Comprehensive Physiology Wiley Online Library

Renal Injury and Urinary Excretion

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Abstract

The sections in this article are:

1 Acute Renal Failure
2 Nephrotic Syndrome and Tubular Dysfunction
2.1 Inorganic Mercury
2.2 Atomic Mercury Vapor
2.3 Organomercurials
2.4 Uranium
2.5 Cadmium
3 Chronic Nephritis
4 Proteinuria and Excretion of Heavy Metals
5 Factors Affecting Renal Toxicity and Excretion
5.1 Storage Capacity of the Tubular Cells
5.2 Tolerance
5.3 Complexing Agents
6 Summary
Figure 1. Figure 1.

Cumulative excretion and kidney level of mercury after the ip administration of 1 μg (open symbols) and 100 μg Hg (solid symbols) as mercuric nitrate. Excretion in feces, squares; excretion in urine, circles.

Adapted from Cember
Figure 2. Figure 2.

Organic and inorganic mercury in kidneys of rats injected iv with methyl HgCl given in a dose of Hg of 1 mg/kg body wt.

From Norseth & Clarkson
Figure 3. Figure 3.

Urinary excretion of cadmium and protein of rabbits dosed daily (5 times/wk) sc with 0.25 mg/kg Cd as CdCl2.

From Axelsson & Piscator . Copyright 1966, American Medical Association
Figure 4. Figure 4.

Effect of lead in drinking water on daily urinary excretion and content of lead in kidneys of rats.

From Goyer et al. . Copyright 1970, American Medical Association


Figure 1.

Cumulative excretion and kidney level of mercury after the ip administration of 1 μg (open symbols) and 100 μg Hg (solid symbols) as mercuric nitrate. Excretion in feces, squares; excretion in urine, circles.

Adapted from Cember


Figure 2.

Organic and inorganic mercury in kidneys of rats injected iv with methyl HgCl given in a dose of Hg of 1 mg/kg body wt.

From Norseth & Clarkson


Figure 3.

Urinary excretion of cadmium and protein of rabbits dosed daily (5 times/wk) sc with 0.25 mg/kg Cd as CdCl2.

From Axelsson & Piscator . Copyright 1966, American Medical Association


Figure 4.

Effect of lead in drinking water on daily urinary excretion and content of lead in kidneys of rats.

From Goyer et al. . Copyright 1970, American Medical Association
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L. Magos, T. W. Clarkson. Renal Injury and Urinary Excretion. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 503-512. First published in print 1977. doi: 10.1002/cphy.cp090132