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Homeostatic Responses to Prolonged Cold Exposure: Human Cold Acclimatization

Andrew J. Young

10.1002/cphy.cp040119

Source: Supplement 14: Handbook of Physiology, Environmental Physiology

Originally published: 1996

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Naturally Occurring Cold Acclimatization
1.1 Circumpolar Residents
1.2 Primitive People Living in Temperate‐Weather Regions
1.3 Modern People Repeatedly lmmersed in Cold Water
2 Experimentally Induced Cold Acclimation
2.1 Acclimation Induced by Repeated Cold‐Air Exposure
2.2 Acclimation Induced by Repeated Cold‐Water Immersion
3 Determinants of the Acclimatization Pattern
4 Summary
Figure 1.

Physiological responses during overnight cold exposure measured in nine nomadic Norwegian Lapps and five European control subjects. The subjects began the night covered in blankets and lying on a wire mesh bed in a chamber with an air temperature of 0°C; after 2 h, the blankets were removed, leaving the subjects covered only in a thin windproof cover. Drawn from data of Andersen et al. 3.
Figure 2.

Whole‐body thermal conductivity of Inuit and non‐Inuit subjects plotted as a function of subcutaneous fat thickness. Conductivity was measured during the final 30 min of a 1 h immersion in 33°C water; subjects were not shivering and were assumed to be maximally vasoconstricted, since digital blood flow was virtually zero during the conductivity measurements. Redrawn from data of Rennie et al. 58.
Figure 3.

Steady‐state blood flow (mean ± SE) to the hand of Inuit and non‐Inuit control subjects during immersion of the hand in water of various temperatures. Redrawn from data of Brown and Page 9.
Figure 4.

Responses of control subjects (open circles) and Central Australian Aborigines (closed circles) while sleeping naked at 5°C. Redrawn from Hammel et al. 24.
Figure 5.

Blood‐pressure responses of control subjects, Gaspé fishermen, and Inuits upon immersing one OOhand in cold water. Redrawn from Leblanc 46.
Figure 6.

Incidence of shivering in three groups of Koreans immersed in water at different temperatures. The number of subjects tested is shown parenthetically for each group, and the value indicated by the arrow depicts the water temperature at which 50% of the subjects in each group could not tolerate 3 h of immersion without shivering. Redrawn from Hong 30.
Figure 7.

Regression lines depicting the relationship between maximum tissue insulation and subcutaneous fat thickness measurements made in nondiving Korean men and women and Ama divers. Redrawn from Hong 31.
Figure 8.

Forearm blood flow (upper panel) and forearm skin heat loss (lower panel) of six Ama diving women and six nondiving women from the same Korean community. Redrawn from the data of Hong et al. 32.
Figure 9.

Increment in resting metabolic rate exhibited by cold‐acclimated and nonacclimated subjects during exposure to 20°C, expressed as a percent of basal metabolic rate (BMR) measured in thermoneutral condition. Drawn from data reported by Scholander et al. 60.
Figure 10.

Top panel: Effect of cold acclimation by repeated cold‐air exposure on metabolic rate assessed by open‐circuit spirometry and shivering of the thigh and upper arm assessed by EMG activity during the second hour of exposure to 12°C air; redrawn from Davis 14. Bottom panel: Data from the top panel redrawn to depict the metabolic rate as a function of the corresponding EMG activity for that measurement day.
Figure 11.

Top panel: Effect of acclimation by repeated cold‐water immersion on rectal temperature before (0 min) and during 90‐min resting exposures to cold air. Bottom panel: Effect of acclimation by repeated cold‐water immersion on the change in rectal temperature, relative to initial values, during cold‐air exposure. Values are means ± SE of measurements in 7 men; *Significant (p < 0.01) difference between pre‐ and postacclimation. From Young et al. 68.
Figure 12.

Effect of acclimation by repeated cold‐water immersion on mean weighted skin temperature before and during a 90‐min resting cold‐air exposure. Values are means ± SE of measurements in 7 men; *Significant (p < 0.01) difference between pre‐ and postacclimation. From Young et al. 68.
Figure 13.

Effect of acclimation by repeated cold‐water immersion on temperature gradient between core (rectal temperature) and skin (mean weighted skin temperature) before and during a 90‐min exposure to cold air. Values are means ± SE in 7 men. *Significant (p < 0.01) difference pre‐ versus postacclimation. From Young et al. 68.
Figure 14.

Flowchart illustrating a theoretical scheme to explain the development of different patterns of cold acclimatization/acclimation that are observed in humans.


Figure 1.

Physiological responses during overnight cold exposure measured in nine nomadic Norwegian Lapps and five European control subjects. The subjects began the night covered in blankets and lying on a wire mesh bed in a chamber with an air temperature of 0°C; after 2 h, the blankets were removed, leaving the subjects covered only in a thin windproof cover. Drawn from data of Andersen et al. 3.



Figure 2.

Whole‐body thermal conductivity of Inuit and non‐Inuit subjects plotted as a function of subcutaneous fat thickness. Conductivity was measured during the final 30 min of a 1 h immersion in 33°C water; subjects were not shivering and were assumed to be maximally vasoconstricted, since digital blood flow was virtually zero during the conductivity measurements. Redrawn from data of Rennie et al. 58.



Figure 3.

Steady‐state blood flow (mean ± SE) to the hand of Inuit and non‐Inuit control subjects during immersion of the hand in water of various temperatures. Redrawn from data of Brown and Page 9.



Figure 4.

Responses of control subjects (open circles) and Central Australian Aborigines (closed circles) while sleeping naked at 5°C. Redrawn from Hammel et al. 24.



Figure 5.

Blood‐pressure responses of control subjects, Gaspé fishermen, and Inuits upon immersing one OOhand in cold water. Redrawn from Leblanc 46.



Figure 6.

Incidence of shivering in three groups of Koreans immersed in water at different temperatures. The number of subjects tested is shown parenthetically for each group, and the value indicated by the arrow depicts the water temperature at which 50% of the subjects in each group could not tolerate 3 h of immersion without shivering. Redrawn from Hong 30.



Figure 7.

Regression lines depicting the relationship between maximum tissue insulation and subcutaneous fat thickness measurements made in nondiving Korean men and women and Ama divers. Redrawn from Hong 31.



Figure 8.

Forearm blood flow (upper panel) and forearm skin heat loss (lower panel) of six Ama diving women and six nondiving women from the same Korean community. Redrawn from the data of Hong et al. 32.



Figure 9.

Increment in resting metabolic rate exhibited by cold‐acclimated and nonacclimated subjects during exposure to 20°C, expressed as a percent of basal metabolic rate (BMR) measured in thermoneutral condition. Drawn from data reported by Scholander et al. 60.



Figure 10.

Top panel: Effect of cold acclimation by repeated cold‐air exposure on metabolic rate assessed by open‐circuit spirometry and shivering of the thigh and upper arm assessed by EMG activity during the second hour of exposure to 12°C air; redrawn from Davis 14. Bottom panel: Data from the top panel redrawn to depict the metabolic rate as a function of the corresponding EMG activity for that measurement day.



Figure 11.

Top panel: Effect of acclimation by repeated cold‐water immersion on rectal temperature before (0 min) and during 90‐min resting exposures to cold air. Bottom panel: Effect of acclimation by repeated cold‐water immersion on the change in rectal temperature, relative to initial values, during cold‐air exposure. Values are means ± SE of measurements in 7 men; *Significant (p < 0.01) difference between pre‐ and postacclimation. From Young et al. 68.



Figure 12.

Effect of acclimation by repeated cold‐water immersion on mean weighted skin temperature before and during a 90‐min resting cold‐air exposure. Values are means ± SE of measurements in 7 men; *Significant (p < 0.01) difference between pre‐ and postacclimation. From Young et al. 68.



Figure 13.

Effect of acclimation by repeated cold‐water immersion on temperature gradient between core (rectal temperature) and skin (mean weighted skin temperature) before and during a 90‐min exposure to cold air. Values are means ± SE in 7 men. *Significant (p < 0.01) difference pre‐ versus postacclimation. From Young et al. 68.



Figure 14.

Flowchart illustrating a theoretical scheme to explain the development of different patterns of cold acclimatization/acclimation that are observed in humans.

References
 1. Adams, T., and B. G. Covino. Racial variations to a standardized cold stress. J. Appl. Physiol. 12: 9-12, 1958.
 2. Andersen, K. L., J. S. Hart, H. T. Hammel, and H. B. Sabean. Metabolic and thermal response of Eskimos during muscular exertion in the cold. J. Appl. Physiol. 18: 613-618, 1963.
 3. Andersen, K. L., Y. Loyning, J. D. Nelms, O. Wilson, R. H. Fox, and A. Boldstad. Metabolic and thermal response to a moderate cold exposure in nomadic Lapps. J. Appl. Physiol. 15: 649-653, 1960.
 4. Armstrong, D. W., and J. R. Thomas. Alterations in resting oxygen consumption in women exposed to 10 days of cold air. FASEB J. 5: A393, 1991, abstract.
 5. Bittel, J. H. M., Heat debt as an index for cold adaptation in men. J. Appl. Physiol. 62: 1627-1634, 1987.
 6. Bittel, J. H. M., G. H. Livecchi‐Gonnot, A. M. Hanniquet, C. Poulain, and J. L. Etienne. Thermal changes observed before and after J.‐L. Etienne's journey to the North Pole. Eur. J. Appl. Physiol. 58: 646-651, 1989.
 7. Bodey, A. S., Changing cold acclimatization patterns of men living in Antarctica. Int. J. Biometeorol. 22: 163-176, 1978.
 8. Brown, G. M., J. D. Hatcher, and J. Page. Temperature and blood flow in the forearm of the Eskimo. J. Appl. Physiol. 5: 410-411, 1953.
 9. Brown, G. M., and J. Page. The effect of chronic exposure to cold on temperature and blood flow of the hand. J. Appl. Physiol. 5: 220-227, 1952.
 10. Budd, G. M., and N. Warhaft. Body temperature, shivering, blood pressure and heart rate during a standard cold stress in Australia and Antarctica. J. Physiol. 186: 216-232, 1966.
 11. Butson, A. R. C., Acclimatization in cold in the Antarctic. Nature 163: 132-133, 1949.
 12. Carlson, L. D., H. L. Burns, T. H. Holmes, and P. P. Webb. Adaptive changes during exposure to cold. J. Appl. Physiol. 5: 672-676, 1953.
 13. Crile, G. W., and D. P. Quiring. Indian and Eskimo metabolisms. J. Nutr. 18: 361-368, 1939.
 14. David, T. R. A., Chamber cold acclimatization in man. J. Appl. Physiol. 16: 1011-1015, 1961.
 15. Dressendorfer, R. H., R. M. Smith, D. G. Baker, and S. K. Hong. Cold tolerance of long‐distance runners and swimmers in Hawaii. Int. J. Biometeorol. 21: 51-63, 1977.
 16. Eagan, C. J., Local vascular adaptation to cold in man. Federation Proc. 22: 947-952, 1963.
 17. Eisner, R. W., K. L. Andersen, and L. Hermansen. Thermal and metabolic responses of Arctic Indians to moderate cold exposure at the end of winter. J. Appl. Physiol. 15: 659-661, 1960.
 18. Eisner, R. W., J. D. Nelms, and L. Irving. Circulation of heat to the hands of Arctic Indians. J. Appl. Physiol. 15: 662-666, 1960.
 19. Enander, A., B. Skoldstrom, and I. Holmer. Reactions to hand cooling in workers occupationally exposed to cold. Scand. J. Work. Environ. Health 6: 58-65, 1980.
 20. Gallow, D., T. E. Graham, and S. Pfeiffer. Comparative thermoregulatory responses to acute cold in women of Asian and European descent. Human Biol. 56: 19-34, 1984.
 21. Golden, F. S. C., I. F. G. Hampton, and D. Smith. Cold tolerance in long‐distance swimmers. J. Physiol. 277: 48p-49p, 1979, abstract.
 22. Hammel, H. T., Thermal and metabolic responses of the Alacaluf Indians to moderate cold exposure. Wright Air Development Technical Report 60-633, 1961.
 23. Hammel, H. T., Terrestrial animals in cold: recent studies of primitive man. In: Handbook of Physiology, Section 4, Adaptation to the Environment, edited by D. B. Dill, E. F. Adolph, and C. G. Wilber. Washington, D.C.: American Physiological Society, 1964, p. 413-434.
 24. Hammel, H. T., R. W. Eisner, D. H. LeMessurier, H. T. Andersen, and F. A. Milan. Thermal and metabolic responses of the Australian Aborigine exposed to moderate cold in summer. J. Appl. Physiol. 14: 605-615, 1959.
 25. Hanna, J. M., and R. M. Smith. Responses of Hawaiian‐born Japanese and Caucasians to a standardized cold exposure. Hum. Biol. 47: 427-440, 1975.
 26. Hart, J. S., H. B. Sabean, J. A. Hildes, F. Depocas, H. T. Hammel, K. L. Andersen, L. Irving, and G. Foy. Thermal and metabolic responses of coastal Eskimos during a cold night. J. Appl. Physiol. 17: 953-960, 1962.
 27. Hesslink, R. L., M. M. D'Alesandro, D. W. Armstrong, and H. L. Reed. Human cold air habituation is independent of thyroxine and thyrotropin. J. Appl. Physiol. 72: 2134-2139, 1992.
 28. Hicks, C. S., Terrestrial animals in cold: exploratory studies of primitive man. In: Handbook of Physiology, section 4, Adaptation to the Environment, edited by D. B. Dill, E. F. Adolph, and C. G. Wilber. Washington, D.C.: American Physiological Society, 1964, p. 405-412.
 29. Hildes, J. A., Comparison of coastal Eskimos and Kalahari Bushmen. Federation Proc. 22: 843-845, 1963.
 30. Hong, S. K., Comparison of diving and nondiving women of Korea. Federation Proc. 22: 831-833, 1963.
 31. Hong, S. K., Pattern of cold adaptation in women divers of Korea (Ama). Federation Proc. 32: 1614-1622, 1973.
 32. Hong, S. K., C. K. Lee, J. K. Kim, S. H. Song, and D. W. Rennie. Peripheral blood flow and heat flux of Korean women divers. Federation Proc. 28: 1143-1148, 1969.
 33. Hong, S. K., D. W. Rennie, and Y. S. Park. Cold acclimatization and deacclimatization of Korean women divers. Exerc. Sport Sci. Rev. 14: 231-268, 1986.
 34. Hong, S. K., D. W. Rennie, and Y. S. Park. Humans can acclimatize to cold: a lesson from Korean women divers. News in Physiological Sciences 2: 79-82, 1987.
 35. Irving, L., K. L. Andersen, A. Boldstad, R. Eisner, J. A. Hildes, Y. Loyning, J. D. Nelms, L. J. Peyton, and R. D. Whaley. Metabolism and temperature of Arctic Indian men during a cold night. J. Appl. Physiol. 15: 635-644, 1960.
 36. Joy, R. J. T., Responses of cold acclimatized men to infused norepinephrine. J. Appl. Physiol. 18: 1209-1212, 1963.
 37. Kang, B. S., D. S. Han, K. S. Paik, Y. S. Park, J. K. Kin, C. S. Kim, D. W. Rennie, and S. K. Hong. Calorigenic action of norepinephrine in the Korean women divers. J. Appl. Physiol. 29: 6-9, 1970.
 38. Kang, B. S., S. H. Song, C. S. Suh, and S. K. Hong. Changes in body temperature and basal metabolic rate of the Ama. J. Appl. Physiol. 18: 483-488, 1963.
 39. Kang, D. H., P. K. Kim, B. S. Kang, S. H. Song, and S. K. Hong. Energy metabolism and body temperature of the Ama. J. Appl. Physiol. 20: 46-50, 1965.
 40. Kang, D. H., Y. S. Park, Y. D. Park, I. S. Lee, D. S. Yeon, S. H. Lee, S. Y. Hong, D. W. Rennie, and S. K. Hong. Energetics of wet‐suit diving in Korean women breath‐hold divers. J. Appl. Physiol. 54: 1702-1707, 1983.
 41. Keatinge, W. R., The effect of repeated daily exposure to cold and of improved physical fitness on the metabolic and vascular response to cold air. J. Physiol. 157: 209-220, 1961.
 42. Kreider, M. B., P. F. Iampietro, E. R. Buskirk, and D. E. Bass. Effect of continuous cold exposure on nocturnal body temperatures of man. J. Appl. Physiol. 14: 43-45, 1959.
 43. Lapp, M. C., and G. K. Gee. Human acclimatization to cold water immersion. Arch. Environ. Health 15: 568-579, 1967.
 44. Leblanc, J., Local adaptation to cold of Gaspé fishermen, J. Appl. Physiol. 17: 950-952, 1962.
 45. Leblanc, J., Factors affecting cold acclimation and thermogenesis in man. Med. Sci. Sports Exerc. 20: S193-S196, 1988.
 46. Leblanc, J., J. A. Hildes, and O. Heroux. Tolerance of Gaspé fishermen to cold water. J. Appl. Physiol. 15: 1031-1034, 1960.
 47. Leftheriotis, G., G. Savourey, J. L. Saumet, and J. Bittel. Finger and forearm vasodilatotory changes after local cold acclimation. Eur. J. Appl. Physiol. 60: 49-53, 1990.
 48. Leppaluoto, J., and J. Hassi. Human physiological adaptations to the Arctic climate. Arctic 44: 139-145, 1991.
 49. Mathew, L., S. S. Purkayastha, A. Jayashankar, and H. S. Nayar. Physiological characteristics of cold acclimatization in man. Int. J. Biometeorol. 25: 191-198, 1981.
 50. Milan, F. A., R. W. Eisner, and K. Rodahl. Thermal and metabolic responses of men in the Antarctic to a standard cold stress. J. Appl. Physiol. 16: 401-404, 1961.
 51. Miller, L. K., and L. Irving. Local reactions to air cooling in an Eskimo population. J. Appl. Physiol. 17: 449-455, 1962.
 52. Muza, S. R., A. J. Young, M. N. Sawka, J. E. Bogart, and K. B. Pandolf. Respiratory and cardiovascular responses to cold stress following repeated cold water immersion. Undersea Biomed. Res. 15: 165-178, 1988.
 53. Nelms, J. D., and D. J. G. Soper. Cold vasodilatation and cold acclimatization in the hands of British fish filleters. J. Appl. Physiol. 17: 444-448, 1962.
 54. Newman, R. W., Cold acclimation in Negro Americans. J. Appl. Physiol. 27: 316-319, 1969.
 55. Park, Y. S., D. W. Rennie, I. S. Lee, Y. D. Park, K. S. Paik, D. H. Kang, D. J. Suh, S. H. Lee, S. Y. Hong, and S. K. Hong. Time course of deacclimatization to cold water immersion in Korean women divers. J. Appl. Physiol. 54: 1708-1716, 1983.
 56. Radomski, M. W., and C. Boutelier. Hormone responses of normal and intermittent cold‐preadapted humans to continuous cold. J. Appl. Physiol. 53: 610-616, 1982.
 57. Rennie, D. W., B. G. Covino, M. R. Blair, and K. Rodahl. Physical regulation of temperature in Eskimos. J. Appl. Physiol. 17: 326-332, 1962.
 58. Rodahl, K., Basal metabolism of the Eskimo. J. Nutr. 48: 359-368, 1952.
 59. Scholander, P. F., H. T. Hammel, K. L. Andersen, and Y. Loyning. Metabolic acclimation to cold in man. J. Appl. Physiol. 12: 1-8, 1958.
 60. Scholander, P. F., H. T. Hammel, J. S. Hart, D. H. LeMessurier, and J. Steen. Cold adaptation in Australian Aborigines. J. Appl. Physiol. 13: 211-218, 1958.
 61. Silami‐Garcia, E., and E. M. Haymes. Effects of repeated short‐term cold exposures on cold induced thermogenesis of women. Int. J. Biometeorol. 33: 222-226, 1989.
 62. Skreslet, S., and F. Aarefjord. Acclimatization to cold in man induced by frequent scuba diving in cold water. J. Appl. Physiol. 24: 177-181, 1968.
 63. So, J. K. Genetic, acclimatizational and anthropometric factors in hand cooling among North and South Chinese. Am. J. Phys. Anthropol. 43: 31-38, 1975.
 64. Stegmann, A. T., Human adaptation to cold. In: Physiological Anthropology, New York: Oxford University Press, 1975, p. 130-166.
 65. Ward, J. S., C. A. C. Bredell, and H. G. Wenzel. Responses of Bushmen and Europeans on exposure to winter night temperatures in the Kalahari. J. Appl. Physiol. 15: 667-670, 1960.
 66. Wyndham, D. H., and J. F. Morrison. Adjustment to cold of Bushmen in the Kalahari desert. J. Appl. Physiol. 13: 219-225, 1958.
 67. Young, A. J., S. R. Muza, M. N. Sawka, and K. B. Pandolf. Human vascular fluid responses to cold stress are not altered by cold acclimation. Undersea Biomed. Res. 14: 215-228, 1987.
 68. Young, A. J., S. R. Muza, M. N. Sawka, R. R. Gonzalez, and K. B. Pandolf. Human thermoregulatory responses to cold air are altered by repeated cold water immersion. J. Appl. Physiol. 60: 1542-1548, 1986.

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Article Title: Homeostatic Responses to Prolonged Cold Exposure: Human Cold Acclimatization
 

How to Cite

Andrew J. Young. Homeostatic Responses to Prolonged Cold Exposure: Human Cold Acclimatization. Compr Physiol 2011, Supplement 14: Handbook of Physiology, Environmental Physiology: 419-438. First published in print 1996. doi: 10.1002/cphy.cp040119