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Tubular Transport of Monocarboxylates, Krebs Cycle Intermediates, and Inorganic Sulfate

Heini Murer, Michel Manganel, Françoise Roch‐Ramel

10.1002/cphy.cp080247

Source: Supplement 25: Handbook of Physiology, Renal Physiology

Originally published: 1992

Published online: January 2011

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 Overall Renal Handling
1.1 Mono‐, Di‐, and Tricarboxylates
1.2 Sulfate and Thiosulfate
2 Tubular Handling as Studied by Micropuncture and Microperfusion
2.1 Monocarboxylates
2.2 Di‐ftricarboxylates
2.3 Sulfate/Thiosulfate
3 Transport in Isolated Membrane Vesicles
3.1 Monocarboxylates
3.2 Di‐ltricarboxylates
3.3 Sulfate/Thiosulfate
4 Characterization of Proteins Involved in Transmembrane Transport
4.1 Reconstitution of Mono‐, Di‐, and Tricarboxylate Transport in Artificial Liposomes
4.2 Partial Purification of a Dicarboxylic Acid‐Binding Protein
4.3 Identification of a Protein Involved in Basolateral Sulfate Transport
5 Cellular Models
5.1 Monocarboxylates
5.2 Di‐/tricarboxylates
5.3 Sulfate/Thiosulfate
Figure 1. Figure 1.

Summary of work of Ullrich et al. 126,127,128 regarding structural requirements for active reabsorption of monocarboxylates in rat proximal tubule in situ, a: aliphatic acid analogs that inhibit transport of d‐lactate. b: analogs of aliphatic acids that do not inhibit d‐lactate transport, c: benzoate and substituted analogs that inhibit transport of d‐lactate. d: substitutes that do not inhibit d‐lactate transport. Alternative substances are shown for individual positions.

Adapted from Ullrich et al. 129
Figure 2. Figure 2.

Reaction scheme for kinetics of succinate uptake by renal brush borders. Carrier on cis side (Cc) of membrane combines with cis sodium and succinate in ordered fashion, whereas dissociation of substrates at trans side (Ct) is random.

From Wright 146
Figure 3. Figure 3.

Structural specificity for dicarboxylic acid binding to renal brush border transporter. Optimal structure is shown, and, at each position, C1 (carboxyl residue), R1, and R2, acceptable analogs (above lines) and unacceptable analogs (below lines) are indicated

From Wright 146
Figure 4. Figure 4.

Cellular scheme for membrane transport systems and their functions in renal proximal tubular reabsorption of monocarboxylates. Boxes with solid lines indicate major aliphatic monocarboxylate substrates. Anions in boxes with dashed lines also interact with transport systems.
Figure 5. Figure 5.

Cellular scheme for membrane transport systems and their functions in renal proximal tubular reabsorption/secretion of aliphatic di‐/tricarboxylates. Boxes with solid lines indicate major substrates. Anions in boxes with dashed lines also interact with transport systems.
Figure 6. Figure 6.

Cellular scheme for membrane transports and their functions in renal proximal tubular reabsorption/secretion of sulfate/thiosulfate. Inorganic anions accepted by the systems are in solid boxes. Other anions interacting with transport pathway are in boxes with dashed lines.


Figure 1.

Summary of work of Ullrich et al. 126,127,128 regarding structural requirements for active reabsorption of monocarboxylates in rat proximal tubule in situ, a: aliphatic acid analogs that inhibit transport of d‐lactate. b: analogs of aliphatic acids that do not inhibit d‐lactate transport, c: benzoate and substituted analogs that inhibit transport of d‐lactate. d: substitutes that do not inhibit d‐lactate transport. Alternative substances are shown for individual positions.

Adapted from Ullrich et al. 129


Figure 2.

Reaction scheme for kinetics of succinate uptake by renal brush borders. Carrier on cis side (Cc) of membrane combines with cis sodium and succinate in ordered fashion, whereas dissociation of substrates at trans side (Ct) is random.

From Wright 146


Figure 3.

Structural specificity for dicarboxylic acid binding to renal brush border transporter. Optimal structure is shown, and, at each position, C1 (carboxyl residue), R1, and R2, acceptable analogs (above lines) and unacceptable analogs (below lines) are indicated

From Wright 146


Figure 4.

Cellular scheme for membrane transport systems and their functions in renal proximal tubular reabsorption of monocarboxylates. Boxes with solid lines indicate major aliphatic monocarboxylate substrates. Anions in boxes with dashed lines also interact with transport systems.



Figure 5.

Cellular scheme for membrane transport systems and their functions in renal proximal tubular reabsorption/secretion of aliphatic di‐/tricarboxylates. Boxes with solid lines indicate major substrates. Anions in boxes with dashed lines also interact with transport systems.



Figure 6.

Cellular scheme for membrane transports and their functions in renal proximal tubular reabsorption/secretion of sulfate/thiosulfate. Inorganic anions accepted by the systems are in solid boxes. Other anions interacting with transport pathway are in boxes with dashed lines.

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Article Title: Tubular Transport of Monocarboxylates, Krebs Cycle Intermediates, and Inorganic Sulfate
 

How to Cite

Heini Murer, Michel Manganel, Françoise Roch‐Ramel. Tubular Transport of Monocarboxylates, Krebs Cycle Intermediates, and Inorganic Sulfate. Compr Physiol 2011, Supplement 25: Handbook of Physiology, Renal Physiology: 2165-2188. First published in print 1992. doi: 10.1002/cphy.cp080247