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Physiological Responses to Natriuretic Hormones

Mark L. Zeidel

10.1002/cphy.cp070311

Source: Supplement 22: Handbook of Physiology, The Endocrine System, Endocrine Regulation of Water and Electrolyte Balance

Originally published: 2000

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Cellular Actions of Natriuretic Peptides
1.1 The Family of Natriuretic Peptides
1.2 Natriuretic Peptide Receptors
1.3 Natriuretic Peptide Signaling
2 Adrenal and Other Endocrine Actions of Natriuretic Peptides
3 Regulation of Blood Pressure by Natriuretic Peptides
3.1 Regulation of Autonomic Reflexes
3.2 Cardiac Output
3.3 Peripheral Vascular Resistance
3.4 Distribution of Fluid Between Intravascular and Extravascular Compartments
3.5 Integrative Effects on Blood Pressure
3.6 Growth of Vascular Cells
4 Renal Actions of Natriuretic Peptides
4.1 Renal Hemodynamics
4.2 Renal Epithelial Actions
4.3 Integrative Effects on Renal Function
5 Integrative Physiology of Natriuretic Peptides
5.1 Roles in Normal Physiology and Disease
6 Summary and Future Directions
Figure 1. Figure 1.

Model of atrial natriuretic factor (ANP) generation and release in atrial myocytes. AA, amino acids.
Figure 2. Figure 2.

Amino Acid Structures of human urodilutin (human URO), human ANF (human ANP), human CNP, and Pig BNP.
Figure 3. Figure 3.

Structural domains of natriuretic peptide receptors (NPR). The different domains, their relative homologies to each other (percentages with arrows), and their amino acid lengths are shown. AA, amino acids.
Figure 4. Figure 4.

Pathways of natriuretic peptide regulation of blood pressure. In the upper, unshaded portion of the figure, the blood pressure‐lowering effects of atrial natriuretic factor are outlined. In the lower shaded portion of the figure, the counterregulatory responses to reduced blood pressure are listed.
Figure 5. Figure 5.

Coordinate actions of atrial natriuretic factor, increasing salt and water excretion along the nephron. GFR, glomerular filtration rate; AII, angiotensin II; ADH, antidiuretic hormone. See text for details.
Figure 6. Figure 6.

Model of atrial natriuretic factor (ANP) inhibition of Na+ reabsorption in the inner medullary collecting duct. On the left is the apical or luminal surface of the cell; on the right is the basolateral membrane. BNP, brain natriuretic peptide; URO, urodilatin; NPR, natriuretic peptide receptor.


Figure 1.

Model of atrial natriuretic factor (ANP) generation and release in atrial myocytes. AA, amino acids.



Figure 2.

Amino Acid Structures of human urodilutin (human URO), human ANF (human ANP), human CNP, and Pig BNP.



Figure 3.

Structural domains of natriuretic peptide receptors (NPR). The different domains, their relative homologies to each other (percentages with arrows), and their amino acid lengths are shown. AA, amino acids.



Figure 4.

Pathways of natriuretic peptide regulation of blood pressure. In the upper, unshaded portion of the figure, the blood pressure‐lowering effects of atrial natriuretic factor are outlined. In the lower shaded portion of the figure, the counterregulatory responses to reduced blood pressure are listed.



Figure 5.

Coordinate actions of atrial natriuretic factor, increasing salt and water excretion along the nephron. GFR, glomerular filtration rate; AII, angiotensin II; ADH, antidiuretic hormone. See text for details.



Figure 6.

Model of atrial natriuretic factor (ANP) inhibition of Na+ reabsorption in the inner medullary collecting duct. On the left is the apical or luminal surface of the cell; on the right is the basolateral membrane. BNP, brain natriuretic peptide; URO, urodilatin; NPR, natriuretic peptide receptor.

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Article Title: Physiological Responses to Natriuretic Hormones
 

How to Cite

Mark L. Zeidel. Physiological Responses to Natriuretic Hormones. Compr Physiol 2011, Supplement 22: Handbook of Physiology, The Endocrine System, Endocrine Regulation of Water and Electrolyte Balance: 410-435. First published in print 2000. doi: 10.1002/cphy.cp070311