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Sympathoneural and Adrenomedullary Responses to Mental Stress

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Abstract

This concept‐based review provides historical perspectives and updates about sympathetic noradrenergic and sympathetic adrenergic responses to mental stress. The topic of this review has incited perennial debate, because of disagreements over definitions, controversial inferences, and limited availability of relevant measurement tools. The discussion begins appropriately with Cannon's “homeostasis” and his pioneering work in the area. This is followed by mental stress as a scientific idea and the relatively new notions of allostasis and allostatic load. Experimental models of mental stress in rodents and humans are discussed, with particular attention to ethical constraints in humans. Sections follow on sympathoneural responses to mental stress, reactivity of catecholamine systems, clinical pathophysiologic states, and the cardiovascular reactivity hypothesis. Future advancement of the field will require integrative approaches and coordinated efforts between physiologists and psychologists on this interdisciplinary topic. Published 2015. Compr Physiol 5:119‐146, 2015.

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Figure 1. Figure 1. Original recordings of muscle sympathetic nerve activity (MSNA) and beat‐to‐beat arterial blood pressure during acute, laboratory‐based mental stress. Taken with permission from Wallin et al. (279).
Figure 2. Figure 2. Muscle sympathetic nerve activity (MSNA) responsiveness to mental stress was not correlated to arterial blood pressure responsiveness; DAP, diastolic arterial pressure. Taken with permission from Carter & Ray (39).
Figure 3. Figure 3. Mental stress increases forearm vascular conductance (FVC) without any change in forearm muscle sympathetic nerve activity (MSNA); VOP, venous occlusion plethysmography; DOPPLER, Doppler ultrasound technique; B, baseline; R, recovery. Modified with permission from Carter et al. (37).
Figure 4. Figure 4. Muscle sympathetic nerve activity correlates strongly with femoral venous (FV) plasma norepinephrine (NE) concentrations and spillover at rest, but not during mental stress elicited via Stroop's color word conflict test (CWT). Taken with permission from Hjemdahl et al. (133).
Figure 5. Figure 5. Skin sympathetic nerve activity (SSNA) responsiveness to mental stress was divergent in the tibial (T) and peroneal (P) nerves of hyperhidrosis patients. Taken with permission from Iwase et al. (137).
Figure 6. Figure 6. Skin sympathetic nerve activity (SSNA) responses to emotionally charged images from the International Affective Picture System (IAPS). Taken with permission from Brown et al. (24).
Figure 7. Figure 7. Panic disorder (PD) patient peripheral sympathetic neurons fire more often in a “multiple spike” pattern when compared to health controls. Taken with permission from Lambert et al. (172).
Figure 8. Figure 8. Hemodynamic and catecholamine responses to mental challenge (playing a video game) in healthy humans. There are increases in heart rate (HR), blood pressure (BP), and forearm blood flow (FBF) and concurrent increases in total body and forearm norepinephrine spillover (TB NE SO and FA NE SO), yet arterial and arm venous concentrations of epinephrine ([EPI]) remain unchanged. Infusion was 3H‐norepinephrine. This pattern exemplifies active attention without distress.
Figure 9. Figure 9. Cannon's denervated heart model demonstrating distress‐induced adrenal secretion. The rate of the denervated heart in a caged cat was recorded upon exposure of the animal to a dog, before and after bilateral adrenal inactivation. The virtual absence of tachycardia in the setting of inactivated adrenals indicated distress‐evoked adrenal release of a hormone into the bloodstream. Taken with permission from Cannon (29).
Figure 10. Figure 10. Estimates of rates of norepinephrine (NE) synthesis, vesicular recycling, release, neuronal, and extraneuronal uptake, and metabolism in cardiac sympathetic nerves in healthy humans and patients with congestive heart failure. Note that under resting conditions most of the turnover of NE is from net vesicular leakage, not release escaping reuptake. Cardiac NE spillover is influenced by both exocytotic release and neuronal reuptake.
Figure 11. Figure 11. Concept diagram depicting proposed mechanisms of takotsubo cardiopathy (stress cardiopathy). Taken with permission from Akashi et al. (3).
Figure 12. Figure 12. Plasma epinephrine (EPI), norepinephrine (NE), forearm vascular resistance (FVR), and mean arterial pressure (MAP) responses to tilt table testing in a patient with neurocardiogenic syncope. Note progressive decrease in FVR and increase in EPI prior to hypotension and syncope. Divergence of EPI from NE responses indicates sympathoadrenal imbalance.
Figure 13. Figure 13. Concept diagram for shifts in blood flow distribution associated with tilt‐induced syncope. The normal response to head‐up tilting includes sympathetically mediated skeletal muscle vasoconstriction, which counters decreased cardiac output and helps preserve cerebral blood flow. Skeletal muscle vasodilation combined with decreased cardiac output decreases brainstem perfusion, evoking syncope.
Figure 14. Figure 14. Meta‐analysis from of prospective studies examining cardiovascular reactivity to stress and subsequent cardiovascular status. Taken with permission from Chida and Steptoe (42).
Figure 15. Figure 15. Meta‐analysis from of prospective studies examining cardiovascular recovery from stress and subsequent cardiovascular status. Taken with permission Chida and Steptoe (42).
Figure 16. Figure 16. Adrenaline and ACTH responses to different stressors in humans, from a meta‐analysis of the literature. There is excellent agreement between adrenomedullary and adrenocortical activation. For instance, exposure to cold exerts little or no adrenomedullary or adrenocortical activation, whereas insulin‐induced hypoglycemia evokes large‐magnitude adrenomedullary and adrenocortical activation.


Figure 1. Original recordings of muscle sympathetic nerve activity (MSNA) and beat‐to‐beat arterial blood pressure during acute, laboratory‐based mental stress. Taken with permission from Wallin et al. (279).


Figure 2. Muscle sympathetic nerve activity (MSNA) responsiveness to mental stress was not correlated to arterial blood pressure responsiveness; DAP, diastolic arterial pressure. Taken with permission from Carter & Ray (39).


Figure 3. Mental stress increases forearm vascular conductance (FVC) without any change in forearm muscle sympathetic nerve activity (MSNA); VOP, venous occlusion plethysmography; DOPPLER, Doppler ultrasound technique; B, baseline; R, recovery. Modified with permission from Carter et al. (37).


Figure 4. Muscle sympathetic nerve activity correlates strongly with femoral venous (FV) plasma norepinephrine (NE) concentrations and spillover at rest, but not during mental stress elicited via Stroop's color word conflict test (CWT). Taken with permission from Hjemdahl et al. (133).


Figure 5. Skin sympathetic nerve activity (SSNA) responsiveness to mental stress was divergent in the tibial (T) and peroneal (P) nerves of hyperhidrosis patients. Taken with permission from Iwase et al. (137).


Figure 6. Skin sympathetic nerve activity (SSNA) responses to emotionally charged images from the International Affective Picture System (IAPS). Taken with permission from Brown et al. (24).


Figure 7. Panic disorder (PD) patient peripheral sympathetic neurons fire more often in a “multiple spike” pattern when compared to health controls. Taken with permission from Lambert et al. (172).


Figure 8. Hemodynamic and catecholamine responses to mental challenge (playing a video game) in healthy humans. There are increases in heart rate (HR), blood pressure (BP), and forearm blood flow (FBF) and concurrent increases in total body and forearm norepinephrine spillover (TB NE SO and FA NE SO), yet arterial and arm venous concentrations of epinephrine ([EPI]) remain unchanged. Infusion was 3H‐norepinephrine. This pattern exemplifies active attention without distress.


Figure 9. Cannon's denervated heart model demonstrating distress‐induced adrenal secretion. The rate of the denervated heart in a caged cat was recorded upon exposure of the animal to a dog, before and after bilateral adrenal inactivation. The virtual absence of tachycardia in the setting of inactivated adrenals indicated distress‐evoked adrenal release of a hormone into the bloodstream. Taken with permission from Cannon (29).


Figure 10. Estimates of rates of norepinephrine (NE) synthesis, vesicular recycling, release, neuronal, and extraneuronal uptake, and metabolism in cardiac sympathetic nerves in healthy humans and patients with congestive heart failure. Note that under resting conditions most of the turnover of NE is from net vesicular leakage, not release escaping reuptake. Cardiac NE spillover is influenced by both exocytotic release and neuronal reuptake.


Figure 11. Concept diagram depicting proposed mechanisms of takotsubo cardiopathy (stress cardiopathy). Taken with permission from Akashi et al. (3).


Figure 12. Plasma epinephrine (EPI), norepinephrine (NE), forearm vascular resistance (FVR), and mean arterial pressure (MAP) responses to tilt table testing in a patient with neurocardiogenic syncope. Note progressive decrease in FVR and increase in EPI prior to hypotension and syncope. Divergence of EPI from NE responses indicates sympathoadrenal imbalance.


Figure 13. Concept diagram for shifts in blood flow distribution associated with tilt‐induced syncope. The normal response to head‐up tilting includes sympathetically mediated skeletal muscle vasoconstriction, which counters decreased cardiac output and helps preserve cerebral blood flow. Skeletal muscle vasodilation combined with decreased cardiac output decreases brainstem perfusion, evoking syncope.


Figure 14. Meta‐analysis from of prospective studies examining cardiovascular reactivity to stress and subsequent cardiovascular status. Taken with permission from Chida and Steptoe (42).


Figure 15. Meta‐analysis from of prospective studies examining cardiovascular recovery from stress and subsequent cardiovascular status. Taken with permission Chida and Steptoe (42).


Figure 16. Adrenaline and ACTH responses to different stressors in humans, from a meta‐analysis of the literature. There is excellent agreement between adrenomedullary and adrenocortical activation. For instance, exposure to cold exerts little or no adrenomedullary or adrenocortical activation, whereas insulin‐induced hypoglycemia evokes large‐magnitude adrenomedullary and adrenocortical activation.
References
 1. Abboud FM . Neurocardiogenic syncope. N Engl J Med 328: 1117‐1120, 1993.
 2. Abercrombie ED . Enhanced tyrosine hydroxylation in hippocampus of chronically stressed rats upon exposure to a novel stressor. J Neurochem 58: 276‐281, 1992.
 3. Akashi YJ , Goldstein DS , Barbaro G , Ueyama T . Takotsubo cardiomyopathy: A new form of acute, reversible heart failure. Circulation 118: 2754‐2762, 2008.
 4. Akashi YJ , Nakazawa K , Sakakibara M , Miyake F , Koike H , Sasaka K . The clinical features of takotsubo cardiomyopathy. QJM 96: 563‐573, 2003.
 5. Akashi YJ , Nakazawa K , Sakakibara M , Miyake F , Musha H , Sasaka K . 123I‐MIBG myocardial scintigraphy in patients with “takotsubo” cardiomyopathy. J Nucl Med 45: 1121‐1127, 2004.
 6. Anderson EA , Mahoney LT , Lauer RM , Clarke WR . Enhanced forearm blood flow during mental stress in children of hypertensive parents. Hypertension 10: 544‐549, 1987.
 7. Anderson EA , Sinkey CA , Mark AL . Mental stress increases sympathetic nerve activity during sustained baroreceptor stimulation in humans. Hypertension 17: III43‐III49, 1991.
 8. Anderson EA , Wallin BG , Mark AL . Dissociation of sympathetic nerve activity in arm and leg muscle during mental stress. Hypertension 9: III114‐III119, 1987.
 9. Aneman A , Eisenhofer G , Olbe L , Dalenback J , Nitescu P , Fandriks L , Friberg P . Sympathetic discharge to mesenteric organs and the liver. Evidence for substantial mesenteric organ norepinephrine spillover. J Clin Invest 97: 1640‐1646, 1996.
 10. Ashino K , Gotoh E , Sumita S , Takasaki I , Sugimoto K , Shionoiri H , Ishii M . Effect of an angiotensin receptor antagonist, TCV‐116, on sympathetic nerve activity in patients with essential hypertension. Blood Press Suppl 5: 122‐129, 1994.
 11. Ax AF . The physiological differentiation between fear and anger in humans. Psychosom Med 15: 433‐442, 1953.
 12. Bales KL , Kramer KM , Lewis‐Reese AD , Carter CS . Effects of stress on parental care are sexually dimorphic in prairie voles. Physiol behav 87: 424‐429, 2006.
 13. Barnett PH , Hines EA, Jr. , Schirger A , Gage RP . Blood pressure and vascular reactivity to the cold pressor test. Restudy of 207 subjects 27 years later. JAMA 183: 845‐848, 1963.
 14. Battelli MG . Dosage colorimetrique de la substance active des capsules surrenales. Compt Rend Soc Biol 54: 571‐573, 1902.
 15. Bernard C. Introduction a l'Etude de la Medicine Experimentale. New York: McMillan, 1927.
 16. Best JD , Halter JB . Release and clearance rates of epinephrine in man: Importance of arterial measurements. J Clin Endocrinol Metab 55: 263‐268, 1982.
 17. Bhargava B , Chandra S , Kacker V , Gupta YK , Kaul U , Seth SD , Wasir HS . Changes in circulatory biogenic amines during head‐up tilt testing in neurocardiogenic syncope. Indian Heart J 48: 659‐662, 1996.
 18. Biaggioni I , Robertson D . Endogenous restoration of noradrenaline by precursor therapy in dopamine‐beta‐hydroxylase deficiency. Lancet 2: 1170‐1172, 1987.
 19. Biederman J , Spencer T . Attention‐deficit/hyperactivity disorder (ADHD) as a noradrenergic disorder. Biol Psychiatry 46: 1234‐1242., 1999.
 20. Blair DA , Glover WE , Greenfield ADM , Roddie IC . Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J Physiol 148: 633‐647, 1959.
 21. Blanchard EB , Kolb LC , Prins A , Gates S , McCoy GC . Changes in plasma norepinephrine to combat‐related stimuli among Vietnam veterans with posttraumatic stress disorder. J Nerv Ment Dis 179: 371‐373, 1991.
 22. Blier P . Neurotransmitter targeting in the treatment of depression. J Clin Psychiatry 74(Suppl 2): 19‐24, 2013.
 23. Breier A , Davis O , Buchanan R , Listwak SJ , Holmes C , Pickar D , Goldstein DS . Effects of alprazolam on pituitary‐adrenal and catecholaminergic responses to metabolic stress in humans. Biol Psychiatry 32: 880‐890, 1992.
 24. Brown R , James C , Henderson LA , Macefield VG . Autonomic markers of emotional processing: Skin sympathetic nerve activity in humans during exposure to emotionally charged images. Front Physiol 3: 394, 2012.
 25. Callister R , Suwarno NO , Seals DR . Sympathetic activity is influenced by task difficulty and stress perception during mental challenge in humans. J Physiol 454: 373‐387, 1992.
 26. Cannon WB . The interrelation of emotions as suggested by recent physiological researches. Am J Psychol 25: 256‐282, 1914a.
 27. Cannon WB . The emergency function of the adrenal medulla in pain and in the major emotions. Am J Physiol 33: 356‐372, 1914b.
 28. Cannon WB. Bodily Changes in Pain, Hunger, fear and Rage. New York: D. Appleton & Co., 1929.
 29. Cannon WB. The Wisdom of the Body. New York: W.W. Norton, 1939.
 30. Cannon WB , Britton SW . The influence of motion and emotion on medulliadrenal secretion. Am J Physiol 79: 433‐465, 1927.
 31. Cannon WB , de la Paz D . Emotional stimulation of adrenal gland secretion. Am J Physiol 28: 64‐70, 1911.
 32. Cannon WB , Lissak K . Evidence for adrenaline in adrenergic neurones. Am J Physiol 97: 592‐595, 1939.
 33. Carroll JF , Wood CE , Pollock ML , Graves JE , Convertino VA , Lowenthal DT . Hormonal responses in elders experiencing pre‐syncopal symptoms during head‐up tilt before and after exercise training. J Gerontol A Biol Sci Med Sci 50: M324‐M329, 1995.
 34. Carter CS , DeVries AC , Getz LL . Physiological substrates of mammalian monogamy: The prairie vole model. Neurosci Biobehav Rev 19: 303‐314, 1995.
 35. Carter JR , Cooke WH , Ray CA . Forearm neurovascular responses during mental stress and vestibular activation. Am J Physiol Heart Circ Physiol 288: H904‐H907, 2004.
 36. Carter JR , Durocher JJ , Kern RP . Neural and cardiovascular responses to emotional stress in humans. Am J Physiol Regul Integr Comp Physiol 295: R1898‐R1903, 2008.
 37. Carter JR , Kupiers NT , Ray CA . Neurovascular responses to mental stress. J Physiol 564: 321‐327, 2005.
 38. Carter JR , Lawrence JE . Effects of the menstrual cycle on sympathetic neural responses to mental stress in humans. J Physiol 585: 635‐641, 2007.
 39. Carter JR , Ray CA . Sympathetic neural responses to mental stress: Responders, nonresponders and sex differences. Am J Physiol Heart Circ Physiol 296: H847‐H853, 2009.
 40. Carter JR , Ray CA , Cooke WH . Vestibulosympathetic reflex during mental stress. J Appl Physiol 93: 1260‐1264, 2002.
 41. Carter JR , Schwartz CE , Yang H , Joyner MJ . Fish oil and neurovascular reactivity to mental stress in humans. Am J Physiol Regul, Integr Comp Physiol 304: R523‐R530, 2013.
 42. Chida Y , Steptoe A . Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: A meta‐analysis of prospective evidence. Hypertension 55: 1026‐1032, 2010.
 43. Cobb S , Rose RM . Hypertension, peptic ulcer, and diabetes in air traffic controllers. JAMA 224: 489‐492, 1973.
 44. Cohen H , Kotler M , Matar MA , Kaplan Z , Miodownik H , Cassuto Y . Power spectral analysis of heart rate variability in posttraumatic stress disorder patients. Biol Psychiatry 41: 627‐629, 1997.
 45. Collins FS , Tabak LA . Policy: NIH plans to enhance reproducibility. Nature 505: 612‐613, 2014.
 46. Corbalan K , Verrier R , Lown B . Psychological stress and ventricular arrhythmias during myocardial infarction in the conscious dog. Am J Cardiol 34: 692‐696, 1974.
 47. Dale HH , Feldberg W . The chemical transmission of secretory impulses to the sweat glands of the cat. J Physiol 82: 121‐128, 1934.
 48. Davern PJ , Nguyen‐Huu TP , La Greca L , Abdelkader A , Head GA . Role of the sympathetic nervous system in Schlager genetically hypertensive mice. Hypertension 54: 852‐859, 2009.
 49. Davies R , Slater JD , Forsling ML , Payne N . The response of arginine vasopressin and plasma renin to postural change in normal man, with observations on syncope. Clin Sci Mol Med 51: 267‐274, 1976.
 50. Delius W , Hagbarth KE , Hongell A , Wallin BG . Manoeuvres affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand 84: 82‐94, 1972a.
 51. Delius W , Hagbarth KE , Hongell A , Wallin BG . Manoeuvres affecting sympathetic outflow in human skin nerves. Acta Physiol Scand 84: 177‐186, 1972b.
 52. DeSilva RA , Verrier RL , Lown B . The effects of psychological stress and vagal stimulation with morphine on vulnerability to ventricular fibrillation (VF) in the conscious dog. Am Heart J 95: 197‐203, 1978.
 53. DiBona GF , Jones SY . Analysis of renal sympathetic nerve responses to stress. Hypertension 25: 531‐538, 1995.
 54. Dickinson CJ . Fainting precipitated by collapse‐firing of venous baroreceptors. Lancet 342: 970‐972, 1993.
 55. Dionne RA , Goldstein DS , Wirdzek PR . Effects of diazepam premedication and epinephrine‐containing local anesthetic on cardiovascular and plasma catecholamine responses to oral surgery. Anesth Analg 63: 640‐646, 1984.
 56. Dishman RK , Jackson EM , Nakamura Y , Ray CA . Augmented limb blood flow during neurovascular stress in physically fit women. Psychophysiology 50: 831‐840, 2013.
 57. Dishman RK , Nakamura Y , Jackson EM , Ray CA . Blood pressure and muscle sympathetic nerve activity during cold pressor stress: Fitness and gender. Psychophysiology 40: 370‐380, 2003.
 58. Donadio V , Liguori R , Elam M , Karlsson T , Giannoccaro MP , Pegenius G , Giambattistelli F , Wallin BG . Muscle sympathetic response to arousal predicts neurovascular reactivity during mental stress. J Physiol 590: 2885‐2896, 2012.
 59. Durocher JJ , Klein JC , Carter JR . Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans. Am J Physiol Heart Circ Physiol 300: H1788‐H1793, 2011.
 60. Durocher JJ , Lufkin KM , King ME , Carter JR . Social technology restriction alters state‐anxiety but not autonomic activity in humans. Am J Physiol Regul Integr Comp Physiol 301: R1773‐R1778, 2011.
 61. Durocher JJ , Schwartz CE , Carter JR . Sympathetic neural responses to mental stress during acute simulated microgravity. J Appl Physiol 107: 518‐522, 2009.
 62. Eckberg DL . Sympathovagal balance: A critical appraisal. Circulation 96: 3224‐3232, 1997.
 63. Ehringer H , Hornykiewicz O . [Distribution of noradrenaline and dopamine (3‐hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system.]. Wien Klin Wochenschr 38: 1236‐1239, 1960.
 64. Eisenhofer G , Aneman A , Friberg P , Hooper D , Fandriks L , Lonroth H , Hunyady B , Mezey E . Substantial production of dopamine in the human gastrointestinal tract. J Clin Endocrinol Metab 82: 3864‐3871, 1997.
 65. Eisenhofer G , Esler MD , Meredith IT , Dart A , Cannon RO, III , Quyyumi AA , Lambert G , Chin J , Jennings GL , Goldstein DS . Sympathetic nervous function in human heart as assessed by cardiac spillovers of dihydroxyphenylglycol and norepinephrine. Circulation 85: 1775‐1785., 1992.
 66. Elam M , Johansson G , Wallin BG . Do patients with primary fibromyalgia have an altered muscle sympathetic nerve activity? Pain 48: 371‐375, 1992.
 67. Eldadah BA , Pacak K , Eisenhofer G , Holmes C , Kopin IJ , Goldstein DS . Cardiac uptake‐1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma. Hypertension 43: 1227‐1232, 2004.
 68. Eldadah BA , Pechnik SL , Holmes CS , Moak JP , Saleem AM , Goldstein DS . Failure of propranolol to prevent tilt‐evoked systemic vasodilatation, adrenaline release and neurocardiogenic syncope. Clin Sci 111: 209‐216, 2006.
 69. Ellenbogen KA , Morillo CA , Wood MA , Gilligan DM , Eckberg DL , Smith ML . Neural monitoring of vasovagal syncope. Pacing Clin Electrophysiol 20: 788‐794, 1997.
 70. Elmadjian F , Hope JM , Lamson ET . Excretion of epinephrine and norepinephrine in various emotional states. J Clin Endocrinol Metab 17: 608‐620, 1965.
 71. Elman I , Goldstein DS , Adler CM , Shoaf SE , Breier A . Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men. Life Sci 68: 1889‐1898., 2001.
 72. Engel GL . Psychologic distress, vasodepressor (vasovagal) syncope, and sudden death. Ann Int Med 89: 403‐412, 1978.
 73. Esler M . The sympathetic system and hypertension. Am J Hypertens 13: 99S‐105S, 2000.
 74. Esler M . The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: The transition from mechanisms to medical management. J Appl Physiol 108: 227‐237, 2010.
 75. Esler M , Ferrier C , Lambert G , Eisenhofer G , Cox H , Jennings G . Biochemical evidence of sympathetic hyperactivity in human hypertension. Hypertension 17: III29‐III‐35, 1991.
 76. Esler M , Jennings G , Biviano B , Lambert G , Hasking G . Mechanism of elevated plasma noradrenaline in the course of essential hypertension. J Cardiovasc Pharmacol 8(Suppl 5): S39‐S43, 1986.
 77. Esler M , Jennings G , Korner P , Blombery P , Burke F , Willett I , Leonard P . Total, and organ‐specific, noradrenaline plasma kinetics in essential hypertension. Clin Exper Hyper 6: 507‐521, 1984.
 78. Esler M , Jennings G , Korner P , Blombery P , Sacharias N , Leonard P . Measurement of total and organ‐specific norepinephrine kinetics in humans. Am J Physiol 247: E21‐E28, 1984.
 79. Esler M , Jennings G , Lambert G , Meredith I , Horne M , Eisenhofer G . Overflow of catecholamine neurotransmitters to the circulation: Source, fate, and functions. Physiol Rev 70: 963‐985, 1990.
 80. Esler M , Jennings G , Leonard P , Sacharias N , Burke F , Johns J , Blombery P . Contribution of individual organs to total noradrenaline release in humans. Acta Physiol Scand 527: 11‐16, 1984.
 81. Esler M , Julius S , Zweifler A , Randall O , Harburg E , Gardiner H , DeQuattro V . Mild high‐renin essential hypertension: Neurogenic human hypertension. N Engl J Med 296: 405‐411, 1977.
 82. Esler M , Lambert G , Jennings G . Increased regional sympathetic nervous activity in human hypertension: Causes and consequences. J Hypertension 8: S53‐S57, 1990.
 83. Esler M , Rumantir M , Kaye D , Lambert G . The sympathetic neurobiology of essential hypertension: Disparate influences of obesity, stress, and noradrenaline transporter dysfunction? Am J Hypertens 14: 139S‐146S, 2001.
 84. Evans JM , Leonelli FM , Ziegler MG , McIntosh CM , Patwardhan AR , Ertl AC , Kim CS , Knapp CF . Epinephrine, vasodilation and hemoconcentration in syncopal, healthy men and women. Auton Neurosci 93: 79‐90, 2001.
 85. Ferreira A , Bettencourt P , Pimenta J , Frioes F , Pestana M , Soares‐da‐Silva P , Cerqueira‐Gomes M . The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure. Am Heart J 143: 391‐397, 2002.
 86. Ferrier C , Jennings GL , Eisenhofer G , Lambert G , Cox HS , Kalff V , Kelly M , Esler MD . Evidence for increased noradrenaline release from subcortical brain regions in essential hypertension. J Hypertens 11: 1217‐1227, 1993.
 87. Fitzpatrick AP , Banner N , Cheng A , Yacoub M , Sutton R . Vasovagal reactions may occur after orthotopic heart transplantation. J Am Coll Cardiol 21: 1132‐1137, 1993.
 88. Flaa A , Eide IK , Kjeldsen SE , Rostrup M . Sympathoadrenal stress reactivity is a predictor of future blood pressure: An 18‐year follow‐up study. Hypertension 52: 336‐341, 2008.
 89. Flaa A , Mundal HH , Eide I , Kjeldsen S , Rostrup M . Sympathetic activity and cardiovascular risk factors in young men in the low, normal, and high blood pressure ranges. Hypertension 47: 396‐402, 2006.
 90. Frazier TW , Weil‐Malherbe H , Lipscomb HS . Psychophysiology of conditioned emotional distrubances in humans. Psychophysiology 5: 478‐503, 1969.
 91. Freyschuss U , Fagius J , Wallin BG , Bohlin G , Perski A , Hjemdahl P . Cardiovascular and sympathoadrenal responses to mental stress: A study of sensory intake and rejection reactions. Acta Physiol Scand 139: 173‐183, 1990.
 92. Funkenstein DH . Nor‐epinephrine‐like and epinephrine‐like substances in relation to human behavior. J Mental Dis 124: 58‐68, 1956.
 93. Geracioti TD, Jr. , Baker DG , Kasckow JW , Strawn JR , Jeffrey Mulchahey J , Dashevsky BA , Horn PS , Ekhator NN . Effects of trauma‐related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin‐releasing hormone concentrations in post‐traumatic stress disorder. Psychoneuroendocrinology 33: 416‐424, 2008.
 94. Glover WE , Greenfield AD , Shanks RG . The contribution made by adrenaline to the vasodilatation in the human forearm during emotional stress. J Physiol 164: 422‐429, 1962.
 95. Goddard AW , Ball SG , Martinez J , Robinson MJ , Yang CR , Russell JM , Shekhar A . Current perspectives of the roles of the central norepinephrine system in anxiety and depression. Depress Anxiety 27: 339‐350, 2010.
 96. Goldstein DS . Plasma norepinephrine during stress in essential hypertension. Hypertension 3: 551‐556, 1981.
 97. Goldstein DS . Arterial baroreflex sensitivity, plasma catecholamines, and pressor responsiveness in essential hypertension. Circulation 68: 234‐240, 1983.
 98. Goldstein DS . Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5: 86‐99, 1983.
 99. Goldstein DS. Stress, Catecholamines, and Cardiovascular Disease. New York: Oxford University Press, 1995.
 100. Goldstein DS. Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine. Baltimore, MD: The Johns Hopkins University Press, 2006.
 101. Goldstein DS . Concepts of scientific integrative medicine applied to the physiology and pathophysiology of catecholamine systems. Comp Physiol 3: 1569‐1610, 2013.
 102. Goldstein DS , Breier A , Wolkowitz OM , Pickar D , Lenders JW . Plasma levels of catecholamines and corticotrophin during acute glucopenia induced by 2‐deoxy‐D‐glucose in normal man. Clin Auton Res 2: 359‐366, 1992.
 103. Goldstein DS , Dionne R , Sweet J , Gracely R , Brewer HB, Jr. , Gregg R , Keiser HR . Circulatory, plasma catecholamine, cortisol, lipid, and psychological responses to a real‐life stress (third molar extractions): effects of diazepam sedation and of inclusion of epinephrine with the local anesthetic. Psychosom Med 44: 259‐272, 1982.
 104. Goldstein DS , Eisenhofer G , Sax FL , Keiser HR , Kopin IJ . Plasma norepinephrine pharmacokinetics during mental challenge. Psychosom Med 49: 591‐605, 1987.
 105. Goldstein DS , Eisenhofer G , Stull R , Folio CJ , Keiser HR , Kopin IJ . Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Invest 81: 213‐220, 1988.
 106. Goldstein DS , Golczynska A , Stuhlmuller J , Holmes C , Rea RF , Grossman E , Lenders J . A test of the “epinephrine hypothesis” in humans. Hypertension 33: 36‐43, 1999.
 107. Goldstein DS , Grossman E , Listwak S , Folio CJ . Sympathetic reactivity during a yohimbine challenge test in essential hypertension. Hypertension 18(Suppl. III): III‐40‐III‐48, 1991.
 108. Goldstein DS , Holmes C . Neuronal source of plasma dopamine. Clin Chem 54: 1864‐1871, 2008.
 109. Goldstein DS , Holmes C , Frank SM , Naqibuddin M , Dendi R , Snader S , Calkins H . Sympathoadrenal imbalance before neurocardiogenic syncope. Am J Cardiol 91: 53‐58, 2003.
 110. Goldstein DS , Kopin IJ . Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: A meta‐analysis. Endo Regul 42: 111‐119, 2008.
 111. Goldstein DS , McEwen B . Allostasis, homeostats, and the nature of stress. Stress 5: 55‐58, 2002.
 112. Goldstein DS , Mezey E , Yamamoto T , Aneman A , Friberg P , Eisenhofer G . Is there a third peripheral catecholaminergic system? Endogenous dopamine as an autocrine/paracrine substance derived from plasma DOPA and inactivated by conjugation. Hypertens Res 18(Suppl 1): S93‐S99, 1995.
 113. Goldstein DS , Spanarkel M , Pitterman A , Toltzis R , Gratz E , Epstein S , Keiser HR . Circulatory control mechanisms in vasodepressor syncope. Am Heart J 104: 1071‐1075, 1982.
 114. Goldstein DS , Swoboda KJ , Miles JM , Coppack SW , Aneman A , Holmes C , Lamensdorf I , Eisenhofer G . Sources and physiological significance of plasma dopamine sulfate. J Clin Endocrinol Metab 84: 2523‐2531, 1999.
 115. Goldstein DS , Tack C , Li ST . Sympathetic innervation and function in reflex sympathetic dystrophy. Ann Neurol 48: 49‐59., 2000.
 116. Grippo AJ , Cushing BS , Carter CS . Depression‐like behavior and stressor‐induced neuroendocrine activation in female prairie voles exposed to chronic social isolation. Psychosom Med 69: 149‐157, 2007.
 117. Gyorke S . Molecular basis of catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 6: 123‐129, 2009.
 118. Hallback M , Jones JV , Bianchi G , Folkow B . Cardiovascular control in the Milan strain of spontaneously hypertensive rat (MHS) at “rest” and during acute mental “stress”. Acta Physiol Scand 99: 208‐216, 1977.
 119. Halliwill JR , Lawler LA , Eickhoff TJ , Dietz NM , Nauss LA , Joyner MJ . Forearm sympathetic withdrawal and vasodilatation during mental stress in humans. J Physiol 504 (Pt 1): 211‐220, 1997.
 120. Hassellund SS , Flaa A , Sandvik L , Kjeldsen SE , Rostrup M . Long‐term stability of cardiovascular and catecholamine responses to stress tests: An 18‐year follow‐up study. Hypertension 55: 131‐136, 2010.
 121. Hasser EM , Bishop VS , Hay M . Interactions between vasopressin and baroreflex control of the sympathetic nervous system. Clin Exp Pharmacol Physiol 24: 102‐108, 1997.
 122. Hausberg M , Mark AL , Winniford MD , Brown RE , Somers VK . Sympathetic and vascular effects of short‐term passive smoke exposure in healthy nonsmokers. Circulation 96: 282‐287, 1997.
 123. Hayashi M , Denjoy I , Extramiana F , Maltret A , Buisson NR , Lupoglazoff JM , Klug D , Takatsuki S , Villain E , Kamblock J , Messali A , Guicheney P , Lunardi J , Leenhardt A . Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia. Circulation 119: 2426‐2434, 2009.
 124. Heindl S , Vahlkamp K , Weitz G , Fehm HL , Dodt C . Differential effects of hydrocortisone on sympathetic and hemodynamic responses to sympathoexcitatory manoeuvres in men. Steroids 71: 206‐213, 2006.
 125. Heiner JD , Bullard‐Berent JH , Inbar S . Deadly proposal: A case of catecholaminergic polymorphic ventricular tachycardia. Pediatr Emerg Care 27: 1065‐1068, 2011.
 126. Hemingway H , Shipley M , Brunner E , Britton A , Malik M , Marmot M . Does autonomic function link social position to coronary risk? The Whitehall II study. Circulation 111: 3071‐3077, 2005.
 127. Hering D , Kara T , Kucharska W , Somers VK , Narkiewicz K . High‐normal blood pressure is associated with increased resting sympathetic activity but normal responses to stress tests. Blood Press 22: 183‐187, 2013.
 128. Hering D , Kucharska W , Kara T , Somers VK , Parati G , Narkiewicz K . Effects of acute and long‐term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension. J Hypertens 31: 739‐746, 2013.
 129. Hering D , Marusic P , Walton AS , Lambert EA , Krum H , Narkiewicz K , Lambert GW , Esler MD , Schlaich MP . Sustained sympathetic and blood pressure reduction 1 year after renal denervation in patients with resistant hypertension. Hypertension 64: 118‐124, 2014.
 130. Heusser K , Vitkovsky J , Raasch W , Schmieder RE , Schobel HP . Elevation of sympathetic activity by eprosartan in young male subjects. Am J Hypertens 16: 658‐664, 2003.
 131. Hines EA , Brown GE . A standard stimulus for measuring vasomotor reactions: Its application in the study of hypertension. Proc Staff Meet Mayo Clinic 7: 332‐335, 1932.
 132. Hines EA, Jr. , Brown GE . The cold pressor test for measuring the reactibility of the blood pressure: Data concerning 571 normal and hypertensive subjects. Am Heart J 11: 1‐9, 1936.
 133. Hjemdahl P , Fagius J , Freyschuss U , Wallin BG , Daleskog M , Bohlin G , Perski A . Muscle sympathetic nerve activity and norepinephrine release during mental challenge in humans. Am J Physiol 257: E654‐E664, 1989.
 134. Hofferberth SC , Cecchin F , Loberman D , Fynn‐Thompson F . Left thoracoscopic sympathectomy for cardiac denervation in patients with life‐threatening ventricular arrhythmias. J Thorac Cardiovasc Surg 147: 404‐409, 2014.
 135. Hornykiewicz O . Biochemical aspects of Parkinson's disease. Neurology 51: S2‐S9, 1998.
 136. Howe JR , Zieglgansberger W . Spinal peptidergic and catecholaminergic systems and nociception. Neurosurgery 15: 904‐912, 1984.
 137. Iwase S , Ikeda T , Kitazawa H , Hakusui S , Sugenoya J , Mano T . Altered response in cutaneous sympathetic outflow to mental and thermal stimuli in primary palmoplantar hyperhidrosis. J Auton Nerv Syst 64: 65‐73, 1997.
 138. Jacobs MC , Goldstein DS , Willemsen JJ , Smits P , Thien T , Dionne RA , Lenders JW . Neurohumoral antecedents of vasodepressor reactions. Eur J Clin Invest 25: 754‐761, 1995.
 139. Jarczok MN , Jarczok M , Mauss D , Koenig J , Li J , Herr RM , Thayer JF . Autonomic nervous system activity and workplace stressors–a systematic review. Neurosci Biobehav Rev 37: 1810‐1823, 2013.
 140. Jardine DL , Melton IC , Crozier IG , Bennett SI , Donald RA , Ikram H . Neurohormonal response to head‐up tilt and its role in vasovagal syncope. Am J Cardiol 79: 1302‐1306, 1997.
 141. Johnston DW , Tuomisto MT , Patching GR . The relationship between cardiac reactivity in the laboratory and in real life. Health Psychol 27: 34‐42, 2008.
 142. Jones PP , Spraul M , Matt KS , Seals DR , Skinner JS , Ravussin E . Gender does not influence sympathetic neural reactivity to stress in healthy humans. Am J Physiol 270: H350‐H357, 1996.
 143. Joyner MJ . Renal denervation: What next? Hypertension 64: 19‐20, 2014.
 144. Jumblatt JE , Hackmiller RC . M2‐type muscarinic receptors mediate prejunctional inhibition of norepinephrine release in the human iris‐ciliary body. Exp Eye Res 58: 175‐180, 1994.
 145. Kamarck TW , Lovallo WR . Cardiovascular reactivity to psychological challenge: Conceptual and measurement considerations. Psychosom Med 65: 9‐21, 2003.
 146. Kamarck TW , Schwartz JE , Janicki DL , Shiffman S , Raynor DA . Correspondence between laboratory and ambulatory measures of cardiovascular reactivity: A multilevel modeling approach. Psychophysiology 40: 675‐683, 2003.
 147. Kamiya A , Iwase S , Michikami D , Fu Q , Mano T . Head‐down bed rest alters sympathetic and cardiovascular responses to mental stress. Am J Physiol Regul Integr Comp Physiol 279: R440‐R447, 2000.
 148. Karlamangla AS , Singer BH , Seeman TE . Reduction in allostatic load in older adults is associated with lower all‐cause mortality risk: MacArthur studies of successful aging. Psychosom Med 68: 500‐507, 2006.
 149. Kato M , Phillips BG , Sigurdsson G , Narkiewicz K , Pesek CA , Somers VK . Effects of sleep deprivation on neural circulatory control. Hypertension 35: 1173‐1175, 2000.
 150. Kaufmann H . Neurally mediated syncope: Pathogenesis, diagnosis, and treatment. Neurology 45: S12‐S18, 1995.
 151. Kenney MJ , Claassen DE , Fels RJ , Saindon CS . Cold stress alters characteristics of sympathetic nerve discharge bursts. J Appl Physiol 87: 732‐742, 1999.
 152. Kikushima S , Kobayashi Y , Nakagawa H , Katagiri T . Triggering mechanism for neurally mediated syncope induced by head‐up tilt test: Role of catecholamines and response to propranolol. J Am Coll Cardiol 33: 350‐357, 1999.
 153. Kjeldsen SE , Flaaten B , Eide I , Helgeland A , Leren P . Evidence of increased peripheral catecholamine release in patients with long‐standing, untreated essential hypertension. Scand J Clin Lab Invest 42: 217‐223, 1982.
 154. Klein JC , Crandall CG , Brothers RM , Carter JR . Combined heat and mental stress alters neurovascular control in humans. J Appl Physiol 109: 1880‐1886, 2010.
 155. Klingenheben T , Kalusche D , Li YG , Schopperl M , Hohnloser SH . Changes in plasma epinephrine concentration and in heart rate during head‐up tilt testing in patients with neurocardiogenic syncope: Correlation with successful therapy with beta‐receptor antagonists. J Cardiovasc Electrophysiol 7: 802‐808, 1996.
 156. Koepke JP , DiBona GF . Central beta‐adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats. Hypertension 7: 350‐356, 1985a.
 157. Koepke JP , DiBona GF . High sodium intake enhances renal nerve and antinatriuretic responses to stress in spontaneously hypertensive rats. Hypertension 7: 357‐363, 1985b.
 158. Kopin IJ , Rundqvist B , Friberg P , Lenders J , Goldstein DS , Eisenhofer G . Different relationships of spillover to release of norepinephrine in human heart, kidneys, and forearm. Am J Physiol 275: R165‐R173, 1998.
 159. Kosten TR , Mason JW , Giller EL , Ostroff RB , Harkness L . Sustained urinary norepinephrine and epinephrine elevation in post‐traumatic stress disorder. Psychoneuroendocrinology 12: 13‐20, 1987.
 160. Krahenbuhl GS , Harris J , Malchow RD , Stern JR . Biogenic amine/metabolite response during in‐flight emergencies. Aviat Space Environ Med 56: 576‐580, 1985.
 161. Krum H , Schlaich M , Whitbourn R , Sobotka PA , Sadowski J , Bartus K , Kapelak B , Walton A , Sievert H , Thambar S , Abraham WT , Esler M . Catheter‐based renal sympathetic denervation for resistant hypertension: A multicentre safety and proof‐of‐principle cohort study. Lancet 373: 1275‐1281, 2009.
 162. Krystal JH , Neumeister A . Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Res 1293: 13‐23, 2009.
 163. Kuipers NT , Sauder CL , Carter JR , Ray CA . Neurovascular responses to mental stress in the supine and upright postures. J Appl Physiol 104: 1129‐1136, 2008.
 164. Kume T , Kawamoto T , Okura H , Toyota E , Neishi Y , Watanabe N , Hayashida A , Okahashi N , Yoshimura Y , Saito K , Nezuo S , Yamada R , Yoshida K . Local release of catecholamines from the hearts of patients with tako‐tsubo‐like left ventricular dysfunction. Circ J 72: 106‐108, 2008.
 165. Kuniyoshi FH , Trombetta IC , Batalha LT , Rondon MU , Laterza MC , Gowdak MM , Barretto AC , Halpern A , Villares SM , Lima EG , Negrao CE . Abnormal neurovascular control during sympathoexcitation in obesity. Obesity Res 11: 1411‐1419, 2003.
 166. Kvetnansky R . Stressor specificity and effect of prior experience on catecholamine biosynthetic enzyme phenylethanolamine N‐methyltransferase. Ann N Y Acad Sci 1032: 117‐129, 2004.
 167. Kvetnansky R , Rusnak M , Dronjak S , Krizanova O , Sabban EL . Effect of novel stressors on tyrosine hydroxylase gene expression in the adrenal medulla of repeatedly immobilized rats. Neurochem Res 28: 625‐630, 2003.
 168. Kvetnansky R , Sabban EL , Palkovits M . Catecholaminergic systems in stress: Structural and molecular genetic approaches. Physiol Rev 89: 535‐606, 2009.
 169. Kvetnansky R , Sun CL , Lake CR , Thoa N , Torda T , Kopin IJ . Effect of handling and forced immobilization on rat plasma levels of epinephrine, norepinephrine, and dopamine‐beta‐hydroxylase. Endocrinology 103: 1868‐1874, 1978.
 170. Lake CR , Ziegler MG , Coleman MD , Kopin IJ . Hydrochlorothiazide‐induced sympathetic hyperactivity in hypertensive patients. Clin Pharmacol Ther 26: 428‐432, 1979.
 171. Lake CR , Ziegler MG , Kopin IJ . Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man. Life Sci 18: 1315‐1325, 1976.
 172. Lambert E , Hotchkin E , Alvarenga M , Pier C , Richards J , Barton D , Dawood T , Esler M , Lambert G . Single‐unit analysis of sympathetic nervous discharges in patients with panic disorder. J Physiol 570: 637‐643, 2006.
 173. Lambert EA , Schlaich MP , Dawood T , Sari C , Chopra R , Barton DA , Kaye DM , Elam M , Esler MD , Lambert GW . Single‐unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover. J Physiol 589: 2597‐2605, 2011.
 174. Lampert R , Jain D , Burg MM , Batsford WP , McPherson CA . Destabilizing effects of mental stress on ventricular arrhythmias in patients with implantable cardioverter‐defibrillators. Circulation 101: 158‐164, 2000.
 175. Lewis T . A lecture on vasovagal syncope and the carotid sinus mechanism. Br Med J 1: 873‐876, 1932.
 176. Lightfoot JT , Rowe SA , Fortney SM . Occurrence of presyncope in subjects without ventricular innervation. Clin Sci 85: 695‐700, 1993.
 177. Lombardi F , Verrier RL , Lown B . Relationship between sympathetic neural activity, coronary dynamics and vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. Am Heart J 105: 958‐965, 1983.
 178. Louis WJ , Doyle AE , Anavekar S . Plasma norepinephrine levels in essential hypertension. N Engl J Med 288: 599‐601, 1973.
 179. Lown B , Verrier RL . Neural activity and ventricular fibrillation. N Engl J Med 294: 1165‐1170, 1976.
 180. Lyon AR , Rees PS , Prasad S , Poole‐Wilson PA , Harding SE . Stress (Takotsubo) cardiomyopathy–a novel pathophysiological hypothesis to explain catecholamine‐induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med 5: 22‐29, 2008.
 181. Mackenbach JP , Bos V , Andersen O , Cardano M , Costa G , Harding S , Reid A , Hemstrom O , Valkonen T , Kunst AE . Widening socioeconomic inequalities in mortality in six Western European countries. Int J Epidemiol 32: 830‐837, 2003.
 182. Man in't Veld AJ , Boomsma H , Moleman P , Schalekamp MADH . Congenital dopamine‐beta‐hydroxylase deficiency. Lancet 1: 183‐188, 1987.
 183. Marjamaa A , Hiippala A , Arrhenius B , Lahtinen AM , Kontula K , Toivonen L , Happonen JM , Swan H . Intravenous epinephrine infusion test in diagnosis of catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol 23: 194‐199, 2012.
 184. Marmot MG . Status syndrome: A challenge to medicine. JAMA 295: 1304‐1307, 2006.
 185. Marmot MG , Rose G , Shipley M , Hamilton PJ . Employment grade and coronary heart disease in British civil servants. J Epidemiol Community Health 32: 244‐249, 1978.
 186. Martinez JM , Garakani A , Kaufmann H , Aaronson CJ , Gorman JM . Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients. Psychosom Med 72: 442‐449, 2010.
 187. Mason JW . A re‐evaluation of the concept of ‘non‐specificity’ in stress theory. J Psychiatry Res 8: 323‐333, 1971.
 188. Mason JW . A historical view of the stress field. J Human Stress 1: 22‐36 concl, 1975.
 189. Mason JW , Brady JV , Tolson WW . Behavioral adaptations and endocrine activity. Psychoendocrine differentiation of emotional states. Res Publ Assoc Res Nerv Ment Dis 43: 227‐250, 1966.
 190. Mason JW , Mangan G, Jr. , Brady JV , Conrad D , Rioch DM . Concurrent plasma epinephrine, norepinephrine and 17‐hydroxycorticosteroid levels during conditioned emotional disturbances in monkeys. Psychosom Med 23: 344‐353, 1961.
 191. Mason JW , Tolson WW , Brady JV , Tolliver GA , Gilmore LI . Urinary epinephrine and norepinephrine responses to 72‐hr. avoidance sessions in the monkey. Psychosom Med 30(Suppl): 654‐665, 1968.
 192. Matsukawa T , Gotoh E , Uneda S , Miyajima E , Shionoiri H , Tochikubo O , Ishii M . Augmented sympathetic nerve activity in response to stressors in young borderline hypertensive men. Acta Physiol Scand 141: 157‐165, 1991.
 193. Matsukawa T , Sugiyama Y , Mano T . Increased muscle sympathetic nerve activity during delayed auditory feedback in humans. Jpn J Physiol 45: 905‐911, 1995.
 194. McDonough P , Duncan GJ , Williams D , House J . Income dynamics and adult mortality in the United States, 1972 through 1989. Am J Public Health 87: 1476‐1483, 1997.
 195. McEwen B , Stellar E . Stress and the individual. Mechanisms leading to disease. Arch Int Med 153: 2093‐2101, 1993.
 196. McNeal N , Scotti MA , Wardwell J , Chandler DL , Bates SL , Larocca M , Trahanas DM , Grippo AJ . Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles. Auton Neurosci 180: 9‐16, 2014.
 197. Meerlo P , Sgoifo A , De Boer SF , Koolhaas JM . Long‐lasting consequences of a social conflict in rats: Behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity. Behav Neurosci 113: 1283‐1290, 1999.
 198. Middlekauff HR , Hui K , Yu JL , Hamilton MA , Fonarow GC , Moriguchi J , Maclellan WR , Hage A . Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients. J Card Fail 8: 399‐406, 2002.
 199. Middlekauff HR , Nguyen AH , Negrao CE , Nitzsche EU , Hoh CK , Natterson BA , Hamilton MA , Fonarow GC , Hage A , Moriguchi JD . Impact of acute mental stress on sympathetic nerve activity and regional blood flow in advanced heart failure: Implications for ‘triggering’ adverse cardiac events. Circulation 96: 1835‐1842, 1997.
 200. Middlekauff HR , Yu JL , Hui K . Acupuncture effects on reflex responses to mental stress in humans. Am J Physiol Regul Integr Comp Physiol 280: R1462‐R1468, 2001.
 201. Moffitt JA , Grippo AJ , Holmes PV , Johnson AK . Olfactory bulbectomy attenuates cardiovascular sympathoexcitatory reflexes in rats. Am J Physiol Heart Circ Physiol 283: H2575‐H2583, 2002.
 202. Morgan‐Hughes NJ , Dark JH , McComb JM , Kenny RA . Vasovagal reactions after heart transplantation. J Am Coll Cardiol 22: 2059, 1993.
 203. Mosqueda‐Garcia R , Fernandez‐Violante R , Tank J , Snell M , Cunningham G , Furlan R . Yohimbine in neurally mediated syncope. Pathophysiological implications. J Clin Invest 102: 1824‐1830, 1998.
 204. Mosqueda‐Garcia R , Furlan R , Fernandez‐Violante R , Desai T , Snell M , Jarai Z , Ananthram V , Robertson RM , Robertson D . Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt. J Clin Invest 99: 2736‐2744, 1997.
 205. Mosqueda‐Garcia R , Furlan R , Tank J , Fernandez‐Violante R . The elusive pathophysiology of neurally mediated syncope. Circulation 102: 2898‐2906, 2000.
 206. Muller MD , Sauder CL , Ray CA . Mental stress elicits sustained and reproducible increases in skin sympathetic nerve activity. Physiol Rep 1: pii: e00002, 2013.
 207. Muscholl E . Peripheral muscarinic control of norepinephrine release in the cardiovascular system. Am J Physiol 239: H713‐H720, 1980.
 208. Ng AV , Callister R , Johnson DG , Seals DR . Sympathetic neural reactivity to stress does not increase with age in healthy humans. Am J Physiol 267: H344‐H353, 1994.
 209. Ngampramuan S , Baumert M , Beig MI , Kotchabhakdi N , Nalivaiko E . Activation of 5‐HT(1A) receptors attenuates tachycardia induced by restraint stress in rats. Am J Physiol Regul Integr Comp Physiol 294: R132‐R141, 2008.
 210. Noll G , Wenzel RR , de Marchi S , Shaw S , Luscher TF . Differential effects of captopril and nitrates on muscle sympathetic nerve activity in volunteers. Circulation 95: 2286‐2292, 1997.
 211. Noll G , Wenzel RR , Schneider M , Oesch V , Binggeli C , Shaw S , Weidmann P , Luscher TF . Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation 93: 866‐869, 1996.
 212. Oquendo MA , Echavarria G , Galfalvy HC , Grunebaum MF , Burke A , Barrera A , Cooper TB , Malone KM , John Mann J . Lower cortisol levels in depressed patients with comorbid post‐traumatic stress disorder. Neuropsychopharmacology 28: 591‐598, 2003.
 213. Ott C , Mahfoud F , Schmid A , Ditting T , Sobotka PA , Veelken R , Spies A , Ukena C , Laufs U , Uder M , Bohm M , Schmieder RE . Renal denervation in moderate treatment‐resistant hypertension. J Am Coll Cardiol 62: 1880‐1886, 2013.
 214. Overton JM . Phenotyping small animals as models for the human metabolic syndrome: Thermoneutrality matters. Int J Obes 34(Suppl 2): S53‐58, 2010.
 215. Pacak K , Palkovits M , Yadid G , Kvetnansky R , Kopin IJ , Goldstein DS . Heterogeneous neurochemical responses to different stressors: A test of Selye's doctrine of nonspecificity. Am J Physiol 275: R1247‐R1255, 1998.
 216. Parati G , Esler M . The human sympathetic nervous system: Its relevance in hypertension and heart failure. Eur Heart J 33: 1058‐1066, 2012.
 217. Patel JN , Coppack SW , Goldstein DS , Miles JM , Eisenhofer G . Norepinephrine spillover from human adipose tissue before and after a 72‐hour fast. J Clin Endocrinol Metab 87: 3373‐3377, 2002.
 218. Paur H , Wright PT , Sikkel MB , Tranter MH , Mansfield C , O'Gara P , Stuckey DJ , Nikolaev VO , Diakonov I , Pannell L , Gong H , Sun H , Peters NS , Petrou M , Zheng Z , Gorelik J , Lyon AR , Harding SE . High levels of circulating epinephrine trigger apical cardiodepression in a beta2‐adrenergic receptor/Gi‐dependent manner: A new model of Takotsubo cardiomyopathy. Circulation 126: 697‐706, 2012.
 219. Perry JC , Bergamaschi CT , Campos RR , Andersen ML , Montano N , Casarini DE , Tufik S . Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats. J Renin Angiotensin‐Aldosterone Syst 12: 146‐152, 2011.
 220. Pessoa PM , Xavier SS , Lima SL , Mansur J , de Almeida AS , Carvalho PA , Gutfilen B , da Fonseca BL . Assessment of takotsubo (ampulla) cardiomyopathy using iodine‐123 metaiodobenzylguanidine scintigraphy. Acta Radiol 47: 1029‐1035, 2006.
 221. Phillips BG , Kato M , Pesek CA , Winnicki M , Narkiewicz K , Davison D , Somers VK . Sympathetic activation by sildenafil. Circulation 102: 3068‐3073, 2000.
 222. Pickering TG , Gerin W . Cardiovascular reactivity in the laboratory and the role of behavioral factors in hypertension: A critical review. Ann Behav Med 12: 3‐16, 1990.
 223. Pietrzak RH , Gallezot JD , Ding YS , Henry S , Potenza MN , Southwick SM , Krystal JH , Carson RE , Neumeister A . Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. JAMA Psychiatry 70: 1199‐1205, 2013.
 224. Proudfit HK . Pharmacologic evidence for the modulation of nociception by noradrenergic neurons. Prog Brain Res 77: 357‐370, 1988.
 225. Randall DC , Brown DR , Brown LV , Kilgore JM . Sympathetic nervous activity and arterial blood pressure control in conscious rat during rest and behavioral stress. Am J Physiol 267: R1241‐R1249, 1994.
 226. Ray CA , Carter JR . Effects of aerobic exercise training on sympathetic and renal responses to mental stress in humans. Am J Physiol Heart Circ Physiol 298: H229‐H234, 2010.
 227. Rea RF , Eckberg DL , Fritsch JM , Goldstein DS . Relation of plasma norepinephrine and sympathetic traffic during hypotension in man. Am J Physiol 258: R982‐R986, 1990.
 228. Resendez SL , Aragona BJ . Aversive motivation and the maintenance of monogamous pair bonding. Rev Neurosci 24: 51‐60, 2013.
 229. Robertson DA , Johnson GA , Robertson RM , Nies AS , Shand DG , Oates JA . Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. Circulation 59: 637‐643, 1979.
 230. Roddie IC . The role of vasoconstrictor and vasodilator nerves to skin and muscle in the regulation of the human circulation. Ann R Coll Surg Engl 32: 180‐193, 1963.
 231. Roddie IC . Human responses to emotional stress. Ir J Med Sci 146: 395‐417, 1977.
 232. Sapolsky RM. Why Zebra don't get Ulcers: An Updated Guide to Stress, Stress‐related Disease, and Coping. New York: W.H. Freeman and Company, 1998, pp. 19‐37.
 233. Sapolsky RM . The influence of social hierarchy on primate health. Science 308: 648‐652, 2005.
 234. Scalco AZ , Rondon MU , Trombetta IC , Laterza MC , Azul JB , Pullenayegum EM , Scalco MZ , Kuniyoshi FH , Wajngarten M , Negrao CE , Lotufo‐Neto F . Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline. J Hypertens 27: 2429‐2436, 2009.
 235. Scherrer U , Vissing S , Morgan BJ , Hanson P , Victor RG . Vasovagal syncope after infusion of a vasodilator in a heart‐transplant recipient. N Engl J Med 322: 602‐604, 1990.
 236. Schlaich MP , Sobotka PA , Krum H , Lambert E , Esler MD . Renal sympathetic‐nerve ablation for uncontrolled hypertension. N Engl J Med 361: 932‐934, 2009.
 237. Schneider HE , Steinmetz M , Krause U , Kriebel T , Ruschewski W , Paul T . Left cardiac sympathetic denervation for the management of life‐threatening ventricular tachyarrhythmias in young patients with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome. Clin Res Cardiol 102: 33‐42, 2013.
 238. Schroeder C , Tank J , Heusser K , Diedrich A , Luft FC , Jordan J . Physiological phenomenology of neurally‐mediated syncope with management implications. PloS One 6: e26489, 2011.
 239. Schroeder KE , Narkiewicz K , Kato M , Pesek C , Phillips B , Davison D , Somers VK . Personality type and neural circulatory control. Hypertension 36: 830‐833, 2000.
 240. Schultz W . Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 57: 87‐115, 2006.
 241. Schultz W . Behavioral dopamine signals. Trends Neurosci 30: 203‐210, 2007.
 242. Schwartz AR , Gerin W , Davidson KW , Pickering TG , Brosschot JF , Thayer JF , Christenfeld N , Linden W . Toward a causal model of cardiovascular responses to stress and the development of cardiovascular disease. Psychosom Med 65: 22‐35, 2003.
 243. Schwartz CE , Durocher JJ , Carter JR . Neurovascular responses to mental stress in prehypertensive humans. J Appl Physiol 110: 76‐82, 2011.
 244. Selye H . A syndrome produced by diverse nocuous agents. Nature 138: 32, 1936.
 245. Selye H. Stress without Distress. New York: New American Library, 1974.
 246. Selye H . Confusion and controversy in the stress field. J Human Stress 1: 37‐44, 1975.
 247. Sgoifo A , Carnevali L , Grippo AJ . The socially stressed heart. Insights from studies in rodents. Neurosci Biobehav Rev 39C: 51‐60, 2014.
 248. Sgoifo A , Koolhaas J , De Boer S , Musso E , Stilli D , Buwalda B , Meerlo P . Social stress, autonomic neural activation, and cardiac activity in rats. Neurosci Biobehav Rev 23: 915‐923, 1999.
 249. Sgoifo A , Koolhaas JM , Musso E , De Boer SF . Different sympathovagal modulation of heart rate during social and nonsocial stress episodes in wild‐type rats. Physiol behav 67: 733‐738, 1999.
 250. Shalev AY , Videlock EJ , Peleg T , Segman R , Pitman RK , Yehuda R . Stress hormones and post‐traumatic stress disorder in civilian trauma victims: A longitudinal study. Part I: HPA axis responses. Int J Neuropsychopharmacol 11: 365‐372, 2008.
 251. Sharabi Y , Goldstein DS , Bentho O , Saleem A , Pechnik S , Geraci MF , Holmes C , Pacak K , Eisenhofer G . Sympathoadrenal function in patients with paroxysmal hypertension: Pseudopheochromocytoma. J Hypertens 25: 2286‐2295, 2007.
 252. Southwick SM , Bremner JD , Rasmusson A , Morgan CA, 3rd , Arnsten A , Charney DS . Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry 46: 1192‐1204, 1999.
 253. Southwick SM , Paige S , Morgan CA, III , Bremner JD , Krystal JH , Charney DS . Neurotransmitter alterations in PTSD: Catecholamines and serotonin. Semin Clin Neuropsychiatry 4: 242‐248., 1999.
 254. Spielberger CD. Manual for the State‐trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press, 1983.
 255. Sterling P , Eyer J . Allostasis: A new paradigm to explain arousal pathology. In: Fisher J , Reason J , editors. Handbook of Life Stress, Cognition, and Health. New York: Johns Wiley & Sons Inc., 1988, pp. 629‐649.
 256. Stowe JR , Liu Y , Curtis JT , Freeman ME , Wang Z . Species differences in anxiety‐related responses in male prairie and meadow voles: The effects of social isolation. Physiol behav 86: 369‐378, 2005.
 257. Sverrisdottir YB , Schultz T , Omerovic E , Elam M . Sympathetic nerve activity in stress‐induced cardiomyopathy. Clin Auton Res 22: 259‐264, 2012.
 258. Swain A , Suls J . Reproducibility of blood pressure and heart rate reactivity: A meta‐analysis. Psychophysiology 33: 162‐174, 1996.
 259. Tagawa M , Nakamura Y , Ishiguro M , Satoh K , Chinushi M , Kodama M , Aizawa Y . Transient left ventricular apical ballooning developing after the Central Niigata Prefecture Earthquake: Two case reports. J Cardiol 48: 153‐158, 2006.
 260. Takahashi LK , Chan MM , Pilar ML . Predator odor fear conditioning: Current perspectives and new directions. Neurosci Biobehav Rev 32: 1218‐1227, 2008.
 261. Takase B , Kastushika S , Hamabe A , Uehata A , Isojima K , Satomura K , Nishioka T , Ohsuzu F , Kurita A . Significance of circulatory epinephrine levels in exercise‐induced neurally mediated syncope. Clin Cardiol 24: 15‐20, 2001.
 262. Takase B , Uehata A , Nishioka T , Isojima K , Satomura K , Ohsuzu F , Kurita A . Different mechanisms of isoproterenol‐induced and nitroglycerin‐induced syncope during head‐up tilt in patients with unexplained syncope: Important role of epinephrine in nitroglycerin‐induced syncope. J Cardiovasc Electrophysiol 12: 791‐796, 2001.
 263. Tatar P , Bulas J , Kvetnansky R , Strec V . Venous plasma adrenaline response to orthostatic syncope during tilting in healthy men. Clin Physiol 6: 303‐309, 1986.
 264. Taylor BK , Roderick RE , Basbaum AI . Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat. Neurosci Lett 291: 139‐142., 2000.
 265. Tonacio AC , Trombetta IC , Rondon MU , Batalha LT , Kuniyoshi FH , Laterza MC , Suzuki PH , Gowdak MM , Barretto AC , Halpern A , Villares SM , Negrao CE . Effects of diet and exercise training on neurovascular control during mental stress in obese women. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas /Sociedade Brasileira de Biofisica [et al] 39: 53‐62, 2006.
 266. Trombetta IC , Batalha LT , Rondon MU , Laterza MC , Frazzatto E , Alves MJ , Santos AC , Brum PC , Barretto AC , Halpern A , Villares SM , Negrao CE . Gly16 + Glu27 beta2‐adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans. J Appl Physiol 98: 787‐794, 2005.
 267. Trueb L , Lepori M , Duplain H , Scherrer U , Sartori C . Nitric oxide mediates the blood pressure response to mental stress in humans. Swiss Med Wkly 142: w13627, 2012.
 268. Vaccaro A , Despas F , Delmas C , Lairez O , Lambert E , Lambert G , Labrunee M , Guiraud T , Esler M , Galinier M , Senard JM , Pathak A . Direct evidences for sympathetic hyperactivity and baroreflex impairment in Tako Tsubo cardiopathy. PLoS ONE 9: e93278.
 269. Vaddadi G , Esler MD , Dawood T , Lambert E . Persistence of muscle sympathetic nerve activity during vasovagal syncope. Eur Heart J 31: 2027‐2033, 2010.
 270. Vaddadi G , Guo L , Esler M , Socratous F , Schlaich M , Chopra R , Eikelis N , Lambert G , Trauer T , Lambert E . Recurrent postural vasovagal syncope: Sympathetic nervous system phenotypes. Circ Arrhythm Electrophysiol 4: 711‐718, 2011.
 271. Vallbo AB , Hagbarth KE , Wallin BG . Microneurography: How the technique developed and its role in the investigation of the sympathetic nervous system. J Appl Physiol 96: 1262‐1269, 2004.
 272. Verrier RL , Hagestad EL , Lown B . Delayed myocardial ischemia induced by anger. Circulation 75: 249‐254, 1987.
 273. Verschure DO , Somsen GA , van Eck‐Smit BL , Knol RJ , Booij J , Verberne HJ . Tako‐tsubo cardiomyopathy: How to understand possible pathophysiological mechanism and the role of I‐MIBG imaging. J Nucl Cardiol 21: 730‐738, 2014.
 274. Videlock EJ , Peleg T , Segman R , Yehuda R , Pitman RK , Shalev AY . Stress hormones and post‐traumatic stress disorder in civilian trauma victims: A longitudinal study. Part II: The adrenergic response. Int J Neuropsychopharmacol 11: 373‐380, 2008.
 275. Volkow ND , Wang GJ , Fowler JS , Tomasi D . Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol 52: 321‐336, 2012.
 276. von Euler US . A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and nor‐adrenaline. Acta Physiol Scand 12: 73‐96, 1946.
 277. von Euler US . The development and applications of the trihydroxyindole method for catechols. Pharmacol Rev 11: 262‐268, 1959.
 278. von Euler US , Hamberg U . Colorimetric determination of noradrenaline and adrenaline. Acta Physiol Scand 19: 74‐84, 1949.
 279. Wallin BG , Delius W , Hagbarth KE . Comparison of sympathetic nerve activity in normotensive and hypertensive subjects. Circ Res 33: 9‐21, 1973.
 280. Wallin BG , Esler M , Dorward P , Eisenhofer G , Ferrier C , Westerman R , Jennings G . Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans. J Physiol 453: 45‐58, 1992.
 281. Wallin BG , Sundlof G . Sympathetic outflow to muscles during vasovagal syncope. J Autonom Nerv Sys 6: 287‐291, 1982.
 282. Wallin BG , Thompson JM , Jennings GL , Esler MD . Renal noradrenaline spillover correlates with muscle sympathetic activity in humans. J Physiol 491(Pt 3): 881‐887, 1996.
 283. Wasmund WL , Westerholm EC , Watenpaugh DE , Wasmund SL , Smith ML . Interactive effects of mental and physical stress on cardiovascular control. J Appl Physiol 92: 1828‐1834, 2002.
 284. Watson D , Clark LA , Tellegen A . Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol 54: 1063‐1070, 1988.
 285. Weil‐Malherbe H . The fluorimetric estimation of adrenaline, noradrenaline and hydroxytyramine in urine. Biochem J 63: 4P, 1956.
 286. Weil‐Malherbe H . The fluorimetric estimation of catechol compounds by the ethylenediamine condensation method. Pharmacol Rev 11: 277‐288, 1959.
 287. Weil‐Malherbe H , Bone AD . The estimation of catecholamines in urine by a chemical method. J Clin Pathol 10: 138‐147, 1957a.
 288. Weil‐Malherbe H , Bone AD . The fluorimetric estimation of adrenaline and noradrenaline in plasma. Biochem J 67: 65‐72, 1957b.
 289. Wilbert‐Lampen U , Leistner D , Greven S , Pohl T , Sper S , Volker C , Guthlin D , Plasse A , Knez A , Kuchenhoff H , Steinbeck G . Cardiovascular events during World Cup soccer. N Engl J Med 358: 475‐483, 2008.
 290. Wilde AA , Bhuiyan ZA , Crotti L , Facchini M , De Ferrari GM , Paul T , Ferrandi C , Koolbergen DR , Odero A , Schwartz PJ . Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia. N Engl J Med 358: 2024‐2029, 2008.
 291. Wilkinson DJ , Thompson JM , Lambert GW , Jennings GL , Schwarz RG , Jefferys D , Turner AG , Esler MD . Sympathetic activity in patients with panic disorder at rest, under laboratory mental stress, and during panic attacks. Arch Gen Psychiatry 55: 511‐520, 1998.
 292. Wittstein IS , Thiemann DR , Lima JA , Baughman KL , Schulman SP , Gerstenblith G , Wu KC , Rade JJ , Bivalacqua TJ , Champion HC . Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352: 539‐548, 2005.
 293. Wolfovitz E , Grossman E , Folio CJ , Keiser HR , Kopin IJ , Goldstein DS . Derivation of urinary dopamine from plasma dihydroxyphenylalanine in humans. Clin Sci 84: 549‐557, 1993.
 294. Wood DL , Sheps SG , Elveback LR , Schirger A . Cold pressor test as a predictor of hypertension. Hypertension 6: 301‐306, 1984.
 295. Yamamoto K , Sobue G , Iwase S , Nagamatsu M , Mano T , Mitsuma T . Skin sympathetic nerve activity in Guillain‐Barre syndrome: A microneurographic study. J Neurol Neurosurg Psychiatry 63: 537‐541, 1997.
 296. Yang H , Drummer TD , Carter JR . Sex differences in sympathetic neural and limb vascular reactivity to mental stress in humans. Am J Physiol Heart Circ Physiol 304: H436‐H443, 2013.
 297. Ylanen K , Poutanen T , Hiippala A , Swan H , Korppi M . Catecholaminergic polymorphic ventricular tachycardia. Eur J Pediatr 169: 535‐542, 2010.
 298. Zanstra YJ , Johnston DW . Cardiovascular reactivity in real life settings: Measurement, mechanisms and meaning. Biol Psychol 86: 98‐105, 2011.

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Jason R. Carter, David S. Goldstein. Sympathoneural and Adrenomedullary Responses to Mental Stress. Compr Physiol 2014, 5: 119-146. doi: 10.1002/cphy.c140030