Comprehensive Physiology Wiley Online Library

Circulation of the pancreas and salivary glands

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Anatomical Considerations
1.1 Blood vessels
1.2 Lymph Vessels
1.3 Nerves
2 Basal Hemodynamics and Oxygenation
3 Intrinsic Regulation of Blood Flow and Oxygenation
3.1 Metabolic Regulation
3.2 Myogenic Regulation
3.3 Kallikrein‐Kinin Regulation
3.4 Evidence for Intrinsic Vasoregulation
4 Functional Hyperemia
4.1 Characteristics of Functional Hyperemia
4.2 Mediators of Functional Hyperemia
5 Circulatory Adjustments to Hyperplasia
6 Transcapillary Fluid and Solute Exchange
6.1 Ultrastructural Basis of Capillary Exchange
6.2 Transcapillary Fluid Exchange
6.3 Interaction of Capillary and Interstitial Forces During Stimulated Secretion
6.4 Microvascular Permeability
7 Extrinsic Regulation of Blood Flow
7.1 Sympathetic Nerve Stimulation
8 Pharmacology
9 Summary
Figure 1. Figure 1.

Schematic representation of intraglandular portal circulations of salivary gland (A) and pancreas (B).

From Ohtani et al.
Figure 2. Figure 2.

Effects of reducing arterial pressure on pancreatic hemodynamics and oxygenation.

From Kvietys et al.
Figure 3. Figure 3.

Effects of graded arterial occlusions on magnitude and duration of postocclusion hyperemic response.

From Kvietys et al.
Figure 4. Figure 4.

Effects of venous pressure elevation (from 2.2 to 12.4 mmHg) on pancreatic hemodynamics and oxygenation.

From Kvietys et al.
Figure 5. Figure 5.

Effect of chorda stimulation on salivary gland secretion rate and blood flow.

From Darke and Smaje
Figure 6. Figure 6.

A: relationship between steady‐state salivary blood flow and frequency of stimulation of the chorda lingual nerve with continuous mode of nerve stimulation. Solid line, before atropine; dashed line, after atropine. B: relationship between steady state salivary vascular resistance and frequency of stimulation of chorda tympani nerve with intermittent mode of nerve stimulation. Open bars, before atropine; solid bars, after atropine; n, number of observations.

A from Darke and Smaje ; B from Andersson et al.
Figure 7. Figure 7.

Relationship between salivary O2 consumption and blood flow during salivary secretion.

Adapted from Terroux et al.
Figure 8. Figure 8.

Effects of intravenous secretin on pancreatic secretion rate and blood flow.

From Beijer et al.
Figure 9. Figure 9.

Effect of CCK‐OP stimulation on pancreatic growth (A) and on tissue blood flow (B). Cholecystokinin octapeptide was administered for 2, 4, 7, and 14 days. BW, body weight.

From Harper et al.
Figure 10. Figure 10.

Binding of cationized ferritin to endothelial surface of capillary in rabbit submandibular gland. × 148,000.

From Smaje
Figure 11. Figure 11.

Relationship between pancreatic capillary pressure and portal venous pressure.

From Kvietys et al.
Figure 12. Figure 12.

Effect of intra‐arterial saline load on pancreaticoduodenal lymph flow and intralymphatic pressure and on pancreatic interstitial fluid pressure in the dog. Solid bar, period of saline infusion.

From Papp et al.


Figure 1.

Schematic representation of intraglandular portal circulations of salivary gland (A) and pancreas (B).

From Ohtani et al.


Figure 2.

Effects of reducing arterial pressure on pancreatic hemodynamics and oxygenation.

From Kvietys et al.


Figure 3.

Effects of graded arterial occlusions on magnitude and duration of postocclusion hyperemic response.

From Kvietys et al.


Figure 4.

Effects of venous pressure elevation (from 2.2 to 12.4 mmHg) on pancreatic hemodynamics and oxygenation.

From Kvietys et al.


Figure 5.

Effect of chorda stimulation on salivary gland secretion rate and blood flow.

From Darke and Smaje


Figure 6.

A: relationship between steady‐state salivary blood flow and frequency of stimulation of the chorda lingual nerve with continuous mode of nerve stimulation. Solid line, before atropine; dashed line, after atropine. B: relationship between steady state salivary vascular resistance and frequency of stimulation of chorda tympani nerve with intermittent mode of nerve stimulation. Open bars, before atropine; solid bars, after atropine; n, number of observations.

A from Darke and Smaje ; B from Andersson et al.


Figure 7.

Relationship between salivary O2 consumption and blood flow during salivary secretion.

Adapted from Terroux et al.


Figure 8.

Effects of intravenous secretin on pancreatic secretion rate and blood flow.

From Beijer et al.


Figure 9.

Effect of CCK‐OP stimulation on pancreatic growth (A) and on tissue blood flow (B). Cholecystokinin octapeptide was administered for 2, 4, 7, and 14 days. BW, body weight.

From Harper et al.


Figure 10.

Binding of cationized ferritin to endothelial surface of capillary in rabbit submandibular gland. × 148,000.

From Smaje


Figure 11.

Relationship between pancreatic capillary pressure and portal venous pressure.

From Kvietys et al.


Figure 12.

Effect of intra‐arterial saline load on pancreaticoduodenal lymph flow and intralymphatic pressure and on pancreatic interstitial fluid pressure in the dog. Solid bar, period of saline infusion.

From Papp et al.
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Peter R. Kvietys, D. Neil Granger, Scot L. Harper. Circulation of the pancreas and salivary glands. Compr Physiol 2011, Supplement 16: Handbook of Physiology, The Gastrointestinal System, Motility and Circulation: 1565-1595. First published in print 1989. doi: 10.1002/cphy.cp060142