Comprehensive Physiology Wiley Online Library

For Authors


Contact Information

Please direct all questions and communications to [email protected].

Scope of the Project

Y. S. Prakash,Professor of Anesthesiology and Physiology, and Chair of the Department of Physiology and Biomedical Engineering at Mayo Clinic, serves as the Editor-in-Chief of Comprehensive Physiology.The work contains 9 Sections;each section is divided into Topics, each led by Topic Editors.


All new and updated articles currently being commissioned for Comprehensive Physiology are defined as Overview articles. These are highly detailed reviews aimed at researchers and advanced students in the field, as well as those in adjacent disciplines. Overview articles should retain the authoritative, in-depth, and well-documented presentation of material as established in the Handbook of Physiology (HoP) series, while the online-only format increases the articles' timeliness, flexibility, and relevance. Upon accepting an Editor's invitation to write an Overview, authors will receive a Word-based template that will guide them as they prepare their submissions. A link to the author template for Overview articles is provided below.


Comprehensive Physiology's 2018 Impact Factor is 6.246. It ranks 5th among all physiology journals.


Resources for Authors

CPHY_Guide_for_Authors_June2019 (Please review this document before writing your article.)


How to cite your Comprehensive Physiology article and previously published HoP chapters:

  • Compr Physiol Year, Volume: Pages. DOI
    Example: Glenny RW, Robertson HT. Determinants of pulmonary blood flow distribution. Compr Physiol 2011, 1:39-59. doi: 10.1002/cphy.c090002
  • The most recently published print HoP volumes are scanned and published online as supplements to the first issue of Comprehensive Physiology. They should be cited using the Supplement number, original print publication year, and online DOI.
    Example: Moss RL, Buck SH. Regulation of Cardiac Contraction by Calcium. Compr Physiol 2011, Supplement 6: Handbook of Physiology, The Cardiovascular System, The Heart: 420-454. First published in print 2002. doi: 10.1002/cphy.cp020111

Wiley English Language Editing Services provides assistance with English language editing, formatting, or figure preparation for a reasonable fee.

Submitting Your Article

Articles commissioned for Comprehensive Physiology are submitted and peer-reviewed using an online article management system called ScholarOne Manuscripts (S1M). When you accept an invitation to contribute an article, a user account will be created and the login information mailed to you. To submit your manuscript online, point your browser to; once you log in, click on the "Author Center" icon to send us your submission.

Detailed instructions on using S1M can be found via the "User Tutorials" button on the right-hand side of the login screen.

Please be sure to study the instructions given at the site carefully, and then let the system guide you through the submission process. You will be able to exit and re-enter the system at any stage before finally submitting your work. All submissions are kept strictly confidential. You can log in periodically and check your Author Center to monitor the movement of your manuscript through the review process.

To facilitate the peer review process, please be sure to enter the names and email addresses of 4–5 potential reviewers who are familiar with the topic.

If you need any help during the submission process, please contact [email protected].

Conflict-of-Interest Statement

Comprehensive Physiology adheres strongly to the guidelines of the Committee on Publication Ethics (COPE). All instances of publishing misconduct, including, but not limited to, plagiarism, data fabrication, image/data manipulation to falsify/enhance results, etc. will result in rejection/retraction of the manuscript in question.

Requesting Permission to Reuse

To request permission to reuse content from Comprehensive Physiology, write to:

Paulette Goldweber
Associate Manager, Permissions
Global Rights
John Wiley & Sons, [email protected]

Authors of Comprehensive Physiology articles transfer copyright to the American Physiological Society. However, authors may make copies of their own articles (for educational purposes only), or republish parts of these articles (e.g., figures, tables), without charge and without requesting permission, provided that full acknowledgement of the source is given in the new work.  

NIH Public Access Policy

Comprehensive Physiology authors may upload the accepted manuscript version (not the published article) to PubMedCentral (PMC) if the work described in the article was supported by NIH funding and that fact is acknowledged explicitly in the article. Comprehensive Physiology articles uploaded to PMC should be made available to the public 12 months after publication, in compliance with the Copyright Transfer Agreement as well as agreements between the APS, Wiley, and the NIH.