Comprehensive Physiology Wiley Online Library

Cellular Mechanisms During Mammalian Fertilization

Full Article on Wiley Online Library



Abstract

The sections in this article are:

1 General Introduction
2 Oogenesis and Spermatogenesis
2.1 Oogenesis: Primordial Germ Cells to Eggs
2.2 Spermatogenesis: Primordial Germ Cells to Spermatozoa
3 Final Preparation of Gametes for Fertilization
3.1 Eggs: “Meiotic Maturation”
3.2 Regulatory Aspects of Oocyte Maturation
3.3 Sperm: “Capacitation”
3.4 Sperm Activity States
4 Binding of Sperm to Eggs
4.1 Structure of the Zona Pellucida
4.2 Identification of a Mammalian Sperm Receptor
4.3 Other Mammalian Sperm Receptors
5 The Acrosome Reaction
5.1 Anatomy of the Acrosome
5.2 Stages of Exocytosis
5.3 Functions of the Acrosome Reaction during Fertilization
5.4 Site of the Acrosome Reaction
5.5 Mechanisms of the Acrosome Reaction
5.6 Initiators of Exocytosis
5.7 Conclusions
5.8 Signaling at the Sperm Plasma Membrane
5.9 Mediators of Receptor‐Activated Second‐Messenger Production in Sperm
5.10 Second‐Messenger Production
5.11 Ca2+ and Ca2+ Channels
5.12 Internal pH
5.13 Downstream Effectors of Receptor Activation
5.14 Gamete Fusion and Cortical Granule Exocytosis
5.15 Cortical Granules
5.16 Gamete Membrane Fusion and the Receptor Question
5.17 From Oolemma to Cortical Granule—Signal Transduction Pathways
References
 1. Aarons, D., T. Battle, H. Boettger‐Tong, and G. R. Poirier. Role of monoclonal antibody J‐23 in inducing acrosome reactions in capacitated mouse spermatozoa. J. Reprod. Fertil. 96: 49–59, 1992.
 2. Aarons, D., H. Boettger‐Tong, and G. R. Poirier. Acrosome reaction induced by immunoaggregation of a proteinase inhibitor bound to the murine sperm head. Mol. Reprod. Dev. 30: 258–264, 1991.
 3. Adelmen, J. P., K.‐Z. Shen, M. P. Kavanaugh, R. A. Warren, Y.‐N. Wu, A. Lagrutta, C. T. Bond, and R. A. North. Calcium‐activated potassium channels expressed from cloned complementary DNAs. Neuron 9: 209–216, 1992.
 4. Ahuja, K. K. Carbohydrate determinants involved in mammalian fertilization. Am. J. Anat. 174: 207–223, 1985.
 5. Aitken, R. J., J. S. Clarkson, M. J. Hulme, and C. J. Henderson. Analysis of calmodulin acceptor proteins and the influence of calmodulin antagonists on human spermatozoa. Gamete Res. 21: 93–111, 1988.
 6. Albertini, D. F. Regulation of meiotic maturation in the mammalian oocyte: interplay between exogenous cues and microtubule cytoskeleton. Bioessays 5: 100–105, 1992.
 7. Albertini, D. F., and E. Anderson. The appearance and structure of the intercellular connections during the ontogeny of the rabbit ovarian follicle with special reference to gap junctions. J. Cell Biol. 2: 234–250, 1974.
 8. Albertini, D. F., D. Fawcett, and P. Olds. Morphological variations in gap junctions of ovarian granulosa cells. Tissue Cell 7: 389–405, 1975.
 9. Albertini, D. F., D. Wickramasinghe, S. M. Messinger, B. A. Mattson, and C. E. Plancha. Nuclear and cytoplasmic changes during oocyte maturation. In: Preimplantation Development of the Mammalian Embryo. Serono Symposia, New York: Springer‐Verlag, 1993, p. 3–21.
 10. Almers, W. Exocytosis. Annu. Rev. Physiol. 52: 607–624, 1990.
 11. Almers, W., and F. W. TSE. Transmitter release from synapses: does a preassembled fusion pore initiate exocytosis? Neuron 4: 813–818, 1990.
 12. Amsterdam, A., R. Josephs, M. Lieberman, and H. Lindner. Organization of intramembrane particles in freeze‐cleaved gap junctions of rat graafian follicles: optical diffraction analysis. J. Cell Sci. 21: 93–105, 1976.
 13. Anderson, E., and E. Albertini. Gap junctions between the oocyte and companion follicle cells in the mammalian ovary. J. Cell Biol. 71: 680–686, 1976.
 14. Andrews, J. C., and B. D. Bavister. Capacitation of hamster spermatozoa with the divalent cation chelators D‐penicillamine, L‐histidine, and L‐cysteine in a protein‐free culture medium. Gamete Res. 23: 159–170, 1989.
 15. Aonuma, S., T. Mayumi, K. Suzuki, T. Noguchi, M. Iwai, and M. Okabe. Studies on sperm capacitation. I. The relationship between a guinea pig sperm coating antigen and a sperm capacitation phenomenon. J. Reprod. Fertil. (Abstr.) 35: 425–432, 1973.
 16. Aonuma, S., M. Okabe, and M. Kawaguchi. The effect of zinc ions on fertilization of mouse ova in vitro. J. Reprod. Fertil. 53: 179–183, 1978.
 17. Aonuma, S., M. Okabe, M. Kawaguchi, and Y. Kishi. Zinc effects on mouse spermatozoa and in vitro fertilization. J. Reprod. Fertil. 63: 463–466, 1981.
 18. Austin, C. R. Observations on the penetration of the sperm into the mammalian egg. Aust. J. Scient. Res. 4: 581–596, 1951.
 19. Austin, C. R. The ‘capacitation’ of the mammalian sperm. Nature 170: 326, 1952.
 20. Austin, C. R. Capacitation and the release of hyaluronidase from spermatozoa. J. Reprod. Fertil. 3: 310–311, 1960.
 21. Austin, C. R. The Mammalian Egg. Oxford: Blackwell Science, 1961.
 22. Austin, C. R., The egg. In: Reproduction in Mammals, Vol. 1, Germ Cells and Fertilization, edited by C. Austin, and R. Short, Cambridge: Cambridge University, 1982, p. 46–62.
 23. Austin, C. R., and M.W.H. Bishop. Role of the rodent acrosome and perforatorium in fertilization. Proc. R. Soc. Lond. [Biol.] 149: 241–248, 1958.
 24. Austin, C. R., and A.W.H. Braden. Passage of the sperm and the penetration of the egg in mammals. Nature 170: 919–921, 1952.
 25. Austin, J., and J. Kimble. glp‐1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell 50: 589–599, 1987.
 26. Austin, C., and R. Short (Eds), Reproduction in Mammals, Vol. 1, Germ Cells and Fertilization. Cambridge: Cambridge University, 1982.
 27. Baba, T., H. B. Hoff, H. Nemoto, H. Lee, J. Orth, Y. Arai, and G. L. Gerton. Acrogranin, an acrosomal cysteine‐rich glycoprotein, is the precursor of the growth‐modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells. Mol. Reprod. Dev. 34: 233–243, 1993.
 28. Babcock, D. F. Examination of the intracellular ionic environment and of ionophore action by null point measurements employing the fluorescein chromophore. J. Biol. Chem. 258: 6380–6389, 1983.
 29. Babcock, D. F. Cross talk between voltage‐dependent components of the signal transduction machinery of bovine spermatozoa. Biol. Reprod. (Abstr.) 38: 60, 1988.
 30. Babcock, D. F., M. M. Bosma, D. E. Battaglia, and A. Darszon. Early persistent activation of sperm K+ channels by the egg peptide speract. Proc. Natl. Acad. Sci. U.S.A. 89: 6001–6005, 1992.
 31. Babcock, D. F., N. L. First, and H. A. Lardy. Transport mechanism for succinate and phosphate localized in the plasma membrane of bovine spermatozoa. J. Biol. Chem. 250: 6488–6495, 1975.
 32. Babcock, D. F., and D. R. Pfeiffer. Independent elevation of cytosolic [Ca2+] and pH of mammalian sperm by voltage‐dependent and pH‐sensitive mechanisms. J. Biol. Chem. 262: 15041–15047, 1987.
 33. Babcock, D. F., G. A. Rufo, and H. A. Lardy. Potassium‐dependent increases in cytosolic pH stimulate metabolism and motility of mammalian sperm. Proc. Natl. Acad. Sci. U.S.A. 80: 1327–1331, 1983.
 34. Babcock, D. F., J. P. Singh, and H. A. Lardy. Alteration of membrane permeability to calcium ions during maturation of bovine spermatozoa. Dev. Biol. 69: 85–93, 1979.
 35. Baccetti, B., The evolution of the acrosomal complex. In: The Spermatozoon, edited by D. W. Fawcett, and J. M. Bedford. Baltimore, MD: Urban and Schwarzenberg, 1979, p. 305–329.
 36. Baccetti, B., and B. A. Afzelius. The biology of the sperm cell. Monogr. Dev. Biol. 10: 1–254, 1976.
 37. Bachvarova, R., Gene expression during oogenesis and oocyte development in mammals. In: Developmental Biology: A Comprehensive Synthesis, Vol. 1, Oogenesis, edited by L. Browder. New York: Plenum, 1985, p. 453–524.
 38. Bachvarova, R., J. Burns, I. Speigelman, J. Choy, and R. Chaganti. Morphology and transcriptional activity of mouse oocyte chromosomes. Chromosoma 86: 181–196, 1982.
 39. Baker, T, Oogenesis and ovarian development. In: Reproductive Biology, edited by H. Balin and S. Glasser. Amsterdam: Excerpta Medica, 1972, p. 398–437.
 40. Baker, T., Oogenesis and ovulation. In: Reproduction in Mammals, Vol. 1, Germ Cells and Fertilization, edited by C. Austin and R. Short. Cambridge: Cambridge University, 1982, p. 17–45.
 41. Baker, T., and L. Franchi. The fine structure of oogonia and oocytes in human ovaries. J. Cell Sci. 2: 213–224, 1967.
 42. Baker, T., and L. Franchi. The structure of the chromosomes in human primordial oocytes. Chromosoma 22: 358–377, 1967.
 43. Baker, T., and L. Franchi. The fine structure of chromosomes in bovine primordial oocytes. J. Reprod. Fertil. 14: 511–513, 1967.
 44. Baker, T., and L. Franchi. The fine structure of oogonia and oocytes in the rhesus monkey (Macaca mulatta). Z. Zellforsch. Mikrosk. Anat. 126: 53–74, 1972.
 45. Bakken, A., and M. McClanahan. Patterns of RNA synthesis in early meiotic prophase oocytes from fetal mouse ovaries. Chromosoma 67: 21–40, 1978.
 46. Balakier, H. Induction of maturation in small oocytes from sexually immature mice by fusion with meiotic or mitotic cells. Exp. Cell Res. 112: 137–141, 1978.
 47. Balakier, H., and R. Czolowska. Cytoplasmic control of nuclear maturation in mouse oocytes. Exp. Cell Res. 110: 466–469, 1977.
 48. Balinski, B. I. An Introduction to Embryology. Philadelphia: W. B. Saunders, 1975.
 49. Barros, C., J. M. Bedford, L. E. Franklin, and C. R. Austin. Membrane vesiculation as a feature of the mammalian acrosome reaction. J. Cell Biol. 34: C1–C5, 1967.
 50. Bavister, B. D., Analysis of culture media for in vitro fertilization and criteria for success. In: Fertilization and Embryonic Development In Vitro, edited by L. Mastroianni and J. D. Biggers. New York: Plenum, 1981, p. 41–60.
 51. Bavister, B. D., Animal in vitro fertilization and embryo development. In: Developmental Biology: A Comprehensive Synthesis, Vol. 4. Manipulation of Mammalian Development, edited by R.B.L. Gwatkin. New York: Plenum, 1986, p. 81–148.
 52. Bedford, J. M., Maturation, transport, and fate of spermatozoa in the epididymis. In: Handbook of Physiology, Endocrinology, Male Reproductive System, edited by D. W. Hamilton, and R. O. Greep. Washington, DC: Am. Physiol. Soc., 1975, sect. 7, vol. V, p. 303–317.
 53. Bedford, J. M. Ultrastructural changes in the sperm head during fertilization in the rabbit. Am. J. Anat. 123: 329–358, 1968.
 54. Bedford, J. M. Morphological aspects of sperm capacitation in mammals. Adv. Biosci. 4: 35–50, 1970.
 55. Bedford, J. M. Significance of the need for sperm capacitation before fertilization in eutherian mammals. Biol. Reprod. 28: 108–120, 1983.
 56. Bedford, J. M., H. Calvin, and G. W. Cooper. The maturation of spermatozoa in the human epididymis. J. Reprod. Fertil. 18: 199–213, 1973.
 57. Beebe, S. J., L. Leyton, D. Burks, M. Ishikawa, T. Fuerst, J. Dean, and P. M. Saling. Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction. Dev. Biol. 151: 48–54, 1992.
 58. Beebe, S. J., O. Oyen, M. Sandberg, A. Froysa, V. Hannson, and T. Jahnsen. Molecular cloning of a tissue‐specific protein kinase C from human testis—representing a third isoform for the catalytic subunit on cAMP‐dependent protein kinase. Mol. Endocrinol. 4: 465–475, 1990.
 59. Beebe, S. J., P. Salomonsky, T. Jahnsen, and Y. LI. The Ct subunit is a unique isozyme of the cAMP‐dependent protein kinase. J. Biol. Chem. 267: 25505–25512, 1992.
 60. Bellve, A. R. and W. Zheng. Growth factors as autocrine and paracrine modulators of male gonadal functions. J. Reprod. Fertil. 85: 771–793, 1989.
 61. Bentley, J. K., D. L. Garbers, S. E. Domino, T. D. Noland, and C. Van Dop. Spermatozoa contain a guanine nucleotide‐binding protein ADP‐ribosylated by pertussis toxin. Biochem. Biophys. Res. Commun. 138: 728–734, 1986.
 62. Berger, T., K. O. Turner, S. Meizel, and J. L. Hedrick. Zona pellucida‐induced acrosome reaction in boar sperm. Biol. Reprod. 40: 525–530, 1989.
 63. Berridge, M. J. Inositol triphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem. 56: 159–194, 1987.
 64. Berridge, M. J. Inositol trisphosphate and calcium signalling. Nature 361: 315–325, 1993.
 65. Berridge, M. J., and D. S. Irvine. Inositol phosphates and cell signalling. Nature 341: 197–205, 1989.
 66. Berruti, G., and E. Martegani. Identification of proteins cross‐reactive to phosphotyrosine antibodies and to a tyrosine kinase activity in boar spermatozoa. J. Cell Sci. 93: 667–674, 1989.
 67. Birnbaumer, L. Receptor‐to‐effector signaling through G proteins: roles for βt dimers as well as subunits. Cell 71: 1069–1072, 1992.
 68. Blackmore, P. F., S. J. Beebe, D. R. Danforth, and N. Alexander. Progesterone and 17a‐hydroxyprogesterone. Novel stimulators of calcium influx in human sperm. J. Biol. Chem. 265: 1376–1380, 1990.
 69. Blackmore, P. F., J. Neulen, F. Lattanzio, and S. J. Beebe. Cell surface‐binding sites for progesterone mediate calcium uptake in human sperm. J. Biol. Chem. 266: 18655–18659, 1991.
 70. Bleil, J. D., Sperm receptors of mammalian eggs. In: Elements of Mammalian Fertilization, Vol. 1, Basic Concepts, edited by P. M. Wassarman, Boca Raton, FL: CRC, 1991, p. 133–151.
 71. Bleil, J. D., and P. M. Wassarman. Structure and function of the zona pellucida: identification and characterization of the proteins of the mouse oocyte's zona pellucida. Dev. Biol. 76: 185–203, 1980.
 72. Bleil, J. D., and P. M. Wassarman. Mammalian sperm‐egg interaction: identification of a glycoprotein in mouse egg zona pellucidae possessing receptor activity for sperm. Cell 20: 873–882, 1980.
 73. Bleil, J. D., and P. M. Wassarman. Sperm‐egg interactions in the mouse: sequence of events and induction of the acrosome reaction by a zona pellucida glycoprotein. Dev. Biol. 95: 317–324, 1983.
 74. Bleil, J. D., and P. M. Wassarman. Autoradiographic visualization of the mouse egg's sperm receptor bound to sperm. J. Cell Biol. 102: 1363–1371, 1986.
 75. Bleil, J. D., and P. M. Wassarman. Galactose at the nonreducing terminus of O‐linked oligosaccharides of mouse egg zona pellucida glycoprotein ZP3 is essential for the glycoprotein's sperm receptor activity. Proc. Natl. Acad. Sci. U.S.A. 85: 6778–6782, 1988.
 76. Bleil, J. D., and P. M. Wassarman. Identification of a ZP3‐binding protein on acrosome‐intact mouse sperm by photoaffinity crosslinking. Proc. Natl. Acad. Sci. U.S.A. 87: 5563–5567, 1990.
 77. Blobel, C. P., D. G. Myles, P. Primakoff, and J. M. White. Proteolytic processing of a protein involved in sperm‐egg fusion correlates with acquisition of fertilization competence. J. Cell Biol. 111: 69–78, 1990.
 78. Blobel, C. P., T. G. Wolfsberg, C. W. Turck, D. G. Myles, P. Primakoff, and J. M. White. A potential fusion peptide and an integrin ligand domain in a protein active in sperm‐egg fusion. Nature 356: 248–252, 1992.
 79. Bock, J., and J. Marsh. Proton Passage Across Cell Membranes. Chichester, UK: Wiley, 1988.
 80. Boldt, J., L. E. Gunter, and A. M. Howe. Characterization of cell surface polypeptides of unfertilized, fertilized, and protease‐treated zona‐free mouse eggs. Gamete Res. 23: 91–101, 1989.
 81. Borland, R. M., J. D. Biggers, C. P. Lechene, and M. L. Taymor. Elemental composition of fluid in the human fallopian tube. J. Reprod. Fertil. 58: 479–482, 1980.
 82. Borland, R. M., S. Hazra, J. D. Biggers, and C. P. Lechene. The elemental composition of the environments of the gametes and preimplantation embryo during the initiation of pregnancy. Biol. Reprod. 16: 147–157, 1977.
 83. Bornslaeger, E., P. Mattei, and R. M. Schultz. Involvement of cAMP‐dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation. Dev. Biol. 114: 453–462, 1986.
 84. Bornslaeger, E., W. Poueymirou, P. Mattei, and R. M. Schultz. Effects of protein kinase C activators on germinal vesicle breakdown and polar body emission of mouse oocytes. Exp. Cell Res. 165: 507–517, 1986.
 85. Bornslaeger, E., and R. M. Schultz. Regulation of mouse oocyte maturation: Effect of elevating cumulus cell cAMP on oocyte cAMP levels. Biol. Reprod. 33: 698–704, 1985.
 86. Bornslaeger, E., M. Wilde, and R. M. Schultz. Regulation of mouse oocyte maturation: involvement of cyclic AMP phosphodiesterase and calmodulin. Dev. Biol. 105: 488–499, 1984.
 87. Bourne, H., and L. Stryer. The target sets the tempo. Nature 358: 541–543, 1992.
 88. Bradley, M. P., and I. T. Forrester. A sodium‐calcium exchange mechanism in plasma membrane vesicles isolated from ram sperm flagella. FEBS Lett. 121: 15–18, 1980.
 89. Brambell, F. The development and morphology of the gonads of the mouse. Part 1. The morphogenesis of the indifferent gonad and of the ovary. Proc. R. Soc. Lond. [Biol.] 101: 391, 409, 1927.
 90. Brambell, F. The development and morphology of the gonads of the mouse. Part III. The growth of the follicles. Proc. R. Soc. Lond. [Biol.] 103: 258–272, 1928.
 91. Brambell, F, Ovarian changes. In: Marshall's Physiology of Reproduction, edited by A. Parkes. New York: Longmans, Green, 1956, vol. 1, p. 397–542.
 92. Bronson, R. A., and F. Fusi. Evidence that an Arg‐Gly‐Asp adhesion sequence plays a role in mammalian fertilization. Biol. Reprod. 43: 1019–1025, 1990.
 93. Brown, A. M. Membrane‐delimited cell signaling complexes: direct ion channel regulation by G proteins. J. Membr. Biol. 131: 93–104, 1993.
 94. Brown, J., J. A. Cebra‐Thomas, J. D. Bleil, P. M. Wassarman, and L. M. Silver. A premature acrosome reaction is programmed by mouse t haplotypes during sperm differentiation and could play a role in transmission ratio distortion. Development 106: 769–773, 1989.
 95. Brown, M. A., and E. R. Casillas. Bovine sperm adenylate cyclase. Inhibition by adenosine and adenosine analogs. J. Androl. 5: 361–368, 1984.
 96. Bryan, J.H.D. Spermatogenesis revisited: III. The course of spermatogenesis in a male‐sterile pink‐eyed mutant type in the mouse. Cell Tissue Res. 180: 173–186, 1977.
 97. Buccione, R., A. C. Schroeder, and J. J. Eppig. Interactions between somatic cells and germ cells throughout mammalian oogenesis. Biol. Reprod. 43: 543–547, 1990.
 98. Busa, W. B., and R. Nuccitelli. Metabolic regulation via intracellular pH. Am. J. Physiol. 246 (Regulatoroy Integrative Comp. Physiol. 15) R409–R438, 1984.
 99. Byskov, A., Primordial germ cells and regulation of meiosis. In: Reproduction in Mammals, edited by C. Austin, and R. Short. Cambridge: Cambridge University, 1982, vol. 1.
 100. Cabot, C. L., and G. Oliphant. The possible role of immunological complement in induction of the rabbit sperm acrosome reaction. Biol. Reprod. 19: 666–672, 1978.
 101. Cadena, D. L., and G. N. Gill. Receptor tyrosine kinases. FASEB J. 6: 2332–2337, 1992.
 102. Calarco, P, The kinetochore in oocyte maturation. In: Oogenesis, edited by J. Biggers, and A. Schuetz. Baltimore: University Park, 1972, p. 65–86.
 103. Calarco, P., R. Donahue, and D. Szollosi. Germinal vesicle breakdown in the mouse oocyte. J. Cell Sci. 10: 369–385, 1972.
 104. Canipari, R., F. Palombi, M. Riminucci, and F. Mangia. Early programming and maturation competence in mouse oogenesis. Dev. Biol. 102: 519–524, 1984.
 105. Caswell, A. H., and J. D. Hutchinson. Selectivity of cation chelation to tetracyclines: evidence for special conformation of calcium chelate. Biochem. Biophys. Res. Commun. 43: 525–530, 1971.
 106. Centola, G., L. Anderson, and C. Channing. Oocyte maturation inhibition activity in porcine granulosa cells. Gamete Res. 4: 451–462, 1981.
 107. Chamberlin, M. E., and J. Dean. Human homolog of the mouse sperm receptor. Proc. Natl. Acad. Sci. U.S.A. 87: 6014–6018, 1990.
 108. Chang, M. C. Fertilizing capacity of spermatozoa deposited into fallopian tubes. Nature 168: 697–698, 1951.
 109. Chang, M. C. Development of fertilizing capacity of rabbit spermatozoa in the uterus. Nature 175: 1036–1037, 1955.
 110. Chang, M. C. The maturation of rabbit oocytes in culture and their maturation, activation, fertilization, and subsequent development in the fallopian tubes. J. Exp. Zool. 128: 378–405, 1955.
 111. Chang, M. C. A detrimental effect of seminal plasma on the fertilizing capacity of sperm. Nature 179: 258–259, 1957.
 112. Chang, M. C., C. R. Austin, J. M. Bedford, B. G. Brackett, R.H.F. Hunter, and R. Yanagimachi. Capacitation of spermatozoa and fertilization in mammals. In: Frontiers in Reproduction and Fertility Control: A Review of Reproductive Sciences and Fertility Control, edited by R. O. Greep and M. A. Koblinsky. Cambridge, MA: MIT, 1977, pp. 434–451.
 113. Chari, S., T. Hillensjo, C. Magnusson, G. Sturm, and E. Daume. In vitro inhibition of rat oocyte meiosis by human follicular fluid fractions. Arch. Gynecol. 233: 155–164, 1983.
 114. Chaudhry, P. S., and E. R. Casillas. Calmodulin‐stimulated cyclic nucleotide phosphodiesterases in plasma membrane of bovine epididymal spermatozoa. Arch. Biochem. Biophys. 262: 439–444, 1988.
 115. Chaudhry, P. S., and E. R. Casillas. Isotypes of protein kinase C in bovine sperm. Arch. Biochem. Biophys. 295: 268–272, 1992.
 116. Cheetham, J. A., and H. A. Lardy. Bovine spermatozoa incorporate 32Pi into ADP by an unknown pathway. J. Biol. Chem. 267: 5186–5192, 1992.
 117. Cherr, G. N., H. Lambert, S. Meizel, and D. F. Katz. In vitro studies of the golden sperm acrosome reaction: completion on the zona pellucida and induction by homologous soluble zonae pellucidae. Dev. Biol. 114: 119–131, 1986.
 118. Chinkers, M., and D. L. Garbers. Signal transduction by guanylyl cyclases. Annu. Rev. Biochem. 60: 553–575, 1991.
 119. Cho, W.‐K., S. Stern, and J. D. Biggers. Inhibitory effect of dibutyryl cAMP on mouse oocyte maturation in vitro. J. Exp. Zool. 187: 383–386, 1974.
 120. Chou, P. Y., and G. D. Fasman. Prediction of the secondary structure of proteins from their amino acid sequence. Adv. Enzymol. 47: 47–148, 1978.
 121. Chrisman, T. D., S. Schulz, L. R. Potter, and D. L. Garbers. Seminal plasma factors that cause large elevations in cellular cyclic GMP are C‐type natriuretic peptides. J. Biol. Chem. 268: 3698–3703, 1993.
 122. Christen, R., R. W. Schackmann, and B. M. Shapiro. Interactions between sperm and sea urchin egg jelly. Dev. Biol. 98: 1–14, 1983.
 123. Chu, F.‐K. Requirements of cleavage of high mannose oligosaccharides in glycoproteins by peptide N‐glycosidase F. J. Biol. Chem. 261: 172–177, 1986.
 124. Clapper, D. L., T. F. Walseth, P. J. Daegie, and H. C. Lee. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate. J. Biol. Chem. 262: 9561–9568, 1987.
 125. Clark, E. N., M. E. Corron, and H. M. Florman. Caltrin, the calcium transport regulatory peptide of spermatozoa, modulates acrosomal exocytosis in response to the egg's zona pellucida. J. Biol. Chem. 268: 5309–5316, 1993.
 126. Clark, J., and E. Eddy. Fine structural observations on the origin and association of primordial germ cells of the mouse. Dev. Biol. 47: 136–155, 1975.
 127. Cohen‐Armon, M., and M. Sokolovsky. Evidence for involvement of the voltage‐dependent Na+ channel gating in depolarization‐induced activation of G proteins. J. Biol. Chem. 268: 9824–9838, 1993.
 128. Coronel, C. E., and H. A. Lardy. Characterization of Ca uptake by guinea pig epididymal spermatozoa. Biol. Reprod. 37: 1097–1107, 1987.
 129. Corselli, J., and P. Talbot. In vitro penetration of hamster oocyte‐cumulus complexes using physiological numbers of sperm. Dev. Biol. 122: 227–242, 1987.
 130. Cowan, A. E., D. G. Myles, and D. E. Koppel. Lateral diffusion of the PH‐20 protein on guinea pig sperm: evidence that barriers to diffusion maintain plasma membrane domains in mammalian sperm. J. Cell Biol. 104: 917–923, 1987.
 131. Cox, T., P. Campbell, and R. N. Peterson. Ion channels in boar sperm plasma membranes: characterization of a cation selective channel. Mol. Reprod. Dev. 30: 135–147, 1991.
 132. Cox, T., and R. N. Peterson. Identification of calcium conducting channels in isolated boar sperm plasma membranes. Biochem. Biophys. Res. Commun. 161: 162–168, 1989.
 133. Cran, D. B., R. M. Moor, and R. F. Irvine. Initiation of the cortical reaction in hamster and sheep oocytes in response to inositol trisphosphate. J. Cell Sci. 91: 139–144, 1988.
 134. Creutz, C. E. The annexins and exocytosis. Science 258: 924–931, 1992.
 135. Cross, P., and R. Brinster. In vitro development of mouse oocytes. Biol. Reprod. 3: 298–307, 1970.
 136. Cross, N. L., P. Morales, J. W. Overstreet, and F. W. Hanson. Induction of acrosome reactions by the human zona pellucida. Biol. Reprod. 38: 235–244, 1988.
 137. Crozet, N. Ultrastructural aspects of in vivo fertilization in the cow. Gamete Res. 10: 241–251, 1984.
 138. Crozet, N., and M. Dumont. The site of the acrosome reaction during in vivo penetration of the sheep oocyte. Gamete Res. 10: 97–105, 1984.
 139. Cummins, J. M., Evolution of sperm form: levels of control and competition. In: Fertilization in Mammals, edited by B. D. Bavister, J. Cummins, and E.R.S. Roldan. Norwell, MA: Serono Symposia, 1990, p. 51–64.
 140. Cummins, J. M., and R. Yanagimachi. Sperm‐egg ratios and the site of the acrosome reaction during in vivo fertilization in the hamster. Gamete Res. 5: 239–256, 1982.
 141. Cummins, J. M., and R. Yanagimachi. Development of ability to penetrate the cumulus oophorus by hamster spermatozoa capacitated in vitro, in relation to the timing of the acrosome reaction. Gamete Res. 15: 187–212, 1986.
 142. Dale, B., L. J. Defelice, and G. Ehrenstein. Injection of a soluble sperm extract into sea urchin eggs triggers the cortical reaction. Experiential 41: 1068–1070, 1985.
 143. Dan, J. C. Studies on the acrosome. I. Reaction to egg water and other stimuli. Biol. Bull. 103: 54–66, 1952.
 144. Dan, J. C. Studies on the acrosome. III. Effect of calcium deficiency. Biol. Bull. 107: 335–349, 1954.
 145. Dan, J. C. The acrosome reaction. Int. Rev. Cytol. 5: 365–393, 1956.
 146. Dan, J., Y. Ohori, and H. Kushida. Studies on the acrosome VII. Formation of the acrosomal process in sea urchin spermatozoa. J. Ultrastr. Res. 11: 508–524, 1964.
 147. Dangott, L. J., J. E. Jordan, R. A. Bellet, and D. L. Garbers. Cloning of the mRNA for the protein that crosslinks to the egg peptide speract. Proc. Natl. Acad. Sci. U.S.A. 86: 2128–2132, 1989.
 148. Daniel, J. (Ed). Methods in Mammalian Embryology. San Francisco: W. H. Freeman, 1971.
 149. Daniel, J. (Ed). Methods in Mammalian Reproduction. New York: Academic, 1978.
 150. Davidson, E. H. Gene Activity in Early Development. New York: Academic, 1986, p. 670.
 151. Davis, B. K. Timing of fertilization in mammals: sperm cholesterol/phospholipid ratio as a determinant of the capacitation interval. Proc. Natl. Acad. Sci. U.S.A. 78: 7560–7564, 1981.
 152. De Felici, M., and G. Siracusa. Survival of isolated, fully‐grown mouse ovarian oocytes is strictly dependent on external Ca2+. Dev. Biol. 92: 539–543, 1982.
 153. De Jong, W. W., Superordinal affinities of rodentia studied by sequence analysis of eye lens protein. In: Evolutionary Relationships Among Rodents—a Multidisciplinary Analysis, edited by W. P. Luckett and J.‐L. Hartenberger. NY: Plenum, 1985, p. 211–226.
 154. Dekel, N., E. Aberdam, and I. Sherizly. Spontaneous maturation in vitro of cumulus‐enclosed rat oocytes is inhibited by forskolin. Biol. Reprod. 31: 244–250, 1984.
 155. Dekel, N., and W. Beers. Rat oocyte maturation in vitro: relief of cyclic AMP inhibition with gonadotropins. Proc. Natl. Acad. Sci. U.S.A. 75: 4369–4373, 1978.
 156. Dekel, N., and W. Beers. Development of the rat oocyte in vitro: inhibition and induction of maturation in the presence or absence of the cumulus oophorus. Dev. Biol. 75: 247–254, 1980.
 157. Dekel, N., T. Hillensjo, and P. Kraicer. Maturational effects of gonadotropins on the cumulus‐oocyte complex of the rat. Biol. Reprod. 20: 191–197, 1979.
 158. Dekel, N., P. Kraicer, D. Phillips, R. Sanchez, and S. Segal. Cellular associations in the rat oocyte‐cumulus cell complex: morphology and ovulatory changes. Gamete Res. 1: 47–57, 1978.
 159. Dekel, N., T. Lawrence, N. Gilula, and W. Beers. Modulation of cell‐to‐cell communication in the cumulus‐oocyte complex and the regulation of oocyte maturation by LH. Dev. Biol. 80: 356–362, 1981.
 160. Delorey, T. M., and R. W. Olsen. γ‐Aminobutyric acidA receptor structure and function. J. Biol. Chem. 267: 16747–16750, 1992.
 161. Dicarlantonio, G., and P. Talbot. Evidence for sequential deployment of secretory enzymes during the normal acrosome reaction of guinea pig sperm in vitro. Gamete Res. 21: 425–438, 1988.
 162. Dietl, J. (Ed). The Mammalian Egg Coat: Structure and Function. Berlin: Springer‐Verlag KG, 1989, p. 156.
 163. Dodd, J., and T. M. Jessell. Lactoseries carbohydrates specify subsets of dorsal root ganglion neurons projecting to the superficial dorsal horn of rat spinal cord. J. Neurosci. 5: 3278–3294, 1985.
 164. Dohlman, H. G., J. Thorner, M. G. Caron, and R. J. Lefkowitz. Model systems for the study of seven‐transmembrane‐segment receptors. Annu. Rev. Biochem. 60: 653–688, 1991.
 165. Dolci, S., D. E. Williams, M. K. Ernst, J. L. Resnick, C. I. Brannan, L. F. Lock, S. D. Lyman, H. S. Boswell, and P. J. Donovan. Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 352: 809–811, 1991.
 166. Domino, S. E., and D. L. Garbers. The fucose‐sulfate glycoconjugate that induces an acrosome reaction in spermatozoa stimulates inositol 1,4,5‐trisphosphate accumulation. J. Biol. Chem. 263: 690–695, 1988.
 167. Donahue, R. Maturation of the mouse oocyte in vitro. 1. Sequence and timing of nuclear progression. J. Exp. Zool. 169: 237–250, 1968.
 168. Doolittle, R. F. Of Urfs and Orfs. Mill Valley, CA: University Science Books, 1986, p. 103.
 169. Douglas, W. W. Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells. Br. J. Pharm. 34: 451–474, 1968.
 170. Downs, S., D. Coleman, P. Ward‐Bailey, and J. Eppig. Hypoxanthine is the principal inhibitor of murine oocyte maturation in a low molecular weight fraction of porcine follicular fluid. Proc. Natl. Acad. Sci. U.S.A. 82: 454–458, 1985.
 171. Downs, S. M., S.A.J. Daniel, E. A. Bornslaeger, P. C. Hoppe, and J. J. Eppig. Maintenance of meiotic arrest in mouse oocytes by purines: modulation of cAMP levels and cAMP phosphodiesterase activity. Gamete Res. 23: 323–334, 1989.
 172. Downs, S., and J. Eppig. Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation. Endocrinology 114: 418 427, 1984.
 173. Drobnis, E. Z., and D. F. Katz. Videomicroscopy of mammalian fertilization. In: Elements of Mammalian Fertilization. Vol. I. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 269–300.
 174. Ducibella, T., Mammalian egg cortical granules and the cortical reaction. In: Elements of Mammalian Fertilization. Vol. I. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 205–231.
 175. Ducibella, T., E. Anderson, D. F. Albertini, J. Aalberg, and S. Rangarajan. Quantitative changes in cortical granule number and distribution in the mouse oocyte during meiotic maturation. Dev. Biol. 130: 184–197, 1988.
 176. Ducibella, T., S. Kurasawa, S. Rangarajan, G. S. Kopf, and R. M. Schultz. Precocious loss of cortical granules during mouse oocyte meiotic maturation and correlation with an egg‐induced modification of the zona pellucida. Dev. Biol. 137: 46–55, 1990.
 177. Ducibella, T., S. Rangarajan, and E. Anderson. The development of mouse oocyte cortical granule competence is accompanied by major changes in cortical vesicles and not cortical granule depth. Dev. Biol. 130: 789–792, 1988.
 178. Dunbar, B. S., and M. G. O'Rand (Eds). A Comparative Overview of Mammalian Fertilization. New York: Plenum, 1991, p. 457.
 179. Dunbar, B. S., S. V. Prasad, and T. M. Timmons. Comparative structure and function of mammalian zonae pellucidae. In: A Comparative Overview of Mammalian Fertilization, edited by B. S. Dunbar, and M. G. O'Rand, New York: Plenum, 1991, p. 97–114.
 180. Dunbar, B., N. Wardrip, and J. Hedrick. Isolation, physiochemical properties, and macromolecular composition of zona pellucida from porcine oocytes. Biochemistry 19: 356–365, 1980.
 181. Duncan, A. E. and L. R. Fraser. Cyclic AMP‐dependent phosphorylation of epididymal mouse sperm proteins during capacitation in vitro: identification of an Mr 95 000 phosphotyrosine‐containing protein. J. Reprod. Fertil. 97: 287–299, 1993.
 182. Dym, M, The male reproductive system. In: Histology. Cell and Tissue Biology, edited by L. Weiss. New York: Elsevier Biomedical, 1983, p. 1000–1053.
 183. Eddy, E. M., The spermatozoon. In: The Physiology of Reproduction, edited by E. Knobil, and J. Neill. New York: Raven, 1988, p. 27–68.
 184. Eddy, E., J. Clark, D. Gong, and B. Fenderson. Origin and migration of primordial germ cells in mammals. Gamete Res. 4: 333–362, 1981.
 185. Eddy, E., and A. Hahnel. Establishment of the germ line in mammals. In: 7th Symposium of British Society for Developmental Biology, edited by A. Mclaren, and C. Wylie, Cambridge: Cambridge University, 1983, p. 41–69.
 186. Eddy, E. M., D. A. O'Brien, and J. E. Welch. Mammalian sperm development in vivo and in vitro. In: Elements of Mammalian Fertilization. I. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC Press, 1990, p. 1–28.
 187. Edge, A.S.B., C. R. Faltynek, L. Hof, L. E. Reichert, and P. Weber. Deglycosylation of glycoproteins by trifluoromethanesulfonic acid. Anal. Biochem. 118: 131–137, 1981.
 188. Eisenbach, M., and D. Ralt. Precontact mammalian sperm‐egg communication and role in fertilization. Am. J. Physiol. 262 (Cell Physiol. 31): C1095–C1101, 1992.
 189. Ekholm, C., and C. Magnusson. Rat oocyte maturation: effects of protein synthesis inhibitors. Biol. Reprod. 21: 1287–1293, 1979.
 190. Endo, Y., M. A. Lee, and G. S. Kopf. Evidence for a role of a guanine nucleotide‐binding regulatory protein in the zona pellucida‐induced mouse sperm acrosome reaction. Dev. Biol. 119: 210–216, 1987.
 191. Endo, Y., M. A. Lee, and G. S. Kopf. Characterization of an islet‐activating protein sensitive site in mouse sperm that is involved in the zona pellucida‐induced acrosome reaction. Dev. Biol. 129: 12–24, 1988.
 192. Endo, Y., P. Mattei, G. S. Kopf, and R. M. Schultz. Effects of a phorbol ester on mouse eggs: dissociation of sperm receptor activity from acrosome reaction‐inducing activity of the mouse zona pellucida protein, ZP3. Dev. Biol. 123: 574–577, 1987.
 193. Endo, Y., R. M. Schultz, and G. S. Kopf. Effects of phorbol esters and a diacylglycerol on mouse eggs: inhibition of fertilization and modification of the zona pellucida. Dev. Biol. 119: 199–209, 1987.
 194. Eng, L. A., and G. Oliphant. Rabbit sperm reversible decapacitation by membrane stabilization with a highly purified glycoprotein from seminal plasma. Biol. Reprod. 19: 1083–1094, 1978.
 195. Eppig, J. A comparison between oocyte growth in coculture with granulosa cells and oocytes with granulosa cell‐oocyte junctional contact maintained in vitro. J. Exp. Zool. 209: 345–353, 1979.
 196. Eppig, J. The relationship between cumulus cell‐oocyte coupling, oocyte meiotic maturation, and cumulus expansion. Dev. Biol. 89: 268–272, 1982.
 197. Eppig, J., Oocyte‐somatic cell interactions during oocyte growth and maturation in the mammal. In: Developmental Biology: A Comprehensive Synthesis, Vol. 1, Oogenesis, edited by L. Browder. New York: Plenum, 1985, p. 313–347.
 198. Eppig, J. Intercommunication between mammalian oocytes and companion somatic cells. Bioessays 13: 569–574, 1991.
 199. Eppig, J., R. Freter, P. Ward‐Bailey, and R. M. Schultz. Inhibition of oocyte maturation in the mouse: participation of cAMP, steroid hormones, and a putative maturation‐inhibitory factor. Dev. Biol. 100: 39–49, 1983.
 200. Eppig, J., and S. Koide. Effects of progesterone and oestradiol‐173 on the spontaneous meiotic maturation of mouse oocytes. J. Reprod. Fertil. 53: 99–101, 1978.
 201. Eppig, J., P. Ward‐Bailey, and D. Coleman. Hypoxanthine and adenosine in murine ovarian follicular fluid: concentrations and activity in maintaining oocyte meiotic arrest. Biol. Reprod. 33: 1041–1049, 1985.
 202. Fawcett, D. W. The mammalian spermatozoon. Dev. Biol. 44: 394–436, 1975.
 203. Fay, S. P., R. G. Posner, W. N. Swann, and L. A. Sklar. Realtime analysis of the assembly of ligand, receptor, and G protein by quantitative fluorescence flow cytometry. Biochemistry 30: 5066–5075, 1991.
 204. Feinberg, J., J. Weinman, S. Weinman, M. P. Walsh, M. C. Harricane, J. Gabrion, and J. G. Demaille. Immunocytochemical and biochemical evidence for the presence of calmodulin in bull sperm flagellum. Biochim. Biophys. Acta. 673: 303–311, 1981.
 205. Fleming, A., W. Khalil, and D. Armstrong. Porcine follicular fluid does not inhibit maturation of rat oocytes in vitro. J. Reprod. Fertil. 69: 665–670, 1983.
 206. Fleming, A., R. Yanagimachi, and H. Yanagimachi. Spermatozoa of the Atlantic bottlenose dolphin, Tursiops truncatus. J. Reprod. Fertil. 63: 509–514, 1981.
 207. Florman, H. M., and D. F. Babcock. Progress toward understanding the molecular basis of capacitation. In: Elements of Mammalian Fertilization. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 105–132.
 208. Florman, H. M., D. F. Babcock, P. M. Bourissa, N. L. First, D. M. Kerlin, and R. M. Tombes. Egg‐activated signal transducing pathways in mammalian sperm: what are they and how are they regulated during development and fertilization? In: Fertilization in Mammals, edited by B. D. Bavister, J. Cummins, and E.R.S. Roldan. Norwell, MA: Serono Symposia, USA, 1990, p. 77–88.
 209. Florman, H. M., K. B. Bechtol, and P. M. Wassarman. Enzymatic dissection of the functions of the mouse egg's receptor for sperm. Dev. Biol. 106: 243–255, 1984.
 210. Florman, H. M., M. E. Corron, T.D.‐H. Kim, and D. Babcock. Activation of voltage‐dependent calcium channels of mammalian sperm is required for zona pellucida‐induced acrosomal exocytosis. Dev. Biol. 152: 304–314, 1992.
 211. Florman, H. M., and N. L. First. The regulation of acrosomal exocytosis. I. Sperm capacitation is required for the induction of acrosome reactions by the bovine zona pellucida in vitro. Dev. Biol. 128: 453–463, 1988.
 212. Florman, H. M., and N. L. First. Regulation of acrosomal exocytosis. II. The zona pellucida‐induced acrosome reaction of bovine spermatozoa is controlled by extrinsic positive regulatory elements. Dev. Biol. 128: 464–473, 1988.
 213. Florman, H. M., P. M. Saling, and B. T. Storey. Fertilization of mouse eggs in vitro. Time resolution of the reactions preceding penetration of the zona pellucida. J. Androl. 3: 373–381, 1982.
 214. Florman, H. M., and B. T. Storey. Inhibition of in vitro fertilization of mouse eggs: 3‐quinuclidinyl benzilate specifically blocks penetration of zonae pellucidae by mouse spermatozoa. J. Exp. Zool. 216: 159–167, 1981.
 215. Florman, H. M., and B. T. Storey. Characterization of cholinomimetic agents that inhibit in vitro fertilization in the mouse. Evidence for a sperm‐specific binding site. J. Androl. 3: 157–164, 1982.
 216. Florman, H. M., and B. T. Storey. Mouse gamete interactions: the zona pellucida is the site of the acrosome reaction leading to fertilization in vitro. Dev. Biol. 91: 121–130, 1982.
 217. Florman, H. M., R. M. Tombes, N. L. First, and D. F. Babcock. An adhesion‐associated agonist from the zona pellucida activates G protein‐promoted elevations of internal Ca and pH that mediate mammalian sperm acrosomal exocytosis. Dev. Biol. 135: 133–146, 1989.
 218. Florman, H. M., and P. M. Wassarman. O‐linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity. Cell 41: 313–324, 1985.
 219. Foltz, K. R., J. S. Partin, and W. J. Lennarz. Sea urchin egg receptor for sperm: sequence similarity of binding domain and hsp70. Science 259: 1421–1425, 1993.
 220. Foresta, C, M. Rossato, and F. Di Virgilio. Extracellular ATP is a trigger for the acrosome reaction in human spermatozoa. J. Biol. Chem. 267: 19443–19447, 1992.
 221. Franchi, L., and A. Mandl. The ultrastructure of oogonia and oocytes in the foetal and neonatal rat. Proc. R. Soc. Lond. [Biol.] 157: 99–114, 1962.
 222. Franchi, L., A. Mandl, and S. Zuckerman. The development of the ovary and the process of oogenesis. In: The Ovary, edited by S. Zuckerman. New York: Academic, 1962, vol. 1, p. 1–88.
 223. Franklin, L. E., C. Barros, and E. N. Fussell. The acrosomal region and the acrosome reaction in sperm of the golden hamster. Biol. Reprod. 3: 180–200, 1970.
 224. Fraser, L. R. Mouse sperm capacitation in vitro involves loss of a surface‐associated inhibitory component. J. Reprod. Fertil. 72: 373–384, 1984.
 225. Fraser, L. R. Adenosine and its analogues, possibly acting at A2 receptors, stimulate mouse sperm fertilizing ability during early stages of capacitation. J. Reprod. Fertil. 89: 467–476, 1990.
 226. Fraser, L. R., and K. K. Ahuja. Metabolic and surface events in fertilization. Gamete Res. 20: 491–519, 1988.
 227. Fraser, L. R., G. Umar, and S. Sayed. Na+‐requiring mechanisms modulate capacitation and acrosomal exocytosis in mouse spermatozoa. J. Reprod. Fertil. 97: 539–549, 1993.
 228. Freter, R., and R. M. Schultz. Regulation of murine oocyte maturation: Evidence for a gonadotropin‐induced, cAMP‐dependent reduction in a maturation inhibitor. J. Cell Biol. 98: 1119–1128, 1984.
 229. Friend, D. S., The organization of the spermatozoal membrane. In: Immunobiology of Gametes, edited by M. Edinin and M. H. Johnson. Cambridge: Cambridge University, 1977, p. 5–30.
 230. Friend, D. S., L. Orci, A. Perrelet, and R. Yanagimachi. Membrane particle changes attending the acrosome reaction in guinea pig spermatozoa. J. Cell Biol. 74: 561–577, 1977.
 231. Fulka, J., T. Jung, and R. M. Moor. The fall of biological maturation promoting factor (MPF) and histone H1 kinase activity during anaphase and telophase in mouse oocytes. Mol. Reprod. Dev. 32: 378–382, 1992.
 232. Fulka, J., J. Motlik, J. Fulfa, and N. Crozet. Inhibition of nuclear maturation in fully‐grown porcine and mouse oocytes after their fusion with growing porcine oocytes. J. Exp. Zool. 235: 255–259, 1985.
 233. Galione, A. Ca2+‐induced Ca2+ release and its modulation by cyclic ADP‐ribose. TIPS 13: 304–306, 1992.
 234. Galione, A. Cyclic ADP‐ribose: a new way to control calcium. Science 259: 325–326, 1993.
 235. Galione, A., H. C. Lee, and W. B. Busa. Ca2+‐induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP‐ribose. Science 253: 1143–1146, 1991.
 236. Ganz, M. B., G. Boyarsky, R. B. Sterzel, and W. F. Boron. Arginine vasopressin enhances pHi regulation in the presence of HCO3 by stimulating three acid‐base transport systems. Nature 337: 648–651, 1989.
 237. Garbers, D. L. Molecular basis of fertilization. Annu. Rev. Biochem. 58: 719–742, 1989.
 238. Garbers, D. L. Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands. Cell 71: 1–4, 1992.
 239. Garbers, D. L., and G. S. Kopf. The regulation of spermatozoa by calcium and cyclic nucleotides. In: Advances in Cyclic Nucleotide Research, edited by P. Greengard and G. A. Robison, New York: Raven, 1980, p. 251–306.
 240. Garnier, J., D. Osguthorpe, and B. Robson. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120: 97–120, 1978.
 241. Garty, N. B., D. Galiani, A. Aharonheim, Y.‐K. Ho, D. M. Phillips, N. Dekel, and Y. Salomon. G‐proteins in mammalian gametes: an immunocytochemical study. J. Cell Sci. 91: 21–31, 1988.
 242. Gearing, D. P., M. R. Comeau, D. J. Friend, S. D. Gimple, C. J. Thut, J. McGourty, K. K. Brasher, J. A. King, S. Gillis, B. Mosley, S. F. Ziegler, and D. Cosman. The IL‐6 signal transducer, gp130: an oncostatic receptor and affinity converter for the LIF receptor. Science 255: 1434–1437, 1992.
 243. Gilula, N., M. Epstein, and W. Beers. Cell‐to‐cell communication and ovulation: a study of the cumulus cell‐oocyte complex. J. Cell Biol. 78: 58–75, 1978.
 244. Gilula, N., O. Reeves, and A. Steinbach. Metabolic coupling, ionic coupling, and cell contacts. Nature 235: 262–265, 1972.
 245. Ginsburg, V., and P. W. Robbins. (Eds). Biology of Carbohydrates. New York: Wiley, 1984, vol. 2, p. 342.
 246. Glabe, C. G. Interaction of the sperm adhesive protein, bindin, with phospholipid vesicles. II. Bindin induces fusion of mixed‐phase vesicles that contain phosphatidylcholine and posphatidylserine in vitro. J. Cell Biol. 100: 800–806, 1985.
 247. Glassner, M., J. Jones, I. Kligman, M. J. Woolkalis, G. L. Gerton, and G. S. Kopf. Immunocytochemical and biochemical characterization of guanine nucleotide‐binding regulatory proteins in mammalian spermatozoa. Dev. Biol. 148: 438–450, 1991.
 248. Glick, D. L., M. R. Hellmich, S. Beushausen, P. Tempst, H. Bayley, and F. Strumwasser. Primary structure of a molluscan egg‐specific NADase, a second‐messenger enzyme. Cell Regul. 2: 211–218, 1991.
 249. Glossmann, H., and J. Striessnig. Calcium channels. Vitam. Horm. 44: 155–328, 1988.
 250. Gluck, S. L. The vacuolar H+‐ATPases: versatile proton pumps participating in constitutive and specialized functions in eukaryotic cells. Int. Rev. Cytol. 137C: 105–137, 1993.
 251. Go, K. J., and D. P. Wolf. Albumin‐mediated changes in the sperm sterol contents during capacitation. Biol. Reprod. 32: 145–152, 1985.
 252. Godin, I., R. Deed, J. Cooke, K. Zsebo, M. Dexter, and C. C. Wylie. Effects of the steel gene product on mouse primordial germ cells in culture. Nature 352: 807–809, 1991.
 253. Gondos, B, Oogonia and oocytes in mammals. In: The Vertebrate Ovary, edited by R. Jones. New York: Plenum, 1978, p. 83–120.
 254. Gould, M., and J. L. Stephano. Electrical responses of eggs to acrosomal protein similar to those induced by sperm. Science 235: 1654–1656, 1987.
 255. Gould, M., J. L. Stephano, and L. Z. Holland. Isolation of protein Urechis sperm acrosomal granules that binds sperm to eggs and initiates development. Dev. Biol. 117: 306–318, 1986.
 256. Green, E. (Ed). Biology of the Laboratory Mouse, New York: Dover, 1975.
 257. Green, D.P.L. The induction of the acrosome reaction in guinea pig sperm by the divalent metal cation ionophore A23187. J. Cell Sci. 32: 137–151, 1978.
 258. Green, D.P.L. Granule swelling and membrane fusion in exocytosis. J. Cell Sci. 88: 547–549, 1987.
 259. Green, D.P.L. The effect of permeant and impermeant osmoticants on exocytosis in guinea pig sperm. J. Cell Sci. 100: 761–769, 1991.
 260. Greve, J., and P. M. Wassarman. Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J. Mol. Biol. 181: 253–264, 1985.
 261. Gross, M. K., D. G. Toscano, and W. A. Toscano. Calmodulin‐mediated adenylate cyclase from mammalian sperm. J. Biol. Chem. 262: 8672–8676, 1987.
 262. Guerrero, A., and A. Darszon. Egg jelly triggers a calcium influx which inactivates and is inhibited by calmodulin antagonists in the sea urchin sperm. Biochim. Biophys. Acta 980: 109–116, 1989.
 263. Guerrero, A., and A. Darszon. Evidence for the activation of two different Ca2+ channels during the egg jelly‐induced acrosome reaction of sea urchin sperm. J. Biol. Chem. 264: 19593–19599, 1989.
 264. Gulyas, B. Cortical granules of mammalian eggs. Int. Rev. Cytol. 63: 357–392, 1980.
 265. Gulyas, B. J., and E. D. Schmell. Sperm‐egg recognition and binding in mammals. In: Bioregulators of Reproduction, edited by G. Jargiello and H. Vogel, New York: Academic, 1981, p. 499–520.
 266. Guraya, S., S. Morphology. histochemistry, and biochemistry of human oogenesis and ovulation. Int. Rev. Cytol. 37: 121–152, 1974.
 267. Gwatkin, R.B.L. Fertilization Mechanisms in Man and Mammals. New York: Plenum, 1976.
 268. Gwatkin, R.B.L., and O. Andersen. Hamster oocyte maturation in vitro: inhibition by follicular components. Life Sci. 19: 527–536, 1976.
 269. Gwatkin, R.B.L., H. W. Carter, and H. Patterson. Association of mammalian sperm with the cumulus cells and the zona pellucida studied by scanning electron microscopy. In: Scanning Electron Microscopy, edited by H. Johari, and R. P. Becker. Chicago: IIT Research Inst., 1976, vol. 2, part 2, p. 379–384.
 270. Habibi, B., and L. Franchi. Fine‐structural changes in the nucleus of primordial oocytes in immature hamsters. J. Cell. Sci. 34: 209–223, 1978.
 271. Hagiwara, S. Membrane Potential‐Dependent Ion Channels in Cell Membrane. Phylogenetic and Developmental Approaches. New York: Raven, 1983.
 272. Hammerstedt, R. H., A. D. Keith, W. Snipes, R. P. Amann, D. Arruda, and L. C. Griel. Use of spin labels to evaluate effects of cold shock and osmolality on sperm. Biol. Reprod. 18: 686–696, 1978.
 273. Handrow, R. R., S. K. Boehm, R. W. Lenz, J. A. Robinson, and R. L. Ax. Specific binding of the glycosaminoglycan 3H‐heparin to bull, monkey, and rabbit spermatozoa in vitro. J. Androl. 5: 51–63, 1984.
 274. Handrow, R. R., N. L. First, and J. J. Parrish. Calcium requirement and increased association with bovine sperm during capacitation by heparin. J. Exp. Zool. 252: 174–182, 1989.
 275. Hardisty, M., Primordial germ cells and the vertebrate germ line. In: The Vertebrate Ovary, edited by R. Jones. New York: Plenum, 1978, p. 1–82.
 276. Harrison, R.A.P., and S. J. Gaunt. Multiple forms of ram and bull sperm hyaluronidase revealed by using monoclonal antibodies. J. Reprod. Fertil. 82: 777–785, 1988.
 277. Harrison, R.A.P., E.R.S. Roldan, D. J. Lander, and R. F. Irvine. Ram spermatozoa produce inositol 1,4,5‐trisphosphate but not inositol 1,3,4,5‐tetrakisphosphate during the Ca2+/ionophore‐induced acrosome reaction. Cell Signal 2: 277–284, 1990.
 278. Hartmann, J. F., R.B.L. Gwatkin, and C. F. Hutchison. Early contact interactions between mammalian gametes in vitro: evidence that the vitellus influences adhesion between sperm and zona pellucida. Proc. Natl. Acad. Sci. U.S.A. 69: 2767–2769, 1972.
 279. Hartree, E. F. Spermatozoa, eggs, and proteinases. Biochem. Soc. Trans. 5: 375–383, 1977.
 280. Hartree, E. F., and P. N. Strivastava. Chemical composition of the acrosomes of ram spermatozoa. J. Reprod. Fertil. 9: 47–60, 1965.
 281. Hartung, M., and A. Stahl. Autoradiographic study of RNA synthesis during meiotic prophase in the human oocyte. Cytogenet. Cell Genet. 20: 51–58, 1978.
 282. Haugen, T. B., E. J. Paulssen, J. O. Gordeladze, and V. Hansson. A unique mRNA species for a subunit of Gs is present in rat haploid germ cells. Biochem. Biophys. Res. Commun. 168: 91–98, 1990.
 283. Hawley, R. S. and T. Arbel. Yeast genetics and the fall of the classical view of meiosis. Cell 72: 301–303, 1993.
 284. Hedrick, J. L., and N. J. Wardrip. Isolation of the zona pellucida and purification of its glycoprotein families from pig oocytes. Anal. Biochem. 157: 63–70, 1986.
 285. Heller, D., D. Cahill, and R. M. Schultz. Biochemical studies of mammalian oogenesis: metabolic cooperativity between granulosa cells and growing mouse oocytes. Dev. Biol. 84: 455–464, 1981.
 286. Heller, D., and R. M. Schultz. Ribonucleoside metabolism by mouse oocytes: metabolic cooperativity between the fully‐grown oocyte and cumulus cells. J. Exp. Zool. 214: 355–364, 1980.
 287. Hepler, J. R., and A. G. Gilman. G proteins. Trends Biochem. Sci. 17: 383–387, 1992.
 288. Herlands, R., and R. M. Schultz. Regulation of mouse oocyte growth: probable nutritional role for intercellular communication between follicle cells and oocytes in oocyte growth. J. Exp. Zool. 229: 317–325, 1984.
 289. Heyting, C., R. J. Dettmers, A.J.J. Dietrich, E.J.W. Redeker, and A.C.G. Vink. Two major components of synatonemal complexes are specific for meiotic prophase nuclei. Chromosoma 96: 325–333, 1988.
 290. Hille, B. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer, 1991.
 291. Hille, B. G. protein‐coupled mechanisms and the nervous system. Neuron 9: 187–195, 1992.
 292. Hinsch, K.‐D., E. Hinsch, G. Aumuller, I. Tychowiecka, G. Schultz, and W.‐B. Schill. Immunological identification of G protein α‐ and β‐subunits in tail membranes of bovine spermatozoa. Biol. Reprod. 47: 337–346, 1992.
 293. Hodgkin, J., T. Domaich, and M. Shen. Sex determination pathway in the nematode Caenorhabditis elegans: variations on a theme. Cold Spring Harb. Symp. Quant. Biol. 50: 585–593, 1985.
 294. Hogan, B., F. Costantini, and E. Lacy (Eds). Manipulating the Mouse Embryo. A Laboratory Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory, 1986.
 295. Hong, K. and V. D. Vacquier. Fusion of liposomes induced by a cationic protein from the acrosome granule of abalone spermatozoa. Biochemistry 25: 543–549, 1986.
 296. Hunt, D. M., and D. R. Johnson. Abnormal spermiogenesis in two pink‐eyed sterile mutants of the mouse. J. Embryol. Exp. Morph. 26: 111–121, 1971.
 297. Hunter, A. G., and H. O. Nornes. Characterization and isolation of a sperm coating antigen from rabbit seminal plasma with capacity to block fertilization. J. Reprod. Fertil. 20: 419–427, 1969.
 298. Hyne, R. V. Bicarbonate‐ and calcium‐dependent induction of rapid guinea pig sperm acrosome reactions by monovalent ionophores. Biol. Reprod. 31: 312–323, 1984.
 299. Hyne, R. V., K. P. Edwards, A. Lopata, and J. D. Smith. Changes in guinea pig sperm intracellular sodium and potassium content during capacitation and treatment with monovalent ionophores. Gamete Res. 12: 65–73, 1985.
 300. Hyne, R. V., and D. L. Garbers. Regulation of guinea pig sperm adenylate cyclase by calcium. Biol. Reprod. 21: 1135–1142, 1979.
 301. Hyne, R. V., and D. L. Garbers. Requirement of serum factors for capacitation and the acrosome reaction of guinea pig spermatozoa in buffered medium below pH 7.8 Biol. Reprod. 24: 257–266, 1981.
 302. Hyne, R. V., and D. L. Garbers. Inhibition of the guinea pig acrosome reaction by a low molecular weight factor(s) in epididymal fluid and serum. J. Reprod. Fertil. 67: 151–156, 1982.
 303. Hyne, R. V., R. E. Higginson, D. Kohlman, and A. Lopata. Sodium requirement for capacitation and membrane fusion during the guinea pig sperm acrosome reaction. J. Reprod. Fertil. 70: 83–94, 1984.
 304. Hyne, R. V., and A. Lopata. Calcium and adenosine affect human sperm adenylate cyclase activity. Gamete Res. 6: 81–89, 1982.
 305. Hynes, R. O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25, 1992.
 306. Igusa, Y., and S. Miyazaki. Periodic increase of cytoplasmic free calcium in fertilized hamster eggs measured with calcium‐sensitive electrodes. J. Physiol. 377: 193–205, 1986.
 307. Igusa, Y., S. Miyazaki, and N. Yamashita. Periodic hyperpolarizing responses in hamster and mouse eggs fertilized with mouse sperm. J. Physiol. 340: 643–647, 1983.
 308. Inoue, M., and D. P. Wolf. Fertilization‐associated changes in the murine zona pellucida: a time sequence study. Biol. Reprod. 13: 546–551, 1975.
 309. Inoue, M., and D. P. Wolf. Sperm binding characteristics of the murine zona pellucida. Biol. Reprod. 13: 340–348, 1975.
 310. Inskeep, P. B., S. F. Magargee, and R. H. Hammerstedt. Alterations in motility and metabolism with sperm interaction with accessory sex gland fluids. Arch. Biochem. Biophys. 241: 1–9, 1985.
 311. Ip, N. Y., S. H. Nye, T. G. Boulton, S. Davis, T. Taga, Y. Li, S. J. Birren, K. Yasukawa, T. Kishimoto, D. J. Anderson, N. Stahl, and G. D. Yancopoulos. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL‐6 signal transducing receptor component gp130. Cell 69: 1121–1132, 1992.
 312. Jaffe, L. F. Calcium explosions as triggers of development. Ann. N. Y. Acad. Sci. 339: 86–101, 1980.
 313. Jaffe, L. F. Sources of calcium in egg activation: a review and hypothesis. Dev. Biol. 99: 256–276, 1983.
 314. Jakoby, F, Ovarian histochemistry. In: The Ovary, edited by S. Zuckerman, New York: Academic, 1962, p. 189–246.
 315. Janis, R. A., P. J. Silver, and D. J. Triggle. Drug action and cellular calcium regulation. Adv. Drug Res. 116: 309–591, 1987.
 316. Jenkins, A. D., C. P. Lechene, and S. S. Howards. Concentrations of seven elements in the intraluminal fluids of the rat seminiferous tubules, rete testis, and epididymis. Biol. Reprod. 23: 981–987, 1980.
 317. Jessell, T. M., and J. Dodd. Structure and expression of differentiation antigens of functional subclasses of sensory neurons. Philos. Trans. R. Soc. Lond. Biol. 308: 271–281, 1985.
 318. Jessell, T. M., and E. R. Kandel. Synaptic transmission: a bidirectional and self‐modifiable form of cell‐cell communication. Neuron 10: 1–30, 1993.
 319. Jones, R. (Ed). The Vertebrate Ovary. New York: Plenum, 1978.
 320. Juliano, R. L., and S. Haskill. Signal transduction from the extracellular matrix. J. Cell Biol. 120: 577–585, 1993.
 321. Kaibara, M., and M. Kameyama. Inhibition of the calcium channel by intracellular protons in single ventricular myocytes of the guinea pig. J. Physiol. 403: 621–640, 1988.
 322. Kandel, E. R., J. H. Schwartz, and T. M. Jessell. Principles of Neural Science. New York: Elsevier, 1991.
 323. Kang, Y. Development of the zona pellucida in the rat oocyte. Am. J. Anat. 139: 535–566, 1974.
 324. Kanwar, K. C., R. Yanagimachi, and A. Lopata. Effects of human seminal plasma on fertilizing capacity of human spermatozoa. Fertil. Steril. 31: 321–327, 1979.
 325. Karnik, N. S., S. Newman, G. S. Kopf, and G. L. Gerton. Developmental expression of G protein a subunits in mouse spermatogenic cells: evidence that Gai is associated with the developing acrosome. Dev. Biol. 152: 393–402, 1992.
 326. Katz, B. Nerve, Muscle, and Synapse. New York: McGraw‐Hill, 1966.
 327. Katz, B., and R. Miledi. The timing of calcium action during neuromuscular transmission. J. Physiol. 189: 535–544, 1967.
 328. Kawakami, E., C. A. Vandevoort, C. A. Mahi‐Brown, and J. W. Overstreet. Induction of acrosome reactions of canine sperm by homologous zona pellucida. Biol. Reprod. 48: 841–845, 1993.
 329. Kelly, R. B. Pathways of protein secretion in eukaryotes. Science 230: 25–32, 1985.
 330. Kelly, R. B. Storage and release of neurotransmitters. Neuron 10: 43–53, 1993.
 331. Kew, D., K. E. Muffly, and D. L. Kilpatrick. Proenkephalin products are stored in the sperm acrosome and may function in fertilization. Proc. Natl. Acad. Sci. USA 87: 9143–9147, 1990.
 332. Kimble, J., M. K. Barton, T. B. Schedl, T. A. Rosenquist, and J. Austin. Controls of postembryonic germ line development in Caenorhabditis elegans. In: Gametogenesis and the Early Embryo, edited by J. Gall. New York: Alan Liss, 1986, pp. 97–110.
 333. Kimble, J., and J. G. White. Control of germ cell development in Caenorhabditis elegans. Dev. Biol. 81: 208–219, 1981.
 334. Kinloch, R. A., S. Mortillo, C. L. Stewart, and P. M. Wassarman. Embryonal carcinoma cells transfected with ZP3 genes differentially glycosylate similar polypeptides and secrete active mouse sperm receptor. J. Cell Biol. 115: 655–664, 1991.
 335. Kinloch, R. A., R. J. Roller, and P. M. Wassarman. Organization and expression of the mouse sperm receptor gene. In: Developmental Biology, edited by E. H. Davidson, J. V. Ruderman, and J. W. Posakony. New York: Wiley‐Liss, 1990, p. 9–20.
 336. Kinloch, R. A., R. J. Roller, C. M. Fimiani, D. A. Wassarman, and P. M. Wassarman. Primary structure of the mouse sperm receptor's polypeptide chain determined by genomic cloning. Proc. Natl. Acad. Sci. U.S.A. 85: 6409–6413, 1988.
 337. Kinloch, R. A., B. Ruiz‐Seiler, and P. M. Wassarman. Genomic organization and polypeptide primary structure of zona pellucida glycoprotein hZP3, the hamster sperm receptor. Dev. Biol. 142: 414–421, 1990.
 338. Kinloch, R. A., and P. M. Wassarman. Nucleotide sequence of the gene encoding zona pellucida glycoprotein ZP3—the mouse sperm receptor. Nucleic Acids Res. 17: 2861–2863, 1989.
 339. Kinloch, R. A., and P. M. Wassarman. Profile of a mammalian sperm receptor gene. New Biol. 1: 232–238, 1989.
 340. Kinloch, R. A., and P. M. Wassarman. Specific gene expression during oogenesis in mice. In: Genes in Mammalian Reproduction, edited by R.B.L. Gwatkin. NY: Wiley‐Liss, 1993, p. 27–44.
 341. Kleuss, C., J. Hescheler, C. Ewel, W. Rosenthal, G. Schultz, and B. Wittig. Assignment of G protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353: 43–48, 1991.
 342. Kline, D., G. S. Kopf, L. F. Muncy, and L. A. Jaffe. Evidence for the involvement of a pertussis toxin‐insensitive G‐protein in egg activation of the frog, Xenopus laevis. Dev. Biol. 143: 218–229, 1991.
 343. Kline, D., L. Simoncini, G. Mandel, R. A. Maue, R. T. Kado, and L. A. Jaffe. Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus eggs. Science 241: 464–467, 1988.
 344. Klingman, I., M. Glassner, B. T. Storey, and G. S. Kopf. Zona pellucida‐mediated acrosomal exocytosis in mouse spermatozoa: characterization of an intermediate stage prior to the completion of the acrosome reaction. Dev. Biol. 145: 344–355, 1991.
 345. Koehler, J. K. Lectins as probes of the spermatozoon surface. Arch. Androl. 6: 197–217, 1981.
 346. Koehler, J. K., E. D. Nudelman, and S. Hakamori. A collagen‐binding protein on the surface of ejaculated rabbit spermatozoa. J. Cell Biol. 86: 529–536, 1980.
 347. Kopf, G. S., and G. L. Gerton. The mammalian sperm acrosome and the acrosome reaction. In: Elements of Mammalian Fertilization. Vol I. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 153–203.
 348. Kopf, G. S., M. J. Woolkalis, and G. L. Gerton. Evidence for a guanine nucleotide‐binding regulatory protein in invertebrate and mammalian sperm. J. Biol. Chem. 261: 7327–7331, 1986.
 349. Kornfeld, R., and S. Kornfeld. Assembly of asparagine‐linked oligosaccharides. Annu. Rev. Biochem. 54: 631–664, 1985.
 350. Krafte, D. S., and R. S. Kass. Hydrogen ion modulation of Ca channel current in cardiac ventricular cells. Evidence for multiple mechanisms. J. Gen. Physiol. 91: 641–657, 1988.
 351. Krarup, T., T. Pedersen, and M. Faber. Regulation of oocyte growth in the mouse ovary. Nature 224: 187–188, 1969.
 352. Kume, S., A. Muto, J. Aruga, T. Nakagawa, T. Michikawa, T. Furuichi, S. Nakade, H. Okano, and K. Mikoshiba. The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs. Cell 73: 555–570, 1993.
 353. Kurasawa, S., R. M. Schultz, and G. S. Kopf. Egg‐induced modifications of the zona pellucida of mouse eggs: effects of microinjected inositol 1,4,5‐trisphosphate. Dev. Biol. 133: 295–304, 1989.
 354. Kyte, J., and R. F. Doolittle. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105–132, 1982.
 355. La Valette St. George. Von Ueber die Genese der Samenkorper. I. Arch. Mikrosk. Anat. 1: 404–414, 1865.
 356. La Valette St. George. Von Ueber die Genese der Samenkorper. IV. Die Spermatogenese bei den Amphibien. Arch. Mikrosk. Anat. 12: 797–825, 1876.
 357. La Valette St. George. Von Ueber die Genese der Samenkorper. V. Die Spermatogenese bei den Saugetheiren und dem Menschen. Arch. Mikrosk. Anat. 15: 261–314, 1878.
 358. La Valette St. George. Von Spermatologische Beitrage. V. Ueber die Bildung der Spermatocysten bei den Lepidopteren. Arch. Mikrosk. Anat. 30: 426–434, 1887.
 359. Langlais, J., F.W.K. Kan, L. Granger, L. Raymond, G. Bleau, and K. D. Roberts. Identification of sterol acceptors that stimulate cholesterol efflux from human spermatozoa during in vitro capacitation. Gamete Res. 20: 185–201, 1988.
 360. Langlais, J., and K. D. Roberts. A molecular membrane model of sperm capacitation and the acrosome reaction of mammalian spermatozoa. Gamete Res. 12: 183–224, 1985.
 361. Langley, J. N. On the contraction of musccle, chiefly in relation to the presence of “receptive” substances. J. Physiol. 36: 347–384, 1907.
 362. Lardy, H. A., and J. San Agustin. Caltrin and calcium regulation of sperm activity. In: The Cell Biology of Fertilization, edited by H. Schatten, and G. Schatten. New York: Academic, 1989, p. 29–39.
 363. Larsen, W., S. Wert, and G. Brunner. A dramatic loss of cumulus cell gap junctions is correlated with germinal vesicle breakdown in rat oocytes. Dev. Biol. 113: 517–521, 1986.
 364. Lawrence, T., W. Beers, and N. Gilula. Transmission of hormonal stimulation by cell‐to‐cell communication. Nature 272: 501–506, 1978.
 365. Lawrence, T., R. Ginzberg, N. Gilula, and W. Beers. Hormonally induced cell shape changes in cultured rat ovarian granulosa cells. J. Cell Biol. 80: 21–36, 1979.
 366. Lee, H. C., and R. Aarhus. ADP‐ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium‐mobilizing metabolite. Cell Regul. 2: 203–209, 1991.
 367. Lee, H. C., C. Johnson, and D. Epel. Changes in internal pH associated with initiation of motility and acrosome reaction of sea urchin sperm. Dev. Biol. 95: 31–45, 1983.
 368. Lee, H. C., T. F. Walseth, G. T. Bratt, R. N. Hayes, and D. L. Clapper. Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+‐mobilizing activity. J. Biol. Chem. 264: 1608–1615, 1990.
 369. Lee, M. A., J. H. Check, and G. S. Kopf. A guanine nucleotide‐binding regulatory protein in human sperm mediates acrosomal exocytosis induced by the human zona pellucida. Mol. Reprod. Dev. 31: 78–86, 1992.
 370. Lee, M. A., and B. T. Storey. Bicarbonate is essential for fertilization of mouse eggs: mouse sperm require it to undergo the acrosome reaction. Biol. Reprod. 34: 349–356, 1986.
 371. Lee, M. A., and B. T. Storey. Evidence for plasma membrane impermeability to small ions in acrosome‐intact mouse spermatozoa bound to mouse zonae pellucidae, using an aminoacridine fluorescent pH probe: time course of the zona‐induced acrosome reaction monitored by both chlortetracycline and pH probe fluorescence. Biol. Reprod. 33: 235–246, 1985.
 372. Lee, M. A., and B. T. Storey. Endpoint of the first stage of zona pellucida‐induced acrosome reaction in mouse spermatozoa characterized by acrosomal H+ and Ca2+ permeability: population and single cell kinetics. Gamete Res. 24: 303–326, 1989.
 373. Lee, M. A., G. S. Trucco, K. B. Bechtol, N. Wummer, G. S. Kopf, L. Blasco, and B. T. Storey. Capacitation and acrosome reactions in human spermatozoa monitored by a chlortetracycline fluorescence assay. Fertil. Steril. 48: 649–658, 1987.
 374. Leibfried, L., and N. First. Effects of divalent cations on in vitro maturation of bovine oocytes. J. Exp. Zool. 210: 575–580, 1979.
 375. Leibfried, L., and N. First. Follicular control of meiosis in the porcine oocyte. Biol. Reprod 23: 705–709, 1980.
 376. Leibfried, L., and N. First. Effect of bovine and porcine follicular fluid and granulosa cells on maturation of oocytes in vitro. Biol. Reprod. 23: 699–704, 1980.
 377. Lewis, R. V., J. San Agustin, W. Kruggel, and H. A. Lardy. The structure of caltrin, the calcium‐transport inhibitor of bovine seminal plasma. Proc. Natl. Acad. Sci. U.S.A. 82: 6490–6491, 1985.
 378. Leyton, L., P. Leguen, D. Bunch, and P. M. Saling. Regulation of mouse gamete interaction by a sperm tyrosine kinasse. Proc. Natl. Acad. Sci. U.S.A. 89: 11692–11695, 1992.
 379. Leyton, L., and P. M. Saling. 95 kd sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 57: 1123–1130, 1989.
 380. Leyton, L., and P. M. Saling. Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction. J. Cell Biol. 108: 2163–2168, 1989.
 381. Lillie, F. R. Problems of Fertilization. Chicago: University of Chicago, 1919.
 382. Lindemann, C. B., T. K. Gardner, E. Westbrook, and K. S. Kanous. The calcium‐induced curvature reversal of rat sperm is potentiated by cAMP and inhibited by anti‐calmodulin. Cell Motil. Cytoskeleton 20: 316–324, 1991.
 383. Lindemann, C. B., and J. S. Goltz. Calcium regulation of flagellar curvature and swimming pattern in Triton‐X‐100‐extracted rat sperm. Cell Motil. Cytoskeleton 10: 420–431, 1988.
 384. Llanos, M. N., and S. Meizel. Phospholipid methylation increases during capacitation of golden hamster sperm in vitro. Biol. Reprod. 28: 1043–1050, 1983.
 385. Macek, M. B., L. C. Lopez, and B. D. Shur. Aggregation of β−1,4‐galactosyltransferase on mouse sperm induces the acrosome reaction. Dev. Biol. 147: 440–444, 1991.
 386. Magnusson, C., and T. Hillensjo. Inhibition of maturation and metabolism of rat oocytes by cyclic AMP. J. Exp. Zool. 201: 138–147, 1977.
 387. Mahanes, M. S., D. L. Ochs, and L. A. Eng. Cell calcium of ejaculated rabbit spermatozoa before and following in vitro capacitation. Biochem. Biophys. Res. Commun. 134: 664–670, 1986.
 388. Mailer, J. L. Interaction of steroids with the cyclic nucleotide system in amphibian oocytes. Adv. Cyclic Nucl. Res. 15: 295–336, 1983.
 389. Mailer, J. L., Oocyte maturation in amphibians. In: Developmental Biology: A Comprehensive Synthesis, Vol. 1, Oogenesis, edited by L. Browder, New York: Plenum, 1985, p. 238–311.
 390. Mancini, R. E., A. Alanso, J. Barquet, and N. R. Nerimovsky. Histo‐immunological localization of hyaluronidase in bull testis. J. Reprod. Fertil. 8: 325–330, 1964.
 391. Mann, T. The Biochemistry of Semen and of the Male Reproductive Tract. New York: Wiley, 1964.
 392. Mann, T. and C. Lutwak‐Mann. Male Reproductive Function and Semen. Themes and Trends in Physiology, Biochemistry, and Investigative Andrology. New York: Springer‐Verlag, 1981.
 393. Masui, Y., Meiotic arrest in animal oocytes. In: Biology of Fertilization, edited by C. Metz, and A. Monroy. New York: Academic, 1985, vol. 1, p. 189–220.
 394. Masui, Y., and H. Clark. Regulation of oocyte maturation. Int. Rev. Cytol. 57: 185–282, 1979.
 395. Matsui, Y., D. Toksoz, S. Nishikawa, S.‐I. Nishikawa, D. Williams, K. Zsebo, and B.L.M. Hogan. Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. Nature 353: 750–752, 1991.
 396. Matsui, Y., K. Zsebo, and B.L.M. Hogan. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 70: 841–847, 1992.
 397. Mattson, B. A., and D. F. Albertini. Oogenesis: chromatin and microtubule dynamics during meiotic prophase. Mol. Reprod. Dev. 25: 374–383, 1990.
 398. McCulloh, D. H., and E. L. Chambers. Fusion of membranes during fertilization. Increases of the sea urchin egg's membrane capacitance and membrane conductance at the site of contact with the sperm. J. Gen. Physiol. 99: 137–175, 1992.
 399. McEwen, B. S. Non‐genomic and genomic effects of steroids on neural activity. TIPS 12: 141–148, 1991.
 400. McGaughey, R. The culture of pig oocytes in minimal medium, and the influence of progesterone and estradiol‐17β on meiotic maturation. Endocrinology 100: 39–45, 1977.
 401. McKinnon, C. A., F. E. Weaver, J. A. Yoder, G. Fairbanks, and D. E. Wolf. Cross‐linking of a maturation‐dependent ram sperm plasma membrane antigen induces the acrosome reaction. Mol. Reprod. Dev. 29: 200–207, 1991.
 402. McLaren, A., and C. Wylie (Eds). Current problems in germ cell differentiation. In: 7th Symposium British Society of Developmental Biology. Cambridge: Cambridge University, 1983.
 403. McLaughlin, J. D., and B. D. Shur. Binding of caput epididymal mouse sperm to the zona pellucida. Dev. Biol. 124: 557–561, 1987.
 404. Meizel, S. The importance of hydrolytic enzymes to an exocytotic event, the mammalian sperm acrosome reaction. Biol. Rev. 59: 125–157, 1984.
 405. Meizel, S. Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am. J. Anat. 174: 285–302, 1985.
 406. Meizel, S., and D. W. Deamer. The pH of the hamster sperm acrosome. J. Histochem. Cytochem. 26: 98–105, 1978.
 407. Meizel, P., M. C. Pillai, E. Diaz‐Perez, and P. Thomas. Initiation of the human sperm acrosome reaction by components of human follicular fluid and cumulus secretions including steroids. In: Fertilization in Mammals, edited by B. D. Bavister, J. Cummins, and E.R.S. Roldan. Norwell, MA: Serono Symposia, 1990, p. 205–222.
 408. Meizel, S., and K. O. Turner. Progesterone acts at the plasma membrane of human sperm. Mol. Cell. Endocrinol. 11: R1–R5, 1991.
 409. Messinger, S. M., and D. F. Albertini. Centrosome and microtubule dynamics during meiotic progression in the mouse oocyte. J. Cell Sci. 100: 289–298, 1991.
 410. Meyerhof, W., R. Muller‐Brechlin, and D. Richter. Molecular cloning of a novel putative G protein coupled receptor expressed during rat spermiogenesis. FEBS Lett. 284: 155–160, 1991.
 411. Millar, S. E., S. M. Chamow, A. W. Baur, C. Oliver, F. Robey, and J. Dean. Vaccination with a synthetic zona pellucida peptide produces long‐term contraception in female mice. Science 246: 935–938, 1989.
 412. Miller, D. J., and R. L. Ax. Carbohydrates and fertilization in animals. Mol. Reprod. Dev. 26: 184–198, 1990.
 413. Miller, D. J., M. B. Macek, and B. D. Shur. Complementarity between sperm surface β−1,4–galactosyltransferase and egg‐coat ZP3 mediates sperm‐egg binding. Nature 357: 589–593, 1992.
 414. Miller, D. J., M. A. Winer, and R. L. Ax. Heparin‐binding proteins from seminal plasma bind to bovine spermatozoa and modulate capacitation by heparin. Biol. Reprod. 42: 899–915, 1990.
 415. Miller, R. J. Voltage‐sensitive Ca2+ channels. J. Biol. Chem. 267: 1403–1406, 1992.
 416. Milligan, G. Techniques used in the identification and analysis of function of pertussis toxin‐sensitive guanine nucleotide binding proteins. Biochem. J. 255: 1–13, 1988.
 417. Miyazaki, S. Cell signalling at fertilization of hamster eggs. J. Reprod. Fertil. Suppl. 42: 163–175, 1990.
 418. Miyazaki, S. Inositol 1,4,5‐trisphosphate‐induced calcium release and guanine nucleotide‐binding protein‐mediated periodic calcium rises in golden hamster eggs. J. Cell Biol. 106: 3455–353, 1988.
 419. Miyazaki, S., N. Hashimoto, Y. Yoshimoto, T. Kishimoto, Y. Igusa, and Y. Hiramoto. Temporal and spatial dynamics of the periodic increase in intracellular calcium at fertilization of golden hamster eggs. Dev. Biol. 118: 259–267, 1986.
 420. Miyazaki, S., and Y. Igusa. Fertilization potential in golden hamster eggs consists of recurring hyperpolarizations. Nature 290: 706–707, 1981.
 421. Miyazaki, S., M. Yuzaki, K. Nakeda, H. Shirakawa, S. Nakanishi, S. Nakade, and K. Mikoshiba. Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5‐trisphosphate receptor in fertilized hamster eggs. Science 257: 251–255, 1992.
 422. Moens, P. B., C. Heyting, A.J.J. Dietrich, W. Van Raamsdonk, and Q. Chen. Synaptonemal complex antigen location and conservation. J. Cell Biol. 105: 93–101, 1987.
 423. Moller, C. C., J. D. Bleil, R. A. Kinloch, and P. M. Wassarman. Structural and functional relationships between mouse and hamster zona pellucida glycoproteins. Dev. Biol. 137: 276–286, 1990.
 424. Monck, J. R., and J. M. Fernandez. The exocytotic fusion pore. J. Cell Biol. 119: 1395–1404, 1992.
 425. Monks, N. J., and L. R. Fraser. Inhibition of adenosinemetabolizing enzymes modulates mouse sperm fertilizing ability: a changing role for endogenously generated adenosine during capacitation. Gamete Res. 21: 267–276, 1988.
 426. Moor, R., J. Osborn, D. Cran, and D. Walters. Selective effect of gonadotrophins on cell coupling, nuclear maturation and protein synthesis in mammalian oocytes. J. Embryol. Exp. Morphol. 61: 347–365, 1981.
 427. Moor, R., M. Smith, and R. Dawson. Measurement of intercellular coupling between oocytes and cumulus cells using intracellular markers. Exp. Cell Res. 126: 15–29, 1980.
 428. Moor, R., and A. Trounson. Hormonal and follicular factors affecting maturation of sheep oocytes in vitro and their subsequent developmental capacity. J. Reprod. Fertil. 49: 101–109, 1977.
 429. Morales, P., N. L. Cross, J. W. Overstreet, and F. W. Hanson. Acrosome intact and acrosome‐reacted human sperm can initiate binding to the zona pellucida. Dev. Biol. 133: 385–392, 1989.
 430. Mortillo, S., and P. M. Wassarman. Differential binding of gold‐labeled zona pellucida glycoproteins mZP2 and mZP3 to mouse sperm membrane compartments. Development 113: 1411–150, 1991.
 431. Moss, J., and M. Vaughan. ADP‐ribosylation of guanyl nucleotide‐binding regulatory proteins by bacterial toxins. Adv. Enzymol. 61: 303–379, 1988.
 432. Mount, S. M. A catalogue of splice junction sequences. Nucleic Acids Res. 10: 459–472, 1982.
 433. Mrsny, R. J., and S. Meizel. Potassium ion influx and Na+, K+‐ATPase activity are required for the hamster sperm acrosome reaction. J. Cell Biol. 91: 77–82, 1981.
 434. Mukherjee, A. Normal progeny from fertilization in vitro of mouse oocytes matured in culture and spermatozoa capacitated in vitro. Nature 237: 397–398, 1972.
 435. Myles, D. G., H. Hyatt, and P. Primakoff. Binding of both acrosome‐intact and acrosome‐reacted guinea pig sperm to the zona pellucida during in vitro fertilization. Dev. Biol. 121: 559–567, 1987.
 436. Myles, D. G., and P. Primakoff. Localized surface antigens of guinea pig sperm migrate to new regions prior to fertilization. J. Cell Biol. 99: 1634–1641, 1984.
 437. Nagae, T., and P. N. Srivastava. Induction of the acrosome reaction in guinea pig spermatozoa by calmodulin antagonist W‐7. Gamete Res. 14: 197–208, 1986.
 438. Nagalla, S. R., S. Vijayaraghavan, H. M. Florman, A. Archibong, K. K. Li, M. Kelly, B. Barry, D. H. Coy, K. Hermsmeyer, D. P. Wolf, and E. R. Spindel. The bombesin‐like peptides gastrin‐releasing peptide (GRP) and ARP, a new splice product of the GRP gene, are endogenous regulators of the acrosome reaction and fertilization (Submitted).
 439. Nanavati, C., and J. M. Fernandez. The secretory granule matrix: a fast‐acting smart polymer. Science 259: 963–965, 1993.
 440. Nehme, C. L., M. M. Cesario, D. G. Myles, D. E. Koppel, and J. R. Bartles. Breaching the diffusion barrier that compartmentalizes the transmembrane glycoprotein CE9 to the posterior‐tail plasma membrane domain of the rat spermatozoon. J. Cell Biol. 120: 687–694, 1993.
 441. Nicosia, S., D. Wolf, and M. Inoue. Cortical granule distribution and cell surface characteristics in mouse eggs. Dev. Biol. 57: 56–74, 1977.
 442. Nikolajczyk, B. S., and M. G. O'Rand. Characterization of rabbit testis β‐galactosidase and arylsulfatase A: purification and localization in spermatozoa during the acrosome reaction. Biol. Reprod. 46: 366–378, 1992.
 443. Nishimoto, I., T. Okamoto, Y. Matsuura, S. Takahashi, Y. Murayama, and E. Ogata. Alzheimer amyloid protein precursor complexes with brain GTP‐binding protein Go. Nature 362: 75–79, 1993.
 444. Noland, T. D., N. A. Abumrad, A. H. Beth, and D. L. Garbers. Protein phosphorylation in intact bovine epididymal spermatozoa: identification of the type II regulatory subunit of cyclic adenosine 3′,5′‐monophosphate‐dependent protein kinase as an endogenous phosphoprotein. Biol. Reprod. 37: 171–180, 1987.
 445. Noland, T. D., and G. E. Olson. Calcium‐induced modification of the acrosomal matrix in digitonin‐permeabilized guinea pig spermatozoa. Biol. Reprod. 40: 1057–1066, 1989.
 446. Noland, T. D., L. J. Van Eldik, D. L. Garbers, and W. H. Burgess. Distibution of calmodulin and calmodulin‐binding proteins in membranes from bovine epididymal spermatozoa. Gamete Res. 11: 297–303, 1985.
 447. Nuccitelli, R., and R. D. Grey. Controversy over the fast, partial, temporary block to polyspermy in sea urchins: a reevaluation. Dev. Biol. 103: 1–17, 1984.
 448. O'Brien, D. A., C. A. Gabel, D. L. Rockett, and E. M. Eddy. Receptor‐mediated endocytosis and differential synthesis of mannpse 6‐phosphate receptors in isolated spermatogenic cells and Sertoli cells. Endocrinologie 125: 2973–2984, 1989.
 449. O'Rand, M. G. Modification of the sperm membrane during capacitation. Ann. N. Y. Acad. Sci. 383: 392–404, 1982.
 450. O'Rand, M. G., and S. J. Fisher. Localization of zona pellucida binding sites on rabbit spermatozoa and induction of the acrosome reaction by solubilized zonae. Dev. Biol. 119: 551–559, 1987.
 451. Okabe, K., K. Takada, T. Adachi, Y. Kohama, and T. Miura. Inconsistent reactivity of an antisperm monoclonal antibody and its relation to sperm capacitation. J. Reprod. Immunol. 9: 67–71, 1986.
 452. Okabe, M., K. Takada, T. Adachi, Y. Kohama, T. Miura, and S. Aonuma. Studies on sperm capacitation using monoclonal antibody‐disappearance of an antigen from the anterior part of the mouse sperm head. J. Pharmacobiodyn. 9: 55–60, 1986.
 453. Okamoto, T., T. Katada, Y. Murayama, M. Ui, E. Ogata, and I. Nishimoto. A simple structure encodes G protein‐activating function of the IGF‐II/mannose‐6‐phosphate receptor. Cell 62: 709–717, 1990.
 454. Okamura, N., A. Fukuda, M. Tanba, Y. Sugita, and T. Nagai. Changes in the nature of calcium transport systems on the porcine sperm plasma membrane during epididymal maturation. Biochim. Biophys. Acta 1108: 110–114, 1992.
 455. Okamura, N., S. Onoe, K. Kawakura, Y. Tajima, and Y. Sugita. Effects of a membrane‐bound trypsin‐like proteinase and seminal proteinase inhibitors on the bicarbonate‐sensitive adenylate cyclase in porcine sperm plasma membranes. Biochim. Biophys. Acta 1035: 83–89, 1990.
 456. Okamura, N., and Y. Sugita. Activation of spermatozoan adenylate cyclase by a low molecular weight factor in porcine seminal plasma. J. Biol. Chem. 258: 13056–13062, 1983.
 457. Okamura, N., Y. Tajima, S. Onoe, and Y. Sugita. Purification of bicarbonate‐sensitive sperm adenylylcyclase by 4‐acetamido‐4′‐isothio‐cyano‐stilbene‐2,2′‐disulfonic acid‐affinity chromatography. J. Biol. Chem. 266: 17754–17759, 1991.
 458. Okamura, N., Y. Tajima, A. Soejima, H. Masuda, and Y. Sugita. Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. J. Biol. Chem. 260: 9699–9705, 1985.
 459. Okamura, N., Y. Tajima, and Y. Sugita. Decrease in bicarbonate transport activities during epididymal maturation of porcine sperm. Biochem. Biophys. Res. Commun. 157: 1280–1287, 1988.
 460. Oliphant, G. Removal of sperm‐bound seminal plasma components as a prerequisite to induction of the rabbit acrosome reaction. Fertil. Steril. 27: 28–38, 1976.
 461. Oliphant, G., and B. G. Brackett. Capacitation of mouse spermatozoa in media with elevated ionic strength and reversible decapacitation with epididymal extracts. Fertil. Steril. 24: 948–955, 1973.
 462. Oliphant, G., and B. G. Brackett. Immunological assessment of surface changes of rabbit sperm undergoing capacitation. Biol. Reprod. 9: 404–414, 1973.
 463. Oliphant, G., A. B. Reynolds, and T. S. Thomas. Sperm surface components involved in the control of the acrosome reaction. Am. J. Anat. 174: 269–283, 1985.
 464. Olsiewski, P., and W. Beers. cAMP synthesis in the rat oocyte. Dev. Biol. 100: 287–293, 1983.
 465. Orgebin‐Crist, M.‐C. Maturation of spermatozoa in the rabbit epididymis. Fertilizing ability and embryonic mortality in does inseminated with epididymal spermatozoa. Ann. Biol. Anim. Biochim. Biophys. 7: 373–389, 1967.
 466. Orgebin‐Crist, M.‐C. Sperm maturation in the rabbit epididymis. Nature 216: 816–818, 1967.
 467. Palade, G. Intracellular aspects of the process of protein synthesis. Science 189: 347–358, 1975.
 468. Paleos, G., and R. Powers. The effect of calcium on the first meiotic division of the mammalian oocyte. J. Exp. Zool. 217: 409–416, 1981.
 469. Parkes, A. (Ed) Marshall's Physiology of Reproduction. New York: Longmans, Green, 1956, vol. 1, part 1.
 470. Parmentier, M., F. Libert, S. Schurmans, S. Schiffmann, A. Lefort, D. Eggerickx, C. Ledent, C. Mollereau, C. Gerard, J. Perret, A. Grootegoed, and G. Vassart. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 355: 453–455, 1992.
 471. Parrish, J. J., J. L. Susko‐Parrish, and N. L. First. Capacitation of bovine sperm by heparin: inhibitory effect of glucose and role of intracellular pH. Biol. Reprod. 41: 683–699, 1989.
 472. Parrish, J. J., J. L. Susko‐Parrish, M. A. Winer, and N. L. First. Capacitation of bovine sperm by heparin. Biol. Reprod. 38: 1171–1180, 1988.
 473. Paul, S. M., and R. H. Purdy. Neuroactive steroids. FASEB J. 6: 2311–2322, 1992.
 474. Paulssen, R. H., E. J. Paulssen, J. O. Gordeladze, V. Hansson, and T. B. Haugen. Cell‐specific expression of guanine nucleotide‐binding proteins in rat testicular cells. Biol. Reprod. 45: 566–571, 1991.
 475. Pawson, T. and G. D. Gish. SH2 and SH3 domains: from structure to function. Cell 71: 359–362, 1992.
 476. Pazin, M. J., and L. T. Williams. Triggering signalling cascades by receptor tyrosine kinases. Trends Biochem. Sci. 17: 374–378, 1992.
 477. Pedersen, T. Follicle growth in the immature mouse ovary. Acta Endocrinol. (Copenh.) 62: 117–132, 1969.
 478. Pedersen, T. Follicle kinetics in the ovary of the cyclic mouse. Acta Endocrinol. (Copenh.) 64: 304–323, 1970.
 479. Pedersen, T., Follicle growth in the mouse ovary. In: Oogenesis, edited by J. Biggers, and A. Schuetz. Baltimore: University Park, 1972, p. 361–367.
 480. Pedersen, T., and H. Peters. Proposal for the classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17: 555–557, 1968.
 481. Persson, H., J. F. Rehfeld, A. Ericsson, M. Schalling, M. Pelto‐Huikko, and T. Hokfelt. Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization. Proc. Natl. Acad. Sci. U.S.A. 86: 6166–6170, 1989.
 482. Peters, H. The development of the mouse ovary from birth to maturity. Acta Endocrinol. (Copenh.) 62: 98–116, 1969.
 483. Peters, H., Folliculogenesis in mammals. In: The Vertebrate Ovary, edited by R. Jones. New York: Plenum, 1978, p. 121–144.
 484. Petersen, O. H. Stimulus‐secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J. Physiol. 448: 1–52, 1992.
 485. Phelps, B. M., D. E. Koppel, P. Primakoff, and D. G. Myles. Evidence that proteolysis of the surface is an initial step in the mechanism of formation of sperm cell surface domains. J. Cell Biol. 111: 1839–1847, 1990.
 486. Phillips, D. M. Surface of the equatorial segment of the mammalian acrosome. Biol. Reprod. 16: 128–137, 1977.
 487. Phillips, D. M., and R. Yanagimachi. Difference in the manner of association of acrosome‐intact and acrosome‐reacted hamster spermatozoa with egg microvilli as revealed by scanning electron microscopy. Dev. Growth Diff. 26: 543–551, 1982.
 488. Philpott, C. C., M. J. Ringuette, and J. Dean. Oocyte‐specific expression and developmental regulation of ZP3, the sperm receptor of the mouse zona pellucida. Dev. Biol. 121: 568–575, 1987.
 489. Pierce, K. E., M. C. Siebert, G. S. Kopf, R. M. Schultz, and P. G. Calarco. Characterization and localization of a mouse egg cortical granule antigen prior to and following fertilization or egg activation. Dev. Biol. 141: 381–392, 1990.
 490. Pietrobon, D., B. Prod'Hom, and P. Hess. Interactions of protons with single open L type calcium channels. pH fluctuations with Cs+,K+, and Na+ as permeant ions. J. Gen. Physiol. 94: 1–21, 1989.
 491. Piko, L., and A. Tyler. Fine structural studies of sperm penetration in the rat. Proc. Vth Int. Congr. Animal Reprod. A. I. Trento 2: 372–377, 1964.
 492. Pincus, G. The Eggs of Mammals. New York: Macmillan, 1936.
 493. Pincus, G., and E. Enzmann. The comparative behavior of mammalian eggs in vivo and in vitro. 1. The activation of ovarian eggs. J. Exp. Med. 62: 665–675, 1935.
 494. Popa, G. T. The distribution of substances in the spermatozoan (Arbacia and Nereis). Biol. Bull. 52: 238–257, 1927.
 495. Powers, R., and G. Paleos. Combined effects of calcium and dibutyryl cAMP on germinal vesicle breakdown in the mouse oocyte. J. Reprod. Fertil. 66: 1–8, 1982.
 496. Primakoff, P., H. Hyatt, and J. Tredick‐Kline. Identification and purification of a sperm surface protein with a potential role in sperm‐egg membrane fusion. J. Cell Biol. 104: 141–149, 1987.
 497. Prod'Hom, B., D. Pietrobon, and P. Hess. Interactions of protons with single open L type calcium channels. Location of protonation site and dependence of proton‐induced fluctuations on concentration and species of permeant ion. J. Gen. Physiol. 94: 23–42, 1989.
 498. Quiocho, F. A. Carbohydrate‐binding proteins: tertiary structures and protein‐sugar interactions. Annu. Rev. Biochem. 55: 287–316, 1986.
 499. Racowsky, C. Antagonistic actions of estradiol and tamoxifen upon forskolin‐dependent meiotic arrest, intercellular coupling, and the cAMP content of hamster oocyte‐cumulus complexes. J. Exp. Zool. 234: 251–260, 1985.
 500. Racowsky, C. Effect of forskolin on the spontaneous maturation and cyclic AMP content of hamster oocyte‐cumulus complexes. J. Exp. Zool. 234: 87–96, 1985.
 501. Racowsky, C., and R. McGaughey. Further studies of the effects of follicular fluid and membrane granulosa cells on the spontaneous maturation of pig oocytes. J. Reprod. Fertil. 66: 505–512, 1982.
 502. Racowsky, C., and R. McGaughey. In the absence of protein, estradiol suppresses meiosis of porcine oocytes in vitro. J. Exp. Zool. 224: 103–110, 1982.
 503. Racowsky, C., and R. Satterlie. Metabolic, fluorescent dye and electrical coupling between hamster oocytes and cumulus cells during meiotic maturation in vivo and in vitro. Dev. Biol. 108: 191–202, 1985.
 504. Rafferty, K. Methods in Experimental Embryology of the Mouse. Baltimore: Johns Hopkins University, 1970.
 505. Ralt, D., M. Goldenberg, P. Fetterolf, D. Thompson, J. Dor, S. Maschiach, D. L. Garbers, and M. Eissenbach. Sperm attraction to follicular factor(s) correlates with human egg fertilizability. Proc. Natl. Acad. Sci. U.S.A. 88: 2840–2844, 1991.
 506. Reeves, J. P. Molecular aspects of sodium‐calcium exchange. Arch. Biochem. Biophys. 292: 329–334, 1992.
 507. Resnick, J. L., L. S. Bixter, L. Cheng, and P. J. Donovan. Long‐term proliferation of mouse primordial germ cells in culture. Nature 359: 550–551, 1992.
 508. Retzius, G. Biologische untersuchungen. Jena: Gustav Fischer, 1909, vol. 14.
 509. Reyes, A., G. Oliphant, and B. G. Brackett. Partial purification and identification of a reversible decapacitation factor from rabbit seminal plasma. Fertil. Steril. 26: 148–157, 1975.
 510. Reynolds, A. B., T. S. Thomas, W. L. Wilson, and G. Oliphant. Concentration of acrosome stabilizing factor (ASF) in rabbit epididymal fluid and species specificity of anti‐ASF antibodies. Biol. Reprod. 40: 673–681, 1989.
 511. Rice, C., and R. McGaughey. Effect of testosterone and dibutyryl cAMP on the spontaneous maturation of pig oocytes. J. Reprod. Fertil. 62: 245–256, 1981.
 512. Ringuette, M., M. Chamberlin, A. Baur, D. Sobieski, and J. Dean. Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida. Dev. Biol. 127: 287–295, 1988.
 513. Rogers, B. J. Mammalian sperm capacitation and fertilization in vitro: a critique of methodology. Gamete Res. 1: 165–223, 1978.
 514. Roldan, E.R.S., and R.A.P. Harrison. Polyphosphoinositide breakdown and subsequent exocytosis in the Ca2+/ionophore‐induced acrosome reaction of mammalian spermatozoa. Biochem. J. 259: 397–406, 1989.
 515. Roldan, E.R.S., and R.A.P. Harrison. Diacylglycerol and phosphatidate production and the exocytosis of the sperm acrosome. Biochem. Biophys. Res. Commun. 172: 8–15, 1990.
 516. Roller, R. Kinloch, B. Hiraoka, S.S.‐L. Li, and P. M. Wassarman. Gene expression during mammalian oogenesis and early embryogenesis: quantification of three messenger RNAs abundant in fully‐grown mouse oocytes. Development 106: 251–261, 1989.
 517. Roller, R. J., and P. M. Wassarman. Role of asparagine‐linked oligosaccharides in secretion of glycoproteins of the mouse egg's extracullar coat. J. Biol. Chem. 258: 13243–13249, 1983.
 518. Roos, A., and W. F. Boron. Intracellular pH. Physiol. Rev. 61: 296–434, 1981.
 519. Rosiere, T. K., and P. M. Wassarman. Identification of a region of mouse zona pellucida glycoprotein mZP3 that possesses sperm receptor activity. Dev. Biol. 154: 309–317, 1992.
 520. Rothman, J. E., and L. Orci. Molecular dissection of the secretory pathway. Nature 355: 409–415, 1992.
 521. Rufo, G. A., P. K. Schoff, and H. A. Lardy. Regulation of calcium content in bovine spermatozoa. J. Biol. Chem. 259: 2547–2552, 1984.
 522. Rufo, G. A., J. P. Singh, D. F. Babcock, and H. A. Lardy. Purification and characterization of a calcium transport inhibitor protein from bovine seminal plasma. J. Biol. Chem. 257: 4627–4632, 1982.
 523. Rugh, R. The Mouse: Its Reproduction and Development. Minneapolis: Burgess, 1968.
 524. Ruknudin, A., and I. A. Silver. Ca2+ uptake during capacitation of mouse spermatozoa and the effect of an anion transport inhibitor on Ca2+ uptake. Mol Reprod. Dev. 26: 63–68, 1990.
 525. Rusinko, N., and H. C. Lee. Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca+‐mobilizing activity. J. Biol. Chem. 264: 11725–11731, 1989.
 526. Russell, L., R. Peterson, and M. Freund. Direct evidence for formation of hybrid vesicles by fusion of plasma and outer acrosomal membranes during the acrosome reaction in boar spermatozoa. J. Exp. Zool. 208: 41–56, 1979.
 527. Russo, J., and C. B. Metz. The ultrastructural lesions produced by antibodies and complement in rabbit spermatozoa. Biol. Reprod. 10: 293–308, 1974.
 528. Russo, R. N., N. L. Shaper, and J. H. Shaper. Bovine β,4‐galacosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino‐terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane‐bound glycoproteins. J. Biol. Chem. 265: 3324–3331, 1990.
 529. Sacco, A. G., E. C. Yurewicz, and M. G. Subramanian. Carbohydrate influences the immunogenic and antigenic characteristics of the ZP3 macromolecule (Mr 55,000) of the pig zona pellucida. J. Reprod. Fertil. 76: 575–586, 1986.
 530. Sacco, A. G., E. C. Yurewicz, A. G. Subramanian, and F. J. Demayo. Zona pellucida composition: Cross‐reactivity and contraceptive potential of antiserum to a pig zona antigen. Biol. Reprod. 25: 997–1008, 1981.
 531. Sacco, A. G., E. C. Yurewicz, M. G. Subramanian, and P. D. Matzat. Porcine zona pellucida: Association of sperm receptor activity with the a‐glycoprotein component of the Mr = 55,000 family. Biol. Reprod. 41: 523–532, 1989.
 532. Saling, P. M. Mouse sperm antigens that participate in fertilization. IV. A monoclonal antibody prevents zona penetration by inhibition of the acrosome reaction. Dev. Biol. 117: 511–519, 1986.
 533. Saling, P. M., J. Sowinski, and B. T. Storey. An ultrastructural study of epididymal mouse spermatozoa binding to zonae pellucidae in vitro: sequential relationship to the acrosome reaction. J. Exp. Zool. 209: 229–238, 1979.
 534. Saling, P. M., and B. T. Storey. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J. Cell Biol. 83: 544–555, 1979.
 535. Saling, P. M., B. T. Storey, and D. P. Wolf. Calcium‐dependent binding of mouse epididymal spermatozoa to the zona pellucida. Dev. Biol. 65: 515–525, 1978.
 536. Salustri, A., and G. Siracusa. Metabolic coupling cumulus expansion and meiotic resumption in mouse cumuli oophori cultured in vitro in the presence of FSH or dbcAMP, or stimulated in vivo by hCG. J. Reprod. Fertil. 68: 335–341, 1983.
 537. Salzmann, G., J. Greve, R. Roller, and P. M. Wassarman. Biosynthesis of the sperm receptor during oogenesis in the mouse. EMBO J. 2: 1451–1456, 1983.
 538. San Agustin, J. T., P. Hughes, and H. A. Lardy. Properties and function of caltrin, the calcium‐transport inhibitor of bull seminal plasma. FASEB J. 1: 60–66, 1987.
 539. Sato, E., and S. Koide. Forskolin and mouse oocyte maturation in vitro. J. Exp. Zool. 230: 125–129, 1984.
 540. Schackmann, R. W., Ionic regulation of the sea urchin sperm acrosome reaction and stimulation by egg‐derived peptides. In: The Cell Biology of Fertilization, edited by H. Schatten, and G. Schatten. New York: Academic, 1989, p. 3–28.
 541. Schackmann, R. W., and B. M. Shapiro. A partial sequence of ionic changes associated with the acrosome reaction of Strongylocentrotus purpuratus. Dev. Biol. 81: 145–154, 1981.
 542. Schalling, M., H. Persson, M. Pelto‐Huikko, L. Odum, P. Ekman, C. Gottlieb, T. Hokfelt, and J. F. Rehfeld. Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells. J. Clin. Invest. 86: 660–669, 1990.
 543. Schill, W.‐B., N. Heimburger, H. Schliessler, R. Stolla, and H. Fritz. Reversible attachment and localization of the acid‐stable seminal plasma acrosin‐trypsin inhibitors on boar spermatozoa as revealed by the indirect immunofluorescent staining techniques. Hoppe Seyler Z. Physiol. Chem. 356: 1473–1475, 1975.
 544. Schmell, E., and B. J. Gulyas. Mammalian sperm‐egg recognition and binding in vitro. I. Specificity of sperm interaction with live and fixed eggs in homologous and heterologous inseminations of hamster, mouse, and guinea pig oocytes. Biol. Reprod. 23: 1075–1085, 1980.
 545. Schoch, C., and R. Blumenthal. Role of the fusion peptide sequence in initial stages of influenza hemagglutinin‐induced cell fusion. J. Biol. Chem. 268: 9267–9274, 1993.
 546. Schroeder, A., and J. Eppig. The developmental capacity of mouse oocytes that matured spontaneously in vitro is normal. Dev. Biol. 102: 493–497, 1984.
 547. Schuel, H., Functions of egg cortical granules. In: Biology of Fertilization, edited by C. Metz, and A. Monroy, New York: Academic, 1985, vol. 3, p. 1–44.
 548. Schultz, R. M., Molecular aspects of mammalian oocyte growth and maturation. In: Experimental Approaches to Mammalian Embryonic Development, edited by J. Rossant, and R. A. Pedersen, Cambridge: Cambridge University, 1986, p. 195–237.
 549. Schultz, R. M., Meiotic maturation of mammalian oocytes. In: Elements of Mammalian Fertilization, Vol. 1, Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 77–104.
 550. Schultz, R. M., R. Montgomery, and J. Belanoff. Regulation of mouse oocyte meiotic maturation: implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Dev. Biol. 97: 264–273, 1983.
 551. Schultz, R. M., R. Montgomery, P. Ward‐Bailey, and J. Eppig. Regulation of oocyte maturation in the mouse: possible roles of intercellular communication, cAMP, and testosterone. Dev. Biol. 95: 294–304, 1983.
 552. Schultz, R. M., and P. M. Wassarman. Biochemical studies of mammalian oogenesis: protein synthesis during oocyte growth and meiotic maturation in the mouse. J. Cell Sci. 24: 167–194, 1977.
 553. Scully, N. F., J. H. Shaper, and B. D. Shur. Spatial and temporal expression of cell surface galactosyltrasferase during mouse spermatogenesis and epididymal maturation. Dev. Biol. 124: 111–124, 1987.
 554. Segall, G. K., and W. J. Lennarz. Chemical characterization of the component of the jelly coat from sea urchin eggs responsible for induction of the acrosome reaction. Dev. Biol. 71: 33–48, 1979.
 555. Segall, G. K., and W. J. Lennarz. Jelly coat and induction of the acrosome reaction in echinoid sperm. Dev. Biol. 86: 87–93, 1981.
 556. Shabanowitz, R. B. Mouse antibodies to human zona pellucida: evidence that human ZP3 is strongly immunogenic and contains two distinct isomer chains. Biol. Reprod. 43: 260–270, 1990.
 557. Shabanowitz, R. B., and M. G. O'Rand. Characterization of the human zona pellucida from fertilized and unfertilized eggs. J. Reprod. Fertil. 82: 151–161, 1988.
 558. Shalgi, R., J. D. Bleil, and P. M. Wassarman. Carbohydrate‐mediated sperm‐egg interactions in mammals. In: Advances in Assisted Reproductive Technologies, edited by Z. Ben‐Rafael. New York: Plenum, 1990, p. 437–441.
 559. Shalgi, R., R. Kaplan, L. Nebel, and P. F. Kraicer. The male factor in fertilization of rat eggs in vitro. J. Exp. Zool. 217: 399–4022, 1981.
 560. Shaper, N. L., G. F. Hollis, J. G. Douglas, I. R. Kirsch, and J. H. Shaper. Characterization of the full length cDNA for murine β−1,4‐galactosyltransferase. Novel features at the 5′‐end predict start sites at two in‐frame AUGs. J. Biol. Chem. 263: 10420–10428, 1988.
 561. Shaper, N. L., W. W. Wright, and J. H. Shaper. Murine β,4‐galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis. Proc. Natl. Acad. Sci. U.S.A. 87: 791–795, 1990.
 562. Sharon, N. Complex Carbohydrates: Their Chemistry, Biosynthesis, and Functions. Reading, MA: Addison‐Wesley, 1975, p. 466.
 563. Shivaji, S., and P. M. Bhargava. Antifertility factors of mammalian seminal fluids. Bioessays 7: 13–17, 1987.
 564. Shivaji, S., K. H. Scheit, and P. M. Bhargava. Proteins of Seminal Plasma. New York: Wiley, 1990.
 565. Short, R., The discovery of the ovaries. In: The Ovary, edited by S. Zuckerman, and B. Weir. New York: Academic, 1977, vol. 1, p. 1–41.
 566. Shur, B. D., and N. G. Hall. Sperm surface galactosyltransferase activities during in vitro capacitation. J. Cell Biol. 95: 567–573, 1982.
 567. Shur, B. D. and C. A. Neely. Plasma membrane association, purification, and partial characterization of mouse sperm β,4‐galactosyltransferase. J. Biol. Chem. 263: 17706–17714, 1988.
 568. Sieghart, W. GABAA receptors: ligand‐gated Cl− ion channels modulated by multiple drug‐binding sites. TIPS 13: 446–450, 1992.
 569. Singh, J. P., D. F. Babcock, and H. A. Lardy. Increased calciumion influx is a component of capacitation of spermatozoa. Biochem. J. 172: 549–556, 1978.
 570. Siracusa, G., M. De Felici, and A. Salustri. The proliferative and meiotic history of mammalian female germ cells. In: Biology of Fertilization, edited by C. Metz, and A. Monroy. New York: Academic, 1985, vol. 1, p. 253–298.
 571. Siracusa, G., D. Whittingham, M. Molinaro, and E. Vivarelli. Parthenogenetic activation of mouse oocytes induced by inhibitors of protein synthesis. J. Embryol. Exp. Morphol. 43: 157–166, 1978.
 572. Smith, D., and D. Tenney. Effect of steroids on mouse oocyte maturation in vitro. J. Reprod. Fertil. 60: 331–338, 1980.
 573. Smith, M. B., D. F. Babcock, and H. A. Lardy. A 31P‐NMR study of the epididymis and epididymal sperm of the bovine and hamster. Biol. Reprod. 33: 1029–1035, 1985.
 574. Snider, D. R., and E. D. Clegg. Alterations in phospholipids in porcine spermatozoa during in vivo uterus and oviduct incubation. J. Anim. Sci. 40: 269–273, 1975.
 575. Sollner, T., S. W. Whiteheart, M. Brunner, H. Erdjument‐Bromage, S. Geromanos, P. Tempst, and J. E. Rothman. SNAP receptors implicated in vesicle targeting and fusion. Nature 362: 318–324, 1993.
 576. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, B. G. Neel, R. B. Birge, J. E. Fajardo, M. M. Chau, H. Hanafusa, B. Schaffhausen, and L. C. Cantley. SH2 domains recognize specific phosphopeptide sequences. Cell 72: 767–778, 1993.
 577. Sorensen, R. A. Cinemicrography of mouse oocyte maturation utilizing Nomarski differential‐interference microscopy. Am. J. Anat. 136: 265–276, 1973.
 578. Sorensen, R. A., M. Cyert, and R. Pedersen. Active maturationpromoting factor is present in mature mouse oocytes. J. Cell. Biol. 100: 1637–1640, 1985.
 579. Sorensen, R. A., and P. M. Wassarman. Relationship between growth and meiotic maturation of the mouse oocyte. Dev. Biol. 50: 531–536, 1976.
 580. Speed, R. Meiosis in the foetal mouse ovary. 1. An analysis at the light microscope level using surface‐spreading. Chromosoma 85: 427–437, 1982.
 581. Spiteri‐Grech, J., and E. Nieschlag. Paracrine factors relevant to the regulations of spermatogenesis‐ a review. J. Reprod. Fertil. 98: 1–14, 1993.
 582. Spruce, A. E., L. Breckenridge, A. K. Lee, and W. Almers. Properties of the fusion pore that forms during exocytosis of a mast cell secretory vesicle. Neuron 4: 643–654, 1990.
 583. Spruce, A. E., A. Iwata, and W. Almers. The first milliseconds of the pore formed by a fusogenic viral envelope protein during membrane fusion. Proc. Natl. Acad. Sci. U.S.A. 88: 3623–3627, 1991.
 584. Spruce, A. E., A. Iwata, J. M. White, and W. Almers. Patch clamp studies of single cell‐fusion events mediated by a viral fusion protein. Nature 342: 555–558, 1989.
 585. Stafanini, M., C. Oura, and L. Zamboni. Ultrastructure of fertilization in the mouse. Penetration of the sperm into the ovum. J. Submicrosc. Cytol. 1: 1–23, 1969.
 586. Steinberger, E., and A. Steinberger. Spermatogenic function of the testis. In: Handbook of Physiology, Endocrinology, Male Reproductive System, edited by D. W. Hamilton, and R. O. Greep. Baltimore: Am. Physiol. Soc., 1975, sect. 7, vol. V, p. 1–19.
 587. Stengel, D., D. Henry, S. Tomova, A. Borsodi, and J. Hanoune. Purification of the proteolytically solubilized, active catalytic subunit of adenylate cyclase from ram sperm. Inhibition by adenosine. Eur. J. Biochem. 161: 241–247, 1986.
 588. Stern, S., J. D. Biggers, and E. Anderson. Mitochondria and early development of the mouse. J. Exp. Zool. 176: 179–192, 1971.
 589. Stevens, C. F. Quantal release of neurotransmitter and long‐term potentiation. Neuron 10: 55–63, 1993.
 590. Stice, S. L., and J. M. Robl. Activation of mammalian oocytes by a factor obtained from rabbit sperm. Mol. Endocrinol. 25: 272–280, 1990.
 591. Storey, B. T. Sperm capacitation and the acrosome reaction. Ann. NY Acad. Sci. 637: 459–473, 1991.
 592. Storey, B. T., C. L. Hourani, and J. B. Kim. A transient rise in intracellular Ca2+ is a precursor reaction to the zona pellucida‐induced acrosome reaction in mouse sperm and is blocked by the induced acrosome reaction inhibitor 3‐quinuclidinyl benzilate. Mol. Reprod. Dev. 32: 41–50, 1992.
 593. Storey, B. T., M. A. Lee, C. Muller, C. R. Ward, and D. G. Wirtshafter. Binding of mouse spermatozoa to the zona pellucida of mouse eggs in cumulus: evidence that the acrosomes remain substantially intact. Biol. Reprod. 31: 1119–1128, 1984.
 594. Strathmann, M., T. M. Wilkie, and M. I. Simon. Diversity of the G‐protein family: sequences from five additional a subunits in the mouse. Proc. Natl. Acad. Sci. U.S.A. 86: 7407–7409, 1989.
 595. Strathmann, M., T. M. Wilkie, and M. I. Simon. Alternative splicing produces transcripts; encoding two forms of the a subunit of GTP binding protein Go. Proc. Natl. Acad. Sci. U.S.A. 87: 6477–6481, 1990.
 596. Stroud, R. M., M. P. McCarthy, and M. Shuster. Nicotinic acetylcholine receptor superfamily of ligand‐gated ion channels. Biochemistry 29: 11009–11023, 1990.
 597. Struck, D. K., and W. J. Lennarz. The function of saccharidelipids in synthesis of glycoproteins. In: The Biochemistry of Glycoproteins and Proteoglycans, edited by W. J. Lennarz. New York: Plenum, 1980, p. 35–84.
 598. Suarez, S. S., D. P. Wolf, and S. Meizel. Induction of the acrosome reaction in human spermatozoa by a fraction of human follicular fluid. Gamete Res. 14: 107–121, 1986.
 599. Sudhof, T. C., and R. Jahn. Proteins of synaptic vesicles involved in exocytosis and membrane recycling. Neuron 6: 665–677, 1991.
 600. Summers, R. G., P. Talbot, E. M. Keough, B. L. Hylander, and L. E. Franklin. Ionophore A23187 induces acrosome reactions in sea urchin and guinea pig spermatozoa. J. Exp. Zool. 196: 381–385, 1976.
 601. Swann, K. A. cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster. Development 110: 1295–1302, 1990.
 602. Sym, M., J. Engebrecht, and G. S. Roeder. ZIP1 is a synatonemal complex protein required for meiotic chromosomal synapsis. Cell 72: 365–378, 1993.
 603. Szollosi, D., Changes of some cell organelles during oogenesis m mammals. In: Oogenesis, edited by J. Biggers, and A. Schuetz. Baltimore: University Park, 1972, p. 47–64.
 604. Szollosi, D., P. Calarco, and R. Donahue. The nuclear envelope: Its breakdown and fate in mammalian oogonia and oocytes. Anat. Rec. 174: 325–340, 1972.
 605. Szybek, K. In vitro maturation of oocytes from sexually immature mice. J. Endocrinol. 54: 527–528, 1972.
 606. Talbot, P. Sperm penetration through oocyte investments in mammals. Am. J. Anat. 174: 331–346, 1985.
 607. Talbot, P., G. Dicarlantonio, P. Zao, J. Penkala, and L. T. Haimo. Motile cells lacking hyaluronidase can penetrate the hamster oocyte cumulus complex. Dev. Biol. 108: 387–398, 1985.
 608. Tang, S., and T. Beeler. Optical response of the indicator chlortetracycline to membrane potential. Cell Calcium 11: 425–429, 1991.
 609. Tang, W.‐J., and A. G. Gilman. Type‐specific regulation of adenylyl cyclase by G protein βt subunits. Science 254: 1500–1503, 1991.
 610. Tarentino, A. L., C. M. Gomez, and T. H. Plummer, Jr.. Deglycosylation of asparagine‐linked glycans by peptide: N‐glycosidase F. Biochemistry 24: 4665–4671, 1985.
 611. Tash, J. S., M. Krinks, J. Patel, R. L. Means, C. B. Klee, and A. R. Means. Identification, characterization, and functional correlation of calmodulin‐dependent protein phosphatase in sperm. J. Cell Biol. 106: 1625–1633, 1988.
 612. Tesarik, J., A. Carreras, and C. Mendoza. Differential sensitivity of progesterone‐ and zona pellucida‐induced acrosome reactions to pertussis toxin. Mol. Reprod. Dev. 34: 183–189, 1993.
 613. Thibault, C., Final stages of mammalian oocyte maturation. In: Oogenesis, edited by J. Biggers, and A. Schuetz. Baltimore: University Park, 1972, p. 397–411.
 614. Thomas, P., and S. Meizel. An influx of extracellular calcium is required for initiation of the human sperm acrosome reaction induced by human follicular fluid. Gamete Res. 20: 397–411, 1988.
 615. Thomas, P., and S. Meizel. Phosphatidylinositol 4,5‐biphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx. Biochem. J. 264: 539–546, 1989.
 616. Thomas, R. C. Bicarbonate and pHi response. Nature 337: 601, 1989.
 617. Thomas, T. S., W. L. Wilson, A. B. Reynolds, and G. Oliphant. Chemical and physical characterization of rabbit sperm acrosomal stabilizing factor. Biol. Reprod. 35: 691–700, 1986.
 618. Tilney, L. G., D. Kiehart, C. Sardet, and M. Tilney. The polymerization of actin. IV. The role of Ca2+ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm. J. Cell Biol. 77: 536–550, 1978.
 619. Trejo, R., and A. Mujica. Changes in calmodulin compartmentalization throughout capacitation and acrosome reaction in guinea pig spermatozoa. Mol. Reprod. Dev. 26: 366–376, 1990.
 620. Triana, L. R., D. F. Babcock, S. P. Lorton, N. L. First, and H. A. Lardy. Release of acrosomal hyaluronidase follows increased membrane permeability to calcium in the presumptive capacitation sequence for spermatozoa of the bovine and other mammalian species. Biol. Reprod. 23: 47–59, 1980.
 621. Triggle, D. J., and D. Rampe. 1,4‐Dihydropyridine activators and antagonists: structural and functional distinctions. TIPS 10: 507–511, 1989.
 622. Tsafriri, A., Oocyte maturation in mammals. In: The Vertebrate Ovary, edited by R. Jones. NY: Plenum, 1978, p. 409–442.
 623. Tsafriri, A., The control of meiotic maturation in mammals. In: Biology of Fertilization, edited by C. Metz, and A. Monroy. New York: Academic, 1985, vol. 1, p. 221–252.
 624. Tsafriri, A., and S. Bar‐Ami. Role of divalent cations in the resumption of meiosis in rat oocytes. J. Exp. Zool. 205: 293–300, 1978.
 625. Tsafriri, A., S. Bar‐Ami, and H. Lindner. Control of the development of meiotic competence and of oocyte maturation in mammals. In: Fertilization of the Human Egg In Vitro, edited by H. Beier, and H. Lindner. Berlin: Springer‐Verlag, 1983, p. 3–17.
 626. Tsafriri, A., and C. Channing. An inhibitory influence of granulosa cells and follicular fluid upon porcine oocyte meiosis in vitro. Endocrinology 96: 992, 1975.
 627. Tsafriri, A., C. Channing, S. Pomerantz, and H. Lindner. Inhibition of maturation of isolated rat oocytes by porcine follicular fluid. J. Endocrinol. 75: 258–291, 1977.
 628. Tsafriri, A., N. Dekel, and S. Bar‐Ami. The role of oocyte maturation inhibitor in follicular regulation of oocyte maturation. J. Reprod. Fertil. 64: 541–551, 1982.
 629. Tsafriri, A., S. Pomerantz, and C. Channing. Inhibition of oocyte maturation by porcine follicular fluid: partial characterization of the inhibitor. Biol. Reprod. 14: 511–516, 1976.
 630. Tsien, R. W., Fluorescent indicators of ion concentration. In: Fluorescence Microscopy of Living Cells in Culture. Part B: Quantitative Fluorescence Microscopy—Imaging and Spectroscopy, edited by D. L. Taylor, and Y.‐L. Wang. New York: Academic, 1989, p. 127–156.
 631. Tsien, R. W., P. T. Ellinor, and W. A. Home. Molecular diversity of voltage‐dependent Ca2+ channels. TIPS 12: 349–354, 1991.
 632. Tsunoda, Y., and M. C. Chang. In vitro fertilization of hamster eggs by ejaculated or epididymal spermatozoa in the presence of male accessory secretions. J. Exp. Zool. 201: 445–450, 1977.
 633. Ullrich, A., and J. Schlessinger. Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203–212, 1990.
 634. Unwin, N. Neurotransmitter action: opening of ligand‐gated ion channels. Neuron 10: 31–41, 1993.
 635. Urch, U. A., Biochemistry and function of acrosin. In: Elements of Mammalian Fertilization. Vol. I. Basic Concepts, edited by P. M. Wassarman. Boca Raton, FL: CRC, 1991, p. 233–248.
 636. Urner, F., W. Herrmann, E. Baulieu, and S. Schorderet‐Slatkine. Inhibition of denuded mouse oocyte maturation of forskolin, an activator of adenylate cyclase. Endocrinology 113: 1170–1172, 1983.
 637. Van Blerkom, J., and R. McGaughey. Molecular differentiation of the rabbit ovum. II. During the preimplantation development of in vivo and in vitro matured oocytes. Dev. Biol. 63: 151–164, 1978.
 638. Van Blerkom, J., and P. Motta. The Cellular Basis of Mammalian Reproduction. Baltimore: Urban & Schwarzenberg, 1979.
 639. Vanha‐Perttula, T., and J. Kasurinen. Purification and characterization of phosphatidylinositol‐specific phospholipase C from bovine spermatozoa. Int. J. Biochem. 21: 997–1007, 1989.
 640. Varner, D. D., C. R. Ward, B. T. Storey, and R. M. Kenney. Induction and characterization of acrosome reaction in equine sperm. Am. J. Vet. Res. 48: 1383–1389, 1987.
 641. Vazquez, M. H., D. M. Phillips, and P. M. Wassarman. Interaction of mouse sperm with purified sperm receptors covalently linked to silica beads. J. Cell Sci. 92: 713–722, 1989.
 642. Vernon, R. B., M. S. Hamilton, and E. M Eddy. Effect of in vivo and in vitro environments on the expression of a surface antigen of the mouse sperm tail. Biol. Reprod. 99: 404–411, 1973.
 643. Von Heijne, G. A new method for predicting signal sequence cleavage sites. Nucleic Acids Res. 14: 4683–4690, 1986.
 644. Wagner, S., J. Freudenstein, and K. H. Scheit. Characterization by cDNA cloning of the mRNA for seminalplasmin, the major basic protein of bull semen. DNA Cell Biol. 9: 437–442, 1990.
 645. Wallace, B. A. Gramicidin channels and pores. Annu. Rev. Biophys. Biophys. Chem. 19: 127–157, 1990.
 646. Ward, C. R., and B. T. Storey. Determination of the time course of capacitation in mouse spermatozoa using a chlortetracycline fluorescence assay. Dev. Biol. 104: 287–296, 1984.
 647. Ward, C. R., B. T. Storey, and G. S. Kopf. Activation of a Gi protein in mouse sperm membranes by solubilized proteins of the zona pellucida, the egg's extracellular matrix. J. Biol. Chem. 267: 14061–14067, 1992.
 648. Wasco, W. M., R. L. Kincaid, and G. A. Orr. Identification and characterization of calmodulin‐binding proteins in mammalian sperm flagella. J. Biol. Chem. 264: 5104–5111, 1989.
 649. Wassarman, P. M., Oogenesis: synthetic events in the developing mammalian egg. In: Mechanism and Control of Animal Fertilization, edited by J. Hartmann. New York: Academic, 1983, p. 1–54.
 650. Wassarman, P. M. Early events in mammalian fertilization. Annu. Rev. Cell Biol. 3: 109–142, 1987.
 651. Wassarman, P. M. The biology and chemistry of fertilization. Science 235: 553–560, 1987.
 652. Wassarman, P. M. Zona pellucida glycoproteins. Annu. Rev. Biochem. 57: 415–442, 1988.
 653. Wassarman, P. M., The mammalian ovum. In: The Physiology of Reproduction, edited by E. Knobil, and J. Neill. New York: Raven Press, 1988, p. 69–102.
 654. Wassarman, P. M., Role of carbohydrates in receptor‐mediated fertilization in mammals. In: Carbohydrate Recognition in Cellular Function, edited by G. Bock, and S. Harnett, New York: Wiley, 1989, p. 135–155.
 655. Wassarman, P. M. Profile of a mammalian sperm receptor. Development 108: 1–17, 1990.
 656. Wassarman, P. M., Cell surface carbohydrates and mammalian fertilization. In: Cell Surface Carbohydrates and Cell Development, edited by M. Fukuda. Boca Raton, FL: CRC, 1991, p. 215–238.
 657. Wassarman, P. M. (Ed). Elements of Mammalian Fertilization. Boca Raton, FL: CRC, 1991, vol. 1 p. 310, vol. 2 p. 183.
 658. Wassarman, P. M. Mammalian fertilization: sperm receptor genes and glycoproteins. Adv. Dev. Biochem. 2: 155–195, 1993.
 659. Wassarman, P. M., J. D. Bleil, H. M. Florman, J. M. Greve, R. J. Roller, G. S. Salzmann, and F. G. Samuels. The mouse egg's receptor for sperm: what is it and how does it work? Cold Spring Harb. Symp. Quant. Biol. 50: 11–19, 1985.
 660. Wassarman, P. M., and M. L. Depamphilis (Eds). Guide to Techniques in Mouse Development, Methods in Enzymology. Orlando, FL: Academic, 1993, vol. 225.
 661. Wassarman, P. M., and K. Fujiwara. Immunofluorescent antitubulin staining of spindles during meiotic maturation of mouse oocytes in vitro. J. Cell Sci. 29: 171–188, 1978.
 662. Wassarman, P. M., and W. Josefowicz. Oocyte development in the mouse: an ultrastructural comparison of oocytes isolated at various stages of growth and meiotic competence. J. Morphol. 156: 209–235, 1978.
 663. Wassarman, P. M., W. Josefowicz, and G. Letourneau. Meiotic maturation of mouse oocytes in vitro: inhibition of maturation at specific stages of nuclear progression. J. Cell Sci. 22: 531–545, 1976.
 664. Wassarman, P. M., and S. Mortillo. Structure of the mouse egg extracellular coat, the zona pellucida. Int. Rev. Cytol. 130: 85–110, 1991.
 665. Wassarman, P. M., R. Schultz, G. Letourneau, M. Lamarca, and J. Bleil. Meiotic maturation of mouse oocytes in vitro. In: Ovarian Follicular and Corpus Luteum Function, edited by C. Channing, J. Marsh, and W. Sadler. New York: Plenum, 1979, p. 251–268.
 666. Weil, A. J., and J. M. Rodenburg. The seminal vesicle as the source of the spermatozoa coating antigen of seminal plasma. Proc. Soc. Exp. Biol. Med. 109: 567–570, 1962.
 667. Weiss, A. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein‐tyrosine kinases. Cell 73: 209–212, 1993.
 668. Whitaker, M. and K. Swann. Lighting the fuse at fertilization. Development 117: 1–12, 1993.
 669. White, D. R., and R. J. Aitken. Relationship between calcium, cyclic AMP, ATP, and intracellular pH and the capacity of hamster spermatozoa to express hyperactivated motility. Gamete Res. 22: 163–177, 1989.
 670. White, J. M. Viral and cellular membrane fusion proteins. Annu. Rev. Physiol. 52: 675–697, 1990.
 671. White, J. M. Membrane fusion. Science 258: 917–924, 1992.
 672. Wickramasinghe, D., and D. F. Albertini. Centrosome phosphorylation and the developmental expression of meiotic competence in mouse oocytes. Dev. Biol. 152: 62–74, 1992.
 673. Wickramasinghe, D., K. M. Ebert, and D. F. Albertini. Meiotic competence acquisition is associated with the appearance of M‐phase characteristics in growing mouse oocytes. Dev. Biol. 143: 162–172, 1991.
 674. Wilde, M. W., C. R. Ward, and G. S. Kopf. Activation of a G protein in mouse sperm by the zona pellucida, an egg‐associated extracellular matrix. Mol. Reprod. Dev. 31: 297–306, 1992.
 675. Williams, C. J., R. M. Schultz, and G. S. Kopf. Role of G proteins in mouse egg activation: stimulatory effects of acetylcholine on the ZP2 to ZP2f conversion and pronuclear formation in eggs expressing a functional m1 muscarinic receptor. Dev. Biol. 151: 288–296, 1992.
 676. Wilson, D. W., S. W. Whiteheart, L. Orci, and J. E. Rothman. Intracellular membrane fusion. Trends Biochem. Sci. 16: 334–337, 1991.
 677. Wilson, E. The Cell in Development and Heredity. New York: Macmillan, 1925.
 678. Wilson, I.B.H., Y. Gavel, and G. Von Heijne. Amino acid distributions around O‐linked glycosylation sites. Biochem. J. 275: 529–534, 1991.
 679. Wilson, W. L., and G. Oliphant. Isolation and biochemical characterization of the subunits of the rabbit sperm acrosome stabilizing factor. Biol. Reprod. 37: 159–169, 1987.
 680. Wolf, D. E., S. S. Hagopian, and S. Isojima. Changes in sperm plasma membrane lipid diffusibility after hyperactivation during in vitro capacitation in the mouse. J. Cell Biol. 102: 1372–1380, 1986.
 681. Wolf, D. E., S. S. Hagopian, R. G. Lewis, J. K. Voglmayr, and G. Fairbanks. Lateral regionalization and diffusion of a maturation‐dependent antigen in the ram sperm plasma membrane. J. Cell Biol. 102: 1826–1831, 1986.
 682. Wolf, D. E., A. C. Lipscomb, and V. M. Maynard. Causes of nondiffusing lipid in the plasma membrane of mammalian spermatozoa. Biochemistry 27: 860–865, 1988.
 683. Wolf, D. E., V. M. Maynard, C. A. McKinnon, and D. L. Melchior. Lipid domains in the ram sperm plasma membrane demonstrated by differential scanning calorimetry. Proc. Natl. Acad. Sci. U.S.A. 87: 6893–6896, 1990.
 684. Wolf, D. E., B. K. Scott, and C. F. Millette. The development of regionalized lipid diffusibility in the germ cell plasma membrane during spermatogenesis in the mouse. J. Cell Biol. 103: 1745–1750, 1986.
 685. Wolf, D. E., and J. K. Voglmayr. Diffusion and regionalization in membranes of maturing ram spermatozoa. J. Cell Biol. 98: 1678–1684, 1984.
 686. Wolfes, H., K. Kogawa, C. F. Millette, and G. M. Cooper. Specific expression of nuclear proto‐oncogenes before entry into meiotic prophase of spermatogenesis. Nature 245: 740–743, 1989.
 687. Wolgemuth, D., G. Jagiello, and A. Henderson. Baboon late diplotene oocytes contain micronucleoli and a low level of extra rDNA templates. Dev. Biol. 78: 598–604, 1980.
 688. Wong, P.Y.D., and W. M. Lee. Potassium movement during sodium‐induced motility initiation in the rat cauda epididymal spermatozoa. Biol. Reprod. 28: 206–212, 1983.
 689. Wong, P.Y.D., W. M. Lee, and A.Y.S. Tsang. The effects of extracellular sodium on acid release and motility initiation in rat caudal epididymal spermatozoa in vitro. Exp. Cell Res. 131: 97–103, 1981.
 690. Wooding, F.B.P. Studies on the mechanism of the Hyamine‐induced acrosome reaction in ejaculated bovine spermatozoa. J. Reprod. Fertil. 44: 185–195, 1975.
 691. Working, P. K., and S. Meizel. Evidence that an ATPase functions in the maintenance of the acidic pH of the hamster sperm acrosome. J. Biol. Chem. 256: 4708–4711, 1981.
 692. Working, P. K., and S. Meizel. Preliminary characterization of a Mg2+‐ATPase in hamster sperm head membranes. Biochem. Biophys. Res. Commun. 104: 1060–1065, 1982.
 693. Working, P. K., and S. Meizel. Correlation of increased intraacrosomal pH with the hamster sperm acrosome reaction. J. Exp. Zool. 227: 97–107, 1983.
 694. Wylie, C. (Ed). Germ cell development. Semin. Dev. Biol. 4: 1993.
 695. Yanagimachi, R. Acceleration of the acrosome reaction and activation of guinea pig spermatozoa by detergents and other reagents. Biol. Reprod. 13: 519–526, 1975.
 696. Yanagimachi, R., The specificity of sperm‐egg interaction. In: Immunobiology of Gametes, edited by M. Edinin, and M. H. Johnson. Cambridge: Cambridge University, 1977, p. 255–295.
 697. Yanagimachi, R., Mechanisms of fertilization in mammals. In: Fertilization and Embryonic Development In Vitro, edited by L. Mastroianni, and J. D. Biggers. New York: Plenum, 1981, p. 81–182.
 698. Yanagimachi, R. Zona‐free hamster eggs: their use in assessing fertilizing capacity and examining chromosomes of human spermatozoa. Gamete Res. 10: 187–232, 1984.
 699. Yanagimachi, R., Mammalian fertilization. In: The Physiology of Reproduction, edited by E. Knobil, and J. Neill. New York: Raven, 1988, p. 135–185.
 700. Yanagimachi, R., and A. Bhattacharyya. Acrosome‐reacted guinea pig spermatozoa become fusion competent in the presence of extracellular potassium ions. J. Exp. Zool. 248: 354–360, 1988.
 701. Yanagimachi, R., and Y. D. Noda. Electron microscopic studies of sperm incorperation into golden hamster eggs. Am. J. Anat. 128: 429–462, 1970.
 702. Yanagimachi, R., and Y. D. Noda. Physiological changes in the postnuclear cap region of mammalian spermatozoa: a necessary preliminary in the membrane fusion between sperm and egg cells. J. Ultrastr. Res. 31: 486–493, 1970.
 703. Yanagimachi, R., and D. M. Phillips. The status of acrosomal caps of hamster spermatozoa immediately before fertilization in vivo. Gamete Res. 9: 1–19, 1984.
 704. Yanagimachi, R., and N. Usui. Calcium dependence of the acrosome reaction and activation of guinea pig spermatozoa. Exp. Cell Res. 89: 161–174, 1974.
 705. Young, R. J., and J. C. Laing. The binding characteristics of cholinergic sites in rabbit spermatozoa. Mol. Reprod. Dev. 28: 55–61, 1991.
 706. Yudin, A. I., W. Gottlieb, and S. Meizel. Ultrastructural studies of the early events of the human sperm acrosome reaction as initiated by human follicular fluid. Gamete Res. 20: 11–24, 1988.
 707. Yurewicz, E. C. B. A. Pack, and A. G. Sacco. Isolation, composition, and biological activity of sugar chains of porcine oocyte zona pellucida 55K glycoproteins. Mol. Reprod. Dev. 30: 126–134, 1991.
 708. Yurewicz, E. C., A. G. Sacco, and M. G. Subramanian. Structural characterization of the Mr = 55,000 antigen (ZP3) of porcine oocyte zona pellucida. J. Biol. Chem. 262: 564–571, 1987.
 709. Zamboni, L. Ultrastructure of mammalian oocytes and ova. Biol. Reprod. (Suppl.) 2: 44–63, 1970.
 710. Zamboni, L., Comparative studies on the ultrastructure of mammalian oocytes. In: Oogenesis, edited by J. Biggers, and A. Schuetz, Baltimore: University Park, 1972, p. 5–46.
 711. Zamboni, L., Fertilization in the mouse. In: Biology of fertilization and implantation, edited by K. S. Moghissi, and E.S.E. Hafez. Springfield, IL: Charles C Thomas, 1972, p. 213–262.
 712. Zao, P.Z.R., S. Meizel, and P. Talbot. Release of hyaluronidase and β‐N‐acetylhexosaminidase during in vitro incubation of hamster sperm. J. Exp. Zool. 234: 63–74, 1985.
 713. Zhou, R., B. Shi, K.C.K. Chou, M. D. Oswalt, and A. Haug. Changes in intracellular calcium of porcine sperm during in vitro incubation with seminal plasma and a capacitating medium. Biochem. Biophys. Res. Commun. 172: 47–53, 1990.
 714. Zimmerberg, J., M. Curran, F. S. Cohen, and M. Brodwick. Simultaneous electrical and optical measurements show that membrane fusion precedes secretory granule swelling during exocytosis of beige mouse mast cells. Proc. Natl. Acad. Sci. U.S.A. 84: 1585–1589, 1987.
 715. Zuckerman, S. (Ed). The Ovary. New York: Academic, 1962, vol. 1.
 716. Zuckerman, S., and T. Baker. The development of the ovary and the process of oogenesis. In: The Ovary, edited by S. Zuckerman, and B. Weir. New York: Academic, 1977, vol. 1, p. 42–68.
 717. Zuckerman, S., and B. Weir (Eds). The Ovary. New York: Academic, 1977.

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Paul M. Wassarman, Harvey M. Florman. Cellular Mechanisms During Mammalian Fertilization. Compr Physiol 2011, Supplement 31: Handbook of Physiology, Cell Physiology: 885-938. First published in print 1997. doi: 10.1002/cphy.cp140124