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Actions of Corticotropin on the Adrenal Cortex: Biochemistry and Cell Biology

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The sections in this article are:

1 Response to Stress
2 Diurnal Rhythm
3 Biosynthetic Pathway: Cholesterol → Cortisol
3.1 Cytochromes P450
4 Action of Corticotropin on Synthesis of Cortisol
4.1 The Corticotropin Receptor
4.2 Second Messengers
5 Locus of Action of Corticotropin and Cyclic Adenosine Monophosphate
6 Transport of Steroidogenic Cholesterol to Inner Mitochondrial Membrane
6.1 Action of Lipase
6.2 Transport of Cholesterol and Lipid Droplets to Mitochondria
7 Transport of Cholesterol Within Mitochondria: Outer to Inner Membrane
8 Additional Responses to Corticotropin
8.1 Synthesis of Slowly Responding Proteins Connected with Steroid Synthesis
8.2 Cytochromes P450
8.3 Electron Carriers
8.4 P450 Genes
9 Other Proteins
9.1 Low‐Density Lipoprotein Receptor
9.2 SCP2
10 Phosphorylation of Proteins
11 Phospholipids
12 Influence of Growth Factors in Responses to Corticotropin
13 Conclusion
Figure 1. Figure 1.

The pathway to cortisol.

Figure 1.

The pathway to cortisol.

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Peter F. Hall. Actions of Corticotropin on the Adrenal Cortex: Biochemistry and Cell Biology. Compr Physiol 2011, Supplement 23: Handbook of Physiology, The Endocrine System, Coping with the Environment: Neural and Endocrine Mechanisms: 61-84. First published in print 2001. doi: 10.1002/cphy.cp070404