Comprehensive Physiology Wiley Online Library

Bronchial Hyperresponsiveness

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Bronchial Smooth Muscle Tension
1.1 Regulation of Airways in Normal Subjects
1.2 Regulation of Airways in Subjects With Bronchial Hyperresponsiveness
1.3 Methods for Measuring Bronchial Smooth Muscle Responses
1.4 Bronckoconstricting Agents
1.5 Bronchodilating Agents
2 Bronchial Responsiveness
3 Bronchial Hyperresponsiveness
3.1 Early Studies
3.2 Dose‐Response Curves
4 Bronchial Hyperresponsiveness in Disease
4.1 Atopic Asthma
4.2 Nonatopic Asthma
4.3 Chronic Obstructive Lung Disease
4.4 Rhinitis
4.5 Upper Respiratory Infections
4.6 Occupational Asthma
4.7 Other Diseases
5 Relationship Between Increased Bronchial Hyperresponsiveness and Atopy
6 Summary
Figure 1. Figure 1.

Dose‐response curves for both histamine and methacholine from data measuring forced expiratory volume in 1 s (FEV1) (top) and specific airway conductance (sGaw) (bottom). Solid lines, individual asthmatics; dashed lines, normal subjects; asterisks, mean data for a number of subjects. URTI, upper respiratory tract infection.

Data from Cockcroft et al. 17, Woenne et al. 106, Townley et al. 101, Fish et al. 33, Parker et al. 73, Miller et al. 60, Orehek et al. 71, and A. Woolcock (unpublished data)
Figure 2. Figure 2.

Dose‐response curves from 7 asthmatics, 3 of whom had past asthma, and 7 normal subjects. Challenge continued until FEV1 fell 40% or plateau formed.

From A. Woolcock, unpublished data
Figure 3. Figure 3.

Dose‐response curves of white 27‐yr‐old woman with pollen rhinitis.

From Townley et al. 100


Figure 1.

Dose‐response curves for both histamine and methacholine from data measuring forced expiratory volume in 1 s (FEV1) (top) and specific airway conductance (sGaw) (bottom). Solid lines, individual asthmatics; dashed lines, normal subjects; asterisks, mean data for a number of subjects. URTI, upper respiratory tract infection.

Data from Cockcroft et al. 17, Woenne et al. 106, Townley et al. 101, Fish et al. 33, Parker et al. 73, Miller et al. 60, Orehek et al. 71, and A. Woolcock (unpublished data)


Figure 2.

Dose‐response curves from 7 asthmatics, 3 of whom had past asthma, and 7 normal subjects. Challenge continued until FEV1 fell 40% or plateau formed.

From A. Woolcock, unpublished data


Figure 3.

Dose‐response curves of white 27‐yr‐old woman with pollen rhinitis.

From Townley et al. 100
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Ann J. Woolcock, Solbert Permutt. Bronchial Hyperresponsiveness. Compr Physiol 2011, Supplement 12: Handbook of Physiology, The Respiratory System, Mechanics of Breathing: 727-736. First published in print 1986. doi: 10.1002/cphy.cp030342