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Electrical Properties of Striated Muscle

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Abstract

The sections in this article are:

1 Cable Theory for Striated Muscle
2 Voltage‐Clamp Methods for Striated Muscle
2.1 Gap Methods
2.2 Microelectrode‐Clamping Methods
3 Action Potential in Striated Muscle
3.1 Sodium Current
3.2 Potassium Current
3.3 Calcium Current
3.4 Action‐Potential Calculations
4 Currents in the Inactive Membrane
4.1 Potassium Conductance
4.2 Chloride Conductance
4.3 Voltage‐Dependent Membrane Capacitance
Figure 1. Figure 1.

Three‐dimensional representation of potential (Vr=a; Eq. 9) across membrane at surface of a cylinder of specific resistivity Ri (200 Ω·cm) and membrane resistance Rm (1,000 Ω·cm2). Current is delivered from a point source represented as the tip of a microelectrode impaling the fiber. Microelectrode tip is at coordinates x′ = 0, θ′ = 0°, r′ = 0.9 a where a is the fiber radius (50 μm). Potential across membrane at any point on surface of cylinder is represented as radial distance between surface of cylinder and surface surrounding cylinder. Marks on x‐axis are at ± 250 μm and ± 500 μm.

From Adrian, Costantin, and Peachey 11
Figure 2. Figure 2.

Disk model of the transverse‐tubular system.

Figure 3. Figure 3.

Circuits referred to in text to illustrate the definition of effective capacitance by means of Equation 75.

From Adrian and Almers 5
Figure 4. Figure 4.

Arrangement of microelectrodes in three‐electrode method adapted to the center of a long cylindrical fiber. Fiber ends are to be understood to be several (more than, say, 5Δ) length constants away from x = 0.

From Adrian and Marshall 14
Figure 5. Figure 5.

Recorded (by S. Nakajima) and calculated action potentials for frog striated muscle. A: recorded action potential at 3.3°C (above) and 21.8°C (below). B: action potentials calculated at 2°C (above) and 20°C (below) by Eqs. 123 and 124. Dotted lines are VT, the potential across the capacitance representing the tubular wall (CT) in the membrane equivalent circuit shown in Fig. 3A (but shown there without any elements to represent potential‐dependent ionic currents).

From Adrian, Chandler, and Hodgkin 9
Figure 6. Figure 6.

Calculated action potentials across surface of a fiber and across wall of T system at various radial distances. Coordinates: vertical, potential in 20‐mV divisions; horizontal to the left, the fiber diameter divided into 6 equal divisions; horizontal to the right, time in 1‐ms divisions. In both calculations no additional resistance is assumed at entrances of the tubular system (access resistance = 0 Ω·cm2). A: no activable sodium or potassium current in tubular system. B: activable sodium and potassium currents in tubular system are assumed.

From Adrian and Peachey 15
Figure 7. Figure 7.

Calculated action potentials across surface of a fiber and across wall of T system at various radial distances. Coordinates as in Fig. 6, and all parameters of calculation in A and B are same as in Fig. 6A and B, respectively, with the exception of access resistance of 150 Ω·cm2.

From Adrian and Peachey 15
Figure 8. Figure 8.

A: records of currents required to impose voltage steps of long duration on a muscle fiber. Three‐electrode method with fiber in an isotonic sulfate Ringer's solution with 5 mM K at 1.5°C. Current for hyperpolarization is initially large but decays with time constant 0.5–1 s. B: initial (open circles) and final (crosses) current plotted against membrane potential during imposed potential step. Outward current is positive.

From Adrian, Chandler, and Hodgkin 10
Figure 9. Figure 9.

Above: records of membrane potential (V), membrane current (ΔV), and electrode current (I0) for control and test 10‐mV steps of V at 2.5°C. Control step is from −90 mV; test step from −52 mV. Membrane capacity at control and test potential (CC, CT) is determined from integral of transient part of membrane current at “on” and “off” of 10‐mV step. Below: point‐by‐point differences in membrane currents (ΔVT − ΔVC) for test and control steps. These records show, for various starting potentials, current that is not present in the control step from −90 mV. Note that the kinetics of this additional polarization current can be complex. In both sets of records the 10‐mV step lasts for 128 ms. Three‐electrode clamp; fiber in a hypertonic solution designed to minimize ionic currents.

From Adrian and Peres 16
Figure 10. Figure 10.

Voltage dependence of nonlinear membrane capacity (CT:CC). For all curves, CC measured at −90 mV; CT at membrane potential indicated on abscissa. Membrane potential was held at −90 mV (half‐filled circles), −40 mV (open circles), and −20 mV (filled circles) except during the measurements of capacity (as in Fig. 9). Note that the behavior of the nonlinear capacity depends on the holding potential.

From Adrian 4. Reproduced, with permission, from Annu. Rev. Biophys. Bioeng., vol. 7, ©1978 by Annual Reviews, Inc.


Figure 1.

Three‐dimensional representation of potential (Vr=a; Eq. 9) across membrane at surface of a cylinder of specific resistivity Ri (200 Ω·cm) and membrane resistance Rm (1,000 Ω·cm2). Current is delivered from a point source represented as the tip of a microelectrode impaling the fiber. Microelectrode tip is at coordinates x′ = 0, θ′ = 0°, r′ = 0.9 a where a is the fiber radius (50 μm). Potential across membrane at any point on surface of cylinder is represented as radial distance between surface of cylinder and surface surrounding cylinder. Marks on x‐axis are at ± 250 μm and ± 500 μm.

From Adrian, Costantin, and Peachey 11


Figure 2.

Disk model of the transverse‐tubular system.



Figure 3.

Circuits referred to in text to illustrate the definition of effective capacitance by means of Equation 75.

From Adrian and Almers 5


Figure 4.

Arrangement of microelectrodes in three‐electrode method adapted to the center of a long cylindrical fiber. Fiber ends are to be understood to be several (more than, say, 5Δ) length constants away from x = 0.

From Adrian and Marshall 14


Figure 5.

Recorded (by S. Nakajima) and calculated action potentials for frog striated muscle. A: recorded action potential at 3.3°C (above) and 21.8°C (below). B: action potentials calculated at 2°C (above) and 20°C (below) by Eqs. 123 and 124. Dotted lines are VT, the potential across the capacitance representing the tubular wall (CT) in the membrane equivalent circuit shown in Fig. 3A (but shown there without any elements to represent potential‐dependent ionic currents).

From Adrian, Chandler, and Hodgkin 9


Figure 6.

Calculated action potentials across surface of a fiber and across wall of T system at various radial distances. Coordinates: vertical, potential in 20‐mV divisions; horizontal to the left, the fiber diameter divided into 6 equal divisions; horizontal to the right, time in 1‐ms divisions. In both calculations no additional resistance is assumed at entrances of the tubular system (access resistance = 0 Ω·cm2). A: no activable sodium or potassium current in tubular system. B: activable sodium and potassium currents in tubular system are assumed.

From Adrian and Peachey 15


Figure 7.

Calculated action potentials across surface of a fiber and across wall of T system at various radial distances. Coordinates as in Fig. 6, and all parameters of calculation in A and B are same as in Fig. 6A and B, respectively, with the exception of access resistance of 150 Ω·cm2.

From Adrian and Peachey 15


Figure 8.

A: records of currents required to impose voltage steps of long duration on a muscle fiber. Three‐electrode method with fiber in an isotonic sulfate Ringer's solution with 5 mM K at 1.5°C. Current for hyperpolarization is initially large but decays with time constant 0.5–1 s. B: initial (open circles) and final (crosses) current plotted against membrane potential during imposed potential step. Outward current is positive.

From Adrian, Chandler, and Hodgkin 10


Figure 9.

Above: records of membrane potential (V), membrane current (ΔV), and electrode current (I0) for control and test 10‐mV steps of V at 2.5°C. Control step is from −90 mV; test step from −52 mV. Membrane capacity at control and test potential (CC, CT) is determined from integral of transient part of membrane current at “on” and “off” of 10‐mV step. Below: point‐by‐point differences in membrane currents (ΔVT − ΔVC) for test and control steps. These records show, for various starting potentials, current that is not present in the control step from −90 mV. Note that the kinetics of this additional polarization current can be complex. In both sets of records the 10‐mV step lasts for 128 ms. Three‐electrode clamp; fiber in a hypertonic solution designed to minimize ionic currents.

From Adrian and Peres 16


Figure 10.

Voltage dependence of nonlinear membrane capacity (CT:CC). For all curves, CC measured at −90 mV; CT at membrane potential indicated on abscissa. Membrane potential was held at −90 mV (half‐filled circles), −40 mV (open circles), and −20 mV (filled circles) except during the measurements of capacity (as in Fig. 9). Note that the behavior of the nonlinear capacity depends on the holding potential.

From Adrian 4. Reproduced, with permission, from Annu. Rev. Biophys. Bioeng., vol. 7, ©1978 by Annual Reviews, Inc.
References
 1. Adrian, R. H. Internal chloride concentration and chloride efflux of frog muscle. J. Physiol. London 156: 623–632, 1961.
 2. Adrian, R. H. The rubidium and potassium permeability of frog muscle membrane. J. Physiol. London 175: 134–159, 1964.
 3. Adrian, R. H. Conduction velocity and gating current in the squid giant axon. Proc. R. Soc. London Ser. B 189: 81–86, 1975.
 4. Adrian, R. H. Charge movement in the membrane of striated muscle. Annu. Rev. Biophys. Bioeng. 7: 85–112, 1978.
 5. Adrian, R. H., and W. Almers. Membrane capacity measurements on frog skeletal muscle in media of low ion content. J. Physiol. London 237: 573–605, 1974.
 6. Adrian, R. H., and W. Almers. Charge movement in the membrane of striated muscle. J. Physiol. London 254: 339–360, 1976.
 7. Adrian, R. H., and S. H. Bryant. On the repetitive discharge in myotonic muscle fibres. J. Physiol. London 240: 505–515, 1974.
 8. Adrian, R. H., W. K. Chandler, and A. L. Hodgkin. Kinetics of mechanical activation in frog muscle. J. Physiol. London 204: 207–230, 1969.
 9. Adrian, R. H., W. K. Chandler, and A. L. Hodgkin. Voltage clamp experiments in striated muscle fibres. J. Physiol. London 208: 607–644, 1970.
 10. Adrian, R. H., W. K. Chandler, and A. L. Hodgkin. Slow changes in potassium permeability in skeletal muscle. J. Physiol. London 208: 645–668, 1970.
 11. Adrian, R. H., L. L. Costantin, and L. D. Peachey. Radial spread of contraction in frog muscle fibres. J. Physiol. London 204: 231–257, 1969.
 12. Adrian, R. H., and W. H. Freygang. The potassium and chloride conductance of frog muscle membrane. J. Physiol. London 163: 61–103, 1962.
 13. Adrian, R. H., and M. W. Marshall. Action potentials reconstructed in normal and myotonic muscle fibres. J. Physiol. London 258: 125–143, 1976.
 14. Adrian, R. H., and M. W. Marshall. Sodium currents in mammalian muscle. J. Physiol. London 268: 223–250, 1977.
 15. Adrian, R. H., and L. D. Peachey. Reconstruction of the action potential in frog sartorius muscle. J. Physiol. London 235: 103–131, 1973.
 16. Adrian, R. H., and A. Peres. Charge movement and membrane capacity in frog muscle. J. Physiol. London 289: 83–97, 1979.
 17. Adrian, R. H., and R. F. Rakowski. Reactivation of membrane charge movement and delayed potassium conductance in skeletal muscle fibres. J. Physiol. London 278: 533–557, 1978.
 18. Adrian, R. H., and C. L. Slayman. Membrane potential and conductance during transport of sodium, potassium and rubidium in frog muscle. J. Physiol. London 184: 970–1014, 1966.
 19. Almers, W. Potassium conductance changes in skeletal muscle and the potassium concentration in the transverse tubules. J. Physiol. London 225: 33–56, 1972.
 20. Almers, W. The decline of potassium permeability during extreme hyperpolarization in frog skeletal muscle. J. Physiol. London 225: 57–83, 1972.
 21. Almers, W., R. H. Adrian, and S. R. Levinson. Some dielectric properties of muscle membrane and their possible importance for excitation‐contraction coupling. Ann. NY Acad. Sci. 264: 278–292, 1975.
 22. Argibay, J. A., and O. F. Hutter. Voltage clamp experiments on the inactivation of the delayed potassium current in skeletal muscle fibres. J. Physiol. London 232: 41P–43P, 1973.
 23. Armstrong, C. M. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58: 413–437, 1971.
 24. Armstrong, C. M., F. M. Bezanilla, and P. Horowicz. Twitches in the presence of ethylene glycol bis(β‐aminoethylether)‐N,N′‐tetraacetic acid. Biochim. Biophys. Acta 267: 605–608, 1972.
 25. Bastian, J., and S. Nakajima. Action potential in the transverse tubules and its role in the activation of skeletal muscle. J. Gen. Physiol. 63: 257–278, 1974.
 26. Beaty, G. N., and E. Stefani. Calcium dependent electrical activity in twitch muscle fibres of the frog. Proc. R. Soc. London Ser. B 194: 141–150, 1976.
 27. Bernard, C., J. C. Cardinaux, and D. Potreau. Long duration responses and slow inward current obtained from isolated skeletal muscle fibres with barium ions. J. Physiol. London 256: 18P–19P, 1976.
 28. Brooks, A. E., and O. F. Hutter. The influence of pH on the chloride conductance of skeletal muscle. J. Physiol. London 163: 9P–10P, 1962.
 29. Bryant, S. H. The electrophysiology of myotonia, with a review of congenital myotonia of goats. In: New Developments in Electromyography and Clinical Neurophysiology, edited by J. E. Desmedt. Basel: Karger, 1972.
 30. Campbell, D. T. Ionic selectivity of the sodium channel of frog skeletal muscle. J. Gen. Physiol. 67: 295–307, 1976.
 31. Campbell, D. T., and B. Hille. Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle. J. Gen. Physiol. 67: 309–323, 1976.
 32. Carslaw, H. S., and J. C. Jaeger. Conduction of Heat in Solids (2nd ed.). Oxford: Oxford Univ. Press, 1959.
 33. Chandler, W. K., R. F. Rakowski, and M. F. Schneider. A non‐linear voltage dependent charge movement in frog skeletal muscle. J. Physiol. London 254: 245–283, 1976.
 34. Chandler, W. K., R. F. Rakowski, and M. F. Schneider. Effects of glycerol treatment and maintained depolarization on charge movement in skeletal muscle. J. Physiol. London 254: 285–316, 1976.
 35. Cleemann, L., and M. Morad. Potassium currents in frog ventricular muscle: evidence from voltage clamp currents and extracellular K accumulation. J. Physiol. London 286: 113–143, 1979.
 36. Costantin, L. L. The effect of calcium on contraction and conductance thresholds in frog skeletal muscle. J. Physiol. London 195: 119–132, 1968.
 37. Costantin, L. L. The role of sodium current in the radial spread of contraction in frog muscle fibers. J. Gen. Physiol. 55: 703–715, 1970.
 38. Costantin, L. L. Activation in striated muscle. In: Handbook of Physiology. The Nervous System, edited by J. M. Brookhart and V. B. Mountcastle. Bethesda, MD: Am. Physiol. Soc., 1977, sect. 1, vol. I, pt. 1, chapt. 7, p. 215–259.
 39. Crank, J. The Mathematics of Diffusion. Oxford: Oxford Univ. Press, 1956.
 40. Curtis, B. A. Ca fluxes in single twitch muscle fibers. J. Gen. Physiol. 50: 255–267, 1966.
 41. Curtis, B. A. Calcium efflux from frog twitch muscle fibers. J. Gen. Physiol. 55: 243–253, 1970.
 42. Davies, P. W. Voltage clamp measurements on skeletal muscle fibers with low resistance internal electrodes (Abstract). Federation Proc. 33: 401, 1974.
 43. Dodge, F. A., and B. Frankenhaeuser. Membrane currents in isolated frog nerve fibre under voltage clamp conditions. J. Physiol. London 143: 76–90, 1958.
 44. Duval, A., and C. Léoty. Ionic currents in mammalian fast skeletal muscle. J. Physiol. London 278: 403–423, 1978.
 45. Duval, A., and C. Léoty. Ionic currents in slow twitch skeletal muscle in the rat. J. Physiol. London 307: 23–41, 1980.
 46. Duval, A., and C. Léoty. Comparison between the delayed outward current in slow and fast twitch skeletal muscle in the rat. J. Physiol. London 307: 43–57, 1980.
 47. Eisenberg, R. S., and E. A. Johnson. Three‐dimensional electrical field problems in physiology. Prog. Biophys. Mol. Biol. 20: 1–65, 1970.
 48. Falk, G., and P. Fatt. Linear electrical properties of striated muscle fibres observed with intracellular electrodes. Proc. R. Soc. London Ser. B 160: 69–123, 1964.
 49. Fitzhugh, R. Theoretical effect of temperature on threshold in the Hodgkin‐Huxley nerve model. J. Gen. Physiol. 49: 989–1005, 1966.
 50. Frankenhaeuser, B. A method for recording resting and action potentials in the isolated myelinated nerve fibre of the frog. J. Physiol. London 135: 550–559, 1957.
 51. Frankenhaeuser, B., B. D. Lindley, and R. S. Smith. Potentiometrie measurement of membrane action potentials in frog muscle fibres. J. Physiol. London 183: 152–166, 1966.
 52. Gage, P. W., and R. S. Eisenberg. Capacitance of the surface and transverse tubular membrane of frog sartorius muscle fibers. J. Gen. Physiol. 53: 265–278, 1969.
 53. Gage, P. W., and R. S. Eisenberg. Action potentials, after‐potentials, and excitation‐contraction coupling in frog sartorius fibers without transverse tubules. J. Gen. Physiol. 53: 298–310, 1969.
 54. Gay, L. A., and P. R. Stanfield. Cs+ causes a voltage‐dependent block of inward K currents in resting skeletal muscle fibres. Nature London 267: 169–170, 1977.
 55. Gilly, W. F., and C. S. Hui. Mechanical activation in slow and twitch skeletal muscle fibres of the frog. J. Physiol. London 301: 137–156, 1980.
 56. Gilly, W. F., and C. S. Hui. Membrane electrical properties of frog slow muscle fibres. J. Physiol. London 301: 157–173, 1980.
 57. Gilly, W. F., and C. S. Hui. Voltage‐dependent charge movement in frog slow muscle fibres. J. Physiol. London 301: 175–190, 1980.
 58. Goldman, D. E. Potential, impedance, and rectification in membranes. J. Gen. Physiol. 27: 37–60, 1943.
 59. Hagiwara, S., S. Miyazaki, W. Moody, and J. Patlak. Blocking effects of barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg. J. Physiol. London 279: 167–185, 1978.
 60. Hagiwara, S., S. Miyazaki, and N. P. Rosenthal. Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish. J. Gen. Physiol. 67: 621–638, 1976.
 61. Hanson, J., and A. Persson. Changes in the action potential and contraction of isolated frog muscle after repetitive stimulation. Acta Physiol. Scand. 81: 340–348, 1971.
 62. Harris, E. J. Anion interaction in frog muscle. J. Physiol. London 141: 351–365, 1958.
 63. Heistracher, P., and C. C. Hunt. The relation of membrane changes to contraction in twitch muscle fibres. J. Physiol. London 201: 589–611, 1969.
 64. Heistracher, P., and C. C. Hunt. Contractile repriming in snake twitch muscle fibres. J. Physiol. London 201: 613–626, 1969.
 65. Hille, B., and D. T. Campbell. An improved vaseline gap voltage clamp for skeletal muscle fibers. J. Gen. Physiol. 67: 265–293, 1976.
 66. Hodgkin, A. L., and P. Horowicz. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J. Physiol. London 148: 127–160, 1959.
 67. Hodgkin, A. L., and P. Horowicz. The effect of sudden changes in ionic concentrations on the membrane potential of single muscle fibres. J. Physiol. London 153: 370–385, 1960.
 68. Hodgkin, A. L., and A. F. Huxley. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. London 117: 500–544, 1952.
 69. Hodgkin, A. L., and B. Katz. The effect of sodium ions on the electrical activity of the giant axon of the squid. J. Physiol. London 108: 37–77, 1949.
 70. Hodgkin, A. L., and S. Nakajima. The effect of diameter on the electrical constants of frog skeletal muscle fibres. J. Physiol. London 221: 105–120, 1972.
 71. Hodgkin, A. L., and W. A. H. Rushton. The electrical constants of a crustacean nerve fibre. Proc. R. Soc. London Ser. B 133: 444–479, 1946.
 72. Hutter, O. F., and D. Noble. The chloride conductance of frog skeletal muscle. J. Physiol. London 151: 89–102, 1960.
 73. Hutter, O. F., and S. M. Padsha. Effect of nitrate and other anions on the membrane resistance of frog skeletal muscle. J. Physiol. London 146: 117–132, 1959.
 74. Hutter, O. F., and A. E. Warner. The pH sensitivity of the chloride conductance of frog skeletal muscle. J. Physiol. London 189: 403–425, 1967.
 75. Hutter, O. F., and A. E. Warner. The effect of pH on the 36Cl efflux from frog skeletal muscle. J. Physiol. London 189: 427–460, 1967.
 76. Hutter, O. F., and A. E. Warner. The voltage dependence of the chloride conductance of frog muscle. J. Physiol. London 227: 275–290, 1972.
 77. Huxley, A. F., and R. E. Taylor. Local activation of striated muscle fibres. J. Physiol. London 144: 426–441, 1958.
 78. Ildefonse, M., and O. Rougier. Voltage‐clamp analysis of the early current in frog skeletal muscle fibre using the double sucrose‐gap method. J. Physiol. London 222: 373–395, 1972.
 79. Ildefonse, M., and G. Roy. Kinetic properties of the sodium current in striated muscle fibres on the basis of the Hodgkin‐Huxley theory. J. Physiol. London 227: 419–431, 1972.
 80. Jack, J. J. B., D. Noble, and R. W. Tsien. Electrical Current Flow in Excitable Cell. London: Oxford Univ. Press, 1975.
 81. Kao, C. Y., and P. R. Stanfield. Action of some anions on the electrical properties and mechanical threshold of frog twitch muscle. J. Physiol. London 198: 291–309, 1968.
 82. Kass, R. S., S. A. Siegelbaum, and R. W. Tsien. Three micro‐electrode voltage clamp experiments in calf cardiac Purkinje fibres: is slow inward current adequately measured? J. Physiol. London 290: 201–225, 1979.
 83. Katz, B. Les constantes électriques de la membrane du muscle. Arch. Sci. Physiol. 3: 285–300, 1949.
 84. Kirsch, G. E., R. A. Nichols, and S. Nakajima. Delayed rectification in the transverse tubules. Origin of late after‐potential in frog skeletal muscle. J. Gen. Physiol. 70: 1–21, 1977.
 85. Kootsey, J. M. Voltage clamp simulation. Federation Proc. 34: 1343–1349, 1975.
 86. Kovács, L., E. Ríos, and M. F. Schneider. Calcium transients and intramembrane charge movement in skeletal muscle fibres. Nature London 279: 391–396, 1979.
 87. Kovács, L., and M. F. Schneider. Contractile activation by voltage clamp depolarization of cut skeletal muscle fibres. J. Physiol. London 277: 483–506, 1978.
 88. Léoty, C., and J. Alix. Some technical improvements for the voltage clamp with the double sucrose gap. Pfluegers Arch. 365: 95–97, 1976.
 89. Lorcovic, H., and C. Edwards. Threshold for contraction and delayed rectification in muscle. Life Sci. 7: 367–370, 1968.
 90. Lynch, C. Kinetic and biochemical separation of delayed rectifier currents in frog striated muscle. Biophys. J. 21: 55a, 1978.
 91. Mathias, R. T., R. S. Eisenberg, and R. Valdiosera. Electrical properties of frog skeletal muscle fibers interpreted with a mesh model of the tubular system. Biophys. J. 17: 57–93, 1977.
 92. Meech, R. W., and N. B. Standen. Potassium activation in Helix aspersa neurones under voltage clamp: a component mediated by calcium influx. J. Physiol. London 249: 211–239, 1975.
 93. Meyer, K. H., and J. F. Sievers. La perméabilité des membranes. I. Théorie de la perméabilité ionique. Helv. Chim. Acta 19: 649–664, 1936.
 94. Moore, L. E. Voltage clamp experiments on single muscle fibers of Rana pipiens. J. Gen. Physiol. 60: 1–19, 1972.
 95. Nakajima, S., S. Iwasaki, and K. Obata. Delayed rectification and anomalous rectification in frog's skeletal muscle membrane. J. Gen. Physiol. 46: 97–115, 1962.
 96. Noble, D., and R. W. Tsien. Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J. Physiol. London 200: 205–231, 1969.
 97. Ohmori, H. Inactivation kinetics and steady‐state current noise in the anomalous rectifier of tunicate egg cell membranes. J. Physiol. London 281: 77–99, 1978.
 98. Pappone, P. A. Voltage clamp experiments in normal and denervated mammalian skeletal muscle fibres. J. Physiol. London 307: 377–410, 1980.
 99. Peskoff, A. Green's function for Laplace's equation in an infinite cylindrical cell. J. Math. Phys. 15: 2112–2120, 1974.
 100. Peskoff, A., and R. S. Eisenberg. A point source in a cylindrical cell: potential for a step‐function of current inside an infinite cylindrical cell in a medium of finite conductivity. Los Angeles, CA: UCLA, 1974. (Tech. Rep. UCLA‐ENG‐7421.)
 101. Peskoff, A., R. S. Eisenberg, and J. P. Cole. Potential induced by a point source of current inside an infinite cylindrical cell. Los Angeles, CA: UCLA, 1973. (Tech. Rep. UCLA‐ENG‐7303.)
 102. Poindessault, P. J., A. Duval, and C. Léoty. Voltage clamp with double sucrose gap technique. External series resistance compensation. Biophys. J. 16: 105–120, 1976.
 103. Rougier, O., G. Vassort, and R. Stämpfli. Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique. Pfluegers Arch. 301: 91–108, 1968.
 104. Sanchez, J. A., and E. Stefani. Inward calcium current in twitch muscle fibres of the frog. J. Physiol. London 283: 197–209, 1978.
 105. Schneider, M. F. Linear electrical properties of the transverse tubules and surface membrane of skeletal muscle fibers. J. Gen. Physiol. 56: 640–671, 1970.
 106. Schneider, M. F., and W. K. Chandler. Effects of membrane potential on the capacitance of skeletal muscle fibers. J. Gen. Physiol. 67: 125–163, 1976.
 107. Standen, N. B., and P. R. Stanfield. A potential‐ and time‐dependent blockade of inward rectification in frog skeletal muscle fibres by barium and strontium ions. J. Physiol. London 280: 169–191, 1978.
 108. Standen, N. B., and P. R. Stanfield. Potassium depletion and sodium block of potassium currents under hyperpolarization in frog sartorius muscle. J. Physiol. London 294: 497–520, 1979.
 109. Stanfield, P. R. The effect of tetraethylammonium ion on the delayed currents of frog skeletal muscle. J. Physiol. London 209: 209–229, 1970.
 110. Stanfield, P. R. A calcium dependent inward current in frog skeletal muscle fibres. Pfluegers Arch. 368: 267–270, 1977.
 111. Stanfield, P. R., F. M. Ashcroft, and T. D. Plant. Gating of a muscle K+ channel and its dependence on the permeating ion species. Nature London 289: 509–511, 1981.
 112. Taylor, R. E. Cable theory. In: Physical Techniques in Biological Research. Electrophysiological Methods, edited by W. L. Nastuk. New York: Academic, 1963, vol. 6, pt. B.
 113. Taylor, R. E., J. W. Moore, and K. S. Cole. Analysis of certain errors in squid axon voltage clamp measurements. Biophys. J. 1: 161–202, 1960.
 114. Thomsen, J. Tonische Krämpfe in willkürlich beweglichen Muskeln in Folge von erebter psychischer Disposition (Ataxis muscularis?). Arch. Psychiatr. Nervenkr. 6: 702–718, 1876.
 115. Thomson, W. (Lord Kelvin). On the theory of the electric telegraph. Proc. R. Soc. London 7: 382–399, 1855.
 116. Valdiosera, R., C. Clausen, and R. S. Eisenberg. Impedance of frog skeletal muscle fibers in various solutions. J. Gen. Physiol. 63: 460–491, 1974.
 117. Warner, A. E. Kinetic properties of the chloride conductance of frog muscle. J. Physiol. London 227: 291–312, 1972.

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Richard H. Adrian. Electrical Properties of Striated Muscle. Compr Physiol 2011, Supplement 27: Handbook of Physiology, Skeletal Muscle: 275-300. First published in print 1983. doi: 10.1002/cphy.cp100110