Comprehensive Physiology Wiley Online Library

Cellular Mechanisms During Mammalian Fertilization

Full Article on Wiley Online Library


The sections in this article are:

1 General Introduction
2 Oogenesis and Spermatogenesis
2.1 Oogenesis: Primordial Germ Cells to Eggs
2.2 Spermatogenesis: Primordial Germ Cells to Spermatozoa
3 Final Preparation of Gametes for Fertilization
3.1 Eggs: “Meiotic Maturation”
3.2 Regulatory Aspects of Oocyte Maturation
3.3 Sperm: “Capacitation”
3.4 Sperm Activity States
4 Binding of Sperm to Eggs
4.1 Structure of the Zona Pellucida
4.2 Identification of a Mammalian Sperm Receptor
4.3 Other Mammalian Sperm Receptors
5 The Acrosome Reaction
5.1 Anatomy of the Acrosome
5.2 Stages of Exocytosis
5.3 Functions of the Acrosome Reaction during Fertilization
5.4 Site of the Acrosome Reaction
5.5 Mechanisms of the Acrosome Reaction
5.6 Initiators of Exocytosis
5.7 Conclusions
5.8 Signaling at the Sperm Plasma Membrane
5.9 Mediators of Receptor‐Activated Second‐Messenger Production in Sperm
5.10 Second‐Messenger Production
5.11 Ca2+ and Ca2+ Channels
5.12 Internal pH
5.13 Downstream Effectors of Receptor Activation
5.14 Gamete Fusion and Cortical Granule Exocytosis
5.15 Cortical Granules
5.16 Gamete Membrane Fusion and the Receptor Question
5.17 From Oolemma to Cortical Granule—Signal Transduction Pathways
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Paul M. Wassarman, Harvey M. Florman. Cellular Mechanisms During Mammalian Fertilization. Compr Physiol 2011, Supplement 31: Handbook of Physiology, Cell Physiology: 885-938. First published in print 1997. doi: 10.1002/cphy.cp140124