Comprehensive Physiology Wiley Online Library

Biliary Excretion

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Bile Production
2 Classification of Foreign Compounds Excreted Into Bile
3 Role of Ligandin in Hepatic Uptake
4 Polarity and Molecular Size in Biliary Excretion
5 “First‐Pass“ Effect
6 Species Differences in Biliary Excretion
7 Effect of Liver Injury on Biliary Excretion
8 Effect of Microsomal Enzyme Inducers on Biliary Excretion
9 Biliary Excretion in the Newborn
10 Enterohepatic Circulation
11 Conclusion
Figure 1. Figure 1.

Effect of varying taurocholate excretion rate, during the course of a single study, on bile flow during cholinergic blockade.

From Preisig et al.
Figure 2. Figure 2.

Biliary mannitol clearance in ml/min (ordinate) plotted against rate of bile acid secretion. Solid regression lines (obtained by method of least squares) relate mannitol clearance C to rate R of bile acid secretion as follows: dog Ha, C = 0.10 + 0.0058R. Dashed lines show relationship between bile flow F and rate of bile acid secretion and have the following equation: dog Ha, F = 0.05 + 0.0055R.

From Wheeler et al.
Figure 3. Figure 3.

The X, Y, and Z sulfobromophthalein (BSP)‐binding protein fractions from 110,000‐g supernate from 2‐g rat liver containing 58 mg protein with 2.4 μmole BSP added in vitro and eluted from a column of Sephadex G75 (3.2 × 55 cm) at a flow rate of 32.8 ml/h. Collections were 4.9 ml/tube. Solid line, (left ordinate), optical density 280 nm; dashed line, (right ordinate), optical density 580 nm. Optical density at 280 nm indicates protein and at 580 nm after alkalinization indicates BSP.

From Levi et al.
Figure 4. Figure 4.

Threshold molecular weight for appreciable biliary excretion (10% of dose) in female rat.

From Hirom et al.
Figure 5. Figure 5.

Effect of bile duct ligation (BDL) on the plasma disappearance of diethylstilbestrol.

From Klaassen


Figure 1.

Effect of varying taurocholate excretion rate, during the course of a single study, on bile flow during cholinergic blockade.

From Preisig et al.


Figure 2.

Biliary mannitol clearance in ml/min (ordinate) plotted against rate of bile acid secretion. Solid regression lines (obtained by method of least squares) relate mannitol clearance C to rate R of bile acid secretion as follows: dog Ha, C = 0.10 + 0.0058R. Dashed lines show relationship between bile flow F and rate of bile acid secretion and have the following equation: dog Ha, F = 0.05 + 0.0055R.

From Wheeler et al.


Figure 3.

The X, Y, and Z sulfobromophthalein (BSP)‐binding protein fractions from 110,000‐g supernate from 2‐g rat liver containing 58 mg protein with 2.4 μmole BSP added in vitro and eluted from a column of Sephadex G75 (3.2 × 55 cm) at a flow rate of 32.8 ml/h. Collections were 4.9 ml/tube. Solid line, (left ordinate), optical density 280 nm; dashed line, (right ordinate), optical density 580 nm. Optical density at 280 nm indicates protein and at 580 nm after alkalinization indicates BSP.

From Levi et al.


Figure 4.

Threshold molecular weight for appreciable biliary excretion (10% of dose) in female rat.

From Hirom et al.


Figure 5.

Effect of bile duct ligation (BDL) on the plasma disappearance of diethylstilbestrol.

From Klaassen
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Curtis D. Klaassen. Biliary Excretion. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 537-553. First published in print 1977. doi: 10.1002/cphy.cp090134