Comprehensive Physiology Wiley Online Library

Adaptation to the Microbial Environment

Full Article on Wiley Online Library


The sections in this article are:

1 Relationships Between Microbes and Vertebrates
1.1 Commensal and Mutual Interactions: The Normal Flora
1.2 Parasitic Interactions
2 Antimicrobial Host Defense
2.1 Innate or Nonspecific Immunity
2.2 Acquired or Specific Immunity
2.3 Other Factors in Host Defense
3 Summary
 1. Abernethy, T. J., and O. T. Avery. The occurrence during acute injection of a protein not normally present in blood. I. Distribution of the reactive protein in patients' sera and the effect of calcium in the flocculation reaction with the C polysaccharide of pneumococcus. J. Exp. Med. 73: 173–182, 1941.
 2. Adam, A., and E. Lederer. Muramyl peptides: immunomodulators, sleep factors, and vitamins. Med. Res. Rev. 4: 111–152, 1984.
 3. Akin, D. E., and W. S. Borneman. Role of rumen fungi in fiber degradation. J. Dairy Sci. 73: 3023–3032, 1990.
 4. Albelda, S. M., and C. A. Buck. Integrins and other cell adhesion molecules. FASEB J. 4: 2868–2880, 1990.
 5. Allison, M. J. Microbiology of the rumen and small and large intestines. In: Dukes' Physiology of Domestic Animals (10th ed.), edited by M. J. Swenson. Ithaca, NY: Cornell University Press, 1984, p. 340–349.
 6. Allison, M. J., S. E. Maloy, and R. R. Matson. Inactivation of Clostridium botulinum toxin by ruminal microbes from cattle and 2sheep. Appl. Environ. Microbiol. 32: 685–688, 1976.
 7. Anderson, P., M. L. Blue, C. Moromoto, and S. F. Schlossman. Cross‐linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T‐lymphocytes. J. Immunol. 139: 678–682, 1987.
 8. Anderson, R. M., and R. M. May. Population biology of infectious diseases: part I. Nature 280: 361–367, 1979.
 9. Anderson, R. M., and R. M. May. Coevolution of hosts and parasites. Parasitology 85: 411–426, 1982.
 10. Andersson, L., S. Paabo, and L. Rask. Is allograft rejection a clue to the mechanism promoting MHC polymorphism? Immunol. Today 8: 206–209, 1987.
 11. Arden, B., and J. Klein. Biochemical comparison of major histocompatibility complex molecules from different subspecies of Mus musculus: evidence for trans‐specific evolution of alleles. Proc. Natl. Acad. Sci. USA 79: 2342–2346, 1982.
 12. Atkins, E. Evolving notions on the cause and purpose of fever. In: Neuro‐Immunology of Fever, edited by T. Bartfai and D. Ottoson. Oxford: Pergamon, 1992, p.1–10.
 13. Bagley, G. J., C. H. Lang, D. M. Hargrove, J. J. Thompson, C. A. Wilson, and J. J. Spitzer. Glucose kinetics in rats infused with endotoxin‐induced monokines or tumor necrosis factor. Circ. Shock 24: 111–121, 1988.
 14. Bagley, G. J., C. H. Lang, N. Skrepnik, and J. J. Spitzer. Attenuation of glucose metabolic changes resulting from TNF‐α administration by adrenergic blockade, Am. J. Physiol. 262 (Regulatory Integrative Comp. Physiol. 33): R628–R635, 1992.
 15. Balish, E., C. E. Yale, and R. Hong. Serum proteins of gnotobiotic rats. Infect. Immun. 6: 112–118, 1972.
 16. Banet, M. Fever in mammals; is it beneficial? Yale J. Biol. Med. 59: 117–124, 1986.
 17. Baracos, V. E., W. T. Whitmore, and R. Gale. The metabolic cost of fever, Can. J. Physiol. Pharmacol. 65:1248‐1254, 1987.
 18. Bateman, A., A. Singh, T. Kral, and S. Solomon. The immune‐hypothalamic‐pituitary‐adrenal axis. Endocr. Rev. 10: 92–112, 1982.
 19. Bauer, J., C. Lengyel, T. M. Bauer, G. Acs, and W. Gerok. Regulation of interleukin‐6 receptor expression in human monocytes and hepatocytes. FEBS Lett. 249: 27–30, 1989.
 20. Baumann, H., and J. Gauldie. Regulation of hepatic acute phase plasma protein genes by hepatocyte‐stimulating factors and other mediators of inflammation. Mol. Biol. Med. 7: 147–160, 1990.
 21. Baumann, H., K. R. Prowse, S. Marinkovic, K.‐A. Won, and G. P. Jahreis. Stimulation of hepatic acute phase response by cytokines and glucocorticoids. Ann. N. Y. Acad. Sci. 557: 280–296, 1989.
 22. Baumann, H., C. Richards, and J. Gauldie. Interaction among hepatocyte‐stimulating factors, interleukin‐1, and glucocorticoids for regulation of acute‐phase plasma proteins in human hepatoma (Hep G2) cells. J. Immunol. 139: 4122–4128, 1987.
 23. Beasley, D., C. A. Dinarello, and J. G. Cannon. Interleukin‐1 induces natriuresis in conscious rats: role of renal prostaglandins. Kidney Int. 33: 1059–1065, 1988.
 24. Beekhuizen, H., and R. van Furth. Monocyte adherence to human vascular endothelium. J. Leukoc. Biol. 54: 363–378, 1993.
 25. Beisel, W. R. Impact of infection on nutritional status: concluding comments and summary. Am. J. Clin. Nutr. 30: 1564–1566, 1977.
 26. Beisel, W. R. Metabolic effects of infection. Prog. Food Nutr. Sci. 8: 43–75, 1984.
 27. Beisel, W. R., and M. I. Rapoport. Inter‐relations between adrenocortical functions and infectious illness. N. Engl. J. Med. 280: 541–546, 1969.
 28. Beisel, W. R., W. D. Sawyer, E. D. Ryll, and D. Crozier. Metabolic effects of intracellular infections in man. Ann. Intern. Med. 67: 744–779, 1969.
 29. Benacerraf, B. Role of MHC gene products in immune regulation. Science 212: 1229–1238, 1981.
 30. Berg, E. L. Homing receptors and vascular addressins: cell adhesion molecules that direct lymphocyte traffic. Immunol. Rev. 108: 5–18, 1989.
 31. Berg, R. D., and A. W. Garlington. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect. Immun. 23: 403–411, 1979.
 32. Berg, R. D., and W. E. Owens. Inhibition of translocation of viable Escherichia coli from gastrointestinal tract of mice by bacterial antagonism. Infect. Immun. 25: 820–827, 1979.
 33. Berkenbosch, F., D. E. C. de Goeij, A. del Rey, and H. Besedovsky. Neuroendocrine, sympathetic and metabolic responses induced by interleukin‐1. Neuroendocrinology 50: 570–576, 1989.
 34. Berkenbosch, F., R. De Rijk, K. Schotanus, D. Wolvers, and A.‐ M. van Dam. The immune‐hypothalamo‐pituitary‐adrenal axis: its role in immunoregulation and tolerance to self‐antigens. In: Interleukin‐1 in the Brain, edited by N. J. Rothwell and R. D. Dantzer. Oxford: Pergamon, 1992, p. 75–91.
 35. Besedovsky, H. O., and A. del Rey. Interleukin‐1 and glucose homeostasis: an example of the biological relevance of immuno‐neuroendocrine interactions. Horm. Res. 31: 94–99, 1989.
 36. Besedovsky, H. O., and A. del Rey. Metabolic and endocrine actions of interleukin‐1. Effects on insulin‐resistant animals. Ann. N. Y. Acad. Sci. 594: 214–221, 1990.
 37. Besedovsky, H. O., and A. del Rey. Immune‐neuroendocrine circuits: integrative role of cytokines. In: Frontiers in Neuroendocrinology. New York: Raven, 1992, vol. 13, p. 61–94.
 38. Bevilacqua, M. P., J. S. Pober, M. E. Wheeler, R. S. Cotran, and M. A. Gimbrone. Interleukin‐1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J. Clin. Invest. 26: 2003–2011, 1985.
 39. Binder, H. J., B. Filburn, and M. Floch. Bile acid inhibition of intestinal anaerobic organisms. Am. J. Clin. Nutr. 28: 119–125, 1975.
 40. Biozzi, G., D. Mouton, C. Stiffel, and Y. Bouthillier. A major role of the macrophage in quantitative genetic regulation of immunoresponsiveness and antiinfectious immunity. Adv. Immunol. 36: 189–234, 1984.
 41. Bistrian, B. R., J. Schwartz, and N. W. Istfan. Cytokines, muscle proteolysis, and the catabolic response to infection and inflammation. Proc. Soc. Exp. Biol. Med. 200: 220–223, 1992.
 42. Blalock, J. E. (Ed). Neuroimmunoendocrinology (2nd rev. ed.), Chemical Immunol., Basel: Karger, 1992, vol. 52.
 43. Blatteis, C. M. Influence of body weight and temperature on the pyrogenic effect of endotoxin in guinea pigs. Toxicol. Appl. Pharmacol. 29: 249–258, 1974.
 44. Blatteis, C. M. Fever: is it beneficial? Yale J. Biol. Med. 59: 107–116, 1986.
 45. Blatteis, C. M. Thermal homeostasis during the neonatal period. Prog. Biometeor. 7: 37–42, 1989.
 46. Blatteis, C. M. Cytokines as endogenous pyrogens. In: Cellular and Molecular Aspects of Endotoxin Reactions, edited by A. Nowotny, J. J. Spitzer, and E. J. Ziegler. Amsterdam: Elsevier, 1990, p. 447–454.
 47. Blatteis, C. M. Neuromodulative actions of cytokines. Yale J. Biol. Med. 63: 133–146, 1990.
 48. Blatteis, C. M. Role of the OVLT in the febrile response to circulating pyrogens. Prog. Brain Res. 91: 409–412, 1992.
 49. Blatteis, C. M. The pyrogenic action of cytokines. In: Interleukin‐1 in the Brain, edited by N. J. Rothwell and R. D. Dantzer. Oxford: Pergamon, 1992, p. 93–114.
 50. Blatteis, C. M., W. S. Hunter, J. Llanos‐Q, R. A. Ahokas, and T. A. Mashburn, Jr. Activation of acute‐phase responses by intrapreoptic injections of endogenous pyrogen in guinea pigs. Brain Res. Bull. 12: 689–695, 1984.
 51. Blatteis, C. M., N. Quan, L. Xin, and A. Ungar. Neuromodulation of acute‐phase responses to interleukin‐6 in guinea pigs. Brain Res. Bull. 25: 895–901, 1990.
 52. Blatteis, C. M., and A. A. Romanovsky. Endogenous opioids and fever. In: Pharmacology of Thermoregulation, edited by E. Zeisberger, P. Lomax, and E. Schönbaum. Basel: Birkhäuser, 1994, p. 435–441.
 53. Blatteis, C. M., and K. A. Smith. Hypothalamic sensitivity to leukocytic pyrogen of adult and newborn guinea‐pigs. J. Physiol. (Lond.) 296: 177–192, 1979.
 54. Blatteis, C. M., A. Ungar, and R. D. Howell. Thermal effects of interleukin‐1 (IL1) and various prostaglandins (PG) microinjected into different brain regions, FASEB J. 2: A1531, 1988.
 55. Blatteis, C. M., L. Xin, and N. Quan. Attenuation of fever by distress, FASEB J. 5: A1402, 1991.
 56. Blatteis, C. M., L. Xin, and N. Quan. Neuromodulation of fever: apparent involvement of opioids. Brain Res. Bull. 26: 219–223, 1991.
 57. Blatteis, C. M., L. Xin, and N. Quan. Neuromodulation of fever: a possible role for substance P. Ann. N. Y. Acad. Sci. 741: 162–173, 1994.
 58. Bornstein, D. L. Leukocytic pyrogen: a major mediator of the acute‐phase reaction. Ann. N. Y. Acad. Sci. 389: 323–337, 1982.
 59. Borriello, S. P. The influence of the normal flora on Clostridium difficile colonisation of the gut. Ann. Med. 22: 61–67, 1990.
 60. Boulant, J. A. Hypothalamic neurons regulating body temperature. In: Handbook of Physiology. Environmental Physiology, edited by M. J. Fregly. New York: Oxford University Press, 1995, sect. 11, chapt. 6 (this volume).
 61. Boulant, J. A., and N. L. Silva. Interactions of reproductive steroids, osmotic pressure and glucose on thermosensitive neurons in preoptic tissue slices. Can. J. Physiol. Pharmacol. 65: 1267–1273, 1987.
 62. Bremermann, H. J. Sex and polymorphism as strategies in host‐pathogen interactions. J. Theor. Biol. 87: 671–702, 1980.
 63. Brown, M. G., J. Driscoll, and J. J. Monaco. Structural and serological similarity of MHC‐linked LMP and proteasome (multi‐catalytic proteinase) complexes. Nature 353: 355–357, 1991.
 64. Brown, M. R. W., and P. Williams. The influence of environment on envelope properties affecting survival of bacteria in infections. Annu. Rev. Microbiol. 39: 527–556, 1985.
 65. Brubaker, R. R. Mechanisms of bacterial virulence. Annu. Rev. Microbiol. 39: 21–50, 1985.
 66. Bryson, Y. J., H. S. Winter, S. E. Gard, T. J. Fischer, and E. R. Stiehm. Deficiency of immune interferon production by leukocytes of normal newborns. Cell. Immunol. 55: 191–200, 1980.
 67. Busbridge, N. J., M. J. Dascombe, F. J. H. Tilders, J. W. A. M. van Oers, E. A. Linton, and N. J. Rothwell. Central activation of thermogenesis and fever by interleukin‐1β and interleukin‐1α involves different mechanisms. Biochem. Biophys. Res. Commun. 62: 591–593, 1989.
 68. Cannon, J. G., J. B. Tatro, S. Reichlin, and C. A. Dinarello. α‐Melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin‐1 J. Immunol. 137: 2232–2236, 1986.
 69. Cannon, J. G., R. G. Tompkins, J. A. Gelfand, M. R. Michie, G. G. Stanford, J. W. M. van der Meer, S. Endres, G. Lonnemann, J. Corsetti, B. Chernow, D. W. Wilmore, S. M. Wolff, J. F. Burke, and C. A. Dinarello. Circulating interleukin‐1 and tumor necrosis factors in humans during sepsis and endotoxin fever. J. Infect. Dis. 161: 79–84, 1990.
 70. Carp, H. Mitochondrial N‐formylmethionyl proteins as chemoattractants for neutrophils. J. Exp. Med. 155: 264–275, 1982.
 71. Carter, R. H., and D. T. Fearon. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256: 105–107, 1992.
 72. Chan, R. C. Y., A. W. Bruce, and G. Reid. Adherence of cervical, vaginal and distal urethral normal microbial flora to human uroepithelial cells and the inhibition of adherence of gram‐negative uropathogens by competitive exclusion. J. Urol. 131: 596–601, 1984.
 73. Chan, R. C. Y., G. Reid, R. T. Irvin, A. W. Bruce, and J. W. Costerton. Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Infect. Immun. 47: 84–89, 1985.
 74. Chandra, R. K. Nutrition, immunity, and infection: present knowledge and future directions. Lancet i: 688–691, 1983.
 75. Chang, S. L., T. Ren, and J. E. Zadina. Interleukin‐1 activation of FOS proto‐oncogene protein in the rat hypothalamus. Brain Res. 617: 123–130, 1993.
 76. Chedid, L., M. Parant, F. Parant, P. Lefrancier, J. Choay, and E. Lederer. Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N‐acetylmuramyl‐L‐alanyl‐D‐isoglutamine) and several analogs. Proc. Natl. Acad. Sci. USA 74: 2089–2093, 1977.
 77. Chensue, S. W., P. D. Terebuh, D. G. Remick, W. E. Scales, and S. L. Kunkel. In vivo biologic and immunohistochemical analysis of interleukin‐1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Am. J. Pathol. 138: 395–402, 1991.
 78. Chestnut, R. W., and H. M. Grey. Studies of the capacity of B‐cells to serve as antigen‐presenting cells. J. Immunol. 126: 1075–1079, 1981.
 79. Chisari, F. V., L. K. Curtiss, and F. C. Jensen. Physiologic concentrations of normal human plasma lipoproteins inhibit the immortalization of peripheral B‐lymphocytes by the Epstein Barr virus. J. Clin. Invest. 68: 329–336, 1981.
 80. Chowers, I., H. T. Hammel, J. Eisenman, R. M. Abrams, and S. M. McCann. A comparison of the effects of environmental and preoptic heating and pyrogen on plasma cortisol levels. Am. J. Physiol. 210: 606–610, 1966.
 81. Claesson, H. E., and J. Haeggstrom. Metabolism of leukotriene A4 by human endothelial cells: evidence for leukotriene C4 and D4 formation by leukocyte‐endothelial cell interaction. In: Advances in Prostaglandins, Thromboxane and Leukotriene Research, edited by B. Samuelsson, R. Paoletti, and P. W. Ramwell. New York: Raven, 1989, vol. 17, p. 115–123.
 82. Clark, S. C. Interleukin‐6. Multiple activities in regulation of the hematopoietic and immune systems. Ann. N. Y. Acad. Sci. 557: 438–443, 1989.
 83. Clark, W., H. Ostergaard, K. Gorman, and B. Torbett. Molecular mechanisms of CTL‐mediated lysis: a cellular perspective. Immunol. Rev. 103: 37–51, 1988.
 84. Coates, M. E. Gnotobiotic animals in nutrition research. Proc. Nutr. Soc. 32: 53–58, 1973.
 85. Coceani, F. Prostaglandins and fever. Facts and controversies. In: Fever: Basic Mechanisms and Management, edited by P. Mackowiak. New York: Raven, 1991, p. 59–70.
 86. Cohen, K., R. F. Diegelmann, and W. J. Lindblad. Wound Healing: Biochemical and Clinical Aspects. Philadelphia: Saunders, 1992.
 87. Cooper, K. E. The neurobiology of fever: thoughts on recent developments. Annu. Rev. Neurosci. 10: 297–324, 1987.
 88. Cooper, K. E., W. I. Cranston, and A. J. Honour. Observations on the site and mode of action of pyrogens in the rabbit brain. J. Physiol. (Lond.) 191: 325–337, 1967.
 89. Cooper, K. E., W. L. Veale, and Q. J. Pittman. Pathogenesis of fever. In: Brain Dysfunction in Infantile Febrile Convulsions, edited by M. A. B. Brazier and F. Coceani. New York: Raven, 1976, p. 107–115.
 90. Cooper, M. D. B‐lymphocytes: normal development and function. N. Engl. J. Med. 317: 1452–1457, 1987.
 91. Corman, L. C. The relationship between nutrition, infection, and immunity. Med. Clin. North Am. 69: 519–531, 1985.
 92. Cornelius, P., M. Marlowe, M. D. Lee, and P. H. Pekala. The growth factor‐like effects of tumor necrosis factor‐α. Stimulation of glucose transport activity and induction of glucose transporter and immediate early gene expression in 3T3‐L1 preadipocytes. J. Biol. Chem. 265: 20506–20516, 1990.
 93. Cornell, R. P., and D. B. Schwartz. Central administration of interleukin‐1 elicits hyperinsulinemia in rats, Am. J. Physiol. 256 (Regulatory Integrative Comp. Physiol. 27): R772‐R777, 1989.
 94. Cowan, J. J., A. J. Ammann, D. W. Wara, V. M. Howie, L. Schultz, H. Doyle, and M. Kaplan. Pneumococcal polysaccharide immunization in infants and children, Pediatrics 62:721‐727, 1978.
 95. Cunha, F. Q., B. B. Lorenzetti, S. Poole, and S. H. Ferreira. Interleukin‐8 as a mediator of sympathetic pain. Br. J. Pharmacol. 104: 765–767, 1991.
 96. Cunha, F. Q., S. Poole, B. B. Lorenzetti, and S. H. Ferreira. The pivotal role of tumor necrosis factor α in the development of inflammatory hyperalgesia. Br. J. Pharmacol. 107: 660–664, 1992.
 97. Cybulsky, M. I., M. K. W. Chan, and H. Z. Movat. Acute inflammatory and microthrombosis induced by endotoxin, interleukin‐1, and tumor necrosis factor and their implication in gram‐negative infection. Lab. Invest. 58: 365–378, 1988.
 98. Darling, G., D. S. Goldstein, R. Stull, C. M. Gorschboth, and J. A. Norton. Tumor necrosis factor: immune‐endocrine interaction. Surgery 106: 1155–1160, 1989.
 99. Dascombe, M. J. The pharmacology of fever. Prog. Neurobiol. 25: 327–373, 1985.
 100. Davis, M. M., and P. J. Bjorkman. T‐cell antigen receptor genes and T‐cell recognition. Nature 334: 395–402, 1988.
 101. Dawson, M. M. Lymphokines and Interleukins. Boca Raton, FL: CRC, 1991.
 102. Dejana, E., F. Breviaro, A. Erroi, F. Bussolino, M. Gramse, G. Pintucci, B. Casali, C. A. Dinarello, J. Van Damme, and A. Mantovani. Modulation of endothelial cell junction by different molecular species of interleukin‐1. Blood 69: 695–699, 1987.
 103. del Rey, A., and H. Besedovsky. Interleukin‐1 affects glucose homeostasis, Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 24): R794–R798, 1987.
 104. Densen, P. Complement. In: Principles and Practice of Infectious Diseases (3rd ed.), edited by G. L. Mandell, R. G. Douglas, and J. E. Bennett. New York: Churchill‐Livingstone, 1990, p. 62–81.
 105. DeRijk, R., N. Van Rooyen, F. J. H. Tilders, H. O. Besedovsky, A. del Rey, and F. Berkenbosch. Selective depletion of macrophages prevents pituitary‐adrenal activation in response to sub‐pyrogenic but not to pyrogenic doses of bacterial endotoxin in rats. Endocrinology 128: 330–338, 1991.
 106. De Simoni, M. G., A. De Luigi, L. Gemma, M. Sironi, A. Manfridi, and P. Ghezzi. Modulation of systemic interleukin‐6 induction by central interleukin‐1, Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 36): R739–R742, 1993.
 107. De Simoni, M. G., M. Sironi, A. De Luigi, A. Manfridi, A. Mantovani, and P. Ghezzi. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 171: 1773–1778, 1990.
 108. deWaal Malefyt, R., J. Abrams, B. Bennett, C. G. Fidgor, and J. E. deVries. Interleukin‐10 (IL‐10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL‐10 produced by monocytes. J. Exp. Med. 174: 1209–1220, 1991.
 109. Dimmock, N. J. Mechanisms of neutralization of animal viruses. J. Gen. Virol. 65: 1015–1022, 1984.
 110. Dinarello, C. A. Endogenous pyrogens. The role of cytokines in the pathogenesis of fever. In: Fever: Basic Mechanisms and Management, edited by P. Mackowiak. New York: Raven, 1991, p. 23–47.
 111. Dinarello, C. A. Role of interleukin‐1 in systemic responses to LPS. In: Bacterial Endotoxic Lipopolysaccharides, edited by J. L. Ryan and D. C. Morrison. Boca Raton, FL: CRC, 1992, vol. II, p. 105–144.
 112. Dinarello, C. A., H. A. Bernheim, G. S. Duff, H. V. Le, T. L. Nagabhushan, N. C. Hamilton, and F. Coceani. Mechanisms of fever induced by recombinant human interferon. J. Clin. Invest. 74: 906–918, 1984.
 113. Di Padova, F., C. Pozzi, M. J. Tondre, and R. Tritapepe. Selective and early increase of IL‐1 inhibitors, IL‐6 and cortisol after elective surgery. Clin. Exp. Immunol. 85: 137–142, 1991.
 114. Doherty, D. W., Jr., and C. M. Blatteis. Hypoxic reduction of endotoxic fever in guinea pigs. J. Appl. Physiol. 49: 294–299, 1980.
 115. DuBois, E. F. Fever. Springfield, IL: Thomas, 1948.
 116. Dubuis, J.‐M., J.‐M. Dayer, C. A. Siegrist‐Kaiser, and A. G. Burger. Human recombinant interleukin‐1β decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats. Endocrinology 123: 2175–2181, 1988.
 117. Duff, G. W., and S. K. Durum. Fever and immunoregulation: hyperthermia, interleukin 1 and 2, and T‐cell proliferation. Yale J. Biol. Med. 55: 437–442, 1982.
 118. Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. Induction by IL 1 and interferon‐γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM‐1). J. Immunol. 137: 245–254, 1986.
 119. Eden, C. S., R. Shahin, and D. Briles. Host resistance to mucosal gram‐negative infection: susceptibility of lipopolysaccharide nonresponder mice. J. Immunol. 140: 3180–3185, 1988.
 120. Ehrlich, H. A., and U. B. Gyllensten. Shared epitopes among HLA class II alleles: gene conversion, common ancestry and balancing selection. Immunol. Today 12: 411–414, 1991.
 121. Eisenman, J. S. Electrophysiology of the anterior hypothalamus. Thermoregulation and fever. In: Pyretics and Antipyretics, edited by A. S. Milton. Berlin: Springer, 1982, p. 187–217.
 122. Ellwood, D. C., and D. W. Tempest. Effects of environment on bacterial wall content and composition. Adv. Microbiol. Physiol. 7: 83–118, 1972.
 123. Elsbach, P., and J. Weiss. A reevaluation of the roles of the O2‐dependent and O2‐independent microbicidal system of phagocytes. Rev. Infect. Dis. 5: 843–853, 1983.
 124. English, B. K., and C. B. Wilson. Neonate as an immunocompromised host. In: Infections of Immunocompromised Infants and Children, edited by C. C. Patrick. New York: Churchill‐Livingstone, 1992, p. 95–118.
 125. Evans, R. D., V. Ilic, and D. H. Williamson. Acute administration of tumor necrosis factor‐α or interleukin‐1‐α does not mimic the hypoketonaemia associated with sepsis and inflammatory stress in the rat. Clin. Sci. 82: 205–209, 1992.
 126. Ewald, P. W. Evolutionary biology and the treatment of signs and symptoms of infectious disease. J. Theor. Biol. 86: 169–176, 1980.
 127. Eyssen, H. J., G. G. Parmentier, and J. A. Mertens. Sulfated bile acids in germ‐free and conventional mice. Eur. J. Biochem. 66: 507–514, 1976.
 128. Farrar, W. L., P. L. Killian, M. R. Ruff, J. M. Hill, and C. B. Pert. Visualization and characterization of interleukin‐1 receptors in brain. J. Immunol. 139: 459–463, 1987.
 129. Feingold, K. R., and C. Grunfeld. Tumor necrosis factor‐alpha stimulates hepatic lipogenesis in the rat in vivo. J. Clin. Invest. 80: 184–190, 1987.
 130. Feingold, K. R., S. Mounzer, M. K. Serio, A. H. Moser, C. A. Dinarello, and C. Grunfeld. Multiple cytokines stimulate hepatic lipid synthesis in vivo. Endocrinology 125: 267–274, 1989.
 131. Felten, D. L., S. Y. Felten, D. L. Bellinger, S. L. Carlson, K. D. Ackerman, K. S. Madden, J. A. Olschowka, and S. Livnat. Noradrenergic sympathetic neural interactions with the immune system: structure and function. Immunol. Rev. 100: 225–260, 1987.
 132. Fletcher, M. P., B. E. Seligmann, and J. I. Gallin. Correlation of human neutrophil secretion, chemoattractant receptor mobilization, and enhanced functional capacity. J. Immunol. 128: 941–948, 1982.
 133. Flohé, S., P. C. Heinrich, J. Schneider, A. Wendel, and L. Flohé Time course of IL‐6 and TNFα release during endotoxin‐induced endotoxin tolerance in rats. Biochem. Pharmacol. 41: 1607–1614, 1991.
 134. Fong, Y., L. L. Moldawer, M. Marano, H. Wei, S. B. Tatter, R. M. Clarick, U. Santhanam, D. Sherris, L. T. May, P. B. Sehgal, and S. F. Lowry. Endotoxemia elicits increased circulating β2‐IFN/IL‐6 in man. J. Immunol. 142: 2321–2324, 1989.
 135. Foster, H. L. Gnotobiology. In: The Laboratory Rat, edited by H. L. Baker, J. R. Lindsey, and S. H. Weisbroth. New York: Academic, 1980, vol. II, p. 43–57.
 136. Fox, A., and K. Fox. Rapid elimination of a synthetic adjuvant peptide from the circulation after systemic administration and absence of detectable natural muramyl peptides in normal serum at current analytical levels. Infect. Immun. 59: 1202–1205, 1991.
 137. Gaillard, R. C., D. Turnill, P. Sappino, and A. F. Muller. Tumor necrosis factor‐α inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 127: 101–106, 1990.
 138. Gallis, H. A. Normal flora and opportunistic infections. In: Zinsser's Microbiology (19th ed.), edited by W. K. Joklik, H. P. Willett, D. B. Amos, C. M. Wilfert. Norwalk, CT: Appleton and Lange, 1988, p. 337–342.
 139. Ganz, T., M. E. Selsted, D. Szklarek, S. S. L. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer. Defensins: natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76: 1427–1435, 1985.
 140. Gauldie, J., and H. Baumann. Cytokines and acute‐phase protein expression. In: Cytokines and Inflammation, edited by E. S. Kimball. Boca Raton, FL: CRC, 1991, p. 275–305.
 141. Gauldie, J., L. Lamontagne, and A. Stadnyk. The acute‐phase response in infectious disease. Surv. Syn. Pathol. Res. 4: 126–151, 1985.
 142. Gelfand, R. A., D. E. Matthews, D. M. Bier, and R. S. Sherwin. Role of counterregulatory hormones in the catabolic response to stress. J. Clin. Invest. 74: 2238–2248, 1984.
 143. George, D. T., F. B. Abeles, C. A. Mapes, P. E. Sobocinski, T. V. Zenser, and M. C. Powanda. Effect of leukocyte endogenous mediator on endocrine pancreas secretory responses, Am. J. Physiol. 233 (Endocrinol. Metab. Gastrointest. Physiol. 2): E240–E275, 1977.
 144. Gibbons, R. J., and J. Van Houte. Bacterial adherence in oral microbial ecology. Annu. Rev. Microbiol. 29: 19–44, 1975.
 145. Gilbert, P., and M. R. W. Brown. Effect of R‐plasmid RP1 and nutrient depletion on the gross cellular composition of Escherichia coli and its resistance to some uncoupling phenols. J. Bacteriol. 133: 1062–1065, 1978.
 146. Gillin, F. D., and D. S. Reiner. Human milk kills parasitic intestinal protozoa. Science 221: 1290–1292, 1983.
 147. Glynne, R., S. H. Powis, S. Beck, A. Kelly, L. A. Kerr, and J. Trowsdale. A proteasome‐related gene between the two ABC transporter loci in the class II region of the human MHC. Nature 353: 357–360, 1991.
 148. Goetzl, E. J., and S. P. Sreedharan. Mediators of communication and adaptation in the neuroendocrine and immune systems. FASEB J. 6: 2646–2652, 1992.
 149. Goldacre, M. J., B. Watt, N. Loudon, L. J. R. Milne, J. D. O. Loudon, and M. P. Vessey. Vaginal microbial flora in normal young women. BMJ 1: 1450–1453, 1979.
 150. Goldstein, E., W. Lippert, and D. Warshauer. Pulmonary alveolar macrophage: defender against bacterial infection of the lung. J. Clin. Invest. 54: 519–528, 1974.
 151. Goldstein, I. M., H. B. Kaplan, H. S. Edelson, and G. Weissmann. Ceruloplasmin: an acute‐phase reactant that scavenges oxygen‐derived free radicals. Ann. N. Y. Acad. Sci. 389: 368–379, 1982.
 152. Goldstein, I. M., H. B. Kaplan, A. Radin, and M. Frosch. Independent effects of IgG and complement upon human polymorphonuclear leukocyte function. J. Immunol. 117: 1282–1287, 1976.
 153. Golub, E. S., and D. R. Green. Immunology: A Synthesis. Sunderlund: Sinauer, 1991, p. 117–132, 352‐359.
 154. Gordon, A. H., and A. Koj. The Acute‐Phase Response to Injury and Infection. Amsterdam: Elsevier, 1985.
 155. Gordon, J. R., P. R. Burd, and S. J. Galli. Mast cells as a source of multifunctional cytokines. Immunol. Today 11: 458–464, 1990.
 156. Grant, R. Emotional hypothermia in rabbits. Am. J. Physiol. 160: 285–290, 1950.
 157. Greisman, S. E. Cardiovascular alterations during fever. In: Fever: Basic Mechanisms and Management, edited by P. Mackowiak, New York: Raven, 1991, p. 143–165.
 158. Gridland, R. A., and N. W. Kasting. A critical role for central vasopressin in regulation of fever during bacterial infection, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 34): R1235–R1240, 1992.
 159. Griegy, T. A., and M. J. Kluger. Fever and survival: the role of serum iron. J. Physiol. (Lond.) 279: 187–196, 1978.
 160. Griffin, F. M. Roles of macrophage Fc and C3b receptors in phagocytosis of immunologically coated Cryptococcus neoformans. Proc. Natl. Acad. Sci. USA 78: 3853–3857, 1981.
 161. Griffin, F. M. Mononuclear cell phagocytic mechanisms and host defense. In: Advances in Host Defense Mechanisms, edited by J. I. Gallin and A. S. Fauci. New York: Raven, 1982, vol. 1, p. 31–55.
 162. Griffiths, G. M., and C. Mueller. Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells. Immunol. Today 12: 415–419, 1991.
 163. Grunfeld, C., and K. R. Feingold. Tumor necrosis factor, interleukin, and interferon induced changes in lipid metabolism as part of host defense. Proc. Soc. Exp. Biol. Med. 200: 224–227, 1992.
 164. Grunfeld, C., R. Gulli, A. H. Moser, L. A. Gavin, and K. R. Feingold. Effect of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat. J. Lipid Res. 30: 579–586, 1989.
 165. Grunfeld, C., and M. A. Palladino, Jr. Tumor necrosis factor: immunologic, antitumor, metabolic, and cardiovascular activities. Arch. Intern. Med. 35: 45–72, 1990.
 166. Grunfeld, C., M. Soued, S. Adi, A. H. Moser, C. A. Dinarello, and K. R. Feingold. Interleukin‐4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin‐1 and interleukin‐6 but not by interferon‐alpha. Cancer Res. 51: 2803–2807, 1991.
 167. Grunfeld, C., J. A. Verdier, R. A. Neese, A. H. Moser, and F. R. Feingold. Mechanisms by which tumor necrosis factor stimulates hepatic fatty acid synthesis in vivo. J. Lipid Res. 29: 1327–1335, 1988.
 168. Gustafsson, B. E. Vitamin K deficiency in germfree rats. Ann. N. Y. Acad. Sci. 78: 166–174, 1959.
 169. Gustafsson, B. E., F. S. Daft, E. G. McDaniel, J. C. Smith, and R. J. Fitzgerald. Effects of vitamin K‐active compounds and intestinal microorganisms in vitamin K‐deficient rats. J. Nutr. 78: 461–468, 1962.
 170. Hamilton, W. D., R. Axelrod, and R. Tanese. Sexual reproduction as an adaptation to resist parasites (a review). Proc. Natl. Acad. Sci. USA 87: 3566–3573, 1991.
 171. Harbuz, M. S., A. Stephanou, R. A. Knight, A. J. Chover‐Gonzalez, and S. L. Lightman. Action of interleukin‐2 and interleukin‐4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary. Brain Behav. Immun. 6: 214–222, 1992.
 172. Harel‐Bellan, A., A. Quillet, C. Marchol, R. DeMars, T. Tursz, and D. Fradelizi. Natural killer susceptibility of human cells may be regulated by genes in the HLA region on chromosome 6. Proc. Natl. Acad. Sci. USA 83: 5688–5692, 1985.
 173. Harris, H. W., C. Grunfeld, K. R. Feingold, and J. R. Rapp. Human VLDL and chylomicrons can protect against endotoxin‐induced death in mice. J. Clin. Invest. 86: 696–702, 1990.
 174. Harrison, J., and A. Fox. Degradation of muramyl dipeptide by mammalian serum. Infect. Immun. 50: 320–321, 1985.
 175. Hart, B. L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12: 123–137, 1988.
 176. Hart, B. L., and K. L. Powell. Antibacterial properties of saliva: role in maternal periparturient grooming and in licking wounds. Physiol. Behav. 48: 383–386, 1990.
 177. Hart, P. H., G. F. Vitti, D. R. Burgess, G. A. Whitty, D. S. Piccoli, and J. A. Hamilton. Potential anti‐inflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor α, interleukin 1, and prostaglandin E2. Proc. Natl. Acad. Sci. USA 86: 3803–3807, 1989.
 178. Heinzel, F. P., and R. K. Root. Antibodies. In: Principles and Practice of Infectious Diseases (3rd ed.), edited by G. L. Mandell, R. G. Douglas, and J. E. Bennett. New York: Churchill‐Livingstone, 1990, p. 41–61.
 179. Helstrom, P. B., and E. Balish. Effect of oral tetracycline, the microbial flora, and the athymic state on gastrointestinal colonization and infection of BALB/c mice with Candida albicans. Infect. Immun. 23: 764–774, 1979.
 180. Hensler T., M. Köller, J. E. Alouf, and W. König. Bacterial toxins induce heat shock proteins in human neutrophils. Biochem. Biophys. Res. Commun. 179: 872–879, 1991.
 181. Henson, P. M., J. E. Henson, C. Fittschen, D. L. Bratton, and D. W. H. Riches. Degranulation and secretion by phagocytic cells. In: Inflammation: Basic Principles and Clinical Correlates (2nd ed.), edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 511–539.
 182. Herbermann, R. B., and J. R. Ortaldo. Natural killer cells: their role in defenses against disease. Science 214: 24–30, 1981.
 183. Hesse, D. G., K. J. Tracey, Y. Fong, K. R. Manogue, M. A. Palladino, Jr., A. Cerami, G. T. Shires, and S. F. Lowry. Cytokine appearance in human endotoxin and primate bacteremia. Surg. Gynecol. Obstet. 166: 147–153, 1988.
 184. Hill, M. R., R. D. Stith, and R. E. McCallum. Human recombinant IL‐1 alters glucocorticoid receptor function in Renfer hepatoma cells. J. Immunol. 141: 1522–1528, 1988.
 185. Hill, M. R., R. D. Stith, and R. E. McCallum. Mechanims of action of interferon‐β2/interleukin‐6 on induction of hepatic glucose enzymes. Ann. N. Y. Acad. Sci. 557: 502–505, 1989.
 186. Hodes, R. J. T‐cell‐mediated regulation: help and suppression. In: Fundamental Immunology (2nd ed.), edited by W. E. Paul. New York: Raven, 1989, p. 587–620.
 187. Hoffman‐Goetz, L., D. McFarlane, B. R. Bistrian, and G. L. Blackburn. Febrile and plasma iron responses of rabbits injected with endogenous pyrogen from malnourished patients. Am. J. Clin. Nutr. 34: 1109–1116, 1981.
 188. Hori, T. An update on thermosensitive neurons in the brain: from cellular biology to thermal and nonthermal homeostatic functions. Jpn. J. Physiol. 41: 1–22, 1991.
 189. Huber, A. R., S. L. Kunkel, R. F. Todd, III, and S. J. Weiss. Regulation of transendothelial neutrophil migration by endogenous interleukin‐8. Science 254: 99–102, 1991.
 190. Husseini, R. H., C. Sweet, M. H. Collie, and H. Smith. Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence. J. Infect. Dis. 145: 520–524, 1982.
 191. Ignarro, L. J. Endothelium‐derived nitric oxide: actions and properties. FASEB J. 3: 31–36, 1989.
 192. Ihle, J. N. Lymphokine regulation of hematopoietic cell development. In: Immunophysiology. The Role of Cells and Cytokines in Immunity and Inflammation, edited by J. J. Oppenheim and E. M. Shevach. New York: Oxford University Press, 1991, p. 166–193.
 193. Imeri, L., M. R. Opp, and J. M. Krueger. An IL‐1 receptor and an IL‐1 receptor antagonist attenuate muramyl dipeptide and IL‐1‐induced sleep and fever, Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 36): R907‐R913, 1993.
 194. Imura, H., J. Fukata, Y. Nakai, T. Usui, Y. Naito, T. Tominaga, N. Murakami, H. Kobayashi, O. Ebisui, and H. Segawa. Effects of cytokines on the hypothalamo‐pituitary system. In: New Trends in Autonomic Nervous System Research, edited by M. Yoshikawa. Amsterdam: Elsevier, 1990, p. 51–54.
 195. Itoh, K., and R. Freter. Control of Escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous‐flow cultures. Infect. Immun. 57: 559–565, 1989.
 196. Janeway, C. A. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13: 11–16, 1992.
 197. Johannsen, L., J. Wecke, F. Obal, and J. M. Krueger. Macrophages produce somnogenic and pyrogenic muramyl peptides during digestion of staphylococci, Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 31): R126–R133, 1991.
 198. Jolles, P. A possible physiological function of lysozyme. Bio‐medicine 25: 275–276, 1976.
 199. Jones, S. R. Fever in the elderly. In: Fever: Basic Mechanisms and Clinical Management, edited by P. Mackowiak. New York: Raven, 1991, p. 233–242.
 200. Kalra, P. S., A. Sahn, and S. P. Kalra. Interleukin‐1 inhibits the ovarian steroid‐induced luteinizing hormone surge and release of hypothalamic luteinizing hormone‐releasing hormone in rats. Endocrinology 126: 2145–2152, 1990.
 201. Kaneko, J. J. Carbohydrate metabolism and its diseases. In: Clinical Biochemistry of Domestic Animals (4th ed.), edited by J. J. Kaneko. New York: Academic, 1989, p. 44–85.
 202. Kapás, L., L. Hong, A. B. Cady, M. R. Opp, A. E. Postlethwaite, J. M. Seyer, and J. M. Krueger. Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor‐α and TNF‐α fragments, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 34): R708–R715, 1992.
 203. Kapás, L., and J. M. Krueger. Tumor necrosis factor‐β induces sleep, fever, and anorexia, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 34): R703‐R707, 1992.
 204. Kappler, J. W., and P. C. Marrack. Helper T cells recognize antigen and macrophage surface components simultaneously. Nature 262: 797–799, 1976.
 205. Kappler, J. W., B. Skidmore, J. White, and P. Marrack. Antigen‐inducible, H‐2‐restricted, interleukin‐2‐producing T cell hybridomas: lack of independent antigen and H‐2 recognition. J. Exp. Med. 153: 1198–1214, 1981.
 206. Karnovsky, M. L. Muramyl peptides in mammalian tissues and their effects at the cellular level. Federation Proc. 42: 2556–2560, 1986.
 207. Kasting, N. W. Criteria for establishing a physiological role of vasopressin in thermoregulation during fever and antipyresis. Brain Res. Rev. 14: 143–153, 1989.
 208. Kasting, N. W., and M. F. Wilkinson. Vasopressin functions as endogenous antipyretic in the newborn. Biol. Neonate 51: 249–254, 1987.
 209. Kawakami, M., N. Watanabe, H. Ogawa, T. Murase, N. Yamada, H. Sando, S. Shibata, T. Oda, and F. Takaku. Specificity in metabolic effects of cachectin/TNF and other related cytokines. Ann. N. Y. Acad. Sci. 587: 339–350, 1990.
 210. Keenan, R. A., L. L. Moldawer, R. D. Yang, I. Kawamura, G. L. Blackburn, and B. R. Bistrian. An altered response by peripheral leukocytes to synthesize or release leukocyte endogenous mediator in critically ill, protein‐malnourished patients. J. Lab. Clin. Med. 100: 844–857, 1982.
 211. Kimura‐Takeuchi, M., J. A. Majde, L. A. Toth, and J. M. Krueger. Influenza virus‐induced changes in rabbit sleep and acute‐phase responses, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 34): R1115–R1121, 1992.
 212. Kishimoto, T. K., and D. C. Anderson. The role of integrins in inflammation. In: Inflammation: Basic Principles and Clinical Correlates (2nd ed.), edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 353–406.
 213. Kita, A., K. Imano, and H. Nakamura. Involvement of corticotropin‐releasing factor in the antinociception produced by interleukin‐1 in mice. Eur. J. Pharmacol. 237: 317–322, 1993.
 214. Klebanoff, S. J. Oxygen metabolites from phagocytes. In: Inflammation: Basic Principles and Clinical Correlates (2nd ed.), edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 541–588.
 215. Kluger, M. J. Fever. Its Biology, Evolution, and Function. Princeton, NJ: Princeton University Press, 1979.
 216. Kluger, M. J. Fever: role of pyrogens and cryogens. Physiol. Rev. 71: 93–127, 1991.
 217. Kluger, M. J., C. A. Conn, B. Franklin, R. Freter, and G. D. Abrams. Effect of gastrointestinal flora on body temperature of rats and mice, Am. J. Physiol. 258 (Regulatory Integrative Comp. Physiol. 29): R552–R557, 1990.
 218. Kluger, M. J., R. O'Reilly, T. R. Shope, and A. J. Vander. Further evidence that stress hyperthermia is a fever. Physiol. Behav. 39: 763–766, 1987.
 219. Kluger, M. J., and B. A. Rothenburg. Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science 203: 374–376, 1979.
 220. Koj, A. Biological functions of acute‐phase proteins. In: The Acute‐Phase Response to Injury and Infection, edited by A. H. Gordon and A. Koj. Amsterdam: Elsevier, 1985, p. 145–160.
 221. Krahenbuhl, O., and J. Tschopp. Perforin‐induced pore formation. Immunol. Today 12: 399–402, 1991.
 222. Krauss, R. M., C. Grunfeld, W. T. Doerrler, and K. R. Feingold. Tumor necrosis factor acutely increases plasma levels of very low density lipoproteins of normal size and composition. Endocrinology 127: 1016–1021, 1990.
 223. Krensky, A. M., F. Sanchez‐Madrid, E. Robbins, J. A. Nagy, T. A. Springer, and S. J. Burakoff. The functional significance, distribution, and structure of LFA‐1, LFA‐2, and LFA‐3: cell surface antigens associated with CTL‐target interactions. J. Immunol. 131: 611–616, 1983.
 224. Krueger, J. M., J. R. Pappenheimer, and M. L. Karnovsky. Sleep‐promoting effects of muramyl peptides. Proc. Natl. Acad. Sci. USA 79: 6102–6106, 1982.
 225. Kunkel, S. L., and D. G. Remick. Cytokines in Health and Disease. New York: Dekker, 1992.
 226. Kuriyama, K., T. Hori, T. Mori, and T. Nakashima. Actions of interferon‐α and interleukin‐1β on the glucose‐responsive neurons in the ventromedial hypothalamus. Brain Res. Bull. 24: 803–810, 1990.
 227. Kushner, I. The phenomenon of the acute‐phase response. Ann. N. Y. Acad. Sci. 389: 39–48, 1982.
 228. Kushner, I., M. Ganapathi, and D. Schultz. The acute‐phase response is mediated by heterogeneous mechanisms. Ann. N. Y. Acad. Sci. 557: 19–30, 1989.
 229. Kushner, I., and A. Mackiewicz. Acute‐phase proteins as disease markers. Dis. Markers 5: 1–11, 1987.
 230. LaMont, J. T., E. B. Sonnenblick, and S. Rothman. Role of clostridial toxin in the pathogenesis of clindamycin colitis in rabbits. Gastroenterology 76: 356–361, 1979.
 231. Lanza‐Jacoby, S., and A. Tabares. Triglyceride kinetics, tissue lipoprotein lipase and liver lipogenesis in septic rats, Am. J. Physiol. 258 (Endocrinol. Metab. 21): E678–E685, 1990.
 232. Larson, H. E., A. B. Price, P. Honour, and S. P. Borriello. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet i: 1063–1066, 1978.
 233. Lasky, L. A., and S. D. Rosen. The selectins. In: Inflammation: Basic Principles and Clinical Correlates (2nd ed.), edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 407–419.
 234. Ledbetter, J. A., C. H. June, P. S. Rabinovitch, A. Grossman, T. T. Tsu, and J. B. Imboden. Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor. Eur. J. Immunol. 18: 525–532, 1988.
 235. Lee, D. A., J. R. Hoidal, D. J. Garlich, C. C. Clawson, P. G. Quie, and P. K. Peterson. Opsonin‐independent phagocytosis of surface‐adherent bacteria by human alveolar macrophages. J. Leukocyte Biol. 36: 689–701, 1984.
 236. LeMay, D. R., L. G. LeMay, M. J. Kluger, and L. G. D'Alecy. Plasma profiles of IL6 and TNF with fever‐inducing doses of lipopolysaccharides in dogs, Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 30): R126–R132, 1990.
 237. LeMay, L. G., A. J. Vander, and M. J. Kluger. Role of interleukin‐6 fever in rats, Am. J. Physiol. 258 (Regulatory Integrative Comp. Physiol. 29): R798–R803, 1990.
 238. Lewin, H. A. Disease resistance and immune response genes in cattle: strategies for their detection and evidence of their existence. J. Dairy Sci. 72: 1334–1348, 1989.
 239. Li, J. J., K. P. W. J. McAdam, and L. L. Bausserman. The regulatory role of acute‐phase reactants in human immune responses, Ann. N. Y. Acad. Sci. 389: 456, 1982.
 240. Lilly, F., E. A. Boyse, and L. J. Old. Genetic basis of susceptibility to viral leukaemogenesis. Lancet ii: 1207–1209, 1964.
 241. Lindahl, K. F., and D. B. Wilson. Histocompatibility antigen‐activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors. J. Exp. Med. 145: 508–522, 1977.
 242. Lipscomb, M. F., J. M. Onofrio, E. J. Nash, A. K. Pierce, and G. B. Toews. A morphological study of the role of phagocytes in the clearance of Staphylococcus aureus from the lung. J. Reticuloendothel. Soc. 33: 429–442, 1983.
 243. Lipton, J. M., and A. Catania. α‐MSH peptides modulate fever and inflammation. In: Neuro‐Immunology of Fever, edited by T. Bartfai and D. Ottoson. Oxford: Pergamon, 1992, p. 123–136.
 244. Lipton, J. M., and G. P. Trczinka. Persistence of febrile responses to pyrogens after PO/AH lesions in squirrel monkeys. Am. J. Physiol. 231: 1638–1648, 1976.
 245. Lipton, J. M., J. P. Welch, and W. G. Clark. Changes in body temperature produced by injecting prostaglandin E1, EGTA and bacterial endotoxins into the PO/AH region and the medulla oblongata of the rat. Experientia 29: 806–808, 1973.
 246. Long, C. L. Energy balance and carbohydrate metabolism in infection and sepsis. Am. J. Clin. Nutr. 30: 1301–1310, 1977.
 247. Lorenzo, J. A. Cytokines and bone metabolism: resorption and formation. In: Cytokines and Inflammation, edited by E. S. Kimball. Boca Raton, FL: CRC, 1991, p. 145–168.
 248. Mackie, R. I., and B. A. White. Recent advances in rumen microbial ecology and metabolism: potential impact of nutrient output. J. Dairy Sci. 73: 2971–2995, 1990.
 249. Mackiewicz, A., and I. Kushner. Role of IL6 in acute‐phase protein glycosylation. Ann. N. Y. Acad. Sci. 557: 515–517, 1989.
 250. Mackowiak, P. A. The normal microbial flora. N. Engl. J. Med. 307: 83–93, 1982.
 251. Madsen, D., M. Beaver, L. Chang, E. Bruckner‐Kardoss, and B. Wostmann. Analysis of bile acids in conventional and germfree rats. J. Lipid Res. 17: 107–111, 1976.
 252. Maeda, H., and T. Akaike. Oxygen free radicals as pathogenic molecules in viral diseases. Proc. Soc. Exp. Biol. Med. 198: 721–727, 1991.
 253. Malech, H. L., and J. I. Gallin. Neutrophils in human diseases. N. Engl. J. Med. 317: 687–694, 1987.
 254. Mantovani, A., F. Bussolino, and E. Dejana. Cytokine regulation of endothelial cell function. FASEB J. 6: 2591–2599, 1992.
 255. Mantovani, A., and E. Dejana. Functional responses elicited in endothelial cells by cytokines. In: Cytokines in Health and Disease, edited by S. L. Kunkel and D. G. Remick. New York: Dekker, 1992, p. 297–307.
 256. Marasco, W. A., S. H. Phan, H. Krutzsch, H. J. Showell, D. E. Feltner, R. Nairn, E. L. Becker, and P. A. Ward. Purification and identification of formyl‐methionyl‐leucyl‐phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem. 259: 5430–5439, 1984.
 257. Marshall, J. C., N. V. Christou, and J. L. Meakins. Immuno‐modulation by altered gastrointestinal tract flora. Arch. Surg. 123: 1465–1469, 1988.
 258. Martin, L. W., L. B. Deeter, and J. M. Lipton. Acute‐phase response to endogenous pyrogen in rabbit: effects of age and route of administration, Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 28): R189–R193, 1989.
 259. Martin, S., K. Maruta, V. Burkart, S. Gillis, and H. Kolb. IL‐1 and IFN‐γ increase vascular permeability. Immunology 64: 301–305, 1988.
 260. Mastuda, T., T. Hori, and T. Nakashima. Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices. J. Physiol. (Lond.) 454: 197–212, 1992.
 261. Matsushima, K., and J. J. Oppenheim. Interleukin‐8 and MCAF: novel inflammatory cytokines inducible by IL1 and TNF. Cytokine 1: 2–13, 1989.
 262. May, R. M., and R. M. Anderson. Population biology of infectious diseases: part II. Nature 280: 455–461, 1979.
 263. McCann, S. M., S. Karanth, A. Kamat, W. L. Dees, K. Lyson, M. Gimeno, and V. Rettori. Induction by cytokines of the pattern of pituitary hormone secretion in infection. Neuroimmunomodulation 1: 2–13, 1994.
 264. McConnel, T. J., W. S. Talbot, R. A. McIndoe, and E. K. Wakeland. The origin of MHC class II gene polymorphism within the genus Mus. Nature 332: 651–654, 1988.
 265. Meszaros, K., J. Bojta, A. P. Bautista, C. H. Lang, and J. J. Spitzer. Glucose utilization by Kupfer cells, endothelial cells, and granulocytes in endotoxemic rat liver, Am. J. Physiol. 260 (Gastrointest. Liver Physiol. 23): G7–G12, 1991.
 266. Meszaros, K., C. H. Lang, G. J. Bagley, and J. J. Spitzer. Contribution of different organs to increased glucose consumption after endotoxin administration. J. Biol. Chem. 262: 10965–10970, 1987.
 267. Michael, J. G., and F. S. Rosen. Association of “natural” antibodies to gram‐negative bacteria with the γ1‐macroglobulins. J. Exp. Med. 118: 619–626, 1963.
 268. Michie, H. R., K. R. Manogue, D. R. Spriggs, A. Revhaug, S. O'Dwyer, C. A. Dinarello, A. Cerami, S. M. Wolff, and D. W. Wilmore. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318: 1481–1486, 1988.
 269. Milton, A. S. Thermoregulatory actions of eicosanoids in the central nervous system with particular regard to the pathogenesis of fever. Ann. N. Y. Acad. Sci. 539: 392–410, 1989.
 270. Miñano, F. J., and R. D. Myers. Anorexia and adipsia: dissociation from fever after MIP‐1 injection into ventromedial hypothalamus and preoptic area of rats. Brain Res. Bull. 27: 273–278, 1991.
 271. Miñano, F. J., M. Sancibrian, M. Vizcaino, X. Paez, G. Davatelis, T. Fahey, B. Sherry, A. Cerami, and R. D. Myers. Macrophage inflammatory protein‐1: unique action in the hypothalamus to evoke fever. Brain Res. Bull. 24: 849–852, 1990.
 272. Modlin, R. L., J. Melancon‐Kaplan, S. M. M. Young, C. Pirmez, H. Kino, J. Convit, T. H. Rea, and B. R. Bloom. Learning from lesions: patterns of tissue inflammation in leprosy. Proc. Natl. Acad. Sci. USA 85: 1213–1217, 1988.
 273. Moldawer, L. L., C. Andersen, J. Gerlin, and K. G. Lundholm. Regulation of food intake and hepatic protein synthesis by recombinant derived cytokines, Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G450–G456, 1988.
 274. Morgan, E. L., and W. O. Weigle. Biological activities residing in the Fc region of immunoglobulin. Adv. Immunol. 40: 61–134, 1987.
 275. Morimoto, A., N. Murakami, T. Nakamori, and T. Watanabe. Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood‐brain barrier in rabbits. J. Physiol. (Lond.) 383: 629–637, 1987.
 276. Morimoto, A., N. Murakami, M. Takada, S. Teshigori, and T. Watanabe. Fever and acute‐phase responses induced in rabbits by human recombinant interferon‐γ. J. Physiol. (Lond.) 391: 209–218, 1987.
 277. Morimoto, A., Y. Sakata, T. Watanabe, and N. Murakami. Leukocytosis induced in rabbits by intravenous or central injection of granulocyte colony stimulating factor. J. Physiol. (Lond.) 426: 117–126, 1990.
 278. Morrone, G., G. Ciliberto, S. Oliviero, R. Arcones, L. Dente, J. Content, and E. Cortese. Recombinant interleukin‐6 regulates the transcriptional activation of a set of human acute‐phase genes. J. Biol. Chem. 263: 12554–12558, 1988.
 279. Moshage, H. J., H. M. J. Roelofs, J. F. van Pelt, B. P. C. Hazenberg, M. A. van Leeuwen, P. C. Limburg, L. A. Arden, and S. H. Yap. The effect of interleukin‐1, interleukin‐6 and its interrelationship on the synthesis of serum amyloid A and C‐reactive protein in primary cultures of adult human hepatocytes. Biochem. Biophys. Res. Commun. 155: 112–117, 1988.
 280. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348–2357, 1986.
 281. Mosmann, T. R., and R. L. Coffman. Two types of mouse helper T‐cell clones: implications for immune regulation. Immunol. Today 8: 233–236, 1987.
 282. Muller, C., D. Kagi, T. Aebischer, B. Odermatt, W. Held, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus. Eur. J. Immunol. 19: 1253–1259, 1989.
 283. Mundy, G., and L. F. Bonewald. Effects of immune cell products on bone. In: Macrophage‐Derived Cell Regulatory Factors, edited by C. Sorg. Basel: Karger, 1989, p. 38–53.
 284. Murray, M. J., and A. B. Murray. Anorexia of infection as a mechanism of host defense. Am. J. Clin. Nutr. 32: 593–596, 1979.
 285. Najjar, V. A. Tuftsin, a natural activator of phagocyte cells: an overview. Ann. N. Y. Acad. Sci. 419: 1–11, 1983.
 286. Namba, Y., Y. Hidaka, K. Taki, and T. Morimoto. Effect of oral administration of lysozyme or digested bacterial cell walls on immunostimulation in guinea pigs. Infect. Immun. 31: 580–583, 1981.
 287. Nealson, K. H., and J. W. Hastings. Bacterial bioluminescence: its control and ecological significance. Microbiol. Rev. 43: 496–518, 1979.
 288. Nussler, A. K., and T. R. Billiar. Inflammation, immunoregulation and inducible nitric oxide synthase. J. Leukoc. Biol. 54: 171–178, 1993.
 289. Obál, F., Jr., M. Opp, A. B. Cady, L. Johannsen, A. E. Postlethwaite, H. M. Poppleton, J. M. Seyer, and J. M. Krueger. Interleukin‐1α and interleukin‐1β fragments are somnogenic, Am. J. Physiol. 259 (Regulatory Integrative Comp. Physiol. 30): R439–R446, 1990.
 290. O'Brien, A. D., D. L. Rosenstreich, I. Scher, G. H. Campbell, R. P. MacDermott, and S. B. Formal. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol. 124: 20–24, 1980.
 291. Ohashi, K., F. Saji, M. Kato, A. Wakimoto, and O. Tanisawa. Tumor necrosis factor‐α inhibits human chorionic gonadotropin secretion. J. Clin. Endocrinol. Metab. 74: 130–134, 1992.
 292. Oladehin, A., J. A. Barriga‐Calle, and C. M. Blatteis. Lipopoly‐saccharide (LPS)‐induced FOS expression in the brains of febrile rats. In: Thermal Physiology 1993, edited by A. S. Milton. Basel: Birkhaüser, 1994, p. 81–85.
 293. Olson, G. B., and B. S. Wostmann. Lymphocytopoiesis, plasmacytopoiesis and cellular proliferation in nonantigenically stimulated germfree mice. J. Immunol. 97: 267–274, 1966.
 294. Opp, M., and J. M. Krueger. Interleukin‐1 receptor antagonist blocks interleukin‐1‐induced sleep and fever, Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 31): R453–R457, 1991.
 295. Packham, M. A., E. Nishizawa, and J. F. Mustard. Response of platelets to tissue injury, Biochem. Pharmacol. 17 (suppl.): 171–184, 1968.
 296. Page, C. P. Platelets as inflammatory cells. Immunopharmacology 17: 51–59, 1989.
 297. Palma, C., A. Cassone, D. Serbousek, C. A. Pearson, and J. Y. Djeu. Lactoferrin release and interleukin‐1, interleukin‐6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: relationship to growth inhibition of Candida albicans. Infect. Immun. 60: 4604–4611, 1992.
 298. Palmes, E. D., and C. R. Park. The regulation of body temperature during fever. Arch. Environ. Health 11: 749–759, 1965.
 299. Pang, X.‐P., J. M. Hershman, C. J. Mirell, and A. E. Pekary. Impairment of hypothalamic‐pituitary‐thyroid function in rats treated with human recombinant tumor necrosis factor‐α (cachectin). Endocrinology 125: 76–84, 1989.
 300. Parant, M., C. Damais, F. Audibert, F. Parant, L. Chedid, E. Sache, P. Lefrancier, J. Choay, and E. Lederer. In vivo and in vitro stimulation of nonspecific immunity by the b‐D‐p‐amino‐phenyl glycoside of N‐acetylmuramyl‐L‐alanyl‐D‐isoglutamine and an oligomer prepared by cross‐linking with glutaraldehyde. J. Infect. Dis. 138: 378–386, 1978.
 301. Payne, L. C., F. Obál, Jr., M. R. Opp, and J. M. Krueger. Stimulation and inhibition of growth hormone secretion by interleukin‐1β: the involvement of growth hormone releasing hormone. Neuroendocrinology 56: 118–123, 1992.
 302. Pepys, M. B., and M. L. Baltz. Acute phase proteins with special reference to C‐reactive protein and related proteins (pentaxins) and serum amyloid A protein. Adv. Immunol. 34: 141–212, 1983.
 303. Peterson, P. K., B. J. Wilkinson, Y. Kim, D. Schmeling, S. D. Douglas, P. G. Quie, and J. Verhoef. The key role of peptidoglycan in the opsonization of Staphylococcus aureus. J. Clin. Invest. 61: 597–609, 1978.
 304. Petroni, K. C., L. Shen, and P. M. Guyre. Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor‐mediated functions by IFN‐γ and glucocorticoids. J. Immunol. 140: 3467–3472, 1988.
 305. Plata‐Salamán, C. R. Interferons and central regulation of feeding, Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 34): R1222–R1227, 1992.
 306. Plata‐Salamán, C. R., and J. P. Borkoski. Interleukin‐8 modulates feeding by direct action in the central nervous system, Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 36): R877–R882, 1993.
 307. Plata‐Salamán, C. R., Y. Oomura, and Y. Kai. Tumor necrosis factor and interleukin‐1β: suppression of food intake by direct action in the central nervous system. Brain Res. 448: 106–114, 1988.
 308. Pober, J. S., and R. S. Cotran. Cytokines and endothelial cell biology. Physiol. Rev. 70: 427–451, 1990.
 309. Pober, J. S., and R. S. Cotran. Overview: the role of endothelial cells in inflammation. Transplantation 50: 537–544, 1990.
 310. Pober, J. S., M. R. Slowik, L. G. de Luca, and A. J. Ritchie. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF‐induced endothelial leukocyte adhesion molecule‐1 and vascular cell adhesion molecule‐1, but not intercellular adhesion molecule‐1. J. Immunol. 150: 5114–5123, 1993.
 311. Polla, B. S. A role for heat shock proteins in inflammation? Immunol. Today 9: 134–137, 1988.
 312. Redondo‐Lopez, V., R. L. Cook, and J. D. Sobel. Emerging role of lactobacilli in the control and maintenance of vaginal bacterial microflora. Rev. Infect. Dis. 12: 856–872, 1990.
 313. Rehg, J. E., and S. P. Pakes. Clostridium difficile antitoxin neutralization of cecal toxin(s) from guinea pigs with penicillin‐associated colitis. Lab. Anim. Sci. 31: 156–160, 1981.
 314. Remington, J. S., and S. C. Schimpff. Please don't eat the salads. N. Engl. J. Med. 304: 433–434, 1981.
 315. Rettori, V., J. Jurcovicova, and S. M. McCann. Central action of interleukin‐1 in altering the release of TSH, growth hormone, and prolactin in the male rat. J. Neurosci. Res. 18: 179–183, 1987.
 316. Rettori, V., L. Milenkovic, B. A. Beutler, and S. M. McCann. Hypothalamic action of cachectin to alter pituitary hormone release. Brain Res. Bull. 23: 471–475, 1989.
 317. Richardson, R. P., C. D. Rhyne, Y. Fong, D. G. Hesse, K. J. Tracey, M. A. Marano, S. F. Lowry, A. C. Antonacci, and S. E. Calvano. Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects. Ann. Surg. 210: 239–245, 1989.
 318. Riedel, W. Mechanics of fever. J. Basic Clin. Physiol. Pharmacol. 1: 291–322, 1990.
 319. Rivier, C., R. Chizzonite, and W. Vale. In the mouse, the activation of the hypothalamic‐pituitary‐adrenal axis by a lipopolysaccharide (endotoxin) is mediated through interleukin‐1. Endocrinology 125: 2800–2805, 1989.
 320. Rivier, C., and W. Vale. In the rat, interleukin‐1α acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion. Endocrinology 124: 2105–2109, 1989.
 321. Rivier, C., W. Vale, and M. Brown. In the rat, interleukin‐1α and β stimulate adrenocorticotropin and catecholamine release. Endocrinology 125: 3096–3102, 1989.
 322. Robbins, J. B., R. L. Myerowitz, J. K. Whisnant, M. Argaman, R. Schneerson, Z. T. Handzel, and E. C. Gotschlich. Enteric bacteria cross‐reactive with Neisseria meningitidis groups A and C and Diplococcus pneumoniae types I and III. Infect. Immun. 6: 651–656, 1972.
 323. Robertson, M. Proteasomes in the pathway. Nature 353: 300–301, 1991.
 324. Rogers, M. J., R. Moore, and J. Cohen. The relationship between faecal endotoxin and faecal microflora of the C57BL mouse. J. Hyg. 95: 397–402, 1985.
 325. Rokita, H., J. Bereta, A. Koj, A. H. Gordon, and J. Gauldie. Epidermal growth factor and transferring growth factor‐β differently modulate the acute phase response elicited by interleukin‐6 in cultured liver cells from man, rat and mouse, Comp. Biochem. Physiol. 95A: 41–45, 1990.
 326. Romagnani, S. Induction of TH1 and TH2 responses: a key role for the “natural” immune response? Immunol. Today 13: 379–381, 1992.
 327. Rosendorff, C., and J. J. Mooney. Central nervous system sites of action of a purified leukocyte pyrogen. Am. J. Physiol. 220: 597–603, 1971.
 328. Rosenstreich, D. L., A. C. Weinblatt, and A. D. O'Brien. Genetic control of resistance to infection in mice. Crit. Rev. Immunol. 3: 263–330, 1982.
 329. Rothwell, N. J. Metabolic responses to interleukin‐1. In: Interleukin‐1 in the Brain, edited by N. J. Rothwell and R. D. Dantzer. Oxford: Pergamon, 1992, p. 115–134.
 330. Rothwell, N. J., A. Hardwick, and L. Lindley. Central actions of interleukin‐8 in the rat are independent of prostaglandins. Horm. Metabol. Res. 22: 595–596, 1990.
 331. Rotrosen, D., H. L. Malech, and J. I. Gallin. Formyl peptide leukocyte chemoattractant uptake and release by cultured human umbilical vein endothelial cells. J. Immunol. 139: 3034–3040, 1987.
 332. Rubanyi, G. M., and L. H. Butelho. Endothelins. FASEB J. 5: 2713–2720, 1991.
 333. Rudensky, A. Y., P. Preston‐Hurlburt, S. C. Hong, A. Barlow, and C. A. Janeway. Sequence analysis of peptides bound to MHC class II molecules. Nature 353: 622–627, 1991.
 334. Ryan, G. B., and G. Majno. Acute inflammation. Am. J. Pathol. 86: 183–276, 1977.
 335. Sacco‐Gibson, N., and J. P. Filkins. Glucoregulatory effects of interleukin‐1: implications to the carbohydrate dyshomeostasis of septic shock. Prog. Clin. Biol. Res. 264: 355–360, 1988.
 336. Sacerdote, P., M. Bianchi, P. Ricciardi‐Castagnoli, and A. E. Panerai. Tumor necrosis factor alpha and interleukin‐1 alpha increase pain thresholds in the rat. Ann. N. Y. Acad. Sci. 650: 197–201, 1992.
 337. Saigh, J. H., C. C. Sanders, and W. E. Sanders. Inhibition of Neisseria gonorrhoeae by aerobic and facultatively anaerobic components of the endocervical flora: evidence for a protective effect against infection. Infect. Immun. 19: 704–710, 1978.
 338. Saigusa, T. Participation of interleukin‐1 and tumor necrosis factor in the responses of the sympathetic nervous system during lipopolysaccharide‐induced fever. Pflügers Arch. 416: 225–229, 1989.
 339. Scarborough, D. E. Cytokine modulation of pituitary hormone secretion. Ann. N. Y. Acad. Sci. 594: 169–187, 1990.
 340. Scarborough, D. E. Somatostatin regulation by cytokines, Metabolism 39 (suppl. 2): 108–111, 1990.
 341. Schaedler, R. W., and R. P. Orcutt. Gastrointestinal microflora. In: The Mouse in Biomedical Research, edited by H. L. Foster, J. D. Small, and J. G. Fox. New York: Academic, 1983, vol. III, p. 327–345.
 342. Scheffel, J. W., and Y. B. Kim. Role of environment in the development of “natural” hemagglutinins in Minnesota miniature swine. Infect. Immun. 26: 202–210, 1979.
 343. Schindler, R., J. Mancilla, S. Endres, R. Ghorbani, S. C. Clark, and C. A. Dinarello. Correlations and interactions in the production of interleukin‐6 (IL‐6), IL‐1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL‐6 suppresses IL‐1 and TNF. Blood 75: 40–47, 1990.
 344. Schneerson, R., and J. B. Robbins. Induction of serum Haemophilus influenzae type B capsular antibodies in adult volunteers fed cross‐reacting Escherichia coli 075: K100: H5. N. Engl. J. Med. 292: 1093–1096, 1975.
 345. Schöbitz, B., D. A. M. Voorhuis, and E. R. DeKloet. Localization of interleukin‐6 mRNA and interleukin‐6 receptor mRNA in rat brain. Neurosci. Lett. 136: 189–192, 1992.
 346. Schreiber, G. A., A. Tsykin, A. R. Aldred, T. Thomas, W. P. Fung, P. W. Dickson, T. Cole, H. Birch, F. A. De Jong, and J. Milland. The acute‐phase response in the rodent. Ann. N. Y. Acad. Sci. 557: 61–85, 1989.
 347. Segal, P. B., G. Grieninger, and G. Tosato (Eds). Regulation of the acute phase and immune responses: interleukin‐6. Ann. N. Y. Acad. Sci. 557: 1–583, 1989.
 348. Seganti, L., M. Grassi, P. Mastromarino, A. Pan'a, F. Superti, and N. Orsi. Activity of human serum lipoproteins on the infectivity of rhabdoviruses. Microbiology 6: 91–99, 1983.
 349. Selwyn, S. Natural antibiosis among skin bacteria as a primary defense against infection. Br. J. Dermatol. 93: 487–493, 1975.
 350. Seydoux, J., J. Llanos‐Q, and C. M. Blatteis. Possible involvement of the ventromedial hypothalamus (VMH) in fever production, Federation Proc. 44: 438, 1985.
 351. Shibata, M., and C. M. Blatteis. Differential effects of cytokines on thermosensitive neurons in guinea pig preoptic area slices, Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 32): R1096–R1103, 1991.
 352. Shoham, S., and J. M. Krueger. Muramyl dipeptide‐induced sleep and fever: effects of ambient temperature and time of injections, Am. J. Physiol. 255 (Regulatory Integrative Comp. Physiol. 26): R157–R165, 1988.
 353. Silverstein, R. The endocrine response to endotoxin. In: Bacterial Endotoxic Lipopolysaccharides, edited by J. L. Ryan and D. C. Morrison. Boca Raton, FL: CRC, 1992, p. 295–309.
 354. Simberkoff, M. S., N. H. Moldover, and J. J. Rahal. Absence of detectable bacteriocidal and opsonic activities in normal and infected human cerebrospinal fluids. J. Lab. Clin. Med. 95: 362–372, 1980.
 355. Singer, S. J. Intercellular communication and cell‐cell adhesion. Science 255: 1671–1677, 1992.
 356. Sipe, J. D. Cellular and humoral components of the early inflammatory reaction. In: The Acute‐Phase Response to Injury and Infection, edited by A. H. Gordon and A. Koj. Amsterdam: Elsevier, 1985, p. 3–21.
 357. Sipe, J. D. The acute‐phase response. In: Immunophysiology. The Role of Cells and Cytokines in Immunity and Inflammation, edited by J. J. Oppenheim and E. M. Shevach. New York: Oxford University Press, 1990, p. 259–273.
 358. Skamene, E. Genetic control of susceptibility to mybobacterial infection, Rev. Infect. Dis. 11: S394–S399, 1989.
 359. Small, J. D. Fatal enterocolitis in hamsters given lincomycin hydrochloride. Lab. Anim. Care 18: 411–420, 1968.
 360. Smith, D. H., G. Peter, D. L. Ingram, A. L. Harding, and P. Anderson. Responses of children immunized with capsular polysaccharide of Haemophilus influenzae. Pediatrics 52: 637–665, 1973.
 361. Smith, H. Microbial surfaces in relation to pathogenicity. Bact. Rev. 41: 475–500, 1977.
 362. Smith, W., T. K. Kishimoto, O. Abbass, B. Hughes, R. Rothlein, L. V. McIntire, E. Butcher, and D. C. Anderson. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM‐1)—dependent neutrophil adhesion to cytokine‐stimulated endothelial cells in vitro. J. Clin. Invest. 87: 609–618, 1991.
 363. Southorn, P. A., and G. Powis. Free radicals in medicine. Mayo Clin. Proc. 63: 381–408, 1988.
 364. Spangelo, B. L., and R. M. MacLeod. Regulation of the acute‐phase response and neuroendocrine function by interleukin‐6. Prog. Neuroendocrinimmunol. 3: 167–175, 1990.
 365. Spatz, M., D. W. E. Smith, E. G. McDaniel, and G. L. Laqueur. Role of intestinal microorganisms in determining cycasin toxicity. Proc. Soc. Exp. Biol. Med. 124: 691–697, 1967.
 366. Springer, T. A. Adhesion receptors of the immune system. Nature 346: 425–434, 1990.
 367. Sprunt, K., and W. Redman. Evidence suggesting importance of role of interbacterial inhibition in maintaining balance of normal flora. Ann. Intern. Med. 68: 579–590, 1968.
 368. Stedler, J., B. G. Harbrecht, M. DiSilvio, R. D. Curran, M. L. Jordan, R. L. Simmonds, and T. R. Billar. Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin‐6 by rat Kupffer cells. J. Leukoc. Biol. 53: 165–172, 1993.
 369. Stern, P., M. Gidlund, A. Orn, and H. Wigzell. Natural killer cells mediate lysis of embryonal carcinoma cells lacking MHC. Nature 285: 341–342, 1980.
 370. Stevens, R. L., and K. F. Austen. Recent advances in the cellular and molecular biology of mast cells. Immunol. Today 10: 381–386, 1989.
 371. Stitt, J. T. Fever versus hyperthermia. Federation Proc. 38: 39–43, 1979.
 372. Stitt, J. T. Differential sensitivity in the sites of fever production by prostaglandin E1 within the hypothalamus of the rat. J. Physiol. (Lond.) 432: 99–110, 1991.
 373. Stott, E. J., and R. A. Killington. Rhinoviruses. Annu. Rev. Microbiol. 26: 503–524, 1972.
 374. Suegara, N., M. Morotomi, T. Watanabe, Y. Kawai, and M. Mutai. Behavior of microflora in the rat stomach: adhesion of lactobacilli to the keratinized epithelial cells of rat stomach in vitro. Infect. Immun. 12: 173–179, 1975.
 375. Székely, M., and Z. Szelényi. The pathophysiology of fever in the neonate. In: Pyretics and Antipyretics, edited by A. S. Milton. Berlin: Springer, 1982, p. 479–528.
 376. Tamaki, Y., and T. Nakayama. Effects of air constituents on thermosensitivities of preoptic neurons: hypoxia versus hypercapnia. Pflügers Arch. 409: 1–6, 1987.
 377. Templeton, J. W., R. Smith, and G. Adams. Natural disease resistance in domestic animals. J. Am. Vet. Med. Assoc. 192: 1306–1315, 1988.
 378. Tizard, I. Immunity in the fetus and newborn animal. In: An Introduction to Veterinary Immunology. Philadelphia: Saunders, 1974, p. 165–177.
 379. Thadepalli, H., W. H. Chan, J. E. Maidman, and E. C. Davidson. Microflora of the cervix during normal labor and the puerperium. J. Infect. Dis. 137: 568–572, 1978.
 380. Toth, L. A., and J. M. Krueger. Alterations in sleep during Staphylococcus aureus infection in rabbits. Infect. Immun. 56: 1785–1791, 1988.
 381. Toth, L. A., and J. M. Krueger. Effects of microbial challenge on sleep in rabbits. FASEB J. 3: 2062–2066, 1989.
 382. Toth, L. A., and J. M. Krueger. Somnogenic, pyrogenic, and hematologic effects of experimental pasteurellosis in rabbits, Am. J. Physiol. 258 (Regulatory Integrative Comp. Physiol. 29): R536–R542, 1990.
 383. Toth, L. A., E. A. Tolley, and J. M. Krueger. Sleep as a prognostic indicator during infectious disease in rabbits. Proc. Soc. Exp. Biol. Med. 203: 179–192, 1993.
 384. Tracey, K. J., and A. Cerami. Metabolic responses to cachectin/TNF. A brief review. Ann. N. Y. Acad. Sci. 587: 325–331, 1990.
 385. Tracey, K. J., and A. Cerami. Tumor necrosis factor and regulation of metabolism in infection: role of systemic versus tissue levels. Proc. Exp. Soc. Biol. Med. 200: 233–239, 1992.
 386. Tracey, K. J., S. Morgello, B. Koplin, T. J. Fahey III, J. Fox, and A. Aledo. Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. J. Clin. Invest. 86: 2014–2024, 1990.
 387. Tredget, E. E., Y. M. Yu, S. Zhong, R. Burini, S. Okusawa, J. A. Gelfand, C. A. Dinarello, V. R. Young, and J. F. Burke. Role of interleukin‐1 and tumor necrosis factor on energy metabolism in rabbits, Am. J. Physiol. 255 (Endocrinol. Metab. 18): E760–E768, 1988.
 388. Tupasi, T. E., M. A. Velmonte, M. E. G. Sanvictores, L. Abraham, L. E. De Leon, S. A. Tan, C. A. Miguel, and M. C. Saniel. Determinants of morbidity and mortality due to acute respiratory infections: implications for intervention. J. Infect. Dis. 157: 615–623, 1988.
 389. Uehara, A., T. Okumura, Y. Kumei, Y. Takasugi, and M. Namiki. Indomethacin reverses interleukin‐1‐induced hyperin‐sulinemia in conscious and freely moving rats. Eur. J. Pharmacol. 192: 185–187, 1992.
 390. Uehara, A., T. Okumura, C. Sekiya, K. Okamura, Y. Takasugi, and M. Namiki. Interleukin‐1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin. Biochem. Biophys. Res. Commun. 162: 1578–1581, 1989.
 391. Ulevitch, R. J., A. R. Johnston, and D. B. Weinstein. New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides. J. Clin. Invest. 64: 1516–1524, 1979.
 392. Unanue, E. R., and P. M. Allen. The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236: 551–557, 1987.
 393. Valinger, Z., B. Ladesic, and J. Tomasic. Partial purification and characterization of N‐acetylmuramyl‐L‐alanine amidase from human and mouse serum. Biochim. Biophys. Acta 701: 63–71, 1982.
 394. Vandenbroucke‐Grauls, C. M. J. E., and J. Verhoef. Bacteria, phagocytes, and bystander cells: interactions between Staphylococcus aureus, polymorphonuclear leukocytes, and endothelial cells. Pathol. Immunopathol. Res. 7: 149–161, 1988.
 395. van der Waaij, D. Colonization pattern of the digestive tract by potentially pathogenic microorganisms: colonization‐controlling mechanisms and consequences for antibiotic treatment, Infection 11: S90–S92, 1983.
 396. van der Waaij, D., J. M. Berghuis, and J. E. C. Lekkerkerk. Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. J. Hyg. 70: 605–610, 1972.
 397. van Eden, W., N. M. Gonzalez, R. R. P. de Vries, J. Convit, and J. J. van Rood. HLA‐linked control of predisposition to lepromatous leprosy. J. Infect. Dis. 151: 9–14, 1985.
 398. Van Epps, D. E., J. G. Bender, S. J. Simpson, and D. E. Chenoweth. Relationship of chemotactic receptors for formyl peptide and C5a to CR1, CR3, and Fc receptors on human neutrophils. J. Leukocyte Biol. 47: 519–527, 1990.
 399. Vanhoutte, P. M. Platelet‐derived serotonin, the endothelium and cardiovascular disease, J. Cardiovasc. Pharmacol. 17 (suppl. 5): S6–S12, 1991.
 400. Vankelecom, H., P. Carmeliet, H. Heremans, J. van Damme, R. Dijkmans, A. Billiau, and C. Denef. Interferon‐γ inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures. Endocrinology 126: 2919–2926, 1990.
 401. Vermeulon, M. W., and G. R. Grey. Processing of Bacillus subtilis peptidoglycan by a mouse macrophage cell line. Infect. Immun. 46: 476–483, 1984.
 402. Vitetta, E. S., R. Fernandez‐Botran, C. D. Myers, and V. M. Sanders. Cellular interactions in the humoral immune response. Adv. Immunol. 45: 1–105, 1992.
 403. Vogel, S. N., S. S. Douches, E. N. Kaufman, and R. Neta. Induction of colony stimulating factor in vivo by recombinant interleukin‐1 and recombinant tumor necrosis factor. J. Immunol. 138: 2143–2148, 1987.
 404. von Liebermeister, C. Handbuch der Pathologie und Therapie des Fiebers. Leipzig: Vogel, 1875.
 405. Wakasugi, N., and J. L. Virelizier. Defective IFN‐γ production in the human neonate. I. Dysregulation rather than intrinsic abnormality. J. Immunol. 134: 167–171, 1985.
 406. Wakasugi, N., J. L. Virelizier, F. Arenzana‐Seisdedos, B. Rothgut, J. M. M. Huerta, F. Russo‐Marie, and W. Fiers. Defective IFN‐γ production in the human neonate. II. Role of increased sensitivity to the suppressive effects of prostaglandin E. J. Immunol. 134: 172–176, 1985.
 407. Walton, P. E., and M. J. Cronin. Tumor necrosis factor‐α inhibits growth hormone secretion from cultured anterior pituitary cells. Endocrinology 125: 925–929, 1989.
 408. Wan, W., L. Janz, C. Y. Vriend, C. M. Sorensen, A. H. Greenberg, and D. M. Nance. Differential induction of c‐fos immunoreactivity in hypothalamus and brain stem nuclei following central and peripheral administration of endotoxin. Brain Res. Bull. 32: 581–587, 1993.
 409. Ward, P. A., J. S. Warren, J. Varani, and K. J. Johnson. PAF, cytokines, toxic oxygen products and cell injury. Mol. Aspects Med. 12: 169–174, 1991.
 410. Warner, R. G., and F. R. Ehle. Nutritional idiosyncrasies of the golden hamster (Mesocricetus auratus). Lab. Anim. Sci. 26: 670–673, 1976.
 411. Weiss, J., M. Victor, and P. Elsbach. Role of charge and hydrophobic interactions in the action of bactericidal/permeability‐increasing protein of neutrophils on gram‐negative bacteria. J. Clin. Invest. 71: 540–549, 1983.
 412. Wells, C. L., M. A. Maddaus, and R. L. Simmons. Proposed mechanisms for the translocation of intestinal bacteria. Rev. Infect. Dis. 10: 958–979, 1988.
 413. Wilson, C. B., and D. B. Lewis. Basis and implications of selectively diminished cytokine production in neonatal susceptibility to infection, Rev. Infect. Dis. 12: S410–S420, 1990.
 414. Wing, E. J., and J. R. Young. Acute starvation protects mice against Listeria monocytogenes. Infect. Immun. 28: 771–776, 1980.
 415. Wolfe, R. R. Glucose metabolism in sepsis and endotoxicosis. In: Infection: The Physiologic and Metabolic Responses of the Host, edited by M. C. Powanda and P. G. Canonico. Amsterdam: Elsevier, 1987, p. 213–243.
 416. Wostmann, B. S. Intestinal bile acids and cholesterol absorption in the germfree rat. J. Nutr. 103: 982–990, 1973.
 417. Wright, D. G. The neutrophil as a secretory organ of host defense. In: Advances in Host Defense Mechanisms, edited by J. I. Gallin and A. S. Fauci. New York: Raven, 1982, vol. 1, p. 75–110.
 418. Wright, S. D. Receptors for complement and the biology of phagocytosis. In: Inflammation: Basic Principles and Clinical Correlates (2nd ed.), edited by J. I. Gallin, I. M. Goldstein, and R. Snyderman. New York: Raven, 1992, p. 477–495.
 419. Wu, K. K. Endothelial cells in hemostasis, thrombosis, and inflammation. Hosp. Pract. 27: 145–166, 1992.
 420. Xin, L., and C. M. Blatteis. Blockade of interleukin‐1 receptor antagonist (IL1ra) of IL1β‐induced neuronal activity in guinea pig preoptic area slices. Brain Res. 569: 348–352, 1992.
 421. Yamaguchi, M., K. Koike, Y. Yoshimoto, H. Ikegami, A. Miyake, and O. Tanizawa. Effect of TNF‐α on prolactin secretion from rat anterior pituitary and dopamine release from the hypothalamus: comparison with the effect of interleukin‐1β. Endocrinol. Japan. 38: 357–361, 1991.
 422. Yasmineh, W. G. A., Theologides. Effects of tumor necrosis factor on enzymes of gluconeogenesis in the rat. Proc. Soc. Exp. Biol. Med. 199: 97–103, 1992.
 423. Young, J. D., H. Hengartner, E. R. Podack, and Z. A. Cohn. Purification and characterization of a cytolytic pore‐forming protein from granules of cloned lymphocytes with natural killer activity. Cell 44: 849–859, 1988.
 424. Zaslof, M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA 84: 5449–5453, 1987.
 425. Zawalich, W. S., and K. C. Zawalich. Interleukin‐1 is a potent stimulus of islet insulin secretion and phosphoinositide hydrolysis, Am. J. Physiol. 256 (Endocrinol. Metab. 19): E19–E24, 1989.
 426. Zeigler, A. R., C. U. Tuazon, and J. N. Sheagren. Antibody levels to bacterial peptidoglycan in human sera during the time course of endocarditis and bacteremic infections caused by Staphylococcus aureus. Infect. Immun. 33: 795–800, 1981.
 427. Zeisberger, E. Antipyretic action of vasopressin in the ventral septal area of the guinea pig brain. In: Thermoregulation: Research and Clinical Applications, edited by P. Lomax and E. Schönbaum. Basel: Karger, 1989, p. 65–68.
 428. Zeisberger, E. The role of septal peptides in thermoregulation and fever. In: Thermoreception and Temperature Regulation, edited by J. Bligh and K. Voight. Berlin: Springer, 1990, p. 274–283.
 429. Ziegler, E. J., H. Douglas, J. E. Sherman, C. E. Davis, and A. I. Braude. Treatment of E. coli and Klebsiella bacteremia in agranulocytic animals with antiserum to a UDP‐gal epimerase‐deficient mutant. J. Immunol. 111: 433–438, 1973.
 430. Zinkernagel, R. M., and P. C. Doherty. H‐2 compatibility requirement for T‐cell‐mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J. Exp. Med. 141: 1427–1436, 1975.
 431. Zinkernagel, R. M., and P. C. Doherty. MHC‐restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T‐cell restriction‐specificity, function, and responsiveness. Adv. Immunol. 27: 51–177, 1979.
 432. Zipori, D. Regulation of hemopoiesis by cytokines that restrict options for growth and differentiation. Cancer Cells 2: 205–211, 1990.
 433. Zuckerman, S. H., and A. M. Bendele. Regulation of serum tumor necrosis factor in glucocorticoid‐sensitive and ‐resistant rodent endotoxin shock models. Infect. Immun. 57: 3009–3013, 1989.
 434. Zuckerman, S. H., J. Shellhaas, and L. D. Butler. Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis. Eur. J. Immunol. 19: 301–305, 1989.

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Linda A. Toth, Clark M. Blatteis. Adaptation to the Microbial Environment. Compr Physiol 2011, Supplement 14: Handbook of Physiology, Environmental Physiology: 1489-1519. First published in print 1996. doi: 10.1002/cphy.cp040266