Comprehensive Physiology Wiley Online Library

Chemical Agents from Occupational Sources

Full Article on Wiley Online Library


The sections in this article are:

1 Effective Physiological Activity
2 Acids and Alkalies
3 Chemical Carcinogens
4 Plastics
5 Production Hazards
6 Processing Hazards
7 Concluding Remarks
 1. Agricola, G. Re Metallica, Basel, 1556, translated by H. C. Hoover and L. H. Hoover, London: The Mining Magazine, 1912.
 2. Akhmeteli, M. A., A. B. Linnik, and K. S. Cernov. Hepatocarcinogenesis and the appearance of serum alpha‐fetoprotein in mice treated with extracts of barley grain infected with Fusarium trichioides. Bull. World Health Organ. 47: 663–664, 1972.
 3. Aksoy, M., S. Erdem, and G. Dincol. Leukemia in shoe workers exposed chronically to benzene. Blood 44: 837–841, 1974.
 4. American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values for Substances in Workroom Air (3rd ed). Cincinnati, Ohio 1971.
 5. American Conference of Governmental Industrial Hygienists. TLVs,® Threshold Limit Values for Chemical Substances and Physical Agents in the Workroom Environment with Intended Changes for 1973. Cincinnati, Ohio, 1973.
 6. Arcos, J. C., and M. F. Argus. Chemical Induction of Cancer. Structural Bases and Biological Mechanisms. New York: Academic, 1974, vol. LIB.
 7. Ashley, L. M., J. E. Halver, and G. N. Wogan. Hepatoma and aflatoxicosis in trout. Federation Proc. 23: 105, 1964.
 8. Ball, W. L., K. Kay, and J. W. Sinclair. Observations on toxicity of aldrin: growth and estrus in rats. A.M.A. Arch. Ind. Hyg. Occup. Med. 7: 292–300, 1953.
 9. Bingham, E., and H. L. Falk. Combined action of optical brighteners and ultraviolet light in the production of tumours. Food Cosmet. Toxicol. 8: 173–176, 1970.
 10. Blair, D., E. C. Hoadley, and D. H. Hutson. The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration. Toxicol. Appl. Pharmacol. 31: 243–253, 1975.
 11. Bonser, G. M., L. Bradshaw, D. B. Clayson, and J. W. Jull. A further study of the carcinogenic properties of orthohydroxyamines and related compounds by bladder implantation in the mouse. Brit. J. Cancer 10: 539–546, 1956.
 12. Bonser, G. M., D. B. Clayson, and J. W. Jull. The induction of tumours of the subcutaneous tissues, liver and intestine in the mouse by certain dyestuffs and their intermediates. Brit. J. Cancer 10: 653–667, 1956.
 13. Bonser, G. M., D. B. Clayson, and J. W. Jull. Some aspects of the experimental induction of tumors of the bladder. Brit. Med. Bull. 14: 146–152, 1958.
 14. Bonser, G. M., D. B. Clayson, J. W. Jull, and L. N. Pyrah. The carcinogenic activity of 2‐naphthylamine. Brit. J. Cancer 10: 533–538, 1956.
 15. Bontoyan, W. R., J. B. Looker, T. E. Kaiser, P. Giang, and B. M. Olive. Survey of ethylene thiourea in commercial ethylenebisdithiocarbamate formulations. J. Assoc. Offic. Anal. Chem. 55: 923–925, 1972.
 16. Borkovec, A. B. Sexual sterilization of insects by chemicals. Science 137: 1034–1037, 1962.
 17. Borkovec, A. B. Insect chemosterilants: their chemistry and application. Residue Rev. 6: 87–103, 1964.
 18. Boyland, E., and G. Watson. 3‐hydroxyanthranilic acid, a carcinogen produced by endogenous metabolism. Nature 177: 837–838, 1956.
 19. Buckley, S. M., C. C. Stock, R. P. Parker, M. L. Crossley, E. Kuh, and D. R. Seeger. Inhibition studies of some phosphoramides against Sarcoma 180. Proc. Soc. Exptl. Biol. Med. 78: 299–305, 1951.
 20. Butlin, H. T. Cancer of the scrotum in chimney sweeps and others; Lectures II and III. Brit. Med. J. 2: 1–6 and 66–71, 1892.
 21. Carnaghan, R. B. A. and M. Crawford. Relationship between ingestion of aflatoxin and primary liver cancer. Brit. Vet. J. 120: 201–204, 1964.
 22. Case, R. A. M., and M. E. Hooker. Tumour of the urinary bladder as an occupational disease in the rubber industry in England and Wales. Brit. J. Preventive & Social Med. 8: 39–50, 1954.
 23. Case, R. A. M., M. E. Hooker, D. B. McDonald, and J. T. Pearson. Tumours of urinary bladder in workmen engaged in manufacture and use of certain dyestuff intermediates in British chemical industry; role of aniline, benzidine, alpha‐naphthylamine and beta‐naphthylamine. Brit. J. Ind. Med. 11: 75–104, 1954.
 24. Case, R. A. M., and J. T. Pearson. Tumours of the urinary bladder in workmen engaged in manufacture and use of certain dyestuff intermediates in British chemical industry; further consideration of role of aniline and of manufacture of auramine and magenta (fuchsine) or possible causative agents. Brit. J. Ind. Med. 11: 213–216, 1954.
 25. Casida, J., and D. M. Sanderson. Solvent effects on toxicity: reaction of certain phosphorothionate insecticides with alcohols and potentiation by breakdown products. J. Agr. Food Chem. 11: 91–96, 1963.
 26. Chemical Suspected in Six Cases of Lung Cancer. Occup. Health Safety Letter 2: 6, 1972.
 27. Clayson, D. B., J. W. Jull, and G. M. Bonser. The testing of orthohydroxamines and related compounds by bladder implantation and discussion of their structural requirements for carcinogenic activity. Brit. J. Cancer 12: 222–230, 1958.
 28. Cohan, G. F. Industrial Preparation of Polyvinyl Chloride. Paper presented at Conference on Public Health Implications of Components of Plastics Manufacture. National Institute of Environmental Health Sciences, Pinehurst, N.C., July 29, 1974.
 29. Cook, J. W., C. L. Hewett, and I. Hieger. Isolation of a cancer‐producing hydrocarbon from coal tar. II. Isolation of 1,2‐ and 4,5‐benzopyrenes, perylene and 1,2‐benzanthracene. J. Chem. Soc. 1: 395, 1933.
 30. Cronkite, E. P. Evidence for radiation and chemicals as leukemogenic agents. Arch. Environ. Health. 3: 297–303, 1961.
 31. Eckardt, R. E., and R. Hindin. The health hazards of plastics. J. Occupational Med. 15: 808–819, 1973.
 32. Epstein, S. S., and H. Shafner. Chemical mutagens in the human environment. Nature 219: 385–387, 1968.
 33. Figueroa, W. G., R. Raszkowski, and W. Weiss. Lung cancer in chloromethyl methyl ether workers. New Engl. J. Med. 288: 1096–1097, 1973.
 34. Final Rules Set for Exposure to Carcinogens. Chem. Eng. News 52 (6): 12–13, 1974.
 35. Forni, A. M., A. Cappellini, E. Pacifico, and E. C. Vigliani. Chromosome changes and their evolution in subjects with past exposure to benzene. Arch. Environ. Health. 23: 385–391, 1971.
 36. Forni, A., and L. Moreo. Chromosome studies in a case of benzene‐induced erythroleukemia. European J. Cancer. 5: 459–463, 1969.
 37. Forni, A., E. Pacifico, and A. Limonta. Chromosome studies in workers exposed to benzene or toluene or both. Arch. Environ. Health. 22: 373–378, 1971.
 38. Franchi, G., S. Garattini, L. K. J. Kram, and L. M. Van Pitten. Effect of polymethacrylic acid (PMAA) on tumour metastasis. European J. Cancer 9: 383–385, 1973.
 39. Friess, S. L., D. J. Jenden, and J. R. Tureman. The toxicology of a triaryl phosphate. A.M.A. Arch. Ind. Health. 20: 253–257, 1959.
 40. Gibel, W., Kh. Lohs, G. P. Wildner, and D. Ziebarth. Tierexperimentelle Untersuchungen über die Hepatotoxische und Kanzerogene Wirkung Phosphororganischer Verbindungen. I. Mitteilung: Trichlorphon. Arch. Geschwulstforsch. 37: 303–312, 1971.
 41. Gibel, W., Kh. Lohs, G. P. Wildner, D. Ziebarth, and R. Stieglitz. Über die Kanzerogene, Hamatotoxische und Hepatotoxische Wirkung Pestizider Organische Phosphorverbindungen. Arch. Geschwulstforsch., 41: 311–328, 1973.
 42. Goldblatt, M. W. Occupational cancer of the bladder. Brit. Med. Bull. 4: 405–417, 1947.
 43. Gosalvez, M. and J. Merchan. Induction of rat mammary adenomas with the respiratory inhibitor rotenone. Cancer Res. 33: 3047–3050, 1973.
 44. Gross, S., and G. Tarragano. Modern Plastics Encyclopedia. New York: McGraw‐Hill, 1973.
 45. Growth of Polyurethane Foam Slowing Down. Chem. Eng. News 52 (21): 7, 1974.
 46. Guess, W. L. Toxicity profiles of vinyl and polyolefinic plastics and their additives. J. Biomed. Mater. Res. 2: 313–335, 1968.
 47. Halver, J. E. Crystalline aflatoxin and other vectors for trout hepatoma. Trout hepatoma research conference papers. U. S. Fish Wildl. Serv. Res. Rept. 70: 78–102, 1967.
 48. Harris, D. K. Polymer‐fume fever. Lancet 2: 1008–1011, 1951.
 49. Harris, D. K. Some hazards in the manufacture and use of plastics. Brit. J. Ind. Med. 16: 221–229, 1959.
 50. Harris, P. N., W. R. Gibson, and R. D. Dillard. The Oncogenicity of two 1,1‐diaryl‐2‐propynyl‐N‐cycloalkylcarbamates. Cancer Res. 30: 2952–2954, 1970.
 51. Harris, P. N., W. R. Gibson, and R. D. Dillard. Oncogenicity of 1‐(4‐chlorophenyl)‐1‐phenyl‐2‐propynyl carbamate for rats. Toxicol. Appl. Pharmacol. 21: 414–418, 1972.
 52. Hendry, J. A., R. F. Homer, F. L. Rose, and A. L. Walpole. Cytotoxic agents. II. Bisepoxides and related compounds. Brit. J. Pharmacol. 6: 235–255, 1951.
 53. Hendry, J. A., F. L. Rose, and A. L. Walpole. Cytotoxic agents. I. Methylolamides with tumour inhibitory activity and related inactive compounds. Brit. J. Pharmacol. 6: 201–234, 1951.
 54. Henry, M. C., C. D. Port, R. B. Bates, and D. G. Kaufman. Respiratory tract tumors induced by benzo[a]pyrene. Cancer Res. 33: 1585–1592, 1973.
 55. Henshaw, P. S., and H. L. Meyer. Minimal number of anesthetic treatments with urethane required to induce pulmonary tumors. J. Natl. Cancer Inst. 4: 523–525, 1943.
 56. Hieger, I. The spectra of cancer‐producing tars and oils and of related substances. Biochem. J. 24: 505–511, 1930.
 57. Hilgetag, G., and H. Teichmann. The alkylating properties of alkyl thiophosphates. Angew. Chem. Internatl. 4: 914–922, 1965.
 58. Hine, C. H., R. J. Guzman, M. M. Coursey, J. S. Wellington, and H. H. Anderson. An investigation of the oncogenic activity of two representative epoxy resins. Cancer Res. 18: 20–26, 1958.
 59. Hine, C. H., R. J. Guzman, M. K. Dunlap, R. Lima, and G. S. Loquvam. Studies on the toxicity of glycidaldehyde. Arch. Environ. Health. 2: 23–29, 1961.
 60. Hine, C. H., J. K. Kodama, R. J. Guzman, M. K. Dunlap, R. Lima, and G. S. Loquvam. Effects of diglycidyl ether on blood of animals. Arch. Environ. Health 2: 31–37, 1961.
 61. Hueper, W. C., and W. D. Conway. In: Chemical Carcinogenesis and Cancers. Springfield, Ill.: Thomas, 1964. p. 262, 283, 285.
 62. Hunter, D., R. R. Bomford, and D. S. Russell. Poisoning by methyl mercury compounds. Quart. J. Med. 9: 193–213, 1940.
 63. Innes, J. R. M., B. M. Ulland, M. G. Valerio, L. Petrucelli, L. Fishbein, E. R. Hart, A. J. Pallotta, R. R. Bates, H. L. Falk, J. J. Gart, M. Klein, I. Mitchell, and S. Peters. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J. Natl. Cancer Inst. 42: 1101–1114, 1969.
 64. Jaffe, W. G. Carcinogenic action of ethyl urethane on rats. Cancer Res. 7: 107–112, 1947.
 65. Jukes, T. H., and C. B. Shaffer. Antithyroid effects of aminotriazole. Science 132: 296–297, 1960.
 66. Karpov, B. D. Methyl methacrylate from the viewpoint of labor hygiene. Gigiena i. Sanit. 19: 25–28, 1954.
 67. Kay, K. Cost of compensation. Can. Labour 8: 7–10, 1963.
 68. Kay, K. Observations on the occurrence of ill‐effects from exposure to industrial chemicals. Ann. Occupational Hyg. 10: 189–202, 1967.
 69. Kay, K. Toxicology of pesticides: recent advances. Environ. Res. 6: 202–243, 1973.
 70. Kay, K. Occupational cancer risks for pesticide workers. Environ. Res. 7: 243–271, 1974.
 71. Kay, K. Conference on toxicology‐epidemiology‐health effects of pesticides. A review of the problem. Clin. Toxicol. 8: 289–300, 1975.
 72. Kennedy, A. R., and J. B. Little. Localization of polycyclic hydrocarbon carcinogens in the lung following intratracheal instillation in gelatin solution. Cancer Res. 35: 1563–1567, 1975.
 73. Kinosita, R. Researches on cancerogenesis of various chemical substances. Gann 30: 423–426, 1936.
 74. Koss, L. G., M. R. Melamed, and R. E. Kelley. Further cytologic and histologic studies of bladder lesions in workers exposed to para‐aminodiphenyl: progress report. J. Natl. Cancer Inst. 43: 233–243, 1969.
 75. Lancaster, M. C., F. P. Jenkins, and J. M. Philip. Toxicity associated with certain samples of ground nuts. Nature 192: 1095–1096, 1961.
 76. Langard, S. and T. Norseth. A cohort study of bronchial carcinomas in workers producing chromate pigments. Brit. J. Ind. Med. 32: 62–65, 1975.
 77. Laqueur, G. L., O. Mickelsen, M. G. Whiting, and L. T. Kurland. Carcinogenic properties of nuts from Cycas cirinalis L. indigenous to Guam. J. Natl. Cancer Inst. 31: 919–934, 1963.
 78. Larsen, C. D. Evaluation of the carcinogenicity of a series of carbamic acids. J. Natl. Cancer Inst. 8: 99–101, 1947–48.
 79. Laskin, S., M. Kuschner, R. T. Drew, V. P. Cappiello, and N. Nelson. Tumors of the respiratory tract induced by inhalation of bis(chloromethyl)ether. Arch. Environ. Health. 23: 135–136, 1971.
 80. Lefaux, R. Practical toxicology of plastics. Cleveland, Ohio: CRC Press, 1968.
 81. Leibman, K. Styrene Metabolism in Relation to its Toxicity. Paper presented at Conference on Public Health Implications of Components of Plastics Manufacture, National Institute of Environmental Health Sciences, Pinehurst, N.C., July 30, 1974.
 82. Leong, B. K. J., H. N. MacFarland, and W. H. Reese, Jr. Induction of lung adenomas by chronic inhalation of bis(chloromethyl) ether. Arch. Environ. Health. 22: 663–666, 1971.
 83. Lillehoj, E. B., A. Ciegler, and R. W. Detroy. Fungal Toxins. In: Essays in Toxicology, edited by Frank R. Blood. New York: Academic, 1970, p. 1–136.
 84. Linch, A. L., G. B. O'Connor, J. R. Barnes, A. S. Killian, Jr., and W. E. Neeld, Jr. Methylene‐bis‐ortho‐chloroaniline (MOCA). Evaluation of hazards and exposure control. Am. Ind. Hyg. Assoc. J. 32: 802–819, 1971.
 85. Little, J. B., and W. F. O'Toole. Respiratory tract tumors in hamsters induced by benzo[a]pyrene and polonium‐210 alpha radiation. Cancer Res. 34: 3026–3039, 1974.
 86. Loefroth, G., Ch. Kim, and S. Hussain. Alkylating property of 2,2‐dichlorovinyl dimethyl phosphate — a disregarded hazard. Environ. Mutagen. Soc. News Letter 2: 21–27, 1969.
 87. Loefroth, C., and R. Wennerberg. Methylation of purines and nicotinamide in the rat by dichlorvos. Zeit. Naturforsch. 61: 651, 1974.
 88. Ludwig, R. A., G. D. Thorn, and D. M. Miller. Studies on the mechanisms of fungicidal action of disodium ethylenebisdithiocarbamate (Nabam). Can. J. Bot. 32: 48–54, 1954.
 89. Magee, P. N., and J. M. Barnes. The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine. Brit. J. Cancer 10: 114–122, 1956.
 90. Magee, P. N., and J. M. Barnes. Induction of kidney tumours in the rat with dimethylnitrosamine (N‐nitrosodimethylamine). J. Pathol. Bact. 84: 19–31, 1962.
 91. Malten, K. E., and R. L. Zielhuis. Industrial toxicology and dermatology in the production and processing of plastics. New York, Elsevier, 1964.
 92. Maltoni, C., and G. Lefemine. Carcinogenicity bioassays of vinyl chloride. 1. Plan of the project and early results. Environ. Res. 7: 387–405, 1974.
 93. Maltoni, C., C. Sinibaldi, and C. Annoscia. Insorgenza di sarcomi sottocutanei nel ratto in sequito a iniezione locale di grallo e arancio chromo. Tumori 57: 213, 1971.
 94. Matsumoto, H., and H. H. Higa. Studies on methylazoxymethanol, the aglycone of cycasin. Biochem. J. 98: 20C–22C, 1966.
 95. McMichael, A. J., R. Spirtas, L. L. Kupper, and J. F. Gawble. Solvent exposure and leukemia among rubber workers: an epidemiological study. J. Occupational Med. 17: 234–239, 1975.
 96. Mir, G. N., W. H. Lawrence, and J. Autian. Toxicological and pharmacological actions of methacrylate monomers. I. Effects on isolated perfused rabbit heart. J. Pharm. Sci. 62: 778–782, 1973.
 97. Nettleship, A., P. S. Henshaw, and H. L. Meyer. Induction of pulmonary tumors in mice with ethyl carbamate(urethane). J. Natl. Cancer Inst. 4: 309–319, 1943.
 98. Ott, M. G., B. B. Holder, and H. L. Gordon. Respiratory cancer and occupational exposure to arsenicals. Arch. Environ. Health. 29: 250–255, 1974.
 99. Passey, R. D. Experimental soot cancer. Brit. Med. J. 2: 1112–1113, 1922.
 100. Pechiai, L., and U. Saffiotti. Study of the toxicity of diphenyl, diphenyl oxide and their mixture (Dowtherm). Med. Lavoro. 48: 247–254, 1957.
 101. Pedersen, E., A. C. Høgetveit, and A. Andersen. Cancer of respiratory organs among workers at a nickel refinery in Norway. Intern. J. Cancer 12: 32–41, 1973.
 102. Petrosini, G., F. Tafuri, and M. Businelli. Chemical modifications of dithiocarbamate fungicides during storage. Ric. Sci. Rend. Sez. B. 2: 248–257, 1962.
 103. ( Chem. Abstr. 58, 11905h.)
 104. Piver, W. T. Organotin compounds: industrial applications and biological investigation. Environ. Health Perspectives 4: 61–79, 1973.
 105. Pliss, G. B. The blastomogenic action of 3,3′‐dichlorobenzidine. Vopr. Onkol. 5: 524–533, 1959.
 106. Polyvinyl Chloride Production Will Net 8.5 Billion Pounds by 1980. Chem. Eng. News 52 (32): 6, 1974.
 107. Pott, P. Chirurgical Observations. London. Hawes, Clarke and Collings, 1775, p. 63.
 108. Poverenny, A. M., Yu. A. Siomin, A. S. Saenko, and B. I. Sinzinis. Possible mechanisms of lethal and mutagenic action of formaldehyde. Mutation Res. 27: 123–126, 1975.
 109. Preussmann, R. Direct alkylating agents as carcinogens. Food. Cosmet. Toxicol. 6: 576–577, 1968.
 110. Preussmann, R., H. Schneider, and F. Epple. Untersuchungen zum Nachweis alkylierender Agentien. II. Der Nachweis verschiedener Klassen alkylierender Agentien mit einer Modifikation der Farbreaktion mit 4‐(4‐Nitrobenzyl)‐Pyridin (NBP). Arzneimittel‐Forsch. 19: 1059–1073, 1969.
 111. Prival, M. J. Information Available to Date Relevant to the Mutagenicity of Tris(2,3‐dibromopropyl) Phosphate. Washington, D.C.: Office of Toxic Substances, Environmental Protection Agency, 1975.
 112. Rapoport, I. A. Carbonyl compounds and the chemical mechanism of mutations. Compt. Rend. Acad. Sci. URSS 54: 65–67, 1946.
 113. Rehn, L. Ueber Blasentumoren bei Fuchsinarbeitern. Arch. Klin. Chir. Berl. 1: 588–600, 1895.
 114. Roe, F. J. C., and O. M. Glendenning. The carcinogenicity of β‐propiolactone for mouse skin. Brit. J. Cancer 10: 357–362, 1956.
 115. Röhrborn, G. Mutation tests with melamine and trimethylolamine. Drosophila Inform. Serv. 33: 156, 1959.
 116. Röhrborn, G. Chemische Konstitution und mutagene Wirkung. II. Triazinderivative. Z. Verbungslehre 93: 1–6, 1962.
 117. Rose, F. L., J. A. Hendry, and A. L. Walpole. New cytotoxic agents with tumour‐inhibitory activity. Nature 165: 993–996, 1950.
 118. Saffiotti, V., F. Cefis, and L. H. Kolb. A method for experimental induction of bronchogenic carcinoma. Cancer Res. 28: 104–124, 1968.
 119. Sander, J., and G. Bürkle. Induktion maligner Tumoren bei Ratten durch gleichzeitige Verfütterung von Nitrit und sekundären Aminen. Z. Krebsforsch. 73, 54–66, 1969.
 120. Schrader, G. Konstitution und Wirkung organischer Phosphorverbindungen. Z. Naturforsch. 186: 965–975, 1963.
 121. Scott, T. S. The incidence of bladder tumours in a dyestuff factory. Brit. J. Ind. Med. 9: 127–132, 1952.
 122. Searle, C. E. Experiments on the carcinogenicity and reactivity of β‐propiolactone. Brit. J. Cancer 15: 804–811, 1961.
 123. Selikoff, I. J., E. C. Hammond, and J. Churg. Asbestos exposure, smoking and neoplasia. J. Am. Med. Assoc. 204: 106–112, 1968.
 124. Shimkin, M. B. Induced pulmonary tumors in mice. II. Reaction of lungs of strain A mice to carcinogenic hydrocarbons. Arch. Pathol. 29: 239–255, 1940.
 125. Sokol, W. N., Y. Aelony, and G. N. Beall. Meat‐wrapper's asthma. A new syndrome? J. Am. Med. Assoc. 226: 639–641, 1973.
 126. Solomin, G. J. Data substantiating maximum permissible concentration of vinyl in atmospheric air. Gigiena i. Sanit. 26 (5): 3–8, 1961.
 127. Spitz, S., W. H. Maguigan, and K. Dobriner. The carcinogenic action of benzidine. Cancer 3: 789–804, 1950.
 128. State of California, Department of Industrial Relations, Division of Labor Statistics and Research. California Work Injuries, San Francisco, California, 1949 —.
 129. Steinhoff, D. E., and E. Grundman. Cancerogene Wirkung von 3,3′‐Dichloro‐4,4′‐diaminodiphenylmethan bei Ratten. Naturwissenschaften 56: 215–216, 1969.
 130. Steinhoff, D., and E. Grundman. Zur cancerogenen Wirkung von 4,4′‐Diaminodiphenylmethan und 2,4′‐Diaminodi‐phenylmethan. Naturwissenschaften 57: 247–248, 1970.
 131. Stokinger, H. E. Advances in industrial toxicology for the year 1955. Arch. Ind. Health. 14: 206–212, 1956.
 132. Sunderman, F. W., Jr. Metal carcinogenesis in experimental animals. Food Cosmet. Toxicol. 9: 105–120, 1971.
 133. Thiess, A. M., W. Hey, and H. Zeller. Zur Toxicologie von Dichlordimethylather‐verdacht und kanzerogene Wirkung auch beim Menschen. Zbl. Arbeitsmed. 23: 97–102, 1973.
 134. Thorpe, J. J. Epidemiologic survey of leukemia in persons potentially exposed to benzene. J. Occupational Med. 16: 375–383, 1974.
 135. Three Cancer Deaths May Be Job‐Related‐E. F. Goodrich Says. Wall Street Journal, Thursday, January 24, 1974.
 136. Trasko, V. M. Occupational Disease Reporting — A Review of Current Practices Together with a Collection of Incidence Statistics. Washington, D.C.: U.S. Govt. Printing Office, 1953. (Public Health Service Bull. No. 288)
 137. Ulland, B. M., H. H. Weisburger, E. K. Weisburger, J. M. Rice, and R. Cypher. Brief communication: thyroid cancer in rats from ethylene thiourea intake. J. Natl. Cancer Inst. 49: 583–584, 1972.
 138. Umeda, M. Experimental production of sarcoma in rats by injection of rhodamine B. Gann 43: 120–122, 1952.
 139. Umeda, M. Experimental production of sarcoma in rats by injection of rhodamine B., IInd Rept. Gann 46: 369–371, 1955.
 140. Umeda, M. Production of rat sarcoma by injection of propylene glycol solution of m‐toluylenediamine. Gann 46: 597–602, 1955.
 141. Umeda, M. Experimental study of xanthene dyes as carcinogenic agents. Gann 47: 51–78, 1956.
 142. U.S. Department of Health Education and Welfare, Food and Drug Administration. Proposal to establish a zero tolerance for chlordane. Federal Register, December 5, 1963. Washington, D.C.: U.S. Govt. Printing Office, 1963.
 143. U.S. Department of Health, Education and Welfare, National Cancer Institute. Carcinogenesis bioassay of trichloroethylene (CAS, No. 79‐01‐6). Washington, D. C.: U.S. Govt. Printing Office, 1975. (Tech. Rept. Ser. No. 2, Feb. 1975, NCI‐CG‐TR‐2. DHEW publication No. (NIH) 76‐802).
 144. U.S. Department of Labor. Occupational health and environmental control — air contaminants. Federal Register 37 (No. 202): 22139–22142, 1972.
 145. Van Duuren, B. L., B. M. Goldschmidt, and B. S. Katz. Alpha‐halo ethers: a new type of alkylating carcinogen. Arch. Environ. Health. 16: 472–476, 1968.
 146. Van Duuren, B. L., C. Katz, B. M. Goldschmit, K. Frenkel, and A. Sivak. Carcinogenicity of halo ethers. II. Structure — activity relationships of analogs of bis‐(chloromethyl)ether. J. Natl. Cancer Inst. 48: 1431–1439, 1972.
 147. Van Nieuwenhuize, J. P., R. F. M. Herber, A. de Bruin, I. P. B. Meyer, and W. C. Duba. Aflatoxins: epidemiological study on carcinogenicity at chronic low‐level exposure in a factory population. Tijdschr. Soc Geneesk 51: 754–760, 1973.
 148. Vigliani, E. C., and G. Saita. Benzene and leukemia. New Engl. J. Med. 271: 872–876, 1964.
 149. Walpole, A. N. The Walker carcinoma 256 in the screening of tumour inhibitors. Brit. J. Pharmacol. 6: 135–154, 1951.
 150. Walpole, A. L. On substances inducing cancer of the bladder. Acta Unio. Intern. Concra Cancrum 19: 483, 1963.
 151. Walpole, A. L., D. C. Roberts, F. L. Rose, J. A. Hendry, and R. F. Homer. Cytotoxic agents. IV. The carcinogenic actions of some monofunctional ethyleneimine derivatives. Brit. J. Pharmacol. 9: 306–323, 1954.
 152. Walpole, A. L., and M. H. C. Williams. Toxicity of some cross‐linking agents. J. Oil Colour Chemists Assoc. 42: 694–705, 1959.
 153. Ward, J. M., J. H. Weisburger, R. S. Yamato, T. Benjamin, C. A. Brown, and E. K. Weisburger. Long‐term effect of benzene in C57B1/6N mice. Arch. Environ. Health. 30: 22–25, 1975.
 154. Weisburger, E. K., B. M. Ulland, R. L. Schueler, J. H. Weisburger, and P. N. Harris. Carcinogenicity of three dose levels of 1,4‐bis(4‐fluorophenyl)‐2‐propynyl‐N‐cyclooctyl carbamate in male Sprague‐Dawley and F344 rats. J. Natl. Cancer Inst. 54: 975–978, 1975.
 155. Wennerberg, R., and G. Loefroth. Formation of 7‐methylguanine by dichlorvos in bacteria and mice. Chem.‐Biol. Interact. 8: 339–348, 1974.
 156. Wilhelm, R., and A. C. Ivy. A Preliminary study concerning the possibility of dietary carcinogenesis. Gastroenterol. 23: 1–19, 1953.
 157. Wiluams, M. H. C. Toxicity of epoxides. Chem. Age, London 41: 863, 1959.
 158. Wiluams, M. H. C., and G. M. Bonser. Induction of hepatomas in rats and mice following the administration of aura‐mine. Brit. J. Cancer 16: 87–91, 1962.
 159. Wilson, R. H., F. De Eds, and A. J. Cox, Jr. The toxicity and carcinogenicity of 2‐acetaminofluorene. Cancer Res. 1: 595–608, 1941.
 160. Wilson, R. H., and W. E. McCormick. Plastics. The toxicology of synthetic resins. A. M .A. Arch. Ind. Health. 21: 56–68, 1960.
 161. Worker Exposure to Chromate Pigments Can Lead to “Unusually” High Cancer Risks. Chem. Eng. News 53 (41): 8, 1975.
 162. World Health Organization. International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Some Inorganic and Organometallic compounds. Lyon, France: International Agency for Research on Cancer, 1973, vol. 2.
 163. World Health Organization. International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Some Organochlorine Pesticides. Lyons, France: WHO, 1974, vol. 5.
 164. Wray, B. B., and K. G. O'Steen. Mycotoxin‐producing fungi from house associated with leukemia. Arch. Environ. Health 30: 571–577, 1975.
 165. Wyrobek, A. J., and W. R. Bruce. Chemical induction of sperm abnormalities in mice. Proc. Natl. Acad. Sci. 72: 4425–4429, 1975.
 166. Yamagiwa, K., and K. Ichikava. Experimentelle Studie über die Pathogenese der epithelial Gewulste. Mittel. med. facultat kaiser, Univ. Tokyo. 15: 296–344, 1915.
 167. Zapp, J. A., Jr. Toxic and health effects of plastics and resins. Arch. Environ. Health. 4: 125–136, 1962.

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Kingsley Kay. Chemical Agents from Occupational Sources. Compr Physiol 2011, Supplement 26: Handbook of Physiology, Reactions to Environmental Agents: 181-191. First published in print 1977. doi: 10.1002/cphy.cp090111