Comprehensive Physiology Wiley Online Library

Peptides and Blood Vessels

Full Article on Wiley Online Library


The sections in this article are:

1 Vascular Effects
1.1 Angiotensin
1.2 Bradykinin
1.3 Neurotensin
1.4 Opiate Peptides
1.5 Secretin and Glucagon
1.6 Somatostatin
1.7 Substance P
1.8 Thyrotropin‐Releasing Hormone
1.9 Vasoactive Intestinal Peptide
1.10 Vasopressin and Oxytocin
2 Mechanisms of Action
2.1 Molecular Determinants
2.2 Neurogenic Determinants
3 Summary
Figure 1. Figure 1.

Effect of neuropeptides on blood pressure by intravenous injection (iv) in μg/ml and intracerebroventricular injection (ivt) in μg/ml. Chronic, unanesthetized rats. VIP, vasoactive intestinal peptide.

From M. I. Phillips, unpublished data
Figure 2. Figure 2.

Schematic of potential central nervous system sites of action. I, vagal nuclei; II, brain stem catecholamine neurons; III, sympathetic vasomotor neurons; 1, afferents from arterial and cardiopulmonary receptors; 2, ascending and descending brain pathways; 3, preganglionic and postganglionic sympathetic efferents; 4, preganglionic and postganglionic parasympathetic efferents; AVP, arginine vasopressin. Text explains possible influence of vasopressin at these sites.

Figure 1.

Effect of neuropeptides on blood pressure by intravenous injection (iv) in μg/ml and intracerebroventricular injection (ivt) in μg/ml. Chronic, unanesthetized rats. VIP, vasoactive intestinal peptide.

From M. I. Phillips, unpublished data

Figure 2.

Schematic of potential central nervous system sites of action. I, vagal nuclei; II, brain stem catecholamine neurons; III, sympathetic vasomotor neurons; 1, afferents from arterial and cardiopulmonary receptors; 2, ascending and descending brain pathways; 3, preganglionic and postganglionic sympathetic efferents; 4, preganglionic and postganglionic parasympathetic efferents; AVP, arginine vasopressin. Text explains possible influence of vasopressin at these sites.

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Phillip G. Schmid, Fouad M. Sharabi, M. Ian Phillips. Peptides and Blood Vessels. Compr Physiol 2011, Supplement 8: Handbook of Physiology, The Cardiovascular System, Peripheral Circulation and Organ Blood Flow: 815-835. First published in print 1983. doi: 10.1002/cphy.cp020322