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Insulin‐like Growth Factor‐1 and the Endocrine Pancreas

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Abstract

The sections in this article are:

1 Insulin‐like Growth Factor‐1 and Pancreatic Islet Growth, Development, and Regeneration
2 Insulin‐like Growth Factor‐1 and Regulation of Pancreatic Islet Function
3 Insulin‐like Growth Factor Binding Proteins and The Pancreatic Islet
4 Summary
Figure 1. Figure 1.

Comparable effects of continuous intravenous IGF‐1 (0.8μg/kg/min) and insulin (0.8 mU/kg/min) on glucose uptake and production during clamped euglycemic conditions in nonobese, healthy volunteers (n = 21, aged 20–34 yr). Basal data are included for comparison.

[Adapted from Boulware et al. 6.]
Figure 2. Figure 2.

Effect of 120 min primed‐continuous infusion of either IGF‐1 (0.7 μg/kg/min) or insulin (0.8 mU/kg/min) on plasma glucose, glucagon, and growth hormone in nonobese, healthy volunteers (n = 18, aged 18–33 yr). Note the equivalent hypoglycemic stimulus with IGF‐1 and insulin, but impaired glucagon and growth hormone responses and delayed glucose recovery with IGF‐1.

[Adapted from Kerr et al. 35.]
Figure 3. Figure 3.

Suppression of endogenous insulin secretion by IGF‐1 (0.4 μg/kg/min) with plasma glucose clamped at 8 and 13 mM during hyperglycemic clamp procedure in nonobese, healthy volunteers (n = 14, aged 18–34 yr).

[Adapted from Rennert et al. 67.]


Figure 1.

Comparable effects of continuous intravenous IGF‐1 (0.8μg/kg/min) and insulin (0.8 mU/kg/min) on glucose uptake and production during clamped euglycemic conditions in nonobese, healthy volunteers (n = 21, aged 20–34 yr). Basal data are included for comparison.

[Adapted from Boulware et al. 6.]


Figure 2.

Effect of 120 min primed‐continuous infusion of either IGF‐1 (0.7 μg/kg/min) or insulin (0.8 mU/kg/min) on plasma glucose, glucagon, and growth hormone in nonobese, healthy volunteers (n = 18, aged 18–33 yr). Note the equivalent hypoglycemic stimulus with IGF‐1 and insulin, but impaired glucagon and growth hormone responses and delayed glucose recovery with IGF‐1.

[Adapted from Kerr et al. 35.]


Figure 3.

Suppression of endogenous insulin secretion by IGF‐1 (0.4 μg/kg/min) with plasma glucose clamped at 8 and 13 mM during hyperglycemic clamp procedure in nonobese, healthy volunteers (n = 14, aged 18–34 yr).

[Adapted from Rennert et al. 67.]
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David G. Maggs, Robert S. Sherwin. Insulin‐like Growth Factor‐1 and the Endocrine Pancreas. Compr Physiol 2011, Supplement 21: Handbook of Physiology, The Endocrine System, The Endocrine Pancreas and Regulation of Metabolism: 939-948. First published in print 2001. doi: 10.1002/cphy.cp070230