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Neonatal intestinal circulation

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Abstract

The sections in this article are:

1 Hemodynamics and Oxygenation of Fasting Neonatal Intestine
2 Neural Regulation of Neonatal Intestinal Circulation
2.1 Transection of Splanchnic Nerve
2.2 Direct Stimulation of Splanchnic Nerve
2.3 Reflex Control of Neonatal Intestinal Circulation
3 Intrinsic Regulation of Neonatal Intestinal Circulation
3.1 Response to Feeding
3.2 Response to Hypoxemia
3.3 Response to Hypotension
4 Summary
Figure 1. Figure 1.

Effect of feeding on total gastrointestinal blood flow and cardiac output in neonatal swine fasted for 8 h prior to feeding. , perfusion; GI, gastrointestinal system.

From Nowicki et al.
Figure 2. Figure 2.

Effect of feeding on O2 delivery, extraction, and uptake by gastrointestinal tract in neonatal swine fasted for 8 h prior to feeding. Oxygen delivery was calculated as the product of blood flow and arterial O2 content; O2 extraction, as the ratio of arteriovenous O2 difference (a — v O2) to arterial O2 content; and O2 uptake, as the product of blood flow and a — v O2. , oxygen delivery; , oxygen uptake.

From Nowicki et al.
Figure 3. Figure 3.

Intestinal blood flow (;) as a function of arterial O2 content (Cao2) in neonatal swine. Curve, 46 measurements in 23 animals: .

From Nowicki et al.
Figure 4. Figure 4.

Intestinal O2 uptake () as a function of arterial O2 content (Cao2) in neonatal swine. Curve, 46 measurements in 23 animals, .

From Nowicki et al.
Figure 5. Figure 5.

Relationship between normalized intestinal blood flow () and normalized perfusion pressure (P/Po) in neonatal swine. Curve, 6 measurements in each of 9 animals. [From Nowicki et al. .]

Figure 6. Figure 6.

Relationship between normalized arteriovenous O2 difference (a — v O2/a — v O2o) and normalized perfusion pressure (P/Po) in neonatal swine. Curve, 6 measurements from each of 9 animals.

From Nowicki et al.
Figure 7. Figure 7.

Relationship between normalized intestinal O2 uptake () and intestinal perfusion pressure (P/P0) in neonatal swine. Curve, 6 measurements from each of 9 animals.

From Nowicki et al.


Figure 1.

Effect of feeding on total gastrointestinal blood flow and cardiac output in neonatal swine fasted for 8 h prior to feeding. , perfusion; GI, gastrointestinal system.

From Nowicki et al.


Figure 2.

Effect of feeding on O2 delivery, extraction, and uptake by gastrointestinal tract in neonatal swine fasted for 8 h prior to feeding. Oxygen delivery was calculated as the product of blood flow and arterial O2 content; O2 extraction, as the ratio of arteriovenous O2 difference (a — v O2) to arterial O2 content; and O2 uptake, as the product of blood flow and a — v O2. , oxygen delivery; , oxygen uptake.

From Nowicki et al.


Figure 3.

Intestinal blood flow (;) as a function of arterial O2 content (Cao2) in neonatal swine. Curve, 46 measurements in 23 animals: .

From Nowicki et al.


Figure 4.

Intestinal O2 uptake () as a function of arterial O2 content (Cao2) in neonatal swine. Curve, 46 measurements in 23 animals, .

From Nowicki et al.


Figure 5.

Relationship between normalized intestinal blood flow () and normalized perfusion pressure (P/Po) in neonatal swine. Curve, 6 measurements in each of 9 animals. [From Nowicki et al. .]



Figure 6.

Relationship between normalized arteriovenous O2 difference (a — v O2/a — v O2o) and normalized perfusion pressure (P/Po) in neonatal swine. Curve, 6 measurements from each of 9 animals.

From Nowicki et al.


Figure 7.

Relationship between normalized intestinal O2 uptake () and intestinal perfusion pressure (P/P0) in neonatal swine. Curve, 6 measurements from each of 9 animals.

From Nowicki et al.
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How to Cite

Philip T. Nowicki. Neonatal intestinal circulation. Compr Physiol 2011, Supplement 16: Handbook of Physiology, The Gastrointestinal System, Motility and Circulation: 1597-1603. First published in print 1989. doi: 10.1002/cphy.cp060143