The distribution of blood flow in the skin using radioactive krypton 85 clearance technique. In: Biology of the Skin and Hair Growth, edited by A. C. Lyne and B. F. Short. Sydney: Angus & Robertson, 1965, p. 603–615.
 85. Catchpole, B. N., and R. P. Jepson. Hand and finger blood flow. Clin. Sci. 14: 109–120, 1955.
 86. Celander, O., and B. Folkow. A comparison of the sympathetic vasomotor fibre control of vessels within the skin and muscles. Acta Physiol. Scand. 29: 241–250, 1953.
 87. Challoner, A. V. J. Measurement of cutaneous blood flow by thermal, optical and radioisotope methods. In: Clinical Blood Flow Measurements, edited by J. P. Woodcock. London: Sector, 1976, p. 71–75.
 88. Chimoskey, J. E. Skin blood flow by 133Xe disappearance validated by venous occlusion plethysmography. J. Appl. Physiol. 32: 432–435, 1972.
 89. Chimoskey, J. E., W. J. Flanagan, and G. A. Holloway, Jr. Ultraviolet‐induced cutaneous hyperemia measured by Xenon 133 in man. J. Invest. Dermatol. 63: 367–368, 1974.
 90. Chimoskey, J. E., G. A. Holloway, and W. Flanagan. Effect of fluocinolene acetonide cream on human skin blood flow. J. Invest. Dermatol. 65: 241–243, 1975.
 91. Chipman, P., and W. E. Glover. Histamine H2‐receptors in the human peripheral circulation. Br. J. Pharmacol. 56: 494–496, 1976.
 92. Clark, E. R. Arterio‐venous anastomoses. Physiol. Rev. 18: 229–247, 1938.
 93. Clarke, R. S. J. The effect of voluntary overbreathing on the blood flow through the human forearm. J. Physiol. London 118: 537–544, 1952.
 94. Cobbold, A. F., J. Ginsburg, and A. Paton. Circulatory, respiratory and metabolic responses to isopropylnoradrenaline in man. J. Physiol. London 151: 539–550, 1960.
 95. Coles, D. R. Heat elimination from the toes during exposure of the foot to subatmospheric pressures. J. Physiol. London 135: 171–181, 1957.
 96. Coles, D. R., and A. D. M. Greenfield. The reactions of the blood vessels of the hand during increases in transmural pressure. J. Physiol. London 131: 277–289, 1956.
 97. Conrad, M. C. Functional Anatomy of the Circulation to the Lower Extremities. Chicago, IL: Year Book, 1971.
 98. Cooper, K. E., K. W. Cross, A. D. M. Greenfield, D. McK. Hamilton, and H. Scarborough. A comparison of methods for gauging the blood flow through the hand. Clin. Sci. 8: 217–234, 1949.
 99. Cooper, K. E., O. G. Edholm, and R. F. Mottram. The blood flow in skin and muscle of the human forearm. J. Physiol. London 128: 258–268, 1955.
 100. Crawford, D. G., H. M. Fairchild, and A. C. Guyton. Oxygen lack as a possible cause of reactive hyperemia. Am. J. Physiol. 197: 613–616, 1959.
 101. Crockford, G. W., and R. F. Hellon. Vascular responses of human skin to infra‐red radiation. J. Physiol. London 149: 424–432, 1959.
 102. Crossley, R. J., A. D. M. Greenfield, G. C. Plasseras, and D. Stephens. The interrelation of thermoregulatory and baroreceptor reflexes in the control of the blood vessels in the human forearm. J. Physiol. London 183: 628–636, 1966.
 103. Cumming, G. R. Acute hemodynamic effects of angiotensin II. Can. Med. Assoc. J. 88: 827–832, 1963.
 104. Dale, H. H., and C. L. Evans. Effects on the circulation of changes in the carbon dioxide content of the blood. J. Physiol. London 56: 125–145, 1922.
 105. Dalgliesh, C. E., C. C. Toh, and T. S. Work. Fractionation of the smooth muscle stimulants present in extracts of gastrointestinal tract. Identification of 5‐HT and its distinction from substance P. J. Physiol. London 120: 293–310, 1953.
 106. Daniel, H., and D. M. Derry. Criteria for differentiation of brown and white fat in the rat. Can. J. Physiol. Pharmacol. 47: 941–945, 1969.
 107. De Bono, E., G. de J. Lee, F. R. Mottram, G. W. Pickering, J. J. Brown, H. Keen, W. S. Peart, and P. H. Sanderson. The action of angiotensin in man. Clin. Sci. 25: 123–157, 1963.
 108. De Largy, C., A. D. M. Greenfield, R. L. McCorry, and R. F. Whelan. The effects of intravenous infusion of mixtures of l‐adrenaline and l‐noradrenaline on the human subject. Clin. Sci. 9: 71–78, 1950.
 109. Delius, W., K‐E. Hagbarth, A. Hongell, and B. G. Wallin. Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol. Scand. 84: 177–186, 1972.
 110. Detar, R., and D. F. Bohr. Oxygen and vascular smooth muscle contraction. Am. J. Physiol. 214: 241–244, 1968.
 111. Diculescu, I., and M. Stoica. Fluorescence histochemical investigation on the adrenergic innervation of the white adipose in the rat. J. Neuro Visc. Relat. 32: 25–36, 1970.
 112. Diji, A., and A. D. M. Greenfield. The local effect of carbon dioxide on human blood vessels. Am. Heart J. 60: 907–914, 1960.
 113. Di Lorenzo, P. A., D. W. Brown, S. H. Walker, P. L. Dern, and P. W. Goltz. Technetium‐99m pertechnetate disappearance studies in normal and psoriatic skin. J. Invest. Dermatol. 56: 39–43, 1971.
 114. Dole, V. P. A relation between non‐esterified fatty acids in plasma and the metabolism of glucose. J. Clin. Invest. 35: 150–154, 1956.
 115. Dornhorst, A. C. Hyperaemia induced by exercise and ischaemia. Br. Med. Bull. 19: 137–140, 1963.
 116. Dornhorst, A. C., and R. F. Whelan. The blood flow in muscle following exercise and circulatory arrest: the influence of reduction in effective local blood pressure, of arterial hypoxia and adrenaline. Clin. Sci. 12: 33–40, 1953.
 117. Doupe, J., C. H. Cullen, and L. J. Macaulay. Studies in denervation. F. The circulation in the skin in the proximal parts of the limbs. J. Neurol. Neurosurg. Psychiatry 6: 129–132, 1943.
 118. Dripps, R. D., and J. H. Comroe, Jr. The respiratory and circulatory response of normal man to inhalation of 7.6 and 10.4 per cent CO2 with a comparison of the maximal ventilation produced by severe muscular exercise, inhalation of CO2 and maximal voluntary hyperventilation. Am. J. Physiol. 149: 43–51, 1947.
 119. Ducharme, D. W., J. R. Weeks, and R. G. Montgomery. Studies on the mechanism of the hypertensive effect of prostaglandin F2α. J. Pharmacol. Exp. Ther. 160: 1–10, 1968.
 120. Duff, F., A. D. M. Greenfield, J. T. Shepherd, and J. D. Thompson. A quantitative study of the response to acetylcholine and histamine of the blood vessels of the human hand and forearm. J. Physiol. London 120: 160–170, 1953.
 121. Duff, F., A. D. M. Greenfield, and R. F. Whelan. Vasodilatation produced by experimental arterial gas embolism in man. Lancet 2: 230–234, 1953.
 122. Duff, F., A. D. M. Greenfield, and R. F. Whelan. Observations on the mechanism of the vasodilatation following arterial gas embolism. Clin. Sci. 13: 365–376, 1954.
 123. Duff, F., G. C. Patterson, and J. T. Shepherd. A quantitative study of the response to adenosine triphosphate of the blood vessels of the human hand and forearm. J. Physiol. London 125: 581–589, 1954.
 124. Duff, F., G. C. Patterson, and R. F. Whelan. The effect of intra‐arterial antihistamines on the hyperaemia following temporary arrest of the circulation in the human forearm. Clin. Sci. 14: 267–273, 1955.
 125. Duff, F., and J. T. Shepherd. The circulation in the chronically denervated forearm. Clin. Sci. 12: 407–416, 1953.
 126. Duff, F., and R. F. Whelan. The effects of antihistamine substances on the response to histamine of the blood vessels of the human forearm. Br. J. Pharmacol. 9: 413–418, 1954.
 127. Edholm, O. G., R. H. Fox, and R. K. MacPherson. Effect of body heating on the circulation in skin and muscle. J. Physiol. London 134: 612–619, 1956.
 128. Edholm, O. G., R. H. Fox, and R. K. MacPherson. Vasomotor control of the cutaneous blood vessels in the human forearm. J. Physiol. London 139: 455–465, 1957.
 129. Eichna, L. W., and R. W. Wilkins. Blood flow to the forearm and calf. II. Reactive hyperemia: factors influencing the blood flow during the vasodilatation following ischemia. Bull. Johns Hopkins Hosp. 68: 450–476, 1941.
 130. Elliott, D. F., E. W. Horton, and G. P. Lewis. Actions of pure bradykinin. J. Physiol. London 153: 473–480, 1960.
 131. Ellis, L. B., and S. Weiss. A study of the cardiovascular responses in man to the intravenous and intra‐arterial injection of acetylcholine. J. Pharmacol. Exp. Ther. 44: 235–251, 1932.
 132. England, R. M., and J. G. McC. Johnston. The effect of limb position and of venous congestion on the circulation through the toes. Clin. Sci. 15: 587–592, 1956.
 133. Epstein, S. E., G. D. Beiser, R. E. Goldstein, M. Stampfer, G. Glick, A. S. Wechsler, and E. Braunwald. Circulatory effects of electrical stimulation of the carotid sinus nerves in man. Circulation 40: 269–276, 1969.
 134. Ernsting, J., and D. J. Parry. Some observations on the effects of stimulating the stretch receptors in the carotid artery in man (Abstract). J. Physiol. London 137: 45P–46P, 1957.
 135. Erspamer, V., and B. Asero. Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5‐hydroxytryptamine. Nature London 169: 800–801, 1952.
 136. Erspamer, V., and G. Sala. Identification of the stable antidiuretic substance (stable ADS) of serum with 5‐hydroxytryptamine. Br. J. Pharmacol. 9: 31–36, 1954.
 137. Euler, U. S. von. Noradrenaline Chemistry, Physiology, Pharmacology and Clinical Aspects. Springfield, IL: Thomas, 1956.
 138. Fagrell, B. Vital capillaroscopy. A clinical method for studying changes of skin microcirculation in patients suffering from vascular disorders of the leg. Angiology 23: 284–297, 1972.
 139. Fatheree, F. J., and E. V. Allen. Sympathetic vasodilator fibers in the upper and lower extremities. Arch. Intern. Med. 62: 1015–1028, 1938.
 140. Finnerty, F. A., G. De C. Massaro, V. Chupovitch, and J. Tuckman. Evaluation of the pressor, cardiac and renal haemodynamic properties of angiotensin II in man. Circ. Res. 9: 256–263, 1961.
 141. Folkow, B., and E. Neil. Circulation. London: Oxford Univ. Press, 1971.
 142. Forrester, T., and A. R. Lind. Identification of adenosine triphosphate in human plasma and the concentration in the venous effluent of forearm muscles before, during and after sustained contraction. J. Physiol. London 204: 347–364, 1969.
 143. Fox, R. H., R. Goldsmith, and D. J. Kidd. Cutaneous vasomotor control of the human head, neck and chest. J. Physiol. London 161: 298–312, 1962.
 144. Fox, R. H., R. Goldsmith, D. J. Kidd, and G. P. Lewis. Bradykinin as a vasodilator in man. J. Physiol. London 157: 589–602, 1961.
 145. Fox, R. H., and S. M. Hilton. Bradykinin formation in human skin as a factor in heat vasodilatation. J. Physiol. London 142: 210–232, 1958.
 146. Frasher, W. G., Jr., and H. Wayland. A repeating modular organization of the microcirculation of cat mesentery. Microvasc. Res. 4: 62–76, 1972.
 147. Fredholm, B. B. Studies on the sympathetic regulation of circulation and metabolism in isolated subcutaneous adipose tissue. Acta Physiol. Scand. 354: 5–47, 1970.
 148. Fredholm, B. B., B. Linde, B. Oberg, and S. Rosell. Studies on the capillary exchange function in canine subcutaneous adipose tissue. Bibl. Anat. 10: 241, 1969.
 149. Fredholm, B. B., B. Linde, R. L. Prewitt, and P. C. Johnson. Oxygen uptake and tissue oxygen tension during adrenergic stimulation in canine subcutaneous adipose tissue. Acta Physiol. Scand. 97: 48–59, 1976.
 150. Fredholm, B. B., B. Öberg, and S. Rosell. Effects of vasoactive drugs on circulation in canine subcutaneous adipose tissue. Acta Physiol. Scand. 79: 564–574, 1970.
 151. Fredholm, B., and S. Rosell. Effects of adrenergic blocking on lipid mobilization from canine subcutaneous adipose tissue after sympathetic nerve stimulation. J. Pharmacol. Exp. Ther. 159: 1–7, 1968.
 152. Freedman, R. I., N. E. Levan, C. Hyman, S. W. Becker, and E. Elsworth. Tissue clearance. A critical evaluation of its potential in dermatologic investigation. J. Invest. Dermatol. 45: 369–398, 1965.
 153. Freeman, N. E. The effect of temperature on the rate of blood flow in the normal and in the sympathectomized hand. Am. J. Physiol. 113: 384–398, 1935.
 154. Frewin, D. B., D. J. McConnell, and J. A. Downey. Is a kininogenase necessary for human sweating? Lancet 2: 744, 1973.
 155. Gaskell, P. Are there sympathetic vasodilator nerves to the vessels of the hands? J. Physiol. London 131: 647–656, 1956.
 156. Gaskell, P., and A. C. Burton. Local postural vasomotor reflexes arising from the limb veins. Circ. Res. 1: 27–39, 1953.
 157. Gellhorn, E., and I. E. Steck. The effect of the inhalation of gases with a low oxygen and an increased carbon dioxidetension on the peripheral blood flow in man. Am. J. Physiol. 124: 735–741, 1938.
 158. Gersh, J., and M. A. Still. Blood vessels in fat tissues. Relation to problems of gas exchange. J. Exp. Med. 81: 219–232, 1945.
 159. Gibbon, J. H. H., and E. M. Landis. Vasodilatation in the lower extremities in response to immersing the forearms in warm water. J. Clin. Invest. 11: 1019–1036, 1932.
 160. Gibbs, F. A. A thermoelectric blood flow recorder in the form of a needle. Proc. Soc. Exp. Biol. Med. 31: 141–146, 1933.
 161. Glover, W. E., and A. D. M. Greenfield. The blood flow through the human hand immersed in a saturated solution of carbon dioxide (Abstract). J. Physiol. London 143: 67P, 1958.
 162. Glover, W. E., A. D. M. Greenfield, B. S. L. Kidd, and R. F. Whelan. The reactions of the capacity blood vessels of the human hand and forearm to vaso‐active substances infused intra‐arterially. J. Physiol. London 140: 113–121, 1957.
 163. Goldschmidt, S., and A. B. Light. The effect of local temperature upon the peripheral circulation and metabolism of tissues as revealed by the gaseous content of venous blood. Am. J. Physiol. 73: 146–172, 1925.
 164. Goldstein, J. D., and E. L. DuBois. The effect on the circulation in man of rebreathing different concentrations of carbon dioxide. Am. J. Physiol. 81: 650–660, 1927.
 165. Golenhofen, K., and G. Hildebrandt. Psychische Einflüsse auf die Muskeldurchblutung. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 263: 637–646, 1957.
 166. Gordon, R. S., Jr., and A. Cherkes. Unesterified fatty acids in human blood plasma. J. Clin. Invest. 35: 206–212, 1956.
 167. Grant, R. T. Observations on direct communications between arteries and veins in the rabbit's ear. Heart 15: 281–303, 1930.
 168. Grant, R. T., and E. F. Bland. Observations on arteriovenous anastomoses in human skin and in the bird's foot with special reference to the reaction to cold. Heart 15: 385–407, 1931.
 169. Grant, R. T., and H. E. Holling. Further observations on the vascular responses of the human limb to body warming; evidence for sympathetic vasodilator nerves in the normal subject. Clin. Sci. 3: 273–285, 1938.
 170. Grant, R. T., and R. S. B. Pearson. The blood circulation in the human limb: observations on the difference between the proximal and distal parts and remarks on the regulation of body temperature. Clin. Sci. 3: 119–139, 1937.
 171. Grayson, J. Internal calorimetry in the determination of thermal conductivity and blood flow. J. Physiol. London 118: 54–72, 1952.
 172. Green, D. M., A. D. Johnson, A. Lobb, and G. Cusick. The effects of adrenaline in normal and hypertensive patients in relation to the mechanism of sustained pressure elevations. J. Lab. Clin. Med. 33: 332–346, 1948.
 173. Green, H. D., and J. H. Kepchar. Control of peripheral resistance in major systemic vascular beds. Physiol. Rev. 39: 617–686, 1959.
 174. Greenfield, A. D. M. The hemodynamics, measurement and nervous control of the limb circulation. Am. J. Med. 23: 675–683, 1957.
 175. Greenfield, A. D. M. Venous occlusion plethysmography. Methods Med. Res. 8: 293–307, 1960.
 176. Greenfield, A. D. M. The circulation through the skin. In: Handbook of Physiology. Circulation, edited by W. F. Hamilton. Washington, DC: Am. Physiol. Soc., 1963, sect. 2, vol. II, chapt. 39, p. 1325–1351.
 177. Greenfield, A. D. M., R. J. Crossley, G. C. Plassaras, and D. Stephens. The interrelation of thermoregulatory and baroreceptor reflexes in the control of the blood vessels in the human forearm. J. Physiol. London 183: 628–636, 1966.
 178. Greenfield, A. D. M., G. A. Kernohan, R. J. Marshall, J. T. Shepherd, and R. F. Whelan. Heat loss from toes and fore‐feet during immersion in cold water. J. Appl. Physiol. 4: 37–45, 1951.
 179. Greenfield, A. D. M., and G. C. Patterson. Reactions of the blood vessels of the human forearm to increases in transmural pressure. J. Physiol. London 125: 508–524, 1954.
 180. Greenfield, A. D. M., and J. T. Shepherd. A quantitative study of the response to cold of the circulation through the fingers of normal subjects. Clin. Sci. 9: 323–347, 1950.
 181. Greenfield, A. D. M., J. T. Shepherd, and R. F. Whelan. Cold vasoconstriction and vasodilatation. Ir. J. Med. Sci. 309: 415–419, 1951.
 182. Greenfield, A. D. M., J. T. Shepherd, and R. F. Whelan. The loss of heat from the hands and from the fingers immersed in cold water. J. Physiol. London 112: 459–475, 1951.
 183. Greenfield, A. D. M., J. T. Shepherd, and R. F. Whelan. The part played by the nervous system in the response to cold of the circulation through the finger tip. Clin. Sci. 10: 347–360, 1951.
 184. Greenfield, A. D. M., J. T. Shepherd, and R. F. Whelan. Circulatory response to cold in fingers infiltrated with anesthetic solution. J. Appl. Physiol. 4: 785–788, 1952.
 185. Greenfield, A. D. M., R. J. Whitney, and J. F. Mowbray. Investigation of peripheral blood flow. Br. Med. Bull. 19: 101–109, 1963.
 186. Guyton, A. C., J. M. Ross, O. Carrier, and J. R. Walker. Evidence for tissue oxygen demand as the major factor causing autoregulation. Circ. Res. 15: 60–69, 1964.
 187. Hagbarth, K‐E., R. G. Hallin, A. Hongell, H. E. Torebjörk, and B. G. Wallin. General characteristics of sympathetic activity in human skin nerves. Acta Physiol. Scand. 84: 164–176, 1972.
 188. Hanley, H. G., R. G. Sachs, and N. S. Skinner, Jr. Reflex responsiveness of vascular bed of dog subcutaneous adipose tissue. Am. J. Physiol. 220: 993–999, 1971.
 189. Hansen, M., E. Jacobsen, and E. Madsen. Influence of hypoxia and hyperoxia on subcutaneous adipose tissue blood flow in man. Scand. J. Clin. Lab. Invest. 36: 635–660, 1976.
 190. Hardy, J. D., and G. F. Soderstrom. Heat loss from the nude body and peripheral blood flow at temperatures of 22°C to 35°C. J. Nutr. 16: 493–510, 1938.
 191. Harris, R. E. Observations upon a histamine‐like substance in skin extracts. Heart 14: 161–176, 1927.
 192. Hatfield, H. S. A heat‐flow meter (Abstract). J. Physiol. London 111: 10P–11P, 1950.
 193. Hayes, J. E., D. W. Robinson, and F. W. Masters. A simple inexpensive method of evaluating circulation in pedicled tissue. Plast. Reconstr. Surg. 42: 141–147, 1968.
 194. Hellon, R. F., and R. S. J. Clarke. Changes in forearm blood flow with age. Clin. Sci. 18: 1–7, 1959.
 195. Henriksen, O. Local sympathetic reflex mechanism in regulation of blood flow in human subcutaneous tissue. Acta Physiol. Scand. Suppl. 450: 100, 1977.
 196. Hensel, H., and F. Bender. Fortlaufende Bestimmung der Hautdurchblutung am Menschen mit einem electrischen Wärmeleitmesser. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 263: 603–614, 1956.
 197. Hensel, H., and J. Ruef. Fortlaufende Registrierung der Muskeldurchblutung am Menschen mit einer Calorimetersonde. Pfluegers Arch. Gesamte Physiol. Menschen Tiere 259: 267–280, 1954.
 198. Hertzman, A. B. Vasomotor regulation of cutaneous circulation. Physiol. Rev. 39: 280–306, 1959.
 199. Hertzman, A. B., and J. B. Dillon. Selective vascular reaction patterns in the nasal septum and skin of the extremities and head. Am. J. Physiol. 127: 671–684, 1939.
 200. Hertzman, A. B., and L. W. Roth. The absence of vasoconstrictor reflexes in the forehead circulation. Effects of cold. Am. J. Physiol. 136: 692–697, 1942.
 201. Hilton, S. M., and G. P. Lewis. The relationship between glandular activity, bradykinin formation and functional vasodilatation in the submandibular salivary gland. J. Physiol. London 134: 471–483, 1956.
 202. Hilton, S. M., and G. P. Lewis. Vasodilatation in the tongue and its relationship to plasma kinin formation. J. Physiol. London 144: 532–540, 1958.
 203. Himms‐Hagen, J. Sympathetic regulation of metabolism. Pharmacol. Rev. 19: 367–461, 1967.
 204. Himms‐Hagen, J. Adrenergic receptors for metabolic responses in adipose tissue. Federation Proc. 29: 1388–1401, 1970.
 205. Hjemdahl, P., and B. B. Fredholm. Comparison of the lipolytic activity of circulating and locally released noradrenaline during acidosis. Acta Physiol. Scand. 92: 1–11, 1974.
 206. Hjemdahl, P., and B. B. Fredholm. Influence of acidosis on noradrenalin‐induced vasoconstriction in adipose tissue and skeletal muscle. Acta Physiol. Scand. 97: 319–324, 1976.
 207. Hjemdahl, P., and A. Sollevi. Vascular and metabolic responses to adrenergic stimulation in isolated canine subcutaneous adipose tissue at normal and reduced temperature. J. Physiol. London 281: 325–338, 1978.
 208. Hoffbrand, B. I., and R. P. Forsyth. Regional blood flow changes during norepinephrine, tyramine and methoxamine infusions in the unanesthetized rhesus monkey. J. Pharmacol. Exp. Ther. 184: 656–661, 1973.
 209. Holling, H. E., and D. Verel. Circulation in the elevated forearm. Clin. Sci. 16: 197–213, 1957.
 210. Holloway, G. A., Jr., C. H. Daly, D. Kennedy, and J. Chimoskey. Effects of external pressure loading on human skin blood flow measured by 133Xe clearance. J. Appl. Physiol. 40: 597–600, 1976.
 211. Holton, F. A., and P. Holton. The vasodilator activity of spinal roots. J. Physiol. London 118: 310–327, 1952.
 212. Holton, P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J. Physiol. London 145: 494–504, 1959.
 213. Hooker, D. R. The effect of carbon dioxide and of oxygen upon muscular tone in the blood vessels and alimentary canal. Am. J. Physiol. 31: 47–58, 1912.
 214. Hurley, H. J., Jr., and H. Mescon. Cholinergic innervation of the digital arteriovenous anastomoses of human skin. A histochemical localization of cholinesterase. J. Appl. Physiol. 9: 82–84, 1956.
 215. Intaglietta, M., and B. W. Zweifach. Geometrical model of the microvasculature of rabbit omentum from in vivo measurements. Circ. Res. 28: 593–600, 1971.
 216. Johnsen, H. M. Measurement of colloid osmotic pressure of interstitial fluid. Acta Physiol. Scand. 91: 142–144, 1974.
 217. Johnson, J. M. Responses of forearm blood flow to graded leg exercise in man. J. Appl. Physiol. 46: 457–462, 1979.
 218. Johnson, J. M., and L. B. Rowell. Forearm skin and muscle vascular responses to prolonged leg exercise in man. J. Appl. Physiol. 39: 920–924, 1975.
 219. Johnson, J. M., L. B. Rowell, and G. L. Brengelmann. Modification of the skin blood flow‐body temperature relationship by upright exercise. J. Appl. Physiol. 37: 880–886, 1974.
 220. Keatinge, W. R. Effect of general chilling on the vasodilator response to cold. J. Physiol. London 139: 497–507, 1957.
 221. Keatinge, W. R. The effect of low temperatures on the response of arteries to constrictor drugs. J. Physiol. London 142: 395–405, 1958.
 222. Keatinge, W. R. Mechanism of adrenergic stimulation of mammalial arteries and its failure at low temperatures. J. Physiol. London 174: 184–205, 1964.
 223. Keele, C. A., and D. Armstrong. Substance producing pain and itch. Physiological Society Monographs. London: Arnold, 1964.
 224. Keleman, E. The inhibition by sodium salicylate of oedema of the hind paw of the rat induced by 5‐hydroxytryptamine. Br. J. Pharmacol. 12: 28–29, 1957.
 225. Kerslake, D. McK., and K. E. Cooper. Vasodilation in the hand in response to heating the skin elsewhere. Clin. Sci. 9: 31–47, 1950.
 226. Kety, S. S. Quantitative measurement of regional circulation by the clearance of radioactive sodium. Am. J. Med. Sci. 215: 325–353, 1948.
 227. Kety, S. S. Measurement of regional circulation by the local clearance of radioactive sodium. Am. Heart J. 38: 321–328, 1949.
 228. Kety, S. S., and C. F. Schmidt. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men. J. Clin. Invest. 27: 484–492, 1948.
 229. Kiernan, J. A. The involvement of mast cells in vasodilatation due to axon reflexes in infused skin. Q. J. Exp. Physiol. 57: 311–317, 1972.
 230. Kontos, H. A., D. W. Richardson, and J. L. Patterson, Jr. Blood flow and metabolism of forearm muscle in man at rest and during sustained contraction. Am. J. Physiol. 211: 869–876, 1966.
 231. Kontos, H. A., D. W. Richardson, and J. L. Patterson, Jr. Effects of hypercapnia on human forearm blood vessels. Am. J. Physiol. 212: 1070–1080, 1967.
 232. Kovach, A. G. B., S. Rosell, and P. Sandor. Blood flow, oxygen consumption and free fatty acid release in subcutaneous adipose tissue during hemorrhagic shock in control and phenoxybenzamine‐treated dogs. Circ. Res. 26: 733–741, 1970.
 233. Kristensen, J. K., and S. Wadskov. Studies on 133Xe washout from human skin: quantitative measurements of blood flow in normal and corticosteroid‐treated skin. J. Invest. Dermatol. 68: 196–200, 1977.
 234. Kuno, Y. Human Perspiration. Springfield, IL: Thomas, 1956.
 235. Kuroshima, A., N. Konno, and S. Itoh. Increase in blood flow through brown adipose tissue in response to cold exposure and norepinephrine in the rat. Jpn. J. Physiol. 17: 523–537, 1967.
 236. Landis, E. M. Capillary permeability and the factors affecting the composition of capillary filtrate. Ann. NY Acad. Sci. 46: 713–731, 1946.
 237. Lands, A. M., A. Arnold, J. P. McAuliff, F. P. Luduena, and T. G. Brown, Jr. Differentiation of receptor systems activated by sympathomimetic amines. Nature London 214: 597–598, 1967.
 238. Langley, J. N., and K. Uyeno. The secretion of sweat. Part II. The effect of vasoconstriction and of adrenaline. J. Physiol. London 56: 207–226, 1922.
 239. Larsen, O. A., and N. A. Lassen. Fatty tissue blood flow measured by Xe‐133 clearance. Scand. J. Clin. Lab. Invest. 99: 46–49, 1967.
 240. Larsen, O. A., N. A. Lassen, and F. Quaade. Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol. Scand. 66: 337–345, 1966.
 241. Lassen, N. A., and P. Holstein. Use of radioisotopes in assessment of distal blood flow and distal blood pressure in arterial insufficiency. Surg. Clin. North Am. 54: 39–55, 1974.
 242. Leider, M. On the weight of the skin. J. Invest. Dermatol. 12: 187–191, 1949.
 243. Lennox, W. G., and E. L. Gibbs. The blood flow in the brain and leg of man, and the changes induced by alteration of blood gases. J. Clin. Invest. 11: 1155–1177, 1932.
 244. Lever, A. F., J. F. Mobray, and W. S. Peart. Blood flow and blood pressure after noradrenaline infusions. Clin. Sci. 21: 69–74, 1961.
 245. Levin‐Nielsen, S. Measurement of blood flow in adipose tissue from the washout of xenon‐133 after atraumatic labelling. Acta Physiol. Scand. 84: 187–196, 1972.
 246. Lewis, G. P., and J. Matthews. The mechanism of functional vasodilatation in rabbit epigastric adipose tissue. J. Physiol. London 207: 15–30, 1970.
 247. Lewis, T. The Blood Vessels of the Human Skin and Their Responses. London: Shaw, 1927.
 248. Lewis, T. Observations upon the reactions of the vessels of the human skin to cold. Heart 15: 177–208, 1930.
 249. Lewis, T. Vascular Disorders of the Limbs. London: Macmillan, 1936.
 250. Lewis, T., and R. T. Grant. Vascular reactions of the skin to injury. Part II. The liberation of a histamine‐like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions. Heart 11: 209–265, 1924.
 251. Lewis, T., and R. T. Grant. Observations upon reactive hyperaemia in man. Heart 12: 73–120, 1925.
 252. Lewis, T., and G. W. Pickering. Vasodilatation in the limbs in response to warming the body; with evidence for sympathetic vasodilator nerves in man. Heart 16: 33–51, 1931.
 253. Linde, B., and J. Gainer. Disappearance of 133Xenon and 125Iodide and extraction of 85Rubidium in subcutaneous adipose tissue during sympathetic nerve stimulation. Acta Physiol. Scand. 91: 172–179, 1974.
 254. Majno, G. Ultrastructure of the vascular membrane. Handbook of Physiology. Circulation, edited by W. F. Hamilton. Washington, DC: Am. Physiol. Soc., 1965, sect. 2, vol. III, chapt. 64, p. 2293–2375.
 255. Majno, G., and G. E. Palade. Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability: an electron microscopic study. J. Biophys. Biochem. Cytol. 11: 571–605, 1961.
 256. Majno, G., S. M. Shea, and M. Leventhal. Endothelial contraction induced by histamine‐type mediators. J. Cell Biol. 42: 647–672, 1969.
 257. Marchesi, V. T., and H. W. Florey. Electron microscopic observations on the emigration of leucocytes. Q. J. Exp. Physiol. 45: 343–348, 1960.
 258. McArdle, B., and D. Verel. Responses to ischaemic work in the human forearm. Clin. Sci. 15: 305–318, 1956.
 259. McArdle, L., and I. C. Roddie. Vascular responses to carbon dioxide during anaesthesia in man. Br. J. Anaesth. 30: 358–366, 1958.
 260. McArdle, L., I. C. Roddie, J. T. Shepherd, and R. F. Whelan. The effect of inhalation of 30% carbon dioxide on the peripheral circulation of the human subject. Br. J. Pharmacol. 12: 293–296, 1957.
 261. McGirr, E. M. The rate of removal of radioactive sodium following its injection into muscle and skin. Clin. Sci. 11: 91–99, 1952.
 262. McNamara, H. I., J. M. Sikorski, and H. Clavin. The effects of lower body negative pressure on hand blood flow. Cardiovasc. Res. 3: 284–291, 1969.
 263. Mellander, S., and B. Johansson. Control of resistance exchange, and capacitance functions in the peripheral circulation. Pharmacol. Rev. 20: 117–196, 1968.
 264. Mescon, H., H. J. Hurley, Jr., and G. Moretti. Anatomy and histochemistry of the arteriovenous anastomosis in digital skin. J. Invest. Dermatol. 27: 133–145, 1956.
 265. Mjos, O. D., and S. Akre. Effect of catecholamines on blood flow, oxygen consumption, and release/uptake of free fatty acids in adipose tissue. Scand. J. Clin. Lab. Invest. 27: 221–225, 1971.
 266. Moreira, M. F., R. F. Mottram, and A. Y. Werner. The effect of venous pressure on the oxygen content of venous blood in the deep forearm veins. J. Physiol. London 133: 255–265, 1956.
 267. Moreley, J., M. Schacter, and L. H. Smaje. Vasodilatation in the submaxillary gland of the rabbit. J. Physiol. London 187: 595–602, 1966.
 268. Mosley, J. G. A reduction in some vasodilator responses in freestanding man. Cardiovasc. Res. 3: 14–21, 1969.
 269. Moustafa, H. F., and J. W. Hopewell. The evaluation of isotope clearance technique for the measurement of skin blood flow in the pig. Microvasc. Res. 11: 147–153, 1976.
 270. Moustafa, H. F., and J. W. Hopewell. Blood flow clearance changes in pig skin after single doses of X‐rays. Br. J. Radiol. 52: 138–144, 1979.
 271. Mowbray, J. F. Measurement of tissue blood flow using small heated thermocouple needles. J. Appl. Physiol. 14: 647–648, 1959.
 272. Muir, I. F. K., R. H. Fox, W. E. Strang, and F. S. Stewart. The measurement of blood flow by a photoelectric technique and its application to the management of tubed skin pedicles. Br. J. Plast. Surg. 21: 14–31, 1968.
 273. Muth, H. A. V., P. N. Wormald, J. M. Bishop, and K. W. Donald. Further studies of blood flow in resting arm during supine leg exercise. Clin. Sci. 17: 603–610, 1958.
 274. Nagasaka, T., N. Shimada, and K. Nishikura. Vascular and lipolytic responses to infused norepinephrine in canine subcutaneous and omental adipose tissues. Jpn. J. Physiol. 26: 367–374, 1976.
 275. Namm, D. H., and J. L. Zucker. Biochemical alterations caused by hypoxia in the isolated rabbit aorta: correlation with changes in arterial contractility. Circ. Res. 32: 464–470, 1973.
 276. Ngai, S. H., S. Rosell, and L. R. Wallenberg. Nervous regulation of blood flow in the subcutaneous adipose tissue in dogs. Acta Physiol. Scand. 68: 397–403, 1966.
 277. Nichol, J., F. Girling, W. Jerrard, E. B. Claxton, and A. C. Burton. Fundamental instability of the small blood vessels and critical closing pressures in vascular beds. Am. J. Physiol. 164: 330–344, 1951.
 278. Nielsen, P. E., S. L. Nielsen, P. Hostein, H. L. Poulsen, E. H. Hansen, and N. A. Lassen. Intra‐arterial infusion of prostaglandin E1 in normal subjects and patients with peripheral arterial disease. Scand. J. Clin. Lab. Invest. 36: 633–640, 1976.
 279. Nielsen, S. L., V. Bitsch, and O. A. Larsen. Blood flow through human adipose tissue during lipolysis. Scand. J. Clin. Lab. Invest. 22: 124–130, 1968.
 280. Öberg, B., and S. Rosell. Sympathetic control of consecutive vascular sections in canine subcutaneous adipose tissue. Acta Physiol. Scand. 71: 47–56, 1967.
 281. Orö, L., L. Wallenberg, and P. Bolme. Influence of electrical supramedullary stimulation on the plasma level of free fatty acids, blood pressure and heart rate in the dog. Acta Med. Scand. 178: 697–711, 1965.
 282. Palmer, B. Factors influencing the elimination rate of 133Xenon injected intracutaneously. Scand. J. Plast. Reconstr. Surg. 6: 1–5, 1972.
 283. Partington, M. W. The vascular response of the skin to ultraviolet light. Clin. Sci. 13: 425–439, 1954.
 284. Patel, D. J., and A. C. Burton. Reactive hyperemia in the human finger. Circ. Res. 4: 710–712, 1956.
 285. Patterson, G. C. The role of intravascular pressure in the causation of reactive hyperaemia in the human forearm. Clin. Sci. 15: 17–25, 1956.
 286. Patterson, G. C., and J. T. Shepherd. The blood flow in the human forearm following venous congestion. J. Physiol. London 135: 501–507, 1954.
 287. Patterson, G. C., and R. F. Whelan. Reactive hyperaemia in the human forearm. Clin. Sci. 14: 197–211, 1955.
 288. Pickering, G. W. The vasomotor regulation of heat loss from the human skin in relation to external temperature. Heart 16: 115–135, 1933.
 289. Popoff, N. W. The digital vascular system. AMA Arch. Pathol. 18: 295, 1934.
 290. Prichard, M. M. L., and P. M. Daniel. Arteriovenous anastomoses in the human external ear. J. Anat. 90: 309–317, 1956.
 291. Rapport, M. M. Serum vasoconstrictor (serotonin). The presence of creatinine in the complex. A proposed structure of the vasoconstrictor principle. J. Biol. Chem. 180: 961–969, 1949.
 292. Reid, G. Circulatory effect of 5‐hydroxytryptamine. J. Physiol. London 118: 435–453, 1952.
 293. Rhodin, J. A. G. The ultrastructure of mammalian arterioles and precapillary sphincters. J. Ultrastruct. Res. 18: 181–223, 1967.
 294. Rhodin, J. A. G. Ultrastructure of mammalian venous capillaries, venules, and small collecting veins. J. Ultrastruct. Res. 25: 452–500, 1968.
 295. Richardson, D. W., A. J. Wasserman, and J. L. Patterson. General and regional circulatory responses to change in blood pH and carbon dioxide tension. J. Clin. Invest. 40: 31–43, 1961.
 296. Roberts, L. J., S. R. Marney, and J. A. Oakes. Blockade of the flush associated with metastatic gastric carcinoid by combined H1 and H2 receptor antagonists. N. Engl. J. Med. 300: 236–238, 1979.
 297. Robertson, J. I. S., W. S. Peart, and T. M. Andrews. The mechanism of facial flushes in the carcinoid syndrome. Q. J. Med. 31: 103–123, 1962.
 298. Rocha e Silva, M. The physiological significance of bradykinin. Ann. NY Acad. Sci. 104: 190–211, 1963.
 299. Rocha e Silva, M., W. T. Beraldo, and G. Rosenfeld. Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am. J. Physiol. 156: 261–273, 1949.
 300. Roddie, I. C. The decrease in hand blood flow following inflation of an arterial occlusion cuff on the opposite arm. J. Physiol. London 112: 204–210, 1951.
 301. Roddie, I. C., and A. C. Scott. Some effects of oxygen tension on isolated arterial segments (Abstract). J. Physiol. London 179: 59P–60P, 1965.
 302. Roddie, I. C., and J. T. Shepherd. The blood flow through the hand during local heating, release of sympathetic vasomotor tone by indirect heating and a combination of both. J. Physiol. London 131: 657–664, 1955.
 303. Roddie, I. C., and J. T. Shepherd. The reflex nervous control of human skeletal muscle blood vessels. Clin. Sci. 15: 433–440, 1956.
 304. Roddie, I. C., and J. T. Shepherd. Evidence for critical closure of digital resistance vessels with reduced transmural pressure and passive dilatation with increased venous pressure. J. Physiol. London 136: 498–506, 1957.
 305. Roddie, I. C., and J. T. Shepherd. The effects of carotid artery compression in man with special reference to changes in vascular resistance in the limbs. J. Physiol. London 139: 377–384, 1957.
 306. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. The action of 5‐hydroxytryptamine on the blood vessels of the human hand and forearm. Br. J. Pharmacol. 10: 445–450, 1955.
 307. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. Evidence from venous oxygen saturation measurements that the increase in forearm blood flow during body heating is confined to the skin. J. Physiol. London 134: 444–450, 1956.
 308. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. The contribution of constrictor and dilator nerves to the skin vasodilatation during body heating. J. Physiol. London 136: 489–497, 1957.
 309. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. Humoral vasodilatation in the forearm during voluntary hyperventilation. J. Physiol. London 137: 80–85, 1957.
 310. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. A comparison of the heat elimination from the normal and nerve‐blocked finger during body heating. J. Physiol. London 138: 445–448, 1957.
 311. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. Reflex changes in vasoconstrictor tone in human skeletal muscle in response to stimulation of receptors in a low‐pressure area of the intrathoracic vascular bed. J. Physiol. London 139: 369–376, 1957.
 312. Roddie, I. C., J. T. Shepherd, and R. F. Whelan. Reflex changes in human skeletal muscle blood flow associated with intrathoracic pressure changes. Circ. Res. 6: 232–238, 1958.
 313. Roddie, I. C., and W. F. M. Wallace. Methods for the assessment of the effects of drugs on the arterial system in man. Br. J. Clin. Pharmacol. 7: 317–323, 1979.
 314. Roddie, R. A. The effect of arm position on the circulation through the fingers. J. Appl. Physiol. 8: 67–72, 1955.
 315. Rosell, S. Release of free fatty acids from subcutaneous adipose tissue on dogs following sympathetic nerve stimulation. Acta Physiol. Scand. 67: 343–351, 1966.
 316. Rosell, S. Nervous and pharmacological regulation of vascular reaction in adipose tissue. In drugs affecting lipid metabolism. Adv. Exp. Med. Biol. 4: 25–34, 1969.
 317. Rosell, S., and E. Belfrage. Adrenergic receptors in adipose tissue and their relation to adrenergic innervation. Nature London 253: 738–739, 1975.
 318. Rosell, S., and E. Belfrage. Blood circulation in adipose tissue. Physiol. Rev. 59: 1078–1104, 1979.
 319. Rosell, S., M. Intaglietta, and R. F. Tuma. Microvascular flow, velocity in cat omental adipose tissue as affected by sympathetic nerve stimulation. Acta Physiol. Scand. 92: 399–403, 1974.
 320. Rosell, S., P. Sandor, and A. G. B. Kovach. Adipose tissue and hemorrhagic shock. In: Neurohumoral and Metabolic Aspects of Injury, edited by A. G. B. Kovach, H. B. Stoner, and J. J. Spitzer. New York: Plenum, 1973, p. 323–336.
 321. Ross, J. M., H. M. Fairchild, J. Weldy, and A. C. Guyton. Autoregulation of blood flow by oxygen lack. Am. J. Physiol. 202: 21–24, 1962.
 322. Ross, J., G. A. Kaiser, and F. J. Klocke. Observations on the role of diminished oxygen tension in the functional hyperemia of skeletal muscle. Circ. Res. 15: 473–484, 1964.
 323. Roth, G. M. Peripheral Vascular Diseases, edited by E. V. Allen, N. W. Barker, and E. A. T. Hines. Philadelphia, PA: Saunders, 1946.
 324. Rothwell, N. J., and M. S. Stock. A role for brown adipose tissue in diet‐induced thermogenesis. Nature London 281: 31–35, 1979.
 325. Rous, P., H. P. Gilding, and F. Smith. The gradient of vascular permeability. J. Exp. Med. 51: 707–730, 1930.
 326. Rowell, L. B. Reflex control of the cutaneous vasculature. J. Invest. Dermatol. 69: 154–166, 1977.
 327. Rowell, L. B., C. R. Wyss, and G. L. Brengelman. Sustained human skin and muscle vasoconstriction with reduced baroreceptor activity. J. Appl. Physiol. 34: 639–643, 1973.
 328. Royal, N. D. A new operative procedure in the treatment of spastic paralysis and its experimental basis. Med. J. Aust. 1: 77–86, 1924.
 329. Rudman, D., M. Di Girolamo, M. F. Malkin, and L. A. Garcia. The adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology. In: Handbook of Physiology. Adipose Tissue, edited by A. E. Renold and G. F. Cahill, Jr. Washington, DC: Am. Physiol. Soc., 1965, sect. 5, chapt. 54, p. 533–539.
 330. Saameli, K., and T. K. A. B. Eskes. Bradykinin and cardiovascular system: estimation of half‐life. Am. J. Physiol. 203: 261–265, 1962.
 331. Salva, S. J. de, and G. Thompson. Na22Cl skin clearance in humans and its relation to skin age. J. Invest. Dermatol. 45: 315–318, 1965.
 332. Salvador, R. A., and R. Kuntzman. Cholinesterase of adipose tissue. J. Pharmacol. Exp. Ther. 150: 84–91, 1965.
 333. Sarnoff, S. J., and F. A. Simeone. Vasodilator fibres in human skin. J. Clin. Invest. 26: 453–459, 1947.
 334. Schachter, M., and S. Beilenson. Kallikrein and vasodilatation in the submaxillary gland. Gastroenterology 52: 401–405, 1967.
 335. Schachter, M., and S. Beilenson. Mediator of vasodilatation in the submaxillary gland. Federation Proc. 27: 73–75, 1968.
 336. Scow, R. O. Perfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat body. In: Handbook of Physiology. Adipose Tissue, edited by A. E. Renold and G. F. Cahill, Jr. Washington, DC: Am. Physiol. Soc., 1965, sect. 5, chapt. 45, p. 437–453.
 337. Scroop, G. C., J. A. Walsh, and R. F. Whelan. A comparison of the effects of intra‐arterial and intravenous infusions of angiotensin and noradrenaline on the circulation in man. Clin. Sci. 29: 315–326, 1965.
 338. Scroop, G. C., and R. F. Whelan. A central vasomotor action of angiotensin in man. Clin. Sci. 30: 79–91, 1966.
 339. Sejrsen, P. Cutaneous blood flow in man studied by freely diffusible radioactive indicators. Scand. J. Clin. Lab. Invest. Suppl. 99: 52–59, 1967.
 340. Sejrsen, P. Diffusion processes invalidating the intraarterial krypton‐85 beta‐particle clearance method for measurement of skin blood flow in man. Circ. Res. 21: 281–295, 1967.
 341. Sejrsen, P. Epidermal diffusion barrier to 133Xe in man and studies of clearance of 133Xe by sweat. J. Appl. Physiol. 24: 211–216, 1968.
 342. Sejrsen, P. Atraumatic local labeling of skin by inert gas: epicutaneous application of xenon 133. J. Appl. Physiol. 24: 570–572, 1968.
 343. Sejrsen, P. Blood flow in cutaneous tissue in man studied by washout of radioactive xenon. Circ. Res. 25: 215–229, 1969.
 344. Shanks, R. G. The effect of venous congestion on the rate of heat elimination from the fingers. Clin. Sci. 14: 285–294, 1955.
 345. Shepherd, J. T. The blood flow through the calf after exercise in subjects with arteriosclerosis and claudication. Clin. Sci. 9: 49–58, 1950.
 346. Smith, D. J., and J. R. Vane. Effects of oxygen tension on vascular and other smooth muscle. J. Physiol. London 186: 284–294, 1966.
 347. Snell, E. S. The relationship between the vasomotor response in the hand and heat changes in the body induced by intravenous infusions of hot or cold saline. J. Physiol. London 125: 361–372, 1954.
 348. Spealman, G. R. Effect of ambient air temperature and of hand temperature on blood flow in hands. Am. J. Physiol. 145: 218–222, 1945.
 349. Steck, I. E., and E. Gellhorn. The effect of carbon dioxide inhalation on the peripheral blood flow in the normal and in the sympathectomized patient. Am. Heart J. 18: 206–212, 1939.
 350. Stein, I. D., and I. Weinstein. The value of carbon dioxide baths in the treatment of peripheral vascular disease and allied conditions. Am. Heart J. 23: 349–361, 1942.
 351. Steinberg, D., and M. Vaughan. Release of free fatty acids from adipose tissue in vitro in relation to rates of triglyceride synthesis and degradation. In: Handbook of Physiology. Adipose Tissue, edited by A. E. Renold and G. F. Cahill, Jr. Washington, DC: Am. Physiol. Soc., 1965, sect. 5, chapt. 34, p. 335–347.
 352. Stewart, G. N. Studies on the circulation in man. II. The effect of reflex vasomotor excitation on the blood flow in the hand. Heart 3: 76–87, 1911.
 353. Stoner, H. B., and H. N. Green. Experimental limb ischaemia in man with especial reference to the role of adenosine triphosphate. Clin. Sci. 5: 159–175, 1945.
 354. Stürup, G., B. Bolton, D. J. Williams, and E. A. Carmichael. Vasomotor responses in hemiplegic patients. Brain 58: 456–469, 1935.
 355. Su, C., and J. A. Bevan. The release of H3‐norepinephrine in arterial strips studied by the technique of superfusion and transmural stimulation. J. Pharmacol. 172: 62–68, 1970.
 356. Swan, H. J. C. Observations on a central dilator action of adrenaline in man. J. Physiol. London 112: 426–437, 1951.
 357. Tönneson, K. H., A. Uhrenholdt, and O. Pedersen‐Bjergaard. Hand blood flow and cardiac functional response to severe exercise in normal subjects and patients with valvular heart disease. Scand. J. Clin. Lab. Invest. 34: 123–131, 1974.
 358. Trotter, W., and H. M. Davies. Experimental studies on the innervation of the skin. J. Physiol. London 38: 134–246, 1909.
 359. Tuckman, J. Electrical stimulation of the sinus nerves in hypertensive patients: clinical evaluation of physiological studies. In: Neural Control of Arterial Pressure, edited by J. E. Wood. New York: Am. Heart Assoc., 1968.
 360. Twarog, B. M., and I. H. Page. Serotonin content of some mammalian tissues and urine and a method for its determination. Am. J. Physiol. 175: 157–161, 1953.
 361. Uvnäs, B. Sympathetic vasodilator outflow. Physiol. Rev. 34: 608–618, 1954.
 362. Verzar, F. The influence of lack of oxygen on tissue respiration. J. Physiol. London 45: 39–52, 1912.
 363. Wakim, K. G., G. A. Peters, J. C. Terriers, and B. T. Horton. The effects of intravenously administered histamine on the peripheral circulation in man. J. Lab. Clin. Med. 34: 380–386, 1949.
 364. Walker, A. J., R. B. Lynn, and H. Barcroft. On the circulatory changes in the hand and foot after sympathectomy. St. Thomas's Hosp. Report 6: 18, 1950.
 365. Wallin, B. G., G. Sundlöf, and W. Delius. The effect of carotid sinus nerve stimulation on muscle and skin nerve sympathetic activity in man. Pfluegers Arch. 358: 101–110, 1975.
 366. Warren, J. V., C. W. Walter, J. Romano, and E. A. Stead. Blood flow in the hand and forearm after paravertebral block of the sympathetic ganglia. Evidence against sympathetic vasodilator nerves in extremities of man. J. Clin. Invest. 21: 665–673, 1942.
 367. Weiss, S., G. P. Robb, and L. B. Ellis. The systemic effects of histamine in man, with special reference to the responses of the cardiovascular system. Arch. Intern. Med. 49: 360–396, 1932.
 368. Wertheimer, E., and B. Shapiro. The physiology of adipose tissue. Physiol. Rev. 28: 451–464, 1948.
 369. Wetzel, N. C., and Y. Zottermann. On differences in the vascular coloration of various regions of normal human skin. Heart 13: 357–367, 1926.
 370. Whelan, R. F. Control of the Peripheral Circulation in Man. Springfield, IL: Thomas, 1967, p. 221.
 371. Whitney, R. J. The measurement of changes in human limbvolume by means of a mercury‐in‐rubber strain gauge (Abstract). J. Physiol. London 109: 5P–6P, 1949.
 372. Whitney, R. J. The measurement of volume changes in human limbs. J. Physiol. London 121: 1–27, 1953.
 373. Whitney, R. J. Circulatory changes in the forearm and hand of man with repeated exposure to heat. J. Physiol. London 125: 1–24, 1954.
 374. Whittow, G. C. Effect of antihistamine substances on cold vasodilatation in the finger. Nature London 176: 511–512, 1955.
 375. Wilkins, R. W., J. Doupe, and H. W. Newman. The rate of blood flow in normal fingers. Clin. Sci. 3: 403–411, 1938.
 376. Wilkins, R. W., and L. W. Eichna. Blood flow to the forearm and calf. I. Vasomotor reactions; role of the sympathetic nervous system. Bull. Johns Hopkins Hosp. 68: 425–449, 1941.
 377. Wirsén, C. Adrenergic innervation of adipose tissue examined by fluorescence microscopy. Nature London 202: 913, 1964.
 378. Wirsén, C. Distribution of adrenergic nerve fibers in brown and white adipose tissue. In: Handbook of Physiology. Adipose Tissue, edited by A. E. Renold and G. F. Cahill, Jr. Washington, DC: Am. Physiol. Soc., 1965, sect. 5, chapt. 19, p. 197–199.
 379. Wisheart, J. D. Patterns of reactive hyperemia in the hand. Am. Heart J. 60: 116–120, 1960.
 380. Wood, J. E., J. Litter, and R. W. Wilkins. The mechanism of limb segment reactive hyperemia in man. Circ. Res. 3: 581–587, 1955.
 381. Woodland, H. H., and R. Phillips. The distribution of sympathetic fibres in the extremities. J. Anat. London 67: 18–29, 1933.
 382. Wyss, C. R., G. L. Brengelmann, J. M. Johnson, L. B. Rowell, and M. Niederberger. Control of skin blood flow, sweating, and heart rate: role of skin vs. core temperature. J. Appl. Physiol. 36: 726–733, 1974.
 383. Wyss, C. R., G. L. Brengelmann, J. M. Johnson, L. B. Rowell, and D. Silverstein. Altered control of skin blood flow at high skin and core temperatures. J. Appl. Physiol. 38: 839–845, 1975.
 384. Yamada, S. Effects of positive tissue pressure on blood flow of the finger. J. Appl. Physiol. 6: 495–500, 1954.
 385. Yen, A., and I. R. Braverman. Ultrastructure of the human dermal microcirculation: the horizontal plexus of the papillary dermis. J. Invest. Dermatol. 66: 131–142, 1976.
 386. Young, C. M. A., and J. W. Hopewell. The evaluation of an isotope clearance technique in the dermis of pig skin: a correlation of functional and morphological parameters. Microvasc. Res. 20: 182–194, 1980.
 387. Zelis, R., D. T. Mason, and E. Braunwald. Partition of blood flow to the cutaneous and muscular beds of the forearm at rest and during leg exercise in normal subjects and in patients with heart failure. Clin. Res. 24: 799–806, 1969.
 388. Zetterquist, S., U. Bergvall, B. Linde, and B. Pernow. The validity of some conventional methods for the diagnosis of obliterative arterial disease in the lower limb as evaluated by arteriography. Scand. J. Clin. Lab. Invest. 28: 409–421, 1971.
 389. Zucker, M. B. Platelet agglutination and vasoconstriction as factors in spontaneous hemostasis in normal, thrombocytopenic, heparinized and hypoprothrombinemic rats. Am. J. Physiol. 148: 275–288, 1947.
 390. Zweifach, B. W. Functional Behaviour of the Microcirculation. Springfield, IL: Thomas, 1967.
 391. Zweifach, B., and M. Intaglietta. Mechanics of fluid movement across single capillaries in the rabbit. Microvasc. Res. 1: 83–101, 1968.

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Ian C. Roddie. Circulation to Skin and Adipose Tissue. Compr Physiol 2011, Supplement 8: Handbook of Physiology, The Cardiovascular System, Peripheral Circulation and Organ Blood Flow: 285-317. First published in print 1983. doi: 10.1002/cphy.cp020310